EphA2 targeted doxorubicin stealth liposomes as a therapy system for choroidal neovascularization in rats.

abstract：PURPOSE:To determine the prevalence and incidence of epiretinal membranes (ERM) in eyes with inactive extramacular cytomegalovirus (CMV) retinitis in patients with acquired immune deficiency syndrome (AIDS). METHODS:A case-control report from a longitudinal multicenter observational study by the Studies of the Ocular ...

journal_title：Investigative ophthalmology & visual science

authors： Kozak I,Vaidya V,Van Natta ML,Pak JW,May KP,Thorne JE,Studies of the Ocular Complications of AIDS Research Group.

更新日期：2014-06-12 00:00:00

abstract：:An imaging fundus reflectometer has been used to study the distribution and regeneration of visual pigments in the retina of the adult living cat. Measurements were made over an area of tapetal retina extending 25 degrees nasal and 40 degrees temporal to the area centralis on the horizontal meridian and 5 degrees infe...

journal_title：Investigative ophthalmology & visual science

authors： Kemp CM,Faulkner DJ,Jacobson SG

更新日期：1988-07-01 00:00:00

abstract：PURPOSE:To investigate concentrations of growth factors and inflammatory cytokines in eyes with central (CRVO) and branch (BRVO) retinal vein occlusion before and during therapy with bevacizumab and to identify associations with disease activity. METHODS:In a prospective clinical trial, 13 eyes of patients with CRVO (...

journal_title：Investigative ophthalmology & visual science

authors： Funk M,Kriechbaum K,Prager F,Benesch T,Georgopoulos M,Zlabinger GJ,Schmidt-Erfurth U

更新日期：2009-03-01 00:00:00

abstract：:In their IOVS article "Rejuvenating Clinician-Scientist Training" (published March 28, 2014), Balamurali Ambati and Judd Cahoon rightly point out the dearth of new clinician-scientists in ophthalmology. Within the context of their suggestions for increasing the number of successful clinician-scientists, they claim tha...

journal_title：Investigative ophthalmology & visual science

authors： Culican SM,Rupp JD,Margolis TP

更新日期：2014-05-27 00:00:00

abstract：PURPOSE:The purpose of this study was to demonstrate the efficacy of the digital fluoroscopy system (DFS) for the in vivo assessment of pharmacologically induced posterior vitreous detachment (PVD) and vitreous liquefaction in a rabbit model. METHODS:Twenty eyes from 10 New Zealand white rabbits were divided into 5 gr...

journal_title：Investigative ophthalmology & visual science

authors： Bae JH,Park HS,Kim JM,Lee BR,Lee SC,Tandogan T,Auffarth GU,Koss MJ,Choi CY

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:We identified a topographic relation of localized reticular pseudodrusen (RPD) to choroidal watershed zones (CWZ) and to changes in choroidal volumes (CV). METHODS:We included 30 eyes of 30 patients with RPD in an area <10 mm(2) and no other retinal alteration (76.7 ± 6.9 years). Patients underwent spectral-do...

journal_title：Investigative ophthalmology & visual science

authors： Alten F,Clemens CR,Heiduschka P,Eter N

更新日期：2013-05-07 00:00:00

abstract：PURPOSE:1,25-Dihydroxyvitamin D3 (VitD3) has been shown to have immunoregulatory properties in animal models. In this study, we investigated its inhibitory effect on the immune response in Behçet's disease (BD) patients and the possible mechanisms involved. METHODS:Naive CD4(+) T cells from active BD patients and norm...

journal_title：Investigative ophthalmology & visual science

authors： Tian Y,Wang C,Ye Z,Xiao X,Kijlstra A,Yang P

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:Ischemic preconditioning (IPC) protects the rat retina against the injury that ordinarily follows prolonged ischemia. It has been shown that release of adenosine, de novo protein synthesis, and mediators, such as protein kinase C and K(ATP) channels, is required for IPC protection. However, the molecular mechan...

journal_title：Investigative ophthalmology & visual science

authors： Zhang C,Rosenbaum DM,Shaikh AR,Li Q,Rosenbaum PS,Pelham DJ,Roth S

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:To study the vasorelaxing effect of calcitonin gene-related peptide (CGRP) and natriuretic peptides on isolated bovine retinal arteries (BRAs) and to evaluate the possibility of the unidentified retinal relaxing factor (RRF) being one of these peptides. METHODS:Retinal arteries were isolated from bovine eyes a...

journal_title：Investigative ophthalmology & visual science

authors： Boussery K,Delaey C,Van de Voorde J

更新日期：2005-04-01 00:00:00

abstract：:Freshly isolated peripheral blood lymphocytes from patients (PBL-P) with recurrent herpetic corneal and skin lesions, and controls (PBL-C) with no recollection of herpetic disease, effectively lysed herpes simplex virus type 1 (HSV-1) infected but not uninfected allogeneic fibroblasts. However, after 48 hr of stimulat...

