In Vivo Assessment of Pharmacologic Vitreolysis in Rabbits With the Digital Fluoroscopy System.

abstract：:PURPOSE. To investigate the normative data of corneal and anterior segment biometric parameters and their associations in Chinese adults, for use in preoperative assessment for corneal and anterior segment surgery. METHODS. This cross-sectional, population-based study included 750 subjects aged > or =50 years. The sub...

journal_title：Investigative ophthalmology & visual science

authors： Yuen LH,He M,Aung T,Htoon HM,Tan DT,Mehta JS

更新日期：2010-07-01 00:00:00

abstract：:PURPOSE. To solve the shortage of donor corneas, a decellularizing method based on hypertonic saline treatment was introduced, and a favorable outcome was observed in pig-to-rabbit lamellar corneal transplantation. This study was an investigation of the efficacy of pig-to-nonhuman primate lamellar corneal transplantat...

journal_title：Investigative ophthalmology & visual science

authors： Choi HJ,Kim MK,Lee HJ,Ko JH,Jeong SH,Lee JI,Oh BC,Kang HJ,Wee WR

更新日期：2011-08-22 00:00:00

abstract：:Flicker sensitivity was measured in groups of younger and older adult observers to assess its mean values and the test-retest variability both between sessions and in a single session. Test-retest sensitivities differed by less than 15% but tended to decrease slightly in a session and increase slightly between session...

journal_title：Investigative ophthalmology & visual science

authors： Tyler CW

更新日期：1991-08-01 00:00:00

abstract：:The ciliary bodies of five monkey eyes and one human eye were subdivided into five zones. The ciliary epithelium with its bordering stroma was investigated electron microscopically. The number of cell organelles of the nonpigmented (NPE) and pigmented (PE) epithelium (mitochondria, rough endoplasmic reticulum, Golgi c...

journal_title：Investigative ophthalmology & visual science

authors： Ober M,Rohen JW

更新日期：1979-07-01 00:00:00

abstract：PURPOSE:Extremely low gestational age neonates (ELGANs) requiring oxygen therapy often experience frequent episodes of intermittent hypoxia (IH) and are at high risk for severe retinopathy of prematurity (ROP). Using an established model for oxygen-induced retinopathy (OIR), we examined the hypothesis that there is a c...

journal_title：Investigative ophthalmology & visual science

authors： Beharry KD,Cai CL,Sharma P,Bronshtein V,Valencia GB,Lazzaro DR,Aranda JV

更新日期：2013-11-19 00:00:00

abstract：PURPOSE:To perform a mutation screening of TACSTD2 in 13 Iranian Gelatinous Drop-like Corneal Dystrophy (GDLD) pedigrees. To assess genotype-phenotype correlations. To determine intragenic SNP haplotypes associated with the mutations, so as to gain information on their origin. METHODS:The coding region of TACSTD2 was ...

journal_title：Investigative ophthalmology & visual science

authors： Alavi A,Elahi E,Tehrani MH,Amoli FA,Javadi MA,Rafati N,Chiani M,Banihosseini SS,Bayat B,Kalhor R,Amini SS

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:To examine the accommodative accuracy and amplitude in children with Down syndrome. Accommodation is usually assumed to be good in children and is rarely measured. METHODS:A dynamic retinoscopy technique was developed that allows rapid and reliable measures of accuracy and amplitude of accommodation in infants...

journal_title：Investigative ophthalmology & visual science

authors： Woodhouse JM,Meades JS,Leat SJ,Saunders KJ

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:To determine whether the human retinal oxygenation response (deltaPO2) to a hyperoxic provocation is abnormal in patients with type I diabetes. METHODS:Magnetic resonance imaging (MRI) was used to measure deltaPO2 during 100% oxygen breathing in patients with type I diabetes who had either no clinically detect...

journal_title：Investigative ophthalmology & visual science

authors： Trick GL,Edwards P,Desai U,Berkowitz BA

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:Leukocytes play a critical role in ocular diseases such as uveitis, diabetic retinopathy, and choroidal neovascularization. Intercellular adhesion molecule (ICAM)-1 is essential for the migration of leukocytes. Control of ICAM-1 expression may lead to therapies for these diseases. Small-interfering ribonucleic ...

journal_title：Investigative ophthalmology & visual science

authors： Hirano Y,Sakurai E,Matsubara A,Ogura Y

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Glaucoma is the second most frequent cause of visual impairment worldwide. Elevated intraocular pressure (IOP) causes glaucomatous optic nerve damage, especially in the primary open-angle glaucoma (POAG) subtype. As most previous studies on IOP genetics were analyses of glaucomatous families, a study of general...

