Retinal arteriolar and middle cerebral artery responses to combined hypercarbic/hyperoxic stimuli.

abstract：PURPOSE:Autophagy is a lysosomal machinery-dependent process that catabolizes cellular components/organelles and proteins in an autophagic vacuole (AV)-dependent and -independent manner, respectively. Short-term exposure of the retina to bright light results in shortening of the outer segments, concomitant with AV form...

journal_title：Investigative ophthalmology & visual science

authors： Kunchithapautham K,Coughlin B,Lemasters JJ,Rohrer B

更新日期：2011-05-05 00:00:00

abstract：PURPOSE:Inhibiting mechanistic target of rapamycin (mTOR) by pharmacological or genetic approaches can extend lifespan in mammals. The kinase activity of mTOR is controlled by upstream regulatory proteins and its subcellular localization. The purpose of this study was to characterize age-related alterations and functio...

journal_title：Investigative ophthalmology & visual science

authors： Yu B,Xu P,Zhao Z,Cai J,Sternberg P,Chen Y

更新日期：2014-12-09 00:00:00

abstract：PURPOSE:Skeletal and craniofacial muscles are frequently composed of multiple neuromuscular compartments that serve different physiological functions. Evidence of possible regional selectivity in LR intramuscular innervation was sought in a study of the anatomic potential of lateral rectus (LR) muscle compartmentalizat...

journal_title：Investigative ophthalmology & visual science

authors： Peng M,Poukens V,da Silva Costa RM,Yoo L,Tychsen L,Demer JL

更新日期：2010-09-01 00:00:00

abstract：:In their IOVS article "Rejuvenating Clinician-Scientist Training" (published March 28, 2014), Balamurali Ambati and Judd Cahoon rightly point out the dearth of new clinician-scientists in ophthalmology. Within the context of their suggestions for increasing the number of successful clinician-scientists, they claim tha...

journal_title：Investigative ophthalmology & visual science

authors： Culican SM,Rupp JD,Margolis TP

更新日期：2014-05-27 00:00:00

abstract：PURPOSE:The retina of the blind mole rat Spalax ehrenbergi was compared with other vertebrate photosensitive organs in an attempt to correlate its histologic organization with a presumptive nonvisual photoreceptor role. METHODS:The eyes of eight adult animals were analyzed by light and electron microscopy, using conve...

journal_title：Investigative ophthalmology & visual science

authors： Cernuda-Cernuda R,DeGrip WJ,Cooper HM,Nevo E,García-Fernández JM

更新日期：2002-07-01 00:00:00

abstract：:Male albino rats, injected intravenously or intracerebroventricularly with delta 1-tetrahydrocannabinol (THC), develop mudriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 microgram/kg THC. Sympathectomy significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Korczyn AD,Eshel Y

更新日期：1982-03-01 00:00:00

abstract：:The profound visual deficits associated with early monocular form deprivation (MD) are caused largely by competitive binocular interactions in the visual cortex. We tested the hypothesis that disrupting normal cortical binocularity prior to the onset of MD would reduce the degree of form deprivation amblyopia compared...

journal_title：Investigative ophthalmology & visual science

authors： Smith EL 3rd,Harwerth RS,Siderov J,Wingard M,Crawford ML,von Noorden GK

更新日期：1992-04-01 00:00:00

abstract：:Gamma-interferon (G-IFN) exhibits antiproliferative effects, inhibits collagen synthesis by fibroblasts, and may help to regulate the turnover of fibrous tissue. Fibroblasts from Tenon's capsule are cellular components that contribute to unsuccessful glaucoma filtration surgery. Therefore, the authors studied the effe...

journal_title：Investigative ophthalmology & visual science

authors： Latina MA,Belmonte SJ,Park C,Crean E

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:Fractal dimension of retinal vasculature is a global summary measure of retinal vascular network pattern and geometry. This study was conducted to examine the effect of variations in image color, brightness, focus, contrast, and format on the measurement of retinal vascular fractal dimension. METHODS:A set of ...

journal_title：Investigative ophthalmology & visual science

authors： Wainwright A,Liew G,Burlutsky G,Rochtchina E,Zhang YP,Hsu W,Lee JM,Wong TY,Mitchell P,Wang JJ

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Alkali burning of the rabbit cornea is a well-established model for the study of anterior surface inflammation, neovascularization, and wound-healing processes. 12-hydroxyeicosanoids have been implicated as mediators of such responses. 12(S)-hydroxyeicosatetraenoic acid (12[S]-HETE) is a lipoxygenase-derived ar...

