Expression of nerve growth factor receptors on the ocular surface in healthy subjects and during manifestation of inflammatory diseases.

abstract：:Previous studies have used Badal laser optometry to demonstrate significant variance in the distribution of tonic (or "dark-focus") resting positions of accommodation (TA) for groups of observers. This study investigates whether individual differences in TA are due to individual differences in autonomic tone of the ci...

journal_title：Investigative ophthalmology & visual science

authors： Gilmartin B,Hogan RE

更新日期：1985-07-01 00:00:00

abstract：:Myeloid bodies are found in the retinal pigment epithelium of certain vertebrate species. They are organized structural forms of the smooth endoplasmic reticulum which are usually seen as stacks of flattened, smooth saccules having a circular or lens-shaped configuration. Our findings in the frog Rana pipiens suggest ...

journal_title：Investigative ophthalmology & visual science

authors： Matthes MT,Basinger SF

更新日期：1980-03-01 00:00:00

abstract：PURPOSE:Recovery of photoreceptor cells after light damage is thought to involve the physiologic process of disk renewal. However, only indirect evidence is available to support this hypothesis. The present study sought to examine more directly the mechanisms of photoreceptor cell recovery by quantitatively assessing t...

journal_title：Investigative ophthalmology & visual science

authors： Rapp LM,Fisher PL,Dhindsa HS

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:To examine the cross-sectional relationship between blood pressure, perfusion pressure, and prevalence of open angle glaucoma (OAG) in an adult Latino population. METHODS:Participants aged 40 years and older (N = 6130) from the Los Angeles Latino Eye Study (LALES), a large, population-based study of self-ident...

journal_title：Investigative ophthalmology & visual science

authors： Memarzadeh F,Ying-Lai M,Chung J,Azen SP,Varma R,Los Angeles Latino Eye Study Group.

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:As efforts to noninvasively measure intracranial pressure (ICP) increase, we thought it important to investigate the timing of retinal venous pulsation in relation to the intraocular and intracranial pressure pulses. METHODS:Neurosurgical patients undergoing continuous direct ICP monitoring had video recording...

journal_title：Investigative ophthalmology & visual science

authors： Morgan WH,Lind CR,Kain S,Fatehee N,Bala A,Yu DY

更新日期：2012-07-10 00:00:00

abstract：:The Early Treatment Diabetic Retinopathy Study (ETDRS) and other standardized classification schemes have laid a foundation for tremendous advances in the understanding and management of diabetic retinopathy (DR). However, technological advances in optics and image analysis, especially optical coherence tomography (OC...

journal_title：Investigative ophthalmology & visual science

authors： Abramoff MD,Fort PE,Han IC,Jayasundera KT,Sohn EH,Gardner TW

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:There is considerable variation in the degree of form-deprivation myopia (FDM) induced in chickens by a uniform treatment regimen. Sex and pretreatment eye size have been found to be predictive of the rate of FD-induced eye growth. Therefore, this study was undertaken to test whether the greater rate of myopic ...

journal_title：Investigative ophthalmology & visual science

authors： Chen YP,Prashar A,Hocking PM,Erichsen JT,To CH,Schaeffel F,Guggenheim JA

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:Recently, RAP1 (Telomeric Repeat Binding Factor 2, Interacting Protein [TERF2IP]) was discovered as a modulator that selectively regulates nuclear factor light chain kappa enhancer of activated B cells (NFκB) signaling. The roles of RAP1 in regulation of inflammation and angiogenesis for corneal recovery follow...

journal_title：Investigative ophthalmology & visual science

authors： Poon MW,Yan L,Jiang D,Qin P,Tse HF,Wong IY,Wong DS,Tergaonkar V,Lian Q

更新日期：2015-01-08 00:00:00

abstract：PURPOSE:To determine the efficacy of the M1-selective muscarinic antagonist, pirenzepine, in preventing experimentally induced myopia in a mammalian model, the tree shrew. METHODS:Tree shrews were monocularly deprived (MD) using translucent goggles or negative lenses for a period of 12 days. In two of the MD groups, t...

journal_title：Investigative ophthalmology & visual science

authors： Cottriall CL,McBrien NA

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:To examine immune processes in the lacrimal gland of patients with chronic graft-versus-host disease (cGVHD) by evaluating the expression of surface molecules associated with T-cell activation. METHODS:Antibodies to CD4, CD8, CD34, CD40, CD54, CD80, CD86, CD154, and HLA-DR were used for immunohistochemical ana...

journal_title：Investigative ophthalmology & visual science

authors： Ogawa Y,Kuwana M,Yamazaki K,Mashima Y,Yamada M,Mori T,Okamoto S,Oguchi Y,Kawakami Y