journal_title：Investigative ophthalmology & visual science

authors： Lee MK,Woo SJ,Kim JI,Cho SI,Kim H,Sung J,Seo JS,Kim DM

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Defensins are naturally occurring antimicrobial peptides. Recently the authors published evidence of defensin production by the human ocular surface. A study was undertaken to look for intraocular defensins that may account for unexplained antimicrobial activity of intraocular fluids. METHODS:Reverse transcrip...

journal_title：Investigative ophthalmology & visual science

authors： Haynes RJ,McElveen JE,Dua HS,Tighe PJ,Liversidge J

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:Ischemia is a risk factor for eye diseases like ocular vein occlusion or glaucoma. To investigate effects of ischemia-reperfusion (I/R) a lot of different animal models are used, studying one or two different cell types, which creates heterogeneity of data. The aim of this study was to investigate the function ...

journal_title：Investigative ophthalmology & visual science

authors： Schmid H,Renner M,Dick HB,Joachim SC

更新日期：2014-04-28 00:00:00

abstract：PURPOSE:We identified a topographic relation of localized reticular pseudodrusen (RPD) to choroidal watershed zones (CWZ) and to changes in choroidal volumes (CV). METHODS:We included 30 eyes of 30 patients with RPD in an area <10 mm(2) and no other retinal alteration (76.7 ± 6.9 years). Patients underwent spectral-do...

journal_title：Investigative ophthalmology & visual science

authors： Alten F,Clemens CR,Heiduschka P,Eter N

更新日期：2013-05-07 00:00:00

abstract：Purpose:We recently reported that the glycosaminoglycan hyaluronan (HA), which promotes inflammatory angiogenesis in other vascular beds, is an abundant component of the limbal extracellular matrix. Consequently, we have explored the possibility that HA contributes to lymphangiogenesis in the inflamed cornea. Methods:...

journal_title：Investigative ophthalmology & visual science

authors： Sun M,Puri S,Mutoji KN,Coulson-Thomas YM,Hascall VC,Jackson DG,Gesteira TF,Coulson-Thomas VJ

更新日期：2019-03-01 00:00:00

abstract：:To compare the effects on the postnatal development of the eye of both total and partial form deprivation in diurnally reared chicks and of dark-rearing, chicks were reared with occluders covering one eye from hatching for up to 6 weeks. In diurnally reared birds, both total and partial form deprivation resulted in se...

journal_title：Investigative ophthalmology & visual science

authors： Gottlieb MD,Fugate-Wentzek LA,Wallman J

更新日期：1987-08-01 00:00:00

abstract：UNLABELLED:PURPOSE. Test the hypothesis that the developmental increases in rod photoreceptor sensitivity and rod-mediated visual sensitivity at 10 degrees, 20 degrees , and 30 degrees eccentric are concurrent. It is known that maturation of the parafoveal (10 degrees eccentric) rod outer segments and visual sensitivit...

journal_title：Investigative ophthalmology & visual science

authors： Fulton AB,Hansen RM

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:Vasoactive intestinal peptide (VIP) is expressed by corneal endothelial (CE) cells and is present in the aqueous humor, which bathes CE cells in vivo. This study demonstrated the role of CE cell VIP in maintaining the expression level of a CE differentiation marker, N-cadherin, and the hexagonal cell shape. ME...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Chandrasekara K,Abbondandolo CJ,Coll TJ,Rutzen AR

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To decide whether the transitory coexpression of cone visual pigments described in the developing rat and gerbil retina is a universal feature of dichromatic mammalian species. METHODS:The rabbit, a species widely used in eye research, was selected for the study and a search made for the presence of cones that...

journal_title：Investigative ophthalmology & visual science

authors： Szepessy Z,Lukáts A,Fekete T,Barsi A,Röhlich P,Szél A

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:Migration of Müller glial cells is enhanced in proliferative retinopathies, but the mechanisms involved are ill defined. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid synthesized by sphingosine kinase (SphK), which promotes proliferation, migration, and inflammation, acting as an intracellular media...

journal_title：Investigative ophthalmology & visual science

authors： Simón MV,Prado Spalm FH,Politi LE,Rotstein NP

更新日期：2015-09-01 00:00:00

abstract：PURPOSE:We studied morphologic changes of the retinal vasculature in eyes with central retinal vein occlusion (CRVO) through the use of optical coherence tomography (OCT). METHODS:Major retinal vessels in 35 eyes from 35 consecutive patients with acute CRVO were examined prospectively and longitudinally with sequentia...

journal_title：Investigative ophthalmology & visual science

authors： Muraoka Y,Tsujikawa A,Kumagai K,Akagi-Kurashige Y,Ogino K,Murakami T,Miyamoto K,Yoshimura N

