Survey of common eye diseases in laboratory mouse strains.

abstract：Purpose:We investigated the cross-sectional associations between macular pigment optical density (MPOD), plasma lutein (L), and zeaxanthin (Z) concentrations and cognitive function in 184 older adults of the 3-City-Bordeaux cohort. Methods:MPOD was measured using the two-wavelength autofluorescence method with a modif...

journal_title：Investigative ophthalmology & visual science

authors： Ajana S,Weber D,Helmer C,Merle BM,Stuetz W,Dartigues JF,Rougier MB,Korobelnik JF,Grune T,Delcourt C,Féart C

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:To determine the association between ocular dominance and spherical or astigmatic anisometropia, age, and sex. METHODS:Medical records of 10,264 myopic refractive surgery candidates were filtered. Ocular dominance was assessed with the hole-in-the-card test. Manifest refractive error was measured in each subje...

journal_title：Investigative ophthalmology & visual science

authors： Linke SJ,Baviera J,Munzer G,Steinberg J,Richard G,Katz T

更新日期：2011-11-25 00:00:00

abstract：PURPOSE:The RAS association domain family 1 (RASSF1) gene is a tumor-suppressor gene located on chromosome 3p21.3. The alternative transcript (RASSF1a) has been shown to be inactivated by hypermethylation in several human malignancies, including breast, prostate, and lung cancer, and in cutaneous melanoma. The purpose ...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,van der Velden PA,Out-Luiting C,Plug M,Dirks-Mulder A,Jager MJ,Gruis NA

更新日期：2007-02-01 00:00:00

abstract：:Diabetes mellitus has been shown to be a factor in the development of corneal epithelial abnormalities in stressed human eyes, but the biochemical basis for this is not known. To see if sorbitol pathway activation might be involved, ocular surface epithelial healing rates and metabolites of the glycolytic and sorbitol...

journal_title：Investigative ophthalmology & visual science

authors： Friend J,Kiorpes TC,Thoft RA

更新日期：1981-08-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine the test-retest repeatability of microperimetric sensitivity at the border of deep scotomas. METHODS:Thirty normal participants underwent two examinations, each on the Macular Integrity Assessment (MAIA) microperimeter and on the MP-1 microperimeter (four examinations i...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Jung CJ,Ayton LN,Luu CD,Guymer RH

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Visual sensations in patients with blindness and retinal degenerations may be restored by electrical stimulation of retinal neurons with implantable microelectrode arrays. A prospective trial was initiated to evaluate the safety and efficacy of a wireless intraocular retinal implant (EPIRET3) in six volunteers ...

journal_title：Investigative ophthalmology & visual science

authors： Roessler G,Laube T,Brockmann C,Kirschkamp T,Mazinani B,Goertz M,Koch C,Krisch I,Sellhaus B,Trieu HK,Weis J,Bornfeld N,Röthgen H,Messner A,Mokwa W,Walter P

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:To compare the risk factors for bilateral and unilateral disease in normal-tension glaucoma (NTG). METHODS:The study analyzed data from consecutive NTG patients with either bilateral (n = 194) or unilateral (n = 193) disease. Multivariate regression models were used to evaluate the following potential risk fac...

journal_title：Investigative ophthalmology & visual science

authors： Kim C,Kim TW

更新日期：2009-03-01 00:00:00

abstract：:Purpose. Super-selective intra-ophthalmic artery chemotherapy (SSIOAC) is an eye-targeted drug-delivery strategy to treat retinoblastoma, the most prevalent primary ocular malignancy in children. Unfortunately, recent clinical reports associate adverse vascular toxicities with SSIOAC using melphalan, the most commonly...

journal_title：Investigative ophthalmology & visual science

authors： Steinle JJ,Zhang Q,Thompson KE,Toutounchian J,Yates CR,Soderland C,Wang F,Stewart CF,Haik BG,Williams JS,Jackson JS,Mandrell TD,Johnson D,Wilson MW

更新日期：2012-04-30 00:00:00

abstract：PURPOSE:The association of age and blood pressure (BP) with retinal vessel change is widely reported, with inverse relationships between retinal arteriolar and venular diameter and increasing age and elevated BP. No previous studies have dissected the separate effects of age and BP on the diameter of retinal vessels. ...

journal_title：Investigative ophthalmology & visual science

authors： Kaushik S,Kifley A,Mitchell P,Wang JJ

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:To investigate the role of N-cadherin and hepatocyte growth factor (HGF) in the invasion of collagen type I by human retinal pigment epithelial (RPE) cells. METHODS:RPE sheets from eight human eyes were used for characterization through Western blot analysis of the expression of cadherin in total lysates or af...

