Studies on human cataracts. III. Structural elements in nuclear cataracts and their contribution to the turbidity.

abstract：PURPOSE:To conduct clinical and genetic studies in a European family with autosomal dominant Stargardt-like macular dystrophy (adSTGD-like MD) and to investigate the functional consequences of a novel ELOVL4 mutation. METHODS:Ophthalmic examination and mutation screening by direct sequencing of the ELOVL4 gene was per...

journal_title：Investigative ophthalmology & visual science

authors： Maugeri A,Meire F,Hoyng CB,Vink C,Van Regemorter N,Karan G,Yang Z,Cremers FP,Zhang K

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a biodegradable scleral plug containing ganciclovir (GCV) in a rabbit model of human cytomegalovirus (HCMV) retinitis. METHODS:To develop a rabbit model for HCMV retinitis, HCMV solution was injected once into the vitreous cavity of pigmented rabbits. The treated animals were divide...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai E,Matsuda Y,Ozeki H,Kunou N,Nakajima K,Ogura Y

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:To evaluate the occurrence and time course of hem- and lymphangiogenesis after normal-risk corneal transplantation in the mouse model and to test whether pharmacologic strategies inhibiting both processes improve long-term graft survival. METHODS:Normal-risk allogeneic (C57BL/6 to BALB/c) and syngeneic (BALB/c...

journal_title：Investigative ophthalmology & visual science

authors： Cursiefen C,Cao J,Chen L,Liu Y,Maruyama K,Jackson D,Kruse FE,Wiegand SJ,Dana MR,Streilein JW

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:In an earlier study it was reported that thrombin significantly reduces the rate of Na,K-adenosine triphosphatase (ATPase)-mediated ion transport by porcine lens. Because thrombin stimulates the release of endogenous endothelin (ET)-1 stores from some tissues, and because ET-1 can cause Na,K-ATPase inhibition, ...

journal_title：Investigative ophthalmology & visual science

authors： Okafor MC,Mukhopadhyay P,Delamere NA

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:Organized conjunctiva-associated lymphoid tissue (O-CALT) is constantly exposed to environmental antigens and plays a central role in the common mucosal immune system. This study was undertaken to investigate whether O-CALT in rabbit lymphoid tissue, as in other lymphoid tissue in other mammals, changes with ag...

journal_title：Investigative ophthalmology & visual science

authors： Cain C,Phillips TE

更新日期：2008-02-01 00:00:00

abstract：PURPOSE:To further understand alpha2 receptor signaling in the retina and the mechanisms that mediate ocular beneficial effects of brimonidine (an alpha2 agonist) and nimodipine (an L-type Ca(2+) channel blocker). METHODS:The authors used in situ retinal ganglion cells (RGCs) in the isolated rat retina to characterize...

journal_title：Investigative ophthalmology & visual science

authors： Dong CJ,Guo Y,Agey P,Wheeler L,Hare WA

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Abnormalities in the distribution of long-chain polyunsaturated fatty acids (LCPUFA) have been documented in plasma of patients with X-linked retinitis pigmentosa (XLRP). In this study, fatty acid profiles of red blood cells (RBC) were used as an index for LCPUFA metabolism in patients with XLRP because RBC lip...

journal_title：Investigative ophthalmology & visual science

authors： Hoffman DR,Birch DG

更新日期：1995-05-01 00:00:00

abstract：:Prism induced shift of fixation was measured in 12 cooperative patients utilizing electro-oculography. These recordings were compared with a voluntary shift in fixation of the same eye. No differences were noted when comparing voluntary movements with prism induced movements. Trial of the prism induced eye movement fo...

journal_title：Investigative ophthalmology & visual science

authors： Metz HS

更新日期：1984-10-01 00:00:00

abstract：PURPOSE:To determine whether vascular tone of isolated porcine retinal veins can be modulated by tissue-generated vasoactive factors such as endothelin-1 and adenosine. Such information may be useful in understanding the role of the retinal veins in regulating blood flow, and also provide a model for investigating new ...

journal_title：Investigative ophthalmology & visual science

authors： Yu DY,Su EN,Cringle SJ,Morgan WH,McAllister IL,Yu PK

更新日期：2016-02-01 00:00:00

abstract：:This study demonstrated that growth and differentiation of rabbit conjunctival epithelial cells could be promoted by such substrata as collagen gel, matrigel or various mixtures of collagen and matrigel in a defined culture system. On conventional plastic or glass culture, the conjunctival epithelial cells adopted a m...

journal_title：Investigative ophthalmology & visual science

authors： Tsai RJ,Tseng SC

更新日期：1988-10-01 00:00:00

abstract：PURPOSE:Lens case hygiene practices are important in maintaining safe contact lens wear. However, the effectiveness of various lens case cleaning practices have not been evaluated and compared. This in vitro study aimed to evaluate and compare the efficacy of cleaning practices that are most commonly carried out by len...

