Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa.

abstract：PURPOSE:To explore the effect of dominance and laterality on refractive error and axial length. METHODS:Ocular dominance was assessed with the hole-in-the-card test in 543 children during their 2006 follow-up visits for the Singapore Cohort study Of the Risk factors for Myopia (SCORM). Data were compared to cycloplegi...

journal_title：Investigative ophthalmology & visual science

authors： Chia A,Jaurigue A,Gazzard G,Wang Y,Tan D,Stone RA,Saw SM

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Subretinal fibrosis causes damage to visual acuity, especially if the lesion is in the macula, as is frequently observed in advanced age-related macular degeneration. Exudate leukocytes form abnormal vessels that initiate regional inflammation accompanied with local glial proliferation and matrix production. Th...

journal_title：Investigative ophthalmology & visual science

authors： Jo YJ,Sonoda KH,Oshima Y,Takeda A,Kohno R,Yamada J,Hamuro J,Yang Y,Notomi S,Hisatomi T,Ishibashi T

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Amino-amide or amino-ester local anesthetics, which are currently used for topical ocular anesthesia, are short acting and may delay corneal healing with long-term use. In contrast, site 1 sodium channel blockers (S1SCBs) are potent local anesthetics with minimal adverse tissue reaction. In this study, we exami...

journal_title：Investigative ophthalmology & visual science

authors： McAlvin JB,Zhan C,Dohlman JC,Kolovou PE,Salvador-Culla B,Kohane DS

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:We investigated the therapeutic effect of liposomal doxorubicin (Lipo-dox) on experimental proliferative vitreoretinopathy (PVR). METHODS:The toxicity of Lipo-dox was determined in vitro in cultured rabbit retinal pigment epithelium (RPE) cells by tetrazolium-based (MTT) assay for cell viability performed 48 a...

journal_title：Investigative ophthalmology & visual science

authors： Kuo HK,Chen YH,Wu PC,Wu YC,Huang F,Kuo CW,Lo LH,Shiea J

更新日期：2012-06-29 00:00:00

abstract：PURPOSE:To characterize the cellular expression patterns of antiangiogenic factors differentially regulated in the fetal human macula. METHODS:RNA was extracted from macular, nasal, and surround biopsies of three human fetal retinas at midgestation. Relative levels of expression of pigment epithelium-derived factor (P...

journal_title：Investigative ophthalmology & visual science

authors： Kozulin P,Natoli R,Bumsted O'Brien KM,Madigan MC,Provis JM

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Mammalian central nervous system neurons fail to regenerate after injury or disease, in part due to a progressive loss in intrinsic axon growth ability after birth. Whether lost axon growth ability is due to limited growth resources or to changes in the axonal growth cone is unknown. METHODS:Static and time-la...

journal_title：Investigative ophthalmology & visual science

authors： Steketee MB,Oboudiyat C,Daneman R,Trakhtenberg E,Lamoureux P,Weinstein JE,Heidemann S,Barres BA,Goldberg JL

更新日期：2014-06-06 00:00:00

abstract：:Cataracts removed intracapsularly by cryoprobe technique from human diabetics were analyzed for sugars and polyols by gas liquid chromatography. The contents of sorbitol and fructose of lenses followed blood glucose levels at least up to 250 mg/dl. Studies indicate that human lens is capable of synthesizing substantia...

journal_title：Investigative ophthalmology & visual science

authors： Varma SD,Schocket SS,Richards RD

更新日期：1979-03-01 00:00:00

abstract：PURPOSE:The incidence of blindness is increasing, in part, because of abnormal ocular neovascularization. Anti-VEGF therapies have yielded impressive results; however, they are not a cure for blindness. Recently, metallothioneins (MTs) 1 and 2 have been implicated in the process of angiogenesis. Therefore, we investiga...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura S,Shimazawa M,Inoue Y,Takata S,Ito Y,Tsuruma K,Ikeda T,Honda A,Satoh M,Hara H

更新日期：2014-09-23 00:00:00

abstract：PURPOSE:To compare structural properties from spectral-domain optical coherence tomography (SDOCT) and psychophysical measures from a subset of patients enrolled in a larger multicenter natural history study of X-linked retinoschisis (XLRS). METHODS:A subset of males (n = 24) participating in a larger natural history ...

journal_title：Investigative ophthalmology & visual science

authors： Bennett LD,Wang YZ,Klein M,Pennesi ME,Jayasundera T,Birch DG

更新日期：2016-02-01 00:00:00

abstract：Purpose:Because there is a paucity of population-based data on retinal nerve fiber layer thickness (RNFLT) for children, we measured the RNFLT and its associations in schoolchildren. Methods:The population-based Gobi Desert Children Eye Study included all schoolchildren aged 6 to 21 years living in Ejina, Inner Mongol...

