Fundus photography for measurement of macular pigment density distribution in children.

abstract：PURPOSE:To identify the localization of indoleamine 2,3-dioxygenase (IDO) in human corneal cells and to evaluate its functional ability as a local immunosuppressive factor. METHODS:The expression profile of IDO was identified in primary cultures of human corneal cells (fibroblasts, epithelial cells, endothelial cells)...

journal_title：Investigative ophthalmology & visual science

authors： Ryu YH,Kim JC

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To systematically assess the changes in retinal morphology during the healing of retinal photocoagulation lesions of various clinical grades. METHODS:Rabbits were irradiated with a 532-nm Nd:YAG laser with a beam diameter of 330 microm at the retinal surface, a power of 175 mW, and pulse durations between 5 an...

journal_title：Investigative ophthalmology & visual science

authors： Paulus YM,Jain A,Gariano RF,Stanzel BV,Marmor M,Blumenkranz MS,Palanker D

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To explore the susceptibilities of adult retinal neurons in dissociated culture to treatments with excitotoxic agonists and the mechanisms of the resultant retinal cell death. METHODS:C57B6 mice were used. Retinas were removed, dissociated, plated on a polylysine/laminin substrate, and maintained in vitro for ...

journal_title：Investigative ophthalmology & visual science

authors： Luo X,Baba A,Matsuda T,Romano C

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:Doxorubicin chemomyectomy presently represents the only permanent, nonsurgical treatment for blepharospasm and hemifacial spasm. The major deterrent to an otherwise extremely effective treatment protocol is the development in patients of localized inflammation, discomfort, and skin injury over the injection sit...

journal_title：Investigative ophthalmology & visual science

authors： McLoon LK,Wirtschafter JD

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:To adopt micropatterning technology in manufacturing silicone elastomer-based microelectrode arrays for retinal stimulation, a silicone-polyimide hybrid microelectrode array was proposed and tested in vivo. METHODS:Gold microelectrodes were created by semiconductor manufacturing technology based on polyimide a...

journal_title：Investigative ophthalmology & visual science

authors： Kim ET,Kim C,Lee SW,Seo JM,Chung H,Kim SJ

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:To describe hereditary macular degeneration observed in the cynomolgus monkey (Macaca fascicularis), which shares phenotypic features with age-related macular degeneration in humans, and to test the involvement of candidate gene loci by mutation screening and linkage analysis. METHODS:Ophthalmic examinations w...

journal_title：Investigative ophthalmology & visual science

authors： Umeda S,Ayyagari R,Allikmets R,Suzuki MT,Karoukis AJ,Ambasudhan R,Zernant J,Okamoto H,Ono F,Terao K,Mizota A,Yoshikawa Y,Tanaka Y,Iwata T

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:We previously developed a method to measure visual function progression using "Progression sectors," which were derived from a clustering analysis of pointwise rates of glaucomatous visual field (VF) progression; however, only short series of VFs, where pointwise linear regression (PLR) is typically not reliabl...

journal_title：Investigative ophthalmology & visual science

authors： Hirasawa K,Murata H,Asaoka R

更新日期：2015-07-01 00:00:00

abstract：Purpose:Aging is a risk factor for dry eye disease. The aim of this study was to investigate if aging is associated with a range of signs of dry eye disease, including tear hyperosmolarity, reduced nerve density, and increased dendritic cell number, in mice. Method:Healthy C57BL/6 female mice, aged 2 months (young, n ...

journal_title：Investigative ophthalmology & visual science

authors： De Silva MEH,Hill LJ,Downie LE,Chinnery HR

更新日期：2019-06-03 00:00:00

abstract：:The temporal modulation sensitivity function was studied in eight strabismic and/or anisometropic amblyopes and in two subjects with amblyopia resulting from monocular stimulus deprivation (cataract and ptosis). Half of the strabismic/anisometropic amblyopes showed a reduction in the sensitivity of the amblyopic eye. ...

journal_title：Investigative ophthalmology & visual science

authors： Manny RE,Levi DM

更新日期：1982-04-01 00:00:00

abstract：Purpose:We recently reported that the glycosaminoglycan hyaluronan (HA), which promotes inflammatory angiogenesis in other vascular beds, is an abundant component of the limbal extracellular matrix. Consequently, we have explored the possibility that HA contributes to lymphangiogenesis in the inflamed cornea. Methods:...

journal_title：Investigative ophthalmology & visual science

authors： Sun M,Puri S,Mutoji KN,Coulson-Thomas YM,Hascall VC,Jackson DG,Gesteira TF,Coulson-Thomas VJ

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To determine whether a variational Bayesian independent component analysis mixture model (vB-ICA-mm), a form of unsupervised machine learning, can be used to identify and quantify areas of progression in standard automated perimetry fields. METHODS:In an earlier study, it was shown that a model using vB-ICA-mm...