journal_title：Investigative ophthalmology & visual science

authors： Hendricks RL,Sugar J

更新日期：1985-02-01 00:00:00

abstract：PURPOSE:The purpose of this study was to identify a new Pseudomonas protease and determine its possible role in keratitis. METHODS:Concentrated culture supernatants of the Pseudomonas aeruginosa strains PA103 and ATCC 19660 were analyzed by zymography. P. aeruginosa small protease (PASP) was purified from strain PA103...

journal_title：Investigative ophthalmology & visual science

authors： Marquart ME,Caballero AR,Chomnawang M,Thibodeaux BA,Twining SS,O'Callaghan RJ

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:Age-related cataract (ARC) is one of the most common causes of severe visual impairment among the elderly worldwide with four subtypes, such as cortical, nuclear, subcapsular, and mixed types. DNA damage and malfunction of DNA repair are believed to contribute to the pathogenesis of ARC. This study examined the...

journal_title：Investigative ophthalmology & visual science

authors： Su S,Yao Y,Zhu R,Liang C,Jiang S,Hu N,Zhou J,Yang M,Xing Q,Guan H

更新日期：2013-02-01 00:00:00

abstract：Purpose:The purpose of this study was to determine the relative roles of the sympathetic (SNS) and parasympathetic nervous system (PNS) in pupillary hippus. Methods:We used a paired-eye control study design with three cohorts receiving either 1.0% tropicamide (PNS antagonist) in light (TL), 1.0% tropicamide in dark (T...

journal_title：Investigative ophthalmology & visual science

authors： Turnbull PR,Irani N,Lim N,Phillips JR

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To assess corneal epithelial cell survival after keratoplasty. METHODS:Corneal impression cytology (CIC) was performed on sex-mismatched corneal transplants. Fluorescent in situ hybridization (FISH) with sex chromosome-specific probes was performed to identify epithelial cell mosaicism and therefore allocate t...

journal_title：Investigative ophthalmology & visual science

authors： Catanese M,Popovici C,Proust H,Hoffart L,Matonti F,Cochereau I,Conrath J,Gabison EE

更新日期：2011-02-22 00:00:00

abstract：PURPOSE:To investigate if topical treatment of neuroprotectin D1 (NPD1) increases regeneration of functional nerves after lamellar keratectomy. METHODS:An 8-mm stromal dissection was performed in the left eye of each rabbit. The rabbits were treated with NPD1, pigment epithelial-derived factor (PEDF) in combination wi...

journal_title：Investigative ophthalmology & visual science

authors： Cortina MS,He J,Russ T,Bazan NG,Bazan HE

更新日期：2013-06-12 00:00:00

abstract：:The relationship between corneal edema and hydrogel lens oxygen transmissibility was examined for both daily and extended contact lens wear by measuring the corneal swelling response induced by a variety of contact lenses over a 36-hr wearing period. The relationships derived enable average edema levels that occur wit...

journal_title：Investigative ophthalmology & visual science

authors： Holden BA,Mertz GW

更新日期：1984-10-01 00:00:00

abstract：Purpose:The purpose of this study was to describe the cellular architecture of normal human peripapillary sclera (PPS) and evaluate surface topography's role in fibroblast behavior. Methods:PPS cryosections from nonglaucomatous eyes were labelled for nuclei, fibrillar actin (FA), and alpha smooth muscle actin (αSMA) a...

journal_title：Investigative ophthalmology & visual science

authors： Szeto J,Chow A,McCrea L,Mozzer A,Nguyen TD,Quigley HA,Pitha I

更新日期：2021-01-04 00:00:00

abstract：PURPOSE:Refraction, as measured by spherical equivalent, is the need for an external lens to focus images on the retina. While genetic factors play an important role in the development of refractive errors, few susceptibility genes have been identified. However, several regions of linkage have been reported for myopia ...

journal_title：Investigative ophthalmology & visual science

authors： Klein AP,Duggal P,Lee KE,Cheng CY,Klein R,Bailey-Wilson JE,Klein BE

更新日期：2011-07-13 00:00:00

abstract：PURPOSE:We investigated the neuroprotective effect of human serum albumin nanoparticles (HSA-NPs) and their conjugation with brimonidine (HSA-Br-NPs) on retinal ganglion cells (RGCs) in optic nerve crush (ONC) model. METHODS:We fabricated HSA-Br-NPs by ethanol precipitation, including 0.18% brimonidine (Br) and 3.5% h...

journal_title：Investigative ophthalmology & visual science

authors： Kim KE,Jang I,Moon H,Kim YJ,Jeoung JW,Park KH,Kim H

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:Methionine-sulfoxide reductases are unique, in that their ability to repair oxidized proteins and MsrA, which reduces S-methionine sulfoxide, can protect lens cells against oxidative stress damage. To date, the roles of MsrB1, -B2 and -B3 which reduce R-methionine sulfoxide have not been established for any mam...

