Expression of matrix metalloproteinases and inhibitor by human trabecular meshwork.

abstract：Purpose:To assess clinical characteristics, foveal structure, mutation spectrum, and prevalence rate of Åland eye disease (AED)/incomplete congenital stationary night blindness (iCSNB). Methods:A retrospective survey included individuals diagnosed with AED at a national low-vision center from 1980 to 2014. A subset of...

journal_title：Investigative ophthalmology & visual science

authors： Hove MN,Kilic-Biyik KZ,Trotter A,Grønskov K,Sander B,Larsen M,Carroll J,Bech-Hansen T,Rosenberg T

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To investigate the function of connective tissue growth factor (CTGF), a matricellular protein of the CCN (Cyr61/CTGF/Nov) family, in retinal vasculature during development and ischemia. METHODS:CTGF expression was determined using RT-PCR, immunohistochemistry, and transgenic mice carrying CTGF promoter-driven...

journal_title：Investigative ophthalmology & visual science

authors： Pi L,Xia H,Liu J,Shenoy AK,Hauswirth WW,Scott EW

更新日期：2011-11-07 00:00:00

abstract：:Substance P (SP)--like immunoreactivity has been localized to distinct retinal cell populations in the primate Macaca nemestrina by means of immunohistochemical techniques with a well-characterized monoclonal antiserum directed to SP. The specificity of the immunoreactive staining was established by absorption of the ...

journal_title：Investigative ophthalmology & visual science

authors： Brecha N,Hendrickson A,Florén I,Karten HJ

更新日期：1982-08-01 00:00:00

abstract：Purpose:To determine if variation in anterior lamina cribrosa surface depth (ALCSD) differs between glaucoma patients of African (AD) and European descent (ED). Methods:A total of 178 eyes from 123 glaucoma patients in the African Descent and Glaucoma Evaluation Study (ADAGES) and Diagnostic Innovations in Glaucoma St...

journal_title：Investigative ophthalmology & visual science

authors： Girkin CA,Fazio MA,Bowd C,Medeiros FA,Weinreb RN,Liebmann JM,Proudfoot J,Zangwill LM,Belghith A

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:To study the spatial distribution of posterior pole choroidal thickness (CT) in healthy eyes using spectral domain optical coherence tomography (SD-OCT). METHODS:Fifty-nine eyes from 30 subjects with no retinal or choroidal disease were examined with high-definition (HD) OCT using macular volume cube scanning ...

journal_title：Investigative ophthalmology & visual science

authors： Ouyang Y,Heussen FM,Mokwa N,Walsh AC,Durbin MK,Keane PA,Sanchez PJ,Ruiz-Garcia H,Sadda SR

更新日期：2011-09-01 00:00:00

abstract：:Male albino rats, injected intravenously or intracerebroventricularly with delta 1-tetrahydrocannabinol (THC), develop mudriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 microgram/kg THC. Sympathectomy significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Korczyn AD,Eshel Y

更新日期：1982-03-01 00:00:00

abstract：PURPOSE:Identification of novel proteins involved in retinal neovascularization may facilitate new and more effective molecular-based treatments for proliferative retinopathy. Tubedown-1 (Tbdn-1) is a novel protein that shows homology to the yeast acetyltransferase subunit NAT1 and copurifies with an acetyltransferase ...

journal_title：Investigative ophthalmology & visual science

authors： Wall DS,Gendron RL,Good WV,Miskiewicz E,Woodland M,Leblanc K,Paradis H

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:Liquid perfluorocarbons are used as temporary vitreous substitutes in the surgical management of complicated retinal detachment. The purpose of this study was to determine if physiologic benefits could also be derived from the high oxygen solubility of perfluorochemicals relative to vitreous, especially during ...

journal_title：Investigative ophthalmology & visual science

authors： Wilson CA,Berkowitz BA,Srebro R

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:To investigate whether oxygen stresses experienced in retinopathy of prematurity (ROP) trigger signaling through reactive oxygen species (ROS) and whether the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway lead to intravitreous neovascularization (IVNV) in an oxygen-induced ret...

journal_title：Investigative ophthalmology & visual science

authors： Byfield G,Budd S,Hartnett ME

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:Cultured human corneal endothelial cells (cHCECs) are anticipated to become an alternative to donor corneas for the treatment of corneal endothelial dysfunction. However, cHCECs reportedly tend to exhibit chromosomal abnormality during in vitro cell division, thereby hampering their use in the clinical setting....

journal_title：Investigative ophthalmology & visual science

authors： Hamuro J,Ueno M,Toda M,Sotozono C,Montoya M,Kinoshita S

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To evaluate the association between elevated levels of plasma pentraxin 3 (PTX3) and the development and/or progression of diabetic retinopathy (DR). METHODS:In this case-control study, 92 diabetic patients with DR (group 3), 30 diabetic patients without DR (group 2), and 41 normal subjects (group 1) were enro...

journal_title：Investigative ophthalmology & visual science

authors： Yang HS,Woo JE,Lee SJ,Park SH,Woo JM

更新日期：2014-08-26 00:00:00

abstract：PURPOSE:To study the aggregation of bovine gamma-crystallins in aqueous solutions and the effect of gamma(s)-crystallin on the aggregation of other gamma-crystallins. METHODS:Aggregation in aqueous solutions of gamma(s)-, gammaII-, and gammaIVa-crystallin was monitored by quasielastic light scattering. Aggregation in ...

journal_title：Investigative ophthalmology & visual science

authors： Liu C,Pande J,Lomakin A,Ogun O,Benedek GB

更新日期：1998-08-01 00:00:00

abstract：Purpose:The activation of the urokinase-type plasminogen activator and its receptor system is associated with retinal diseases. Among peptide inhibitors of this system, UPARANT acts by preventing the onset of pathologic signs of neovascular ocular diseases. We investigated whether systemic UPARANT may act in a therapeu...

journal_title：Investigative ophthalmology & visual science

authors： Cammalleri M,Locri F,Marsili S,Dal Monte M,Pisano C,Mancinelli A,Lista L,Rusciano D,De Rosa M,Pavone V,Bagnoli P

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:Although much is now understood about the molecular structure of tight junctions (TJs), little is known about the regulation of their function during neural inflammatory disease processes in vivo. The mechanisms by which leukocytes transmigrate the blood-retina barrier (BRB) without affecting endothelial permea...

journal_title：Investigative ophthalmology & visual science

authors： Xu H,Dawson R,Crane IJ,Liversidge J

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:To study the relationships between the refractive power of the crystalline lens, overall refractive error of the eye, and degree of nuclear cataract. METHODS:All phakic participants of the population-based Central India Eye and Medical Study with an age of 50+ years were included. Calculation of the refractive...

journal_title：Investigative ophthalmology & visual science

authors： Iribarren R,Morgan IG,Nangia V,Jonas JB

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:The accessory lacrimal glands are assumed to contribute to the production of tear fluid, but little is known about their function. The goal of this study was to conduct an analysis of gene expression by glands of Wolfring that would provide a more complete picture of the function of these glands. METHODS:Gland...

journal_title：Investigative ophthalmology & visual science

authors： Ubels JL,Gipson IK,Spurr-Michaud SJ,Tisdale AS,Van Dyken RE,Hatton MP

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:Several nonsyndromic high-grade myopia loci have been mapped primarily by microsatellite markers and a limited number of pedigrees. In this study, whole-genome linkage