journal_title：Investigative ophthalmology & visual science

authors： Sample PA,Boden C,Zhang Z,Pascual J,Lee TW,Zangwill LM,Weinreb RN,Crowston JG,Hoffmann EM,Medeiros FA,Sejnowski T,Goldbaum M

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To investigate the mechanism of the neuroprotective effects of the angiotensin II type 1 receptor (AT1-R) blocker against retinal ischemia-reperfusion injury in the rat. METHODS:Retinal ischemia was induced by increasing intraocular pressure. Glutamate release from the rat retina and intravitreal PO(2) (partia...

journal_title：Investigative ophthalmology & visual science

authors： Fujita T,Hirooka K,Nakamura T,Itano T,Nishiyama A,Nagai Y,Shiraga F

更新日期：2012-06-26 00:00:00

abstract：PURPOSE:To evaluate the expression of tissue inhibitor of metalloproteinases (TIMP) mRNA in corneal tissues before and at early time points (6 and 12 hours and 1, 3, and 5 days) after corneal infection with Pseudomonas aeruginosa. METHODS:Ribonuclease protection assays were used to detect and quantitate TIMP mRNA expr...

journal_title：Investigative ophthalmology & visual science

authors： Kernacki KA,Goebel DJ,Poosch MS,Hazlett LD

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:To determine the prevalence of presbyopia in the state of Andhra Pradesh in south India. METHODS:Comprehensive ocular examinations including logMAR (logarithm of the minimum angle of resolution) distance and near (presenting and best corrected) visual acuity, slit lamp biomicroscopy of the anterior segment, an...

journal_title：Investigative ophthalmology & visual science

authors： Nirmalan PK,Krishnaiah S,Shamanna BR,Rao GN,Thomas R

更新日期：2006-06-01 00:00:00

abstract：Purpose:Ocular rigidity (OR) is an important biomechanical property, thought to be relevant in the pathophysiology of open-angle glaucoma (OAG). This study aims to evaluate the relationship between OR and neuroretinal damage caused by glaucoma. Methods:One hundred eight subjects (22 with healthy eyes, 23 with suspect ...

journal_title：Investigative ophthalmology & visual science

authors： Sayah DN,Mazzaferri J,Descovich D,Costantino S,Lesk MR

更新日期：2020-11-02 00:00:00

abstract：PURPOSE:Peroxynitrite generated during the early phase of experimental autoimmune uveoretinitis (EAU) causes peroxidation of docosahexaenoic acid (22:6), a principal unsaturated fatty acid of the photoreceptor membrane, to its hydroperoxide (22:6HP). During this phase, microglia migrate to the site of photoreceptors. T...

journal_title：Investigative ophthalmology & visual science

authors： Saraswathy S,Wu G,Rao NA

更新日期：2006-08-01 00:00:00

abstract：Purpose:Since the combined effects of proteinuria and a moderately decreased eGFR on incident severe eye complications in patients with diabetes are still largely unknown, these associations were determined in a large historical cohort of Japanese patients with diabetes mellitus. Methods:We evaluated the effects of ov...

journal_title：Investigative ophthalmology & visual science

authors： Yamamoto M,Fujihara K,Ishizawa M,Osawa T,Kaneko M,Ishiguro H,Matsubayashi Y,Seida H,Yamanaka N,Tanaka S,Kodama S,Hasebe H,Sone H

更新日期：2019-06-03 00:00:00

abstract：PURPOSE:To evaluate somatic mitochondrial (mt)DNA mutations in the macula during ageing. METHODS:Ten 30-microm cryostat sections from the macula (foveal and perifoveal regions) and peripheral retina of 14 donors (aged 14-94 years) were cut for cytochrome c oxidase cytochemistry. The photoreceptor layer was microdissec...

journal_title：Investigative ophthalmology & visual science

authors： Barron MJ,Johnson MA,Andrews RM,Clarke MP,Griffiths PG,Bristow E,He LP,Durham S,Turnbull DM

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:To investigate the use of topically applied FK506, a new immunosuppressive compound, systemic and ocular absorption was determined in serum and various ocular tissues. METHODS:Two drops of 20 microliters FK506 were applied using oil dissolved (OD-FK506) or liposome-bound (LIP-FK506) drug. FK506 concentrations ...

journal_title：Investigative ophthalmology & visual science

authors： Pleyer U,Lutz S,Jusko WJ,Nguyen KD,Narawane M,Rückert D,Mondino BJ,Lee VH,Nguyen K

更新日期：1993-08-01 00:00:00

abstract：PURPOSE:Modalities for inhibiting neovascularization may be one avenue to the development of effective therapies for retinopathy. The effect of squalamine, an antiangiogenic amino sterol, on oxygen-induced retinopathy (OIR) was assessed in a mouse model. METHODS:OIR was induced in C57BL6 mice by a 5-day exposure to 75...