journal_title：Investigative ophthalmology & visual science

authors： Wu YT,Zhu H,Willcox M,Stapleton F

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To estimate the critical duration of temporal summation for achromatic Goldmann III stimuli under the conditions of standard automated perimetry (SAP) and quantify response variability for short-duration stimuli. METHODS:Contrast thresholds were gathered using the method of constant stimuli for seven circular ...

journal_title：Investigative ophthalmology & visual science

authors： Mulholland PJ,Redmond T,Garway-Heath DF,Zlatkova MB,Anderson RS

更新日期：2014-12-16 00:00:00

abstract：PURPOSE:To determine the effect of triamcinolone acetonide (TA) on outflow facility in mice. METHODS:Animals received 20 μL of TA (40 mg/mL) suspension subconjunctivally either bilaterally or unilaterally and were euthanized after either 1 week or 3 weeks. Before mice were killed, IOP was measured with a rebound tonom...

journal_title：Investigative ophthalmology & visual science

authors： Kumar S,Shah S,Deutsch ER,Tang HM,Danias J

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Retinal nerve fiber (RNFL) thickness and visual field loss data from patients with glaucoma were analyzed in the context of a model, to better understand individual variation in structure versus function. METHODS:Optical coherence tomography (OCT) RNFL thickness and standard automated perimetry (SAP) visual fi...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Anderson SC,Wall M,Raza AS,Kardon RH

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:Familial exudative vitreoretinopathy (FEVR) is a rare hereditary disorder characterized by the failure of peripheral retinal vascularization. The genes FZD4, LRP5, and TSPAN12 are known to be associated with the autosomal inheritance form of FEVR. In this study, we performed mutation screening for FZD4, LRP5, a...

journal_title：Investigative ophthalmology & visual science

authors： Seo SH,Yu YS,Park SW,Kim JH,Kim HK,Cho SI,Park H,Lee SJ,Seong MW,Park SS,Kim JY

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To characterize the pharmacology of the carbachol-induced changes of phospholipase C (PLC) activity and intracellular calcium concentration ([Ca2+]i) in cultured human ciliary muscle cells. METHODS:Changes in PLC activity of cultured human ciliary muscle cells were determined by production of inositol phosphat...

journal_title：Investigative ophthalmology & visual science

authors： Matsumoto S,Yorio T,DeSantis L,Pang IH

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:To investigate the impact of diabetic macular ischemia (DMI) on visual acuity (VA), through the analysis of novel fluorescein angiography (FA) parameters. METHODS:Data were retrospectively collected over a 6-month period. DMI severity was graded using Early Treatment Diabetic Retinopathy Study (ETDRS) protocol...

journal_title：Investigative ophthalmology & visual science

authors： Sim DA,Keane PA,Zarranz-Ventura J,Fung S,Powner MB,Platteau E,Bunce CV,Fruttiger M,Patel PJ,Tufail A,Egan CA

更新日期：2013-03-28 00:00:00

abstract：PURPOSE:Müller glia have multiple functions in the retina, including synthesis of neurotrophic factors, uptake and metabolism of neurotransmitters, spatial buffering of ions, maintenance of the blood-retinal barrier, and response to injury. A population of Müller glia has some stem cell-like characteristics both in viv...

journal_title：Investigative ophthalmology & visual science

authors： Otteson DC,Phillips MJ

更新日期：2010-11-01 00:00:00

abstract：Purpose:To determine the effect of voluntary exercise on choroidal neovascularization (CNV) in mice. Methods:Age-matched wild-type C57BL/6J mice were housed in cages equipped with or without running wheels. After four weeks of voluntary running or sedentariness, mice were subjected to laser injury to induce CNV. After...

journal_title：Investigative ophthalmology & visual science

authors： Makin RD,Argyle D,Hirahara S,Nagasaka Y,Zhang M,Yan Z,Kerur N,Ambati J,Gelfand BD

更新日期：2020-05-11 00:00:00

abstract：PURPOSE:Currently, there are no definitive immunomarkers for epithelial stem cells (corneal and conjunctival) or their poorly understood niche microenvironment. The H2B-GFP/K5tTA mouse enables visualization of label-retaining cells (LRCs), which exhibit the functional marker of stem cell quiescence. We used immunofluor...

journal_title：Investigative ophthalmology & visual science

authors： Parfitt GJ,Kavianpour B,Wu KL,Xie Y,Brown DJ,Jester JV

更新日期：2015-11-01 00:00:00

abstract：:Intravitreal membranes from patients with proliferative vitreoretinopathy (PVR) consist partly of retinal glial (RG) and retinal pigment epithelial (RPE) cells surrounded by varying amounts of extracellular matrix (ECM). The contribution of the ECM to the growth of PVR membranes is unknown. This study was undertaken t...