journal_title：Investigative ophthalmology & visual science

authors： Marchetti MA,Pizarro GO,Sagher D,Deamicis C,Brot N,Hejtmancik JF,Weissbach H,Kantorow M

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:To examine the involvement of p27(KIP1) in the regulation of the proliferation of the developing corneal endothelium. METHODS:Central and peripheral corneas in C57Bl6 mice at postnatal day (P)1, P11, and 12 weeks after birth were analyzed by immunocytochemistry with anti-p27(KIP1), -p57(KIP2), and -proliferati...

journal_title：Investigative ophthalmology & visual science

authors： Yoshida K,Kase S,Nakayama K,Nagahama H,Harada T,Ikeda H,Harada C,Imaki J,Ohgami K,Shiratori K,Ilieva IB,Ohno S,Nishi S,Nakayama KI

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:To evaluate the role of TIMP-1 in inherited retinal degeneration. METHODS:The genomic structure of the TIMP-1 gene was established and male patients with x-linked retinitis pigmentosa 2 from five families were screened for sequence alterations by direct sequencing in all exons, exon-intron boundaries, and the ...

journal_title：Investigative ophthalmology & visual science

authors： Hardcastle AJ,Thiselton DL,Nayudu M,Hampson RM,Bhattacharya SS

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:Increased stromal accumulation of macrophages and submucosal fibrosis due to excessive accumulation of collagens are central histologic features in ocular cicatricial pemphigoid (OCP). Interleukin (IL)-4 plays an important role in both the inflammatory and fibrotic events in several human and experimental disea...

journal_title：Investigative ophthalmology & visual science

authors： Razzaque MS,Ahmed BS,Foster CS,Ahmed AR

更新日期：2003-08-01 00:00:00

abstract：PURPOSE:To decide whether the transitory coexpression of cone visual pigments described in the developing rat and gerbil retina is a universal feature of dichromatic mammalian species. METHODS:The rabbit, a species widely used in eye research, was selected for the study and a search made for the presence of cones that...

journal_title：Investigative ophthalmology & visual science

authors： Szepessy Z,Lukáts A,Fekete T,Barsi A,Röhlich P,Szél A

更新日期：2000-09-01 00:00:00

abstract：:The authors investigated the mechanisms underlying the head shaking shown by some patients with congenital nystagmus (CN). In order to improve visual function by head shaking, a patient with CN must have some visual acuity loss due to retinal image motion created by the nystagmus; an abnormal vestibulo-ocular reflex (...

journal_title：Investigative ophthalmology & visual science

authors： Carl JR,Optican LM,Chu FC,Zee DS

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:To define the phenotypes of retinal degenerations associated with mutations in the gene encoding CRX (cone-rod homeobox), a photoreceptor-specific transcription factor. METHODS:Heterozygotes with the E168 [delta1 bp], E168 [delta2 bp], or G217 [delta1 bp] CRXgene mutation were studied clinically, with visual f...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Huang Y,Hanna DB,Freund CL,Affatigato LM,Carr RE,Zack DJ,Stone EM,McInnes RR

更新日期：1998-11-01 00:00:00

abstract：Purpose:The lysozyme 2 (Lyz2 or LysM) cre mouse is extensively used to achieve genetic manipulation in myeloid cells and it has been widely employed in retinal research. However, LysM has been recently described to be expressed in brain neurons and there is a debate on whether it is also expressed by resident microglia...

journal_title：Investigative ophthalmology & visual science

authors： Fouda AY,Xu Z,Narayanan SP,Caldwell RW,Caldwell RB

更新日期：2020-03-09 00:00:00

abstract：:Posterior eye cups of the frog Rana ridibunda were prefixed in the presence of tannic acid, osmicated and stained en bloc with uranyl acetate. Electron microscopy revealed the following features of membrane traffic in cells of the retinal pigment epithelium (RPE): (1) intracellular membranes with increased electron de...

journal_title：Investigative ophthalmology & visual science

authors： Rungger-Brändle E,Englert U,Leuenberger PM

更新日期：1987-12-01 00:00:00

abstract：PURPOSE:This study was conducted to explore the association of autophagy-related genes (ATGs) single nucleotide polymorphisms (SNPs) with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome in a Chinese Han population. METHODS:A two-stage association study was carried out in 940 BD, 1061 VKH, and 2007 health...

journal_title：Investigative ophthalmology & visual science

authors： Zheng M,Yu H,Zhang L,Li H,Liu Y,Kijlstra A,Yang P

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Peripheral and limbal corneal stromal cells (PLCSCs), which contain keratocytes, have a complex phenotype. Knowledge of keratocyte cell properties, function, and origin is limited. Evidence available thus far has suggested both mesenchymal stromal and hematopoietic characteristics. Multipotent mesenchymal strom...

journal_title：Investigative ophthalmology & visual science

authors： Branch MJ,Hashmani K,Dhillon P,Jones DR,Dua HS,Hopkinson A

更新日期：2012-08-03 00:00:00