Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats.

abstract：:One eye of each of eight subjects was exposed to gases containing oxygen concentrations of 1.0%, 2.5%, 4.9%, 7.5%, 10.1%, and 21.4% (oxygen partial pressures ranging from 8 to 158 mmHg) for 8 hr. The precorneal oxygen concentration required to avoid corneal edema for the group as a whole was 10.1% (an oxygen tension o...

journal_title：Investigative ophthalmology & visual science

authors： Holden BA,Sweeney DF,Sanderson G

更新日期：1984-04-01 00:00:00

abstract：PURPOSE:To examine the relation between grating acuity at age 1 year and Snellen acuity and grating acuity at 5.5 years, in preterm children with birth weights less than 1251 g. METHODS:Subjects were participants in the multicenter study of Cryotherapy for Retinopathy of Prematurity. The Teller acuity card (TAC; Viste...

journal_title：Investigative ophthalmology & visual science

authors： Dobson V,Quinn GE,Siatkowski RM,Baker JD,Hardy RJ,Reynolds JD,Trese MT,Tung B

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD). METHODS:A retrospective study of the time course of fERG amplitude and its relation to visual acuity alterations was performed in 47 CRD patients followed yearly f...

journal_title：Investigative ophthalmology & visual science

authors： Galli-Resta L,Piccardi M,Ziccardi L,Fadda A,Minnella A,Marangoni D,Placidi G,Resta G,Falsini B

更新日期：2013-10-09 00:00:00

abstract：PURPOSE:Dry eye syndrome (DES) is characterized by an increase in tear osmolarity and induction of the expression and nuclear localization of an osmoprotective transcription factor (nuclear factor of activated T-cells 5 [NFAT5]) that plays an important role in providing protection against hyperosmotic tears. In this st...

journal_title：Investigative ophthalmology & visual science

authors： Sawazaki R,Ishihara T,Usui S,Hayashi E,Tahara K,Hoshino T,Higuchi A,Nakamura S,Tsubota K,Mizushima T

更新日期：2014-04-21 00:00:00

abstract：PURPOSE:To determine the profiles of soluble cytokine receptors and cytokines, including mostly their ligands, in the vitreous humor of patients with B-cell vitreoretinal lymphoma (VRL) and uveitis. METHODS:Vitreous samples were collected from immunocompetent patients with VRL (n = 21), uveitis (n = 20), and idiopathi...

journal_title：Investigative ophthalmology & visual science

authors： Takeda A,Yoshikawa H,Fukuhara T,Hikita S,Hijioka K,Otomo T,Arita R,Hisatomi T,Kimura K,Yoshida S,Kawano Y,Sonoda KH,Ishibashi T

更新日期：2015-11-01 00:00:00

abstract：:The comparison of intracellular pH (pHi) regulation between fresh (FBCE) and cultured (CBCE) bovine corneal endothelium was extended to HCO3- transport mechanisms. Upon introduction of CO2/HCO3- Ringer's solution, there was a small, sharp acidification followed by an alkalinization .09 and .18 pH U above the HCO3- fre...

journal_title：Investigative ophthalmology & visual science

authors： Bonanno JA,Giasson C

更新日期：1992-10-01 00:00:00

abstract：PURPOSE:The angiopoietin (Ang) system plays an important role in vascular stabilization and pathologic neovascularization. The hypothesis for the study was that, in addition to modulating endothelial cell behavior, the angiopoietin/Tie-2 system also regulates the pericyte apoptosis and/or the vessel maturation associat...

journal_title：Investigative ophthalmology & visual science

authors： Cai J,Kehoe O,Smith GM,Hykin P,Boulton ME

更新日期：2008-05-01 00:00:00

abstract：:Nonenzymatic glycated lens alpha-crystallin, isolated from human diabetic cataract lenses, does not differ in subunit size and secondary structure from nonglycated alpha-crystallin. The tertiary structure, however, has undergone a significant change as reflected in the changes of near-ultraviolet (UV) circular dichroi...

journal_title：Investigative ophthalmology & visual science

authors： Liang JN,Chylack LT Jr

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:To determine the effect of age on the proportion of apoptotic cells in the RPE and cellular density in human eyes in situ. METHODS:RPE flatmounts prepared from 22 adult human cadaver eyes (11 pairs; ages 19-87) were stained for apoptotic cells by a TUNEL technique. The density of RPE cells was also measured. T...

journal_title：Investigative ophthalmology & visual science

authors： Del Priore LV,Kuo YH,Tezel TH

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:We compared the anti-fibrotic effects of single versus multiple postoperative injections of saratin following glaucoma filtration surgery (GFS) in the rabbit model. METHODS:The experiment was in two parts. To determine the optimal frequency for postoperative therapy, seven New Zealand White (NZW) rabbits recei...