journal_title：Investigative ophthalmology & visual science

authors： Wang CY,Zheng YF,Liu B,Meng ZW,Hong F,Wang XX,Wang XJ,Du L,Wang IY,Zhu D,Tao Y,You QS,Jonas JB

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Estimates of the incidences of severe visual impairment and blindness (SVI/B) and their causes are key to good health service planning. Thus, the database of Germany's largest state's blind registry was used to estimate current incidence rates (IR) and to project rates for Germany in 2010 and 2030. METHODS:The...

journal_title：Investigative ophthalmology & visual science

authors： Finger RP,Fimmers R,Holz FG,Scholl HP

更新日期：2011-06-21 00:00:00

abstract：PURPOSE:This study compared the performance of a video-based infrared three-dimensional eye tracker device (Chronos) with the scleral search coil method. METHODS:Three-dimensional eye movements were measured simultaneously with both systems during fixation, saccades, optokinetic stimulation, and vestibular stimulation...

journal_title：Investigative ophthalmology & visual science

authors： Houben MM,Goumans J,van der Steen J

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To determine whether human retinal pigment epithelial (hRPE) cells produce activin, a growth factor in the transforming growth factor beta family, and to characterize growth regulatory effects of activin on retinal pigment epithelium. METHODS:mRNA expression was examined using polymerase chain reaction with pr...

journal_title：Investigative ophthalmology & visual science

authors： Jaffe GJ,Harrison CE,Lui GM,Roberts WL,Goldsmith PC,Mesiano S,Jaffe RB

更新日期：1994-06-01 00:00:00

abstract：PURPOSE:To compare the diagnostic value of Bruch's membrane opening minimum rim width (BMO-MRW) and retinal nerve fiber layer thickness (RNFLT) in patients with ocular hypertension, preperimetric, and perimetric glaucoma. METHODS:One hundred eighty-one eyes consisting of 40 healthy controls, 41 ocular hypertensive sub...

journal_title：Investigative ophthalmology & visual science

authors： Gmeiner JM,Schrems WA,Mardin CY,Laemmer R,Kruse FE,Schrems-Hoesl LM

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To determine factors affecting the disc-fovea angle (DFA), and to test the hypotheses that adjusting for DFA improves limits of retinal nerve fiber layer (RNFL) variability in normal subjects or enhances performance of RNFL measures for glaucoma detection. METHODS:Disc-fovea angle was measured on scanning lase...

journal_title：Investigative ophthalmology & visual science

authors： Amini N,Nowroozizadeh S,Cirineo N,Henry S,Chang T,Chou T,Coleman AL,Caprioli J,Nouri-Mahdavi K

更新日期：2014-10-09 00:00:00

abstract：PURPOSE:The transdifferentiation of Tenon fibroblasts to myofibroblasts is a pivotal step in filtering bleb scarring. It is mediated by the cytokine TGF-beta, Rho-dependent contractility, and cell-matrix interactions in an interdependent fashion. HMG-CoA-reductase inhibitors (statins) have been shown to inhibit Rho-GTP...

journal_title：Investigative ophthalmology & visual science

authors： Meyer-Ter-Vehn T,Katzenberger B,Han H,Grehn F,Schlunck G

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To investigate the effect of Fas and Fas ligand (FasL) deficiency on the development of herpes stromal keratitis and on the von Szily model of herpes retinitis in C57BL/6 mice, which are ordinarily resistant to development of both of these herpetic diseases. METHODS:Anterior chamber inoculation of the right ey...

journal_title：Investigative ophthalmology & visual science

authors： Nguyen QD,Uy HS,Merchant A,Medina CA,Baltatzis S,Zhao T,Zhao ZS,Cantor H,Foster CS

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:To elucidate the spatial distribution of inactivation of lactate dehydrogenase (LDH) in ultraviolet-B radiation (UVR-B)-exposed eyes. To determine the in vivo penetration depth of UVR-B in the lens. METHODS:LDH activity in cornea and lens was investigated with an enzyme histochemical technique. Thirty rats wer...

journal_title：Investigative ophthalmology & visual science

authors： Löfgren S,Söderberg PG

更新日期：2001-07-01 00:00:00

abstract：PURPOSE:The purpose of this study was to elucidate the differentiated expression patterns and phagocytic activities of two subtypes of microglia. METHODS:A rat optic nerve crush model was used to identify the expression patterns of two subtypes of microglia. Primary microglia were isolated from rat mixed glial culture...

journal_title：Investigative ophthalmology & visual science

authors： Haga A,Takahashi E,Inomata Y,Kawahara K,Tanihara H

更新日期：2016-05-01 00:00:00

abstract：:The authors have put quantitation of human lens fluorescence on a rational basis by using the accompanying Raman signal from lens protein as a normalization factor. The intensity ratio, Fluorescence/Raman (F/R), may be used to compare lenses of different ages when the exciting wavelength is long enough to give a measu...