journal_title：Investigative ophthalmology & visual science

authors： Van Aken EH,De Wever O,Van Hoorde L,Bruyneel E,De Laey JJ,Mareel MM

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:Bacillus cereus causes one of the most rapidly blinding forms of bacterial endophthalmitis. Migration of B. cereus throughout the eye during endophthalmitis is a unique aspect of this disease that may contribute to intraocular virulence. This study was conducted to analyze the contribution of swarming and intra...

journal_title：Investigative ophthalmology & visual science

authors： Callegan MC,Novosad BD,Ramirez R,Ghelardi E,Senesi S

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To determine quantitatively forward light scattering in the human lens as a function of depth. To use this to explain the psychophysical result, verified earlier in vitro, showing total light scattering in the human lens to decrease with scattering angle according to an approximate power law (power -2). METHOD...

journal_title：Investigative ophthalmology & visual science

authors： van den Berg TJ

更新日期：1996-05-01 00:00:00

abstract：PURPOSE:To determine global mRNA expression levels in corneal and conjunctival epithelia and identify transcripts that exhibit preferential tissue expression. METHODS:cDNA samples derived from human conjunctival and corneal epithelia were hybridized in three independent experiments to a commercial oligonucleotide arra...

journal_title：Investigative ophthalmology & visual science

authors： Turner HC,Budak MT,Akinci MA,Wolosin JM

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS:Clinical isolates from 2001 to 2010 were analy...

journal_title：Investigative ophthalmology & visual science

authors： Shen EP,Tsay RY,Chia JS,Wu S,Lee JW,Hu FR

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:To engineer a knockin mouse model that can be used to monitor the effects of treatments on degradation and mislocalization of proline-to-histidine change at codon 23 (P23H) rhodopsin, a common cause of autosomal dominant retinitis pigmentosa (ADRP). The goal was to introduce a gene that expressed rhodopsin at l...

journal_title：Investigative ophthalmology & visual science

authors： Price BA,Sandoval IM,Chan F,Simons DL,Wu SM,Wensel TG,Wilson JH

更新日期：2011-12-28 00:00:00

abstract：:Plasminogen activator (PA) activity during epithelial wound healing in vitamin A-deficient rats was investigated to determine whether a relationship exists between corneal defect formation and PA activity. Uniform, central 3 mm diameter corneal epithelial wounds were made by scalpel debridement in vitamin A-deficient ...

journal_title：Investigative ophthalmology & visual science

authors： Hayashi K,Frangieh G,Kenyon KR,Berman M,Wolf G

更新日期：1988-12-01 00:00:00

abstract：PURPOSE:To understand the involvement of the CYP1B1 gene in cases of primary open-angle (POAG) and primary angle-closure (PACG) glaucomas and obtain the haplotype background of these mutations. METHODS:The entire coding region of CYP1B1 was screened by resequencing in 224 unrelated cases of POAG (n = 134) and PACG (n ...

journal_title：Investigative ophthalmology & visual science

authors： Chakrabarti S,Devi KR,Komatireddy S,Kaur K,Parikh RS,Mandal AK,Chandrasekhar G,Thomas R

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:Neovascular age-related macular degeneration (AMD) resulting in decreased central vision severely impairs affected individuals. Current standard treatment is an intravitreal anti-VEGF therapy (ranibizumab), but responses to treatment show large variability. Genetic factors that influence AMD and that affect the...

journal_title：Investigative ophthalmology & visual science

authors： Kloeckener-Gruissem B,Barthelmes D,Labs S,Schindler C,Kurz-Levin M,Michels S,Fleischhauer J,Berger W,Sutter F,Menghini M

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:Intramuscular innervation of horizontal rectus extraocular muscle (EOMs) is segregated into superior and inferior (transverse) compartments, whereas all EOMs are also divided into global (GL) and orbital (OL) layers with scleral and pulley insertions, respectively. Mechanical independence between both types of ...

journal_title：Investigative ophthalmology & visual science

authors： Shin A,Yoo L,Demer JL

更新日期：2014-12-11 00:00:00

abstract：Purpose:To accelerate the development of new therapies, an inherited retinal degeneration model in a nonhuman primate would be useful to confirm the efficacy in preclinical studies. In this study, we describe the discovery of retinitis pigmentosa in a cynomolgus monkey (Macaca fascicularis) pedigree. Methods:First, sc...