journal_title：Investigative ophthalmology & visual science

authors： Conners MS,Urbano F,Vafeas C,Stoltz RA,Dunn MW,Schwartzman ML

更新日期：1997-09-01 00:00:00

abstract：PURPOSE:Retinal basement membranes (BMs) serve as attachment sites for retinal pigment epithelial cells on Bruch's membrane and Müller cells (MCs) on the inner limiting membrane (ILM), providing polarity cues to adherent cells. The beta2 and gamma3 chains of laminin are key components of retinal BMs throughout developm...

journal_title：Investigative ophthalmology & visual science

authors： Pinzón-Duarte G,Daly G,Li YN,Koch M,Brunken WJ

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:Retinal ganglion cell (RGC) degeneration is an important cause of visual impairment and can be modeled by optic nerve transection, which causes the death of 90% of RGCs within 14 days postaxotomy. We performed a proteomic study to identify and quantify proteins in the rat retina after optic nerve transection. O...

journal_title：Investigative ophthalmology & visual science

authors： Hollander A,D'Onofrio PM,Magharious MM,Lysko MD,Koeberle PD

更新日期：2012-06-26 00:00:00

abstract：Purpose:To investigate transepidermal water loss (TEWL) from the ocular area in dry eye disease (DED) and evaluate the correlation between ocular TEWL and other DED parameters. Methods:Transepidermal water loss from the ocular area in 56 eyes with DED and 38 healthy eyes was measured using a Tewameter TM300 that was e...

journal_title：Investigative ophthalmology & visual science

authors： Jeon HS,Youn SW,Jeon HE,Kim JH,Hyon JY

更新日期：2016-09-01 00:00:00

abstract：PURPOSE:Compelling evidence suggests that alpha2 agonists, such as brimonidine, protect retinal ganglion cells (RGCs) from injury in a wide range of animal models. However, the mechanism of action for this protection and the physiological role of the alpha2 adrenergic system in the retina is not well understood. A majo...

journal_title：Investigative ophthalmology & visual science

authors： Dong CJ,Guo Y,Wheeler L,Hare WA

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:A subset of patients with anterior uveitis express the marker, perinuclear anti-neutrophil cytoplasmic antibody (pANCA). In this study, recombinantly isolated pANCA monoclonal antibodies were used to search for ocular cells expressing the pANCA antigen. METHODS:Paraffin sections of human ocular tissues obtaine...

journal_title：Investigative ophthalmology & visual science

authors： Gordon LK,Eggena M,Targan SR,Braun J

更新日期：1999-05-01 00:00:00

abstract：Purpose:Suberoylanilide hydroxamic acid (SAHA) has been shown to support the maintenance of experimental filtration blebs in animal models. This study was performed to investigate the molecular mechanisms underlying the bleb-maintaining effects of SAHA in modulating wound healing activities of conjunctival fibroblasts....

journal_title：Investigative ophthalmology & visual science

authors： Futakuchi A,Inoue T,Fujimoto T,Kuroda U,Inoue-Mochita M,Takahashi E,Ohira S,Tanihara H

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To evaluate interictal visual dysfunction in persons with migraine in terms of spatiotemporal selectivity and location within the visual pathways. METHODS:The vision of a group of 15 persons who had experienced migraine with aura was compared with that of 15 normal age-matched control subjects. A range of thre...

journal_title：Investigative ophthalmology & visual science

authors： McKendrick AM,Vingrys AJ,Badcock DR,Heywood JT

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:We explored the role of myeloid-related protein 8 and 14 (MRP8/14) in Pseudomonas aeruginosa (PA) keratitis. METHODS:MRP8/14 mRNA levels in human corneal scrapes and mouse corneas infected by PA were tested using real-time PCR. MRP8/14 protein expression in C57BL/6 (B6) corneas was confirmed using Western blot...

journal_title：Investigative ophthalmology & visual science

authors： Deng Q,Sun M,Yang K,Zhu M,Chen K,Yuan J,Wu M,Huang X

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:To determine the toxicity of various doses of intravitreal amphotericin B deoxycholate, amphotericin B lipid complex (ABLC), and liposomal amphotericin B (L-AmB). METHODS:Fifty-two rabbits were divided into two treatment groups (groups A and B). Thirteen treatments were administered intravitreally to the 104 r...

journal_title：Investigative ophthalmology & visual science

authors： Cannon JP,Fiscella R,Pattharachayakul S,Garey KW,De Alba F,Piscitelli S,Edward DP,Danziger LH

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To evaluate somatic mitochondrial (mt)DNA mutations in the macula during ageing. METHODS:Ten 30-microm cryostat sections from the macula (foveal and perifoveal regions) and peripheral retina of 14 donors (aged 14-94 years) were cut for cytochrome c oxidase cytochemistry. The photoreceptor layer was microdissec...

journal_title：Investigative ophthalmology & visual science

authors： Barron MJ,Johnson MA,Andrews RM,Clarke MP,Griffiths PG,Bristow E,He LP,Durham S,Turnbull DM

