Early loss of innervation of cornea epithelium in streptozotocin-induced type 1 diabetic rats: improvement with ilepatril treatment.

abstract：PURPOSE:Endogenous anterior uveitis (AU), when untreated, may lead to vision loss. This study compared the safety and efficacy of difluprednate versus prednisolone acetate for the treatment of this condition. METHODS:This phase III, double-masked, noninferiority study randomized patients with mild to moderate endogeno...

journal_title：Investigative ophthalmology & visual science

authors： Sheppard JD,Toyos MM,Kempen JH,Kaur P,Foster CS

更新日期：2014-05-06 00:00:00

abstract：PURPOSE:Peroxynitrite generated during the early phase of experimental autoimmune uveoretinitis (EAU) causes peroxidation of docosahexaenoic acid (22:6), a principal unsaturated fatty acid of the photoreceptor membrane, to its hydroperoxide (22:6HP). During this phase, microglia migrate to the site of photoreceptors. T...

journal_title：Investigative ophthalmology & visual science

authors： Saraswathy S,Wu G,Rao NA

更新日期：2006-08-01 00:00:00

abstract：Purpose:To evaluate the corneal endothelial characteristics across the primary angle closure (PAC) disease spectrum amongst patients diagnosed as PAC suspects (PACS), PAC, PAC glaucoma (PACG), and previous acute PAC (APAC). Methods:We analyzed a total of 529 subjects (51 PACS, 170 PAC, 234 PACG, and 74 with previous A...

journal_title：Investigative ophthalmology & visual science

authors： Verma S,Nongpiur ME,Husain R,Wong TT,Boey PY,Quek D,Perera SA,Aung T

更新日期：2018-09-04 00:00:00

abstract：Purpose:Although retinal dopamine (DA) has been long implicated in myopia development, current studies demonstrate that retinal DA levels are unaltered in C57BL/6 mice with form-deprivation myopia. This work was undertaken to explore whether and how refractive development is perturbed in this mouse strain when retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Wu XH,Qian KW,Xu GZ,Li YY,Ma YY,Huang F,Wang YQ,Zhou X,Qu J,Yang XL,Zhong YM,Weng SJ

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To evaluate goblet cell density (GCD) on conjunctiva and cornea in patients with ocular chemical burns by in vivo laser scanning confocal microscopy (LSCM) and impression cytology (IC) and to explore the correlation between two methods. METHODS:Fifty-four patients (58 eyes) with chemical burn were enrolled in ...

journal_title：Investigative ophthalmology & visual science

authors： Le QH,Wang WT,Hong JX,Sun XH,Zheng TY,Zhu WQ,Xu JJ

更新日期：2010-03-01 00:00:00

abstract：:Cultured porcine retinal pigment epithelial cells release superoxide, measured as superoxide dismutase (SOD)-suppressible reduction of cytochrome C, and SOD-suppressible luminol-dependent chemiluminescence. Latex beads stimulated a significant release of superoxide that reached 82 nmol/mg protein in the first 15 min a...

journal_title：Investigative ophthalmology & visual science

authors： Dorey CK,Khouri GG,Syniuta LA,Curran SA,Weiter JJ

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:To elucidate the anatomy of the trabecular meshwork (TM) and its connection to ciliary muscle (CM) tendons with two photon excitation microscopic (TPEM) imaging. METHODS:The human aqueous outflow pathway was imaged in an unfixed and nonembeded state by using an inverted TPEM. Laser (Ti:Sapphire) was tuned at 8...

journal_title：Investigative ophthalmology & visual science

authors： Park CY,Lee JK,Kahook MY,Schultz JS,Zhang C,Chuck RS

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To describe lacrimal gland involvement in a murine model of acute graft-versus-host disease (GVHD). METHODS:Histopathologic examination was performed on lacrimal glands of mice affected by GVHD at 1, 2, 4, and 6 weeks after allogeneic bone marrow transplantation (BMT). Histopathologic scoring, based on charact...

journal_title：Investigative ophthalmology & visual science

authors： Hassan AS,Clouthier SG,Ferrara JL,Stepan A,Mian SI,Ahmad AZ,Elner VM

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:The growth of ocular neovascularization is regulated by a balance between stimulating and inhibiting growth factors. Somatostatin affects angiogenesis by inhibiting the growth hormone-insulin-like growth factor axis and also has a direct antiproliferative effect on human retinal endothelial cells. The purpose o...

journal_title：Investigative ophthalmology & visual science

authors： Lambooij AC,Kuijpers RW,van Lichtenauer-Kaligis EG,Kliffen M,Baarsma GS,van Hagen PM,Mooy CM

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To investigate the alterations in gene expression when human retinal pigment epithelial (RPE) cells in culture are treated with vitreous as a model for the changes that occur in proliferative vitreoretinopathy. METHODS:Human RPE cells were cultured with or without human vitreous or collagen. RNA was extracted ...