journal_title：Investigative ophthalmology & visual science

authors： Ikeda Y,Nishiguchi KM,Miya F,Shimozawa N,Funatsu J,Nakatake S,Fujiwara K,Tachibana T,Murakami Y,Hisatomi T,Yoshida S,Yasutomi Y,Tsunoda T,Nakazawa T,Ishibashi T,Sonoda KH

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：PURPOSE:Migration of Müller glial cells is enhanced in proliferative retinopathies, but the mechanisms involved are ill defined. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid synthesized by sphingosine kinase (SphK), which promotes proliferation, migration, and inflammation, acting as an intracellular media...

journal_title：Investigative ophthalmology & visual science

authors： Simón MV,Prado Spalm FH,Politi LE,Rotstein NP

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:Previous studies assessed the associations between Helicobacter pylori infection and open-angle glaucoma (OAG) and produced inconsistent results. Therefore, we performed a meta-analysis to evaluate the effects of H. pylori infection on OAG risk. METHODS:Relevant studies that reported the associations between H...

journal_title：Investigative ophthalmology & visual science

authors： Zeng J,Liu H,Liu X,Ding C

更新日期：2015-08-01 00:00:00

abstract：Purpose:Rapid identification of pathogens causing endophthalmitis may improve treatment outcomes through early administration of species-specific medication. The current study reports a new molecular application of peptide nucleic acid-fluorescence in situ hybridization (PNA-FISH) with Staphylococcus-specific molecular...

journal_title：Investigative ophthalmology & visual science

authors： Patel N,Miller D,Relhan N,Flynn HW Jr

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To report the impact of intravitreous bevacizumab therapy on contrast sensitivity in patients with neovascular age-related macular degeneration (nAMD). METHODS:This was a prospective, multicenter, double-masked, randomized, controlled trial of 131 patients with nAMD. The patients with nAMD had received intravi...

journal_title：Investigative ophthalmology & visual science

authors： Patel PJ,Chen FK,Da Cruz L,Rubin GS,Tufail A,ABC Trial Study Group.

更新日期：2011-05-11 00:00:00

abstract：PURPOSE:This study was designed to investigate the suppressive effects of antithrombin (AT)III on inflammatory reactions during endotoxin-induced uveitis (EIU) in rats by studying leukocyte-endothelium interactions. METHODS:EIU was induced in Lewis rats by footpad injection of lipopolysaccharide (LPS). ATIII was admin...

journal_title：Investigative ophthalmology & visual science

authors： Yamashiro K,Kiryu J,Tsujikawa A,Honjo M,Nonaka A,Miyamoto K,Honda Y,Tanihara H,Ogura Y

更新日期：2001-06-01 00:00:00

abstract：Purpose:To determine if there is structural and functional recovery of the retina from light induced retinal degeneration, and to evaluate the role of the oxidative stress response elements Nrf2, SOD1, DJ-1, and Parkin in such a recovery process. Methods:Eyes from C57BL/6J (B6J) mice and from oxidative stress response...

journal_title：Investigative ophthalmology & visual science

authors： Chen B,Aredo B,Zhu Y,Ding Y,Xin-Zhao C,Ufret-Vincenty RL

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:High intraocular pressure (IOP) is a major risk factor for glaucoma, one of the leading causes of blindness worldwide. Because it has been demonstrated that African populations are at increased risk for glaucoma, the authors investigated the genetic basis of IOP in a sample of West Africans with type 2 diabetes...

journal_title：Investigative ophthalmology & visual science

authors： Rotimi CN,Chen G,Adeyemo AA,Jones LS,Agyenim-Boateng K,Eghan BA Jr,Zhou J,Doumatey A,Lashley K,Huang H,Fasanmade O,Akinsola FB,Ezepue F,Amoah A,Akafo S,Chen Y,Oli J,Johnson T

更新日期：2006-08-01 00:00:00

abstract：Purpose:We investigated whether fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa display a disease-specific lifetime pattern. Methods:Fundus autofluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in two spectral channels (498-560 and 560-720 nm) after excitation with a 473 n...

journal_title：Investigative ophthalmology & visual science

authors： Dysli C,Schuerch K,Escher P,Wolf S,Zinkernagel MS

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible blindness. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Kaurani L,Vishal M,Kumar D,Sharma A,Mehani B,Sharma C,Chakraborty S,Jha P,Ray J,Sen A,Dash D,Ray K,Mukhopadhyay A

更新日期：2014-04-24 00:00:00