journal_title：Investigative ophthalmology & visual science

authors： Yu NT,Bando M,Kuck JF Jr

更新日期：1985-01-01 00:00:00

abstract：:A method for assessing the inward permeability of the blood-retinal barrier by fluorophotometry is presented. The permeability value is calculated with the fluorophotometer computer from fluorophotometric scan values in vitreous and non-protein-bound fluorescein concentration values in plasma. No diffusion coefficient...

journal_title：Investigative ophthalmology & visual science

authors： Kappelhof JP,van Best JA,van Valenberg PL,Oosterhuis JA

更新日期：1987-04-01 00:00:00

abstract：PURPOSE:To investigate concentrations of growth factors and inflammatory cytokines in eyes with central (CRVO) and branch (BRVO) retinal vein occlusion before and during therapy with bevacizumab and to identify associations with disease activity. METHODS:In a prospective clinical trial, 13 eyes of patients with CRVO (...

journal_title：Investigative ophthalmology & visual science

authors： Funk M,Kriechbaum K,Prager F,Benesch T,Georgopoulos M,Zlabinger GJ,Schmidt-Erfurth U

更新日期：2009-03-01 00:00:00

abstract：:Nineteen hundred and seventy-six immature human cataracts extracted intracapsularly were classified according to the Cooperative Cataract Research Group (CCRG) method of cataract classification. Data on cataract location and extent, nuclear color, preoperative visual acuity, age, and sex were organized and stored in t...

journal_title：Investigative ophthalmology & visual science

authors： Chylack LT Jr,Ransil BJ,White O

更新日期：1984-02-01 00:00:00

abstract：PURPOSE:This study was designed to examine whether retinal function can be rescued by allogeneic normal retinal pigment epithelial (RPE) grafts in Royal College of Surgeons (RCS) with retinal degeneration and, if so, whether this rescued function can be measured and followed by recording the corneal electroretinogram (...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Hamasaki D

更新日期：1994-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to use Raman spectra of tears to differentiate between infectious and noninfectious ulcerative keratitis. METHODS:Raman microspectroscopy was applied using the drop-coating deposition method on Ti/Au-coated glass slides to obtain sample spectra from different human tear groups, includ...

journal_title：Investigative ophthalmology & visual science

authors： Kuo MT,Lin CC,Liu HY,Yang MY,Chang HC

更新日期：2012-03-15 00:00:00

abstract：PURPOSE:Severe ocular allergic diseases are characterized by pronounced conjunctival inflammation triggered by T helper 2 (Th2) cells and corneal epithelial damage induced by eosinophils. To examine the role of alarmins released by damaged corneal epithelial cells in tissue eosinophilia, we investigated the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Fukuda K,Ishida W,Tanaka H,Harada Y,Matsuda A,Ebihara N,Fukushima A

更新日期：2013-08-27 00:00:00

abstract：PURPOSE:As in human populations, in which founder mutations have been identified in groups of families, a number of founder mutations have been observed across strains in mice. In this report, we provide a phenotype and genotype survey of three common eye diseases in the collection of JAX mice strains at The Jackson La...

journal_title：Investigative ophthalmology & visual science

authors： Chang B,Hurd R,Wang J,Nishina P

更新日期：2013-07-24 00:00:00

abstract：PURPOSE:TNFalpha is a strong modulator expression of trabecular meshwork (TM) matrix metalloproteinase (MMP) and tissue inhibitor (TIMP). Laser trabeculoplasty appears to rely on this process to restore normal aqueous humor outflow facility. Thus, studies were conducted to determine whether the extracellular signal-reg...

journal_title：Investigative ophthalmology & visual science

authors： Alexander JP,Acott TS

更新日期：2003-01-01 00:00:00

abstract：:The autofluorescence of reduced pyridine nucleotides (NADH and NADPH) and oxidized flavoproteins within the rabbit cornea were noninvasively measured as a function of depth. This was accomplished by combining a corneal specular microscope with a time-shared spectrofluorometer. When either 8 mM sodium pentobarbital or ...

journal_title：Investigative ophthalmology & visual science

authors： Laing RA,Fischbarg J,Chance B

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:Metabolism and transport of glutathione (GSH), the endogenous thiol antioxidant, in conjunctival tissue to date are poorly understood. The purpose of the present study was to define transport characteristics of GSH in primary cultured rabbit conjunctival epithelial cells (RCECs). METHODS:RCECs were grown on me...

journal_title：Investigative ophthalmology & visual science

authors： Gukasyan HJ,Lee VH,Kim KJ,Kannan R

更新日期：2002-04-01 00:00:00