更新日期：2001-11-01 00:00:00

abstract：:Albino rabbits were exposed to repeated microwave irradiations once daily for a month. Clinical examination was carried out for a period up to one year. No changes occurred below 300 mW./cm.2. At and above this level posterior subcapsular iridescence and posterior cortical cataracts were produced. The histologic findi...

journal_title：Investigative ophthalmology & visual science

authors： Hirsch SE,Appleton B,Fine BS,Brown PV

更新日期：1977-04-01 00:00:00

abstract：PURPOSE:To investigate the relationship between photopic open-loop accommodation and vergence and the effect of mental effort on these positions. METHODS:Twenty subjects (11 men and 9 women) viewed monocularly a photopic (25 cdm-2), high-contrast (90%) Maltese cross-target for 3 minutes, through a 0.5-mm pinhole drill...

journal_title：Investigative ophthalmology & visual science

authors： Gray LS,Winn B,Gilmartin B,Eadie AS

更新日期：1993-09-01 00:00:00

abstract：Purpose:Rapid identification of pathogens causing endophthalmitis may improve treatment outcomes through early administration of species-specific medication. The current study reports a new molecular application of peptide nucleic acid-fluorescence in situ hybridization (PNA-FISH) with Staphylococcus-specific molecular...

journal_title：Investigative ophthalmology & visual science

authors： Patel N,Miller D,Relhan N,Flynn HW Jr

更新日期：2017-08-01 00:00:00

abstract：:Treatment of human skin and corneal fibroblasts with prednisolone-21-phosphate did not increase the capacity of these cells to replicate type I herpes simplex virus (HSV). The steroid however was found to (1) inhibit human lymphocytes from mediating antibody-dependent cell-mediated cytotoxicity (ADCC) against HSV-infe...

journal_title：Investigative ophthalmology & visual science

authors： Cooper JA Jr,Daniels CA,Trofatter EF Jr

更新日期：1978-04-01 00:00:00

abstract：PURPOSE:To assess the effects of diabetes mellitus on corneal structure and function. METHODS:The authors measured endothelial permeability to fluorescein and corneal deswelling for 7.5 hours after 2 hours of hypoxic contact lens wear in 20 patients with diabetes who had nonproliferative retinopathy and 21 age-matched...

journal_title：Investigative ophthalmology & visual science

authors： Weston BC,Bourne WM,Polse KA,Hodge DO

更新日期：1995-03-01 00:00:00

abstract：PURPOSE:To investigate modifications with aging of the presence, distribution and morphologic features of conjunctiva-associated lymphoid tissue (CALT) in healthy human subjects using laser scanning in vivo confocal microscopy (IVCM). METHODS:A total of 108 (age range, 17-75 years) subjects were enrolled. In vivo conf...

journal_title：Investigative ophthalmology & visual science

authors： Agnifili L,Mastropasqua R,Fasanella V,Di Staso S,Mastropasqua A,Brescia L,Mastropasqua L

更新日期：2014-07-29 00:00:00

abstract：PURPOSE:To investigate the neural basis of contraction anisocoria and any implications for assessments using pupillary responses, through analysis of topographic variation in amplitudes of direct and consensual pupil responses. METHODS:Direct and consensual pupillary contraction amplitudes were analyzed from six studi...

journal_title：Investigative ophthalmology & visual science

authors： Carle CF,Maddess T,James AC

更新日期：2011-04-12 00:00:00

abstract：PURPOSE:Cornea confocal microscopy is emerging as a clinical tool to evaluate the development and progression of diabetic neuropathy. The purpose of these studies was to characterize the early changes in corneal sensitivity and innervation in a rat model of type 1 diabetes in relation to standard peripheral neuropathy ...

journal_title：Investigative ophthalmology & visual science

authors： Davidson EP,Coppey LJ,Yorek MA

更新日期：2012-12-07 00:00:00

abstract：PURPOSE:To demonstrate corneal endothelial (CE) integrity enhanced during eye banking by a brief treatment of human donor corneoscleral explant (explant) with CE autocrine trophic factor vasoactive intestinal peptide (VIP). METHODS:Paired explants were used as control versus VIP (10 nM)-treated before storage in corne...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Gloria D,Molloy J

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:To investigate changes in macular pigment optical density (MPOD) and visual performance following supplementation with different macular carotenoid formulations. METHODS:Thirty-six subjects (19 male, 17 female; mean SD, age 51 13 years) were recruited into this single-masked placebo-controlled study, and were ...

journal_title：Investigative ophthalmology & visual science

authors： Loughman J,Nolan JM,Howard AN,Connolly E,Meagher K,Beatty S

更新日期：2012-11-29 00:00:00