journal_title：Investigative ophthalmology & visual science

authors： Higgins RD,Sanders RJ,Yan Y,Zasloff M,Williams JI

更新日期：2000-05-01 00:00:00

abstract：Purpose:To investigate the molecular mechanisms of the antiangiogenic activity of UPARANT, an antagonist of the urokinase-type plasminogen activator receptor (uPAR), on primary human retinal endothelial cells (HREC) as a model of in vitro angiogenesis. Methods:The antiangiogenic activity of UPARANT was evaluated on en...

journal_title：Investigative ophthalmology & visual science

authors： Motta C,Lupo G,Rusciano D,Olivieri M,Lista L,De Rosa M,Pavone V,Anfuso CD

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:Previous in vitro studies with transgenic and gene-knockout mice have shown that lenses with elevated levels of glutathione peroxidase (GPX)-1 activity are able to resist the cytotoxic effect of H(2)O(2), compared with normal lenses and lenses from GPX-1-deficient animals. The purpose of this study was to inves...

journal_title：Investigative ophthalmology & visual science

authors： Reddy VN,Giblin FJ,Lin LR,Dang L,Unakar NJ,Musch DC,Boyle DL,Takemoto LJ,Ho YS,Knoernschild T,Juenemann A,Lütjen-Drecoll E

更新日期：2001-12-01 00:00:00

abstract：PURPOSE:Excitotoxicity has been proposed to play a pivotal role in retinal damage, but the mechanisms that underlie retinal damage are not clearly understood. In this study, the role of matrix metalloproteinases in excitotoxin-mediated retinal damage was investigated. METHODS:KA, CNQX (6-cyano-7-nitroquinoxaline-2,3,-...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Cheng M,Chintala SK

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:Recently, a segregation study in families with uveal and cutaneous melanoma identified 9q21 as a potential locus harboring a tumor-suppressor gene (TSG). One of the genes in this area, RASEF, was then analyzed as a candidate TSG, but lack of point mutations and copy number changes could not confirm this. In thi...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,Beiboer SH,Jager MJ,Luyten GP,Gruis NA,van der Velden PA

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:Adipogenesis contributes to the pathogenesis of thyroid eye disease (TED). Thyrotropin receptor (TSHR) transcripts are present in orbital fat. This study was conducted to determine whether they are expressed as functional protein, and if so, whether this is restricted to TED orbits or to a particular stage in a...

journal_title：Investigative ophthalmology & visual science

authors： Crisp M,Starkey KJ,Lane C,Ham J,Ludgate M

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:Liquid perfluorocarbons are used as temporary vitreous substitutes in the surgical management of complicated retinal detachment. The purpose of this study was to determine if physiologic benefits could also be derived from the high oxygen solubility of perfluorochemicals relative to vitreous, especially during ...

journal_title：Investigative ophthalmology & visual science

authors： Wilson CA,Berkowitz BA,Srebro R

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To explore the association of AMD with long-term average blood pressure (BP) parameters, including pulse pressure (PP). METHODS:The ALIENOR study is a population-based study on age-related eye diseases in 963 residents of Bordeaux, France, aged 73 years or older. AMD was graded from nonmydriatic color retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Cougnard-Grégoire A,Delyfer MN,Korobelnik JF,Rougier MB,Malet F,Le Goff M,Dartigues JF,Colin J,Barberger-Gateau P,Delcourt C

更新日期：2013-03-28 00:00:00

abstract：Purpose:To investigate factors associated with visual field (VF) progression in treated myopic normal-tension glaucoma (NTG) using a novel posterior sclera reconstruction method involving swept-source optical coherence tomography (OCT). Methods:Fifty-six myopic patients on ocular hypotensive therapy with the diagnose ...

journal_title：Investigative ophthalmology & visual science

authors： Kim YC,Koo YH,Jung KI,Park CK

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To examine the distribution of human heat shock proteins (HSPs) HSP90, inducible HSP70 (iHSP70), constitutive and inducible HSP70 (cHSP70), HSP65, and human HSP27 in conjunctival biopsy specimens of ocular cicatricial pemphigoid (OCP), atopic keratoconjunctivitis, and healthy persons with cataract. METHODS:Usi...

journal_title：Investigative ophthalmology & visual science

authors： Berra A,Dutt JE,Nouri M,Foster CS

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:To determine the intergrader reproducibility for computer-assisted grading of optical coherence tomography (OCT) images in eyes with neovascular age-related macular degeneration (AMD), by using a standardized grading procedure. METHODS:Sixty OCT image sets (of six radial lines each) were independently analyzed...

journal_title：Investigative ophthalmology & visual science

authors： Joeres S,Tsong JW,Updike PG,Collins AT,Dustin L,Walsh AC,Romano PW,Sadda SR

更新日期：2007-09-01 00:00:00