更新日期：2014-01-07 00:00:00

abstract：PURPOSE:The goal of this study was to functionally evaluate three previously uncharacterized heat shock factor protein 4 (HSF4) mutations (c.595_599delGGGCC, c.1213C>T, c.1327+4A>G) encoding mutant HSF4 proteins (G199EfsX15, R405X, and M419GfsX29) with missing C-terminal ends. These HSF4 mutations were previously ident...

journal_title：Investigative ophthalmology & visual science

authors： Merath K,Ronchetti A,Sidjanin DJ

更新日期：2013-10-11 00:00:00

abstract：PURPOSE:To study heterogeneity for chromosome 3 copy number in mixed choroidal melanoma with discrete populations of spindle and epithelioid cells using chromosome in situ hybridization (CISH) and to correlate chromosomal loss with cell type. METHODS:Twenty-two archival cases of choroidal melanoma with discrete popula...

journal_title：Investigative ophthalmology & visual science

authors： Sandinha T,Farquharson M,McKay I,Roberts F

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:To isolate and characterize ciliary body epithelial antigens reactive with a monoclonal antibody, 2B4.14.1. METHODS:A mouse monoclonal antibody generated against human corneal endothelium, 2B4.14.1 reacts with nonpigmented epithelium of human and guinea pig ciliary bodies. The ciliary body proteins reactive wi...

journal_title：Investigative ophthalmology & visual science

authors： Howell DN,Ross JR,Miller SE,Sanfilippo FP

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) has features of chronic low-grade inflammation. The purpose of our study was to investigate whether the presence of inflammatory cells in fibrovascular membranes (FVMs) from patients with proliferative diabetic retinopathy (PDR) is associated with the activity of PDR and visual acuity ...

journal_title：Investigative ophthalmology & visual science

authors： Urbančič M,Štunf Š,Milutinović Živin A,Petrovič D,GlobočnikPetrovič M

更新日期：2014-11-25 00:00:00

abstract：PURPOSE:To determine the mechanisms underlying prostaglandin (PG) F(2)alpha-(,) carbachol (CCh)-, or latanoprost (a PGF(2)alpha analogue)-induced contraction of the pig iris sphincter muscle. METHODS:Effects of these agents on myofilament Ca(2+) sensitivity were evaluated and compared with the use of receptor-coupled ...

journal_title：Investigative ophthalmology & visual science

authors： Hasegawa Y,Nishimura J,Niiro N,Hirano K,Ishibashi T,Kanaide H

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:To examine the expression of five prostaglandin (PG) receptors, EP(1), EP(2), EP(3), EP(4), and FP and their corresponding mRNA transcripts in human sclera and cultured human scleral fibroblasts (HSFs). METHODS:Primary cultures of HSFs were established from donor eyes. Also, sclera from human donor eyes was sn...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Aihara M,Weinreb RN

更新日期：2001-12-01 00:00:00

abstract：PURPOSE:Diabetes reduces retinal and visual sensitivity to dim light flashes. However, the impact of diabetes on contrast sensitivity in dim light is unknown. Based on the lowered visual sensitivity previously observed, we hypothesized that contrast sensitivity would similarly be reduced. We therefore examined scotopic...

journal_title：Investigative ophthalmology & visual science

authors： Umino Y,Solessio E

更新日期：2013-02-28 00:00:00

abstract：PURPOSE:To apply tissue-engineered cell sheet transplantation after excimer laser keratectomy as a novel approach for the reduction of postoperative corneal haze. METHODS:Limbal biopsy specimens were obtained, and epithelial cells were cultured on temperature-responsive culture inserts without the use of feeder cells....

journal_title：Investigative ophthalmology & visual science

authors： Hayashida Y,Nishida K,Yamato M,Yang J,Sugiyama H,Watanabe K,Hori Y,Maeda N,Kikuchi A,Okano T,Tano Y

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To investigate the retinal-protective effects of the oral iron chelator deferiprone (DFP) in mice lacking the iron regulatory hormone hepcidin (Hepc). These Hepc knockout (KO) mice have age-dependent systemic and retinal iron accumulation leading to retinal degeneration. METHODS:Hepc KO mice were given DFP in ...

journal_title：Investigative ophthalmology & visual science

authors： Song D,Zhao L,Li Y,Hadziahmetovic M,Song Y,Connelly J,Spino M,Dunaief JL

更新日期：2014-06-26 00:00:00

abstract：:Prostaglandins and other eicosanoids in the trabecular meshwork may play important physiological and pharmacological roles in the aqueous outflow pathway. In the present studies, we employed [14C]-arachidonic acid to explore potentially important pathways for the production of eicosanoids in cultured human trabecular ...

journal_title：Investigative ophthalmology & visual science

authors： Weinreb RN,Polansky JR,Alvarado JA,Mitchell MD

更新日期：1988-11-01 00:00:00