journal_title：Investigative ophthalmology & visual science

authors： Min J,Lukowski ZL,Levine MA,Meyers CA,Beattie AR,Schultz GS,Samuelson DA,Sherwood MB

更新日期：2012-11-19 00:00:00

abstract：:To compare the effects on the postnatal development of the eye of both total and partial form deprivation in diurnally reared chicks and of dark-rearing, chicks were reared with occluders covering one eye from hatching for up to 6 weeks. In diurnally reared birds, both total and partial form deprivation resulted in se...

journal_title：Investigative ophthalmology & visual science

authors： Gottlieb MD,Fugate-Wentzek LA,Wallman J

更新日期：1987-08-01 00:00:00

abstract：PURPOSE:In normal eyes and in diseases such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR), retinal pigment epithelial (RPE) cell survival is critically important. Bcl-x(L) has been shown to be among the most highly expressed survival factors in cultured human RPE cells. In the curr...

journal_title：Investigative ophthalmology & visual science

authors： Zhang N,Peairs JJ,Yang P,Tyrrell J,Roberts J,Kole R,Jaffe GJ

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:Previous sequence analyses of hemidesmosomal BP 180/collagen XVII cDNA from human skin and of a similar chicken corneal cDNA showed some similarities, but major differences as well. The authors examined whether, in one species, the same mRNA is present in cornea and skin. They also studied the developmental exp...

journal_title：Investigative ophthalmology & visual science

authors： Gordon MK,Fitch JM,Foley JW,Gerecke DR,Linsenmayer C,Birk DE,Linsenmayer TF

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:To correlate retinal histopathology with functional changes caused by the rhodopsin Q64ter mutation. METHODS:A 50-year-old female heterozygote was evaluated clinically and with psychophysical and electroretinographic measurements of rod and cone function. The retinas obtained after death were examined microsco...

journal_title：Investigative ophthalmology & visual science

authors： Milam AH,Li ZY,Cideciyan AV,Jacobson SG

更新日期：1996-04-01 00:00:00

abstract：Purpose:Extremely preterm infants are at increased risk for retinopathy of prematurity (ROP). We previously identified several inflammatory proteins that were expressed early in life and are associated with an increased risk of ROP and several angiogenic and neurotrophic growth factors in the neonatal systemic circulat...

journal_title：Investigative ophthalmology & visual science

authors： Bulka CM,Dammann O,Santos HP Jr,VanderVeen DK,Smeester L,Fichorova R,O'Shea TM,Fry RC

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To describe and analyze developmental change from birth through maturity of human electroretinogram (ERG) response, especially in terms of rod phototransduction as represented in the ERG a-wave. METHODS:Electroretinograms were recorded from 16 human infants from 5 to 270 days of age, two children 1.9 and 3.4 y...

journal_title：Investigative ophthalmology & visual science

authors： Breton ME,Quinn GE,Schueller AW

更新日期：1995-07-01 00:00:00

abstract：PURPOSE:This study sought to determine the earliest time-point at which evidence of choroidal neovascularization (CNV) could be detected with visible-light optical coherence tomography angiography (vis-OCTA) in a mouse model of laser-induced CNV. METHODS:Visible light-OCTA was used to study laser-induced CNV at differ...

journal_title：Investigative ophthalmology & visual science

authors： Shah RS,Soetikno BT,Yi J,Liu W,Skondra D,Zhang HF,Fawzi AA

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To identify pathogenic mutations in the guanylate cyclase-activating protein 1 (GCAP1) and GCAP2 genes and to characterize the biochemical effect of mutation on guanylate cyclase (GC) stimulation. METHODS:The GCAP1 and GCAP2 genes were screened by direct sequencing for mutations in 216 patients and 421 patient...

journal_title：Investigative ophthalmology & visual science

authors： Nishiguchi KM,Sokal I,Yang L,Roychowdhury N,Palczewski K,Berson EL,Dryja TP,Baehr W

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Retinitis pigmentosa is a clinically and genetically heterogeneous disorder. It is characterized by progressive degeneration of the peripheral retina, leading to night blindness and loss of the peripheral visual field. PRPF31 is one of four pre-mRNA splicing factors identified as causing autosomal dominant reti...

journal_title：Investigative ophthalmology & visual science

authors： Waseem NH,Vaclavik V,Webster A,Jenkins SA,Bird AC,Bhattacharya SS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:To present a new method of performing scanning laser ophthalmoscope perimetry that compensates for eye movements so that the correct retinal location is tested even if fixation changes. This allows for accurate testing of patients with central scotomas and for repeating testing longitudinally at the same retina...