更新日期：2003-05-01 00:00:00

abstract：:Accurate assessment of ocular alignment in monkeys is difficult because typical clinical methods require extensive cooperation by the subject or provide only a rough estimate of the misalignment. Recently, Brodie derived a geometrical model for determining the Hirschberg ratio in humans, and validated it photographica...

journal_title：Investigative ophthalmology & visual science

authors： Quick MW,Boothe RG

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:To examine the effects of transcorneal electrical stimulation (TES) on retinal degeneration of light-exposed rats. METHODS:Thirty-three Sprague Dawley albino rats were divided into three groups: STIM (n = 15) received 60 minutes of TES, whereas SHAM (n = 15) received identical sham stimulation 2 hours before e...

journal_title：Investigative ophthalmology & visual science

authors： Schatz A,Arango-Gonzalez B,Fischer D,Enderle H,Bolz S,Röck T,Naycheva L,Grimm C,Messias A,Zrenner E,Bartz-Schmidt KU,Willmann G,Gekeler F

更新日期：2012-08-15 00:00:00

abstract：PURPOSE:To evaluate a photographic procedure for reflectometry of the topographic distribution of macular pigment density in normal pediatric subjects. METHODS:Digitized blue (480 nm) and green (540 nm) photographic images were aligned and subtracted to generate optical density difference maps. An 8 degrees x 8 degree...

journal_title：Investigative ophthalmology & visual science

authors： Bour LJ,Koo L,Delori FC,Apkarian P,Fulton AB

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:To determine whether the intact isolated ciliary epithelial bilayer retains the alpha-2 and beta adrenergic receptor activation and interaction described for whole ciliary processes and whether this pure epithelial bilayer displays bioelectric parameters sensitive to alterations in cyclic adenosine Monophosphat...

journal_title：Investigative ophthalmology & visual science

authors： Horio B,Sears M,Mead A,Matsui H,Bausher L

更新日期：1996-03-01 00:00:00

abstract：PURPOSE:To evaluate the dynamic changes in refraction during the accommodative facility test in myopes and emmetropes. METHODS:Ten myopes and 10 emmetropes participated in the study. All were young adults, and refractive error in the myopes was corrected with soft contact lenses. Monocular accommodative facility measu...

journal_title：Investigative ophthalmology & visual science

authors： Radhakrishnan H,Allen PM,Charman WN

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:We evaluated the roles of tumor necrosis factor (TNF)-α in alkali-induced corneal neovascularization (CNV). METHODS:CNV was induced by alkali injury and compared in wild-type (WT) BALB/c mice, and TNF receptor 1-deficient (TNF-Rp55 KO) counterparts, or in mice treated with TNF-α antagonist and recombinant TNF-...

journal_title：Investigative ophthalmology & visual science

authors： Lu P,Li L,Liu G,Baba T,Ishida Y,Nosaka M,Kondo T,Zhang X,Mukaida N

更新日期：2012-06-14 00:00:00

abstract：PURPOSE:Microsaccades could indicate the place where our mind is unconsciously focusing, although our gaze is directed elsewhere. Many studies report the importance of microsaccades in visual scene perception, but none of them has addressed their relationship with the perception of a dynamic action and the prediction o...

journal_title：Investigative ophthalmology & visual science

authors： Piras A,Raffi M,Lanzoni IM,Persiani M,Squatrito S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a biodegradable scleral plug containing ganciclovir (GCV) in a rabbit model of human cytomegalovirus (HCMV) retinitis. METHODS:To develop a rabbit model for HCMV retinitis, HCMV solution was injected once into the vitreous cavity of pigmented rabbits. The treated animals were divide...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai E,Matsuda Y,Ozeki H,Kunou N,Nakajima K,Ogura Y

更新日期：2001-08-01 00:00:00

abstract：Purpose:Retinal nonperfusion and hypoxia are important factors in human diabetic retinopathy, and these presumably inhibit energy production and lead to cell death. The purpose of this study was to elucidate the effect of diabetes on inner retinal oxygen delivery and metabolism in a mouse model of diabetes. Methods:Ph...

journal_title：Investigative ophthalmology & visual science

authors： Blair NP,Wanek J,Felder AE,Brewer KC,Joslin CE,Shahidi M

更新日期：2016-11-01 00:00:00

abstract：:The predominant risk factor for the progression of glaucoma is an increase in IOP, mediated via a reduction in aqueous outflow through the conventional (trabecular meshwork and Schlemm's canal) outflow pathway. Current IOP lowering pharmacological strategies target the uveoscleral (nonconventional) outflow pathway or ...

journal_title：Investigative ophthalmology & visual science

authors： Cavet ME,Vittitow JL,Impagnatiello F,Ongini E,Bastia E

更新日期：2014-08-14 00:00:00

abstract：PURPOSE:To determine factors affecting the disc-fovea angle (DFA), and to test the hypotheses that adjusting for DFA improves limits of retinal nerve fiber layer (RNFL) variability in normal subjects or enhances performance of RNFL measures for glaucoma detection. METHODS:Disc-fovea angle was measured on scanning lase...