journal_title：Investigative ophthalmology & visual science

authors： Parapuram SK,Ganti R,Hunt RC,Hunt DM

更新日期：2003-04-01 00:00:00

abstract：Purpose:High myopia (HM) is defined as a refractive error worse than -6.00 diopter (D). This study aims to update the phenotypic and genotypic landscape of nonsyndromic HM and to establish a biological link between the phenotypic traits and genetic deficiencies. Methods:A cross-sectional study involving 731 participan...

journal_title：Investigative ophthalmology & visual science

authors： Cai XB,Zheng YH,Chen DF,Zhou FY,Xia LQ,Wen XR,Yuan YM,Han F,Piao SY,Zhuang W,Lu F,Qu J,Yu AY,Jin ZB

更新日期：2019-09-03 00:00:00

abstract：:Treatment of human skin and corneal fibroblasts with prednisolone-21-phosphate did not increase the capacity of these cells to replicate type I herpes simplex virus (HSV). The steroid however was found to (1) inhibit human lymphocytes from mediating antibody-dependent cell-mediated cytotoxicity (ADCC) against HSV-infe...

journal_title：Investigative ophthalmology & visual science

authors： Cooper JA Jr,Daniels CA,Trofatter EF Jr

更新日期：1978-04-01 00:00:00

abstract：PURPOSE:Primary intraocular lymphoma (PIOL) is a diffuse large B cell lymphoma that initially infiltrates the retina, vitreous, or optic nerve head, with or without central nervous system involvement. This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 m...

journal_title：Investigative ophthalmology & visual science

authors： Wallace DJ,Shen D,Reed GF,Miyanaga M,Mochizuki M,Sen HN,Dahr SS,Buggage RR,Nussenblatt RB,Chan CC

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To identify the mutation leading to syndromic choroideremia (CHM) in two families and to define fundus autofluorescence (FAF) in CHM carriers. METHODS:The ophthalmic and clinical phenotype was investigated including FAF, neuropediatric, otorhinolaryngologic, cardiologic, and nephrologic examinations of three m...

journal_title：Investigative ophthalmology & visual science

authors： Poloschek CM,Kloeckener-Gruissem B,Hansen LL,Bach M,Berger W

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:To examine the association between central corneal thickness (CCT) and glaucoma. METHODS:This was a nested case-control study using 1090 subjects from an eye disease population survey in Singapore and 243 participants from a hospital glaucoma surgery clinical trial in Singapore. RESULTS:Mean CCT in 938 commun...

journal_title：Investigative ophthalmology & visual science

authors： Day AC,Machin D,Aung T,Gazzard G,Husain R,Chew PT,Khaw PT,Seah SK,Foster PJ

更新日期：2011-10-28 00:00:00

abstract：PURPOSE:To examine the temporal summation of a Goldmann III-sized stimulus under the conditions of standard automated perimetry in healthy participants of varying age. METHODS:Twenty-seven healthy individuals of varying age (24-80 years) were tested. Achromatic contrast thresholds were measured for seven 0.48° diamete...

journal_title：Investigative ophthalmology & visual science

authors： Mulholland PJ,Redmond T,Garway-Heath DF,Zlatkova MB,Anderson RS

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To describe the variation in ocular biometry in adult Chinese individuals in Singapore. METHODS:This study was a population-based, cross-sectional survey of adult Chinese persons aged 40 to 81 years residing in Tanjong Pagar district, Singapore. Axial ocular dimensions, including axial length (AL), anterior ch...

journal_title：Investigative ophthalmology & visual science

authors： Wong TY,Foster PJ,Ng TP,Tielsch JM,Johnson GJ,Seah SK

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:To detect the expression of cell adhesion molecules (CAMs), including beta integrins, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1, leukocyte-endothelial cell adhesion molecule-2, E-cadherin, and CD44, in cultured lens epithelial cells (LECs) of human cataracts. To show that LEC...

journal_title：Investigative ophthalmology & visual science

authors： Nishi O,Nishi K,Akaishi T,Shirasawa E

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:To compare the pharmacokinetics and tissue response between intravitreal and microcannulation injections into the suprachoroidal space using bevacizumab. METHODS:Sixty-two pigs were studied. Either a pars plana intravitreal bevacizumab or a viscoelastic-enhanced microcannula suprachoroidal injection was perfor...

journal_title：Investigative ophthalmology & visual science

authors： Olsen TW,Feng X,Wabner K,Csaky K,Pambuccian S,Cameron JD

更新日期：2011-07-01 00:00:00

abstract：Purpose:To assess if ripasudil has a neuroprotective effect using mice with excitatory amino acid carrier 1 (EAAC1) deletion (EAAC1 knockout [KO] mice), a mouse model of normal tension glaucoma. Methods:Topical administration (5 μL/day) of two different concentrations of ripasudil (0.4% and 2%) were applied to EAAC1 K...