journal_title：Investigative ophthalmology & visual science

authors： Sunness JS,Schuchard RA,Shen N,Rubin GS,Dagnelie G,Haselwood DM

更新日期：1995-08-01 00:00:00

abstract：:Nineteen hundred and seventy-six immature human cataracts extracted intracapsularly were classified according to the Cooperative Cataract Research Group (CCRG) method of cataract classification. Data on cataract location and extent, nuclear color, preoperative visual acuity, age, and sex were organized and stored in t...

journal_title：Investigative ophthalmology & visual science

authors： Chylack LT Jr,Ransil BJ,White O

更新日期：1984-02-01 00:00:00

abstract：PURPOSE:To determine whether anthocyanin-enriched bilberry extracts modulate pre- or posttranslational levels of oxidative stress defense enzymes heme-oxygenase (HO)-1 and glutathione S-transferase-pi (GST-pi) in cultured human retinal pigment epithelial (RPE) cells. METHODS:Confluent ARPE-19 cells were preincubated w...

journal_title：Investigative ophthalmology & visual science

authors： Milbury PE,Graf B,Curran-Celentano JM,Blumberg JB

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:Peripheral and limbal corneal stromal cells (PLCSCs), which contain keratocytes, have a complex phenotype. Knowledge of keratocyte cell properties, function, and origin is limited. Evidence available thus far has suggested both mesenchymal stromal and hematopoietic characteristics. Multipotent mesenchymal strom...

journal_title：Investigative ophthalmology & visual science

authors： Branch MJ,Hashmani K,Dhillon P,Jones DR,Dua HS,Hopkinson A

更新日期：2012-08-03 00:00:00

abstract：PURPOSE:To explore connexin43 (Cx43) knockdown as an efficient treatment for corneal endothelial injury in an in vivo rat corneal scrape injury model. METHODS:Scrape injury was induced in the corneal endothelium, and immunolabeling (ZO-1, alpha-SMA, Cx43) was performed to analyze changes in Cx43 expression during woun...

journal_title：Investigative ophthalmology & visual science

authors： Nakano Y,Oyamada M,Dai P,Nakagami T,Kinoshita S,Takamatsu T

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Hyperreflective foci (HFs) are observable within the neurosensory retina in diabetic macular edema (DME) using spectral domain optical coherence tomography (SD-OCT). HFs have also been seen in wet age-related macular degeneration (AMD), although the origin is still unknown; however, they reduced significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Framme C,Schweizer P,Imesch M,Wolf S,Wolf-Schnurrbusch U

更新日期：2012-08-24 00:00:00

abstract：PURPOSE:Neovascular age-related macular degeneration (AMD) resulting in decreased central vision severely impairs affected individuals. Current standard treatment is an intravitreal anti-VEGF therapy (ranibizumab), but responses to treatment show large variability. Genetic factors that influence AMD and that affect the...

journal_title：Investigative ophthalmology & visual science

authors： Kloeckener-Gruissem B,Barthelmes D,Labs S,Schindler C,Kurz-Levin M,Michels S,Fleischhauer J,Berger W,Sutter F,Menghini M

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:To explore factors affecting the glaucoma diagnostic capability of macular thickness and circumpapillary retinal nerve fiber layer (cRNFL) thickness as determined by spectral domain-optical coherence tomography. METHODS:Area under the curve (AUC) of the receiver operating characteristics (ROC) discriminating h...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Sun JH,Lee Y

更新日期：2011-10-11 00:00:00

abstract：PURPOSE:Visibility of low-spatial frequency stimuli improves when their contrast is modulated at 5 to 10 Hz compared with stationary stimuli. Therefore, temporal modulations of visual objects could enhance the performance of low vision patients who primarily perceive images of low-spatial frequency content. We investig...

journal_title：Investigative ophthalmology & visual science

authors： Watson LM,Strang NC,Scobie F,Love GD,Seidel D,Manahilov V

更新日期：2012-09-06 00:00:00

abstract：PURPOSE:To investigate macular photoreceptor structure in patients with inherited retinal degeneration using high-resolution images and to correlate the findings with clinical phenotypes and genetic mutations. METHODS:Adaptive optics scanning laser ophthalmoscopy (AOSLO) images of photoreceptors were obtained in 16 ey...

journal_title：Investigative ophthalmology & visual science

authors： Duncan JL,Zhang Y,Gandhi J,Nakanishi C,Othman M,Branham KE,Swaroop A,Roorda A

更新日期：2007-07-01 00:00:00

abstract：:Extracellular matrix (ECM) turnover and remodeling are initiated, at least in part, by the regulated secretion of members of a family of matrix metalloproteinases. Human and bovine trabecular mesh-work in culture secrete interstitial collagenase, both the 72- and the 92-kD forms of type IV collagenase (gelatinases) an...

journal_title：Investigative ophthalmology & visual science

authors： Alexander JP,Samples JR,Van Buskirk EM,Acott TS

更新日期：1991-01-01 00:00:00