journal_title：Investigative ophthalmology & visual science

authors： Williams DF,Burke JM

更新日期：1990-09-01 00:00:00

abstract：PURPOSE:A prior study showed that cholinergic agonists activate phospholipase D (PLD). The purpose of this study was to determine whether cholinergic agonists use the PLD pathway to alter protein secretion and to identify the molecular signaling components of this pathway in rat lacrimal gland acini. METHODS:Rat lacri...

journal_title：Investigative ophthalmology & visual science

authors： Hodges RR,Guilbert E,Shatos MA,Natarajan V,Dartt DA

更新日期：2011-04-06 00:00:00

abstract：PURPOSE:The primary purpose of this study was to characterize photoreceptor apoptosis in the rd mouse. Given that apoptosis is the final common pathway in many cases of retinal degeneration, the ability to retard or even arrest this process may ameliorate retinal disorders such as retinitis pigmentosa (RP). The absence...

journal_title：Investigative ophthalmology & visual science

authors： Doonan F,Donovan M,Cotter TG

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:Recent studies have suggested the involvement of nerve growth factor (NGF) in the conjunctival inflammatory process and in corneal epithelium proliferation and differentiation. To verify the hypothesis that NGF could locally modulate the inflammatory and reparative processes, the authors evaluated the expressio...

journal_title：Investigative ophthalmology & visual science

authors： Lambiase A,Bonini S,Micera A,Rama P,Bonini S,Aloe L

更新日期：1998-06-01 00:00:00

abstract：Purpose:To examine the coaggregation and cohesion between the commonly isolated bacteria from contact lens cases. Methods:Four or five strains each of commonly isolated bacteria from contact lens cases, Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Serratia marcescens, were grown, wash...

journal_title：Investigative ophthalmology & visual science

authors： Datta A,Stapleton F,Willcox MD

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether 25-hydroxyvitamin D(3) (25(OH)D(3)) and/or its active metabolite, 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), can enhance corneal epithelial barrier function. The authors also determined if corneas contain mRNA for the vitamin D receptor (VDR) and 1α-hydroxy...

journal_title：Investigative ophthalmology & visual science

authors： Yin Z,Pintea V,Lin Y,Hammock BD,Watsky MA

更新日期：2011-09-21 00:00:00

abstract：PURPOSE:Current understanding of the genetic risk factors for age-related macular degeneration (AMD) is not sufficiently predictive of the clinical course. The VEGF pathway is a key therapeutic target for treatment of neovascular AMD; however, risk attributable to genetic variation within pathway genes is unclear. We s...

journal_title：Investigative ophthalmology & visual science

authors： Owen LA,Morrison MA,Ahn J,Woo SJ,Sato H,Robinson R,Morgan DJ,Zacharaki F,Simeonova M,Uehara H,Chakravarthy U,Hogg RE,Ambati BK,Kotoula M,Baehr W,Haider NB,Silvestri G,Miller JW,Tsironi EE,Farrer LA,Kim IK,Park K

更新日期：2014-05-08 00:00:00

abstract：PURPOSE:We evaluated whether UVA-riboflavin collagen cross-linking (CXL) increases transverse stromal shear moduli ex vivo, whether the shear moduli are greater in the anterior compared to the posterior stroma, and whether the shear moduli are affected by CXL. METHODS:The resistance to unidirectional transverse shear ...

journal_title：Investigative ophthalmology & visual science

authors： Søndergaard AP,Ivarsen A,Hjortdal J

更新日期：2013-07-26 00:00:00

abstract：Purpose:Little is known regarding the therapeutic effect of carbonic anhydrase inhibitors (CAIs) in the management of cystic macular lesions in children with X-linked juvenile retinoschisis (XLRS) despite the fact that this disease often manifests during childhood. Therefore, our goal was to determine the efficacy of C...

journal_title：Investigative ophthalmology & visual science

authors： Verbakel SK,van de Ven JP,Le Blanc LM,Groenewoud JM,de Jong EK,Klevering BJ,Hoyng CB

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To enhance drug uptake in RPE cells, improve efficacy for choroidal neovascularization (CNV), and reduce drug toxicity, an EphA2-targeted nanocarrier loaded with doxorubicin (DOX) was developed by conjugation with a homing peptide YSA. METHODS:The YSA was coupled to PEGylated lipid. Then, YSA-modified DOX stea...

journal_title：Investigative ophthalmology & visual science

authors： Wang JL,Liu YL,Li Y,Dai WB,Guo ZM,Wang ZH,Zhang Q

更新日期：2012-10-23 00:00:00