journal_title：Investigative ophthalmology & visual science

authors： Akaiwa K,Namekata K,Azuchi Y,Sano H,Guo X,Kimura A,Harada C,Mitamura Y,Harada T

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:To explore connexin43 (Cx43) knockdown as an efficient treatment for corneal endothelial injury in an in vivo rat corneal scrape injury model. METHODS:Scrape injury was induced in the corneal endothelium, and immunolabeling (ZO-1, alpha-SMA, Cx43) was performed to analyze changes in Cx43 expression during woun...

journal_title：Investigative ophthalmology & visual science

authors： Nakano Y,Oyamada M,Dai P,Nakagami T,Kinoshita S,Takamatsu T

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To identify genes and molecular mechanisms associated with photoreceptor degeneration in a canine model of XLRP caused by an RPGR exon ORF15 microdeletion. Methods. Expression profiles of mutant and normal retinas were compared by using canine retinal custom cDNA microarrays. qRT-PCR, Western blot analysis, and...

journal_title：Investigative ophthalmology & visual science

authors： Genini S,Zangerl B,Slavik J,Acland GM,Beltran WA,Aguirre GD

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Since, to our knowledge, there are no reports on the prevalence of the blaNDM-1 gene among ocular isolates of Enterobacteriaceae, and only limited information on the prevalence of extended spectrum beta-lactamases (ESBLs) among ocular bacterial isolates are available, our study was undertaken. METHODS:A prospe...

journal_title：Investigative ophthalmology & visual science

authors： Sowmiya M,Malathi J,Madhavan HN

更新日期：2012-08-07 00:00:00

abstract：:Using isochromatic luminance gratings and isoluminant red-green color gratings, examined luminance and color discrimination in amblyopia were examined. Complete color and luminance contrast sensitivity functions were measured monocularly from each eye of six normal and six amblyopic observers. Similar spatial frequenc...

journal_title：Investigative ophthalmology & visual science

authors： Bradley A,Dahlman C,Switkes E,De Valois K

更新日期：1986-09-01 00:00:00

abstract：PURPOSE:Defensins are naturally occurring antimicrobial peptides. Recently the authors published evidence of defensin production by the human ocular surface. A study was undertaken to look for intraocular defensins that may account for unexplained antimicrobial activity of intraocular fluids. METHODS:Reverse transcrip...

journal_title：Investigative ophthalmology & visual science

authors： Haynes RJ,McElveen JE,Dua HS,Tighe PJ,Liversidge J

更新日期：2000-09-01 00:00:00

abstract：:A sensitive fluorometric assay for measuring permeability of liposomes containing bovine lens MIP26 has been developed and characterized. Lens membrane proteins were isolated and incorporated into artificial membranes composed of bovine brain phospholipids, sphingomyelin and the fluorescent probe, N-4-nitrobenzo-2-oxa...

journal_title：Investigative ophthalmology & visual science

authors： Scaglione BA,Rintoul DA

更新日期：1989-05-01 00:00:00

abstract：:The lacrimal gland is a functional part of the mucosal immune system and is populated by lymphoid cells that begin to appear early in neonatal development. To define the events controlling the accumulation of these cells, an in vitro adherence assay was used to investigate the interactions of lymphocyte populations wi...

journal_title：Investigative ophthalmology & visual science

authors： O'Sullivan NL,Montgomery PC

更新日期：1990-08-01 00:00:00

abstract：PURPOSE:To investigate possible protective effects of lens epithelium-derived growth factor (LEDGF) against photoreceptor death in light-damaged, Royal College of Surgeons (RCS) and P23H rhodopsin transgenic rats. METHODS:Twelve-week-old Sprague-Dawley (SD), 6-week-old RCS, and 10-day-old P23H (line 1, heterozygote) r...

journal_title：Investigative ophthalmology & visual science

authors： Machida S,Chaudhry P,Shinohara T,Singh DP,Reddy VN,Chylack LT Jr,Sieving PA,Bush RA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:To investigate the specific role of very late antigen-1 (VLA-1; also known as integrin α1β1) in corneal inflammatory lymphangiogenesis in vivo and lymphatic endothelial cell functions in vitro. METHODS:A standard suture-induced corneal inflammatory lymphangiogenesis model was used in normal adult BALB/c mice t...

journal_title：Investigative ophthalmology & visual science

authors： Grimaldo S,Yuen D,Ecoiffier T,Chen L

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To investigate the effect of K-115, a novel Rho kinase (ROCK) inhibitor, on retinal ganglion cell (RGC) survival in an optic nerve crush (NC) model. Additionally, to determine the details of the mechanism of K-115's neuroprotective effect in vivo and in vitro. METHODS:ROCK inhibitors, including K-115 and fasud...

journal_title：Investigative ophthalmology & visual science

authors： Yamamoto K,Maruyama K,Himori N,Omodaka K,Yokoyama Y,Shiga Y,Morin R,Nakazawa T

更新日期：2014-10-02 00:00:00