journal_title：Investigative ophthalmology & visual science

authors： Amini N,Nowroozizadeh S,Cirineo N,Henry S,Chang T,Chou T,Coleman AL,Caprioli J,Nouri-Mahdavi K

更新日期：2014-10-09 00:00:00

abstract：PURPOSE:To enhance drug uptake in RPE cells, improve efficacy for choroidal neovascularization (CNV), and reduce drug toxicity, an EphA2-targeted nanocarrier loaded with doxorubicin (DOX) was developed by conjugation with a homing peptide YSA. METHODS:The YSA was coupled to PEGylated lipid. Then, YSA-modified DOX stea...

journal_title：Investigative ophthalmology & visual science

authors： Wang JL,Liu YL,Li Y,Dai WB,Guo ZM,Wang ZH,Zhang Q

更新日期：2012-10-23 00:00:00

abstract：:The effect of systemic hypoxia on the maintained firing rate (MFR) of single retinal ganglion cells has been measured in the cat at a constant luminance level. Systemic hypoxia was produced by reducing the percentage of oxygen in the respiratory mixture under forced ventilation so that arterial PCO2 and pH were consta...

journal_title：Investigative ophthalmology & visual science

authors： Alder VA,Constable IJ

更新日期：1981-09-01 00:00:00

abstract：PURPOSE:Antimicrobial peptides (AMPs) are multifunctional host defense molecules. Human beta-defensin 9 (HBD9) has previously been shown to be downregulated during ocular surface (OS) infection or inflammation. Here, the authors aimed to study localization of HBD9 protein in different OS regions and to determine the ro...

journal_title：Investigative ophthalmology & visual science

authors： Mohammed I,Suleman H,Otri AM,Kulkarni BB,Chen P,Hopkinson A,Dua HS

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:To characterize the thickness profile of the corneal epithelium and the Bowman's layer across the horizontal meridian. METHODS:Forty-four eyes of 22 healthy subjects were investigated in this study. Ultra-high resolution anterior segment spectral domain-optical coherence tomography (SD-OCT) was used to assess ...

journal_title：Investigative ophthalmology & visual science

authors： Tao A,Wang J,Chen Q,Shen M,Lu F,Dubovy SR,Shousha MA

更新日期：2011-06-01 00:00:00

abstract：Purpose:We determine the feasibility of human conjunctival epithelial cells (hCjECs) on poly(lactic-co-glycolic) acid (PLGA) membranes for corneal epithelium regeneration. hCjECs on PLGA or polyester (PET) membranes with or without coculture of human Tenon's fibroblasts (hTFs) were compared in vitro, and to determine w...

journal_title：Investigative ophthalmology & visual science

authors： Hong S,Yun JH,Kim ES,Kim JS,Tchah H,Hwang C

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Retinal injuries that affect the photoreceptors and/or the retinal pigment epithelium (RPE) may result in the leakage of retinal proteins into the systemic circulation. This study was designed to determine whether an immune response is elicited after an acute retinal injury resulting in circulating anti-retinal...

journal_title：Investigative ophthalmology & visual science

authors： Scott SE,Bouhenni RA,Chomyk AM,Dunmire JJ,Patil J,Nakamura H,Deepak P

更新日期：2012-04-06 00:00:00

abstract：PURPOSE:We reviewed and illustrated the most optimal retinal structural measurements to make in stem cell clinical trials. METHODS:Optical coherence tomography (OCT) and autofluorescence (AF) imaging were used to evaluate patients with severe visual loss from nonsyndromic and syndromic retinitis pigmentosa (RP), ABCA4...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Matsui R,Sumaroka A,Cideciyan AV

更新日期：2016-04-01 00:00:00

abstract：:To evaluate the penetration of ciprofloxacin, a new wide-spectrum oral antibiotic, into the vitreous, ciprofloxacin was administered orally to 21 patients who were scheduled to undergo vitreal surgery. Seven patients received 750 mg ciprofloxacin 4 hr before surgery (group I), seven patients received this dose 8 hr be...

journal_title：Investigative ophthalmology & visual science

authors： Keren G,Alhalel A,Bartov E,Kitzes-Cohen R,Rubinstein E,Segev S,Treister G

更新日期：1991-07-01 00:00:00

abstract：Purpose:To employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related macular degeneration (AMD). Methods:The qAF imaging was performed on eyes of 26 rhesus macaques (me...

journal_title：Investigative ophthalmology & visual science

authors： Tran TM,Kim S,Lin KH,Chung SH,Park S,Sazhnyev Y,Wang Y,Cunefare D,Farsiu S,Thomasy SM,Moshiri A,Yiu G

更新日期：2020-07-01 00:00:00