Abstract:
PURPOSE:The association of age and blood pressure (BP) with retinal vessel change is widely reported, with inverse relationships between retinal arteriolar and venular diameter and increasing age and elevated BP. No previous studies have dissected the separate effects of age and BP on the diameter of retinal vessels. METHODS:This was a population-based, cross-sectional study comprising 3654 participants (82.4% response) aged 49+ years from the Blue Mountains region of Australia. Retinal arteriolar and venular diameters were measured from digital retinal images, using a standardized method, and were summarized as central retinal arteriolar (CRAE) and central retinal venular (CRVE) equivalents. RESULTS:After adjustment for venular diameter, regression plots, and regression coefficients from linear models demonstrated an inverse relationship between arteriolar diameters and mean arterial BP (MABP) in all age groups-greatest in the <60 age group and progressively diminishing thereafter. Increasing age was associated with greater arteriolar narrowing (of lesser magnitude), in each MABP category (<100, 100-109, 109-129, and >120 mm Hg) with the greatest effect in persons with MABP <100. There was evidence of interaction between age and blood pressure in their effects on arteriolar diameter (P = 0.003). After adjustment for arteriolar diameter, age was inversely associated with venular diameter (the effect was progressively greater for persons with progressively higher MABP), and MABP was positively associated with venular diameter in subjects aged <80 years (interaction P = 0.05). CONCLUSIONS:These findings demonstrate the importance of elevated blood pressure in arteriolar narrowing, especially in those younger than 60 years and show that venules tend to widen rather than narrow with increasing blood pressure levels.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Kaushik S,Kifley A,Mitchell P,Wang JJdoi
10.1167/iovs.06-0893subject
Has Abstractpub_date
2007-02-01 00:00:00pages
557-61issue
2eissn
0146-0404issn
1552-5783pii
48/2/557journal_volume
48pub_type
杂志文章abstract:PURPOSE:To investigate the effect of corneal trauma on gene expression in the lacrimal gland and to assess how many genes and what specific genes are regulated in response to corneal trauma. METHODS:A mouse model with acute corneal trauma was created with a chemical burn to the cornea with silver nitrate. Sixty-four f...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.04-0677
更新日期:2005-02-01 00:00:00
abstract:PURPOSE:To investigate the characteristics of retinal nerve fiber layer (RNFL) defects associated with type II diabetes. METHODS:Forty nonglaucomatous eyes with type II diabetes and 54 eyes with early open angle glaucoma that exhibited a localized RNFL defect and 42 eyes from age- and sex-matched nondiabetic, nonglauc...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.16-19525
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:Connexin50 (Cx50) is absolutely essential for normal postnatal lens growth. Deletion of Cx50 or replacement with Cx46 by knockin resulted in smaller lenses containing fewer cells. To determine why Cx50-deficient lenses fail to grow normally, cell proliferation was assayed during the period of growth failure. M...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.04-0194
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:Anterograde intraflagellar transport (IFT) is essential for photoreceptor outer segment formation and maintenance, as well as for opsin trafficking. However, the role of retrograde IFT in vertebrate photoreceptors remains unclear. The purpose of this study was to evaluate zebrafish photoreceptors lacking the re...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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更新日期:2006-01-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.05-0173
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:10.1167/iovs.02-0664
更新日期:2003-05-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract::Retinal ultrastructure was examined at various intervals following a single intravitreal injection of 100-4,000 micrograms of gentamicin in rabbit eyes. Three days after injections of 100-500 micrograms, numerous abnormal lamellar lysosomal inclusions were observed in the retinal pigment epithelium (RPE) and in macrop...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract:PURPOSE:Corneal confocal microscopy is a reiterative, rapid, noninvasive in vivo clinical examination technique capable of imaging corneal nerve fibers. Nerve fiber tortuosity may indicate a degenerative and attempted regenerative response of nerve fibers to diabetes. The purpose of this study was to define alterations...
journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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doi:
更新日期:1999-03-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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doi:
更新日期:1987-05-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::Gross correlation coefficient between light-scattering intensity and the optical parameters obtained for 48 sections of eight lenses with nuclear cataracts were evaluated. On the basis of these and other data in the literature, the structural elements, within the lens fiber are identified. These give rise to the optic...
journal_title:Investigative ophthalmology & visual science
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doi:
更新日期:1981-03-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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更新日期:2015-11-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:2006-02-01 00:00:00
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更新日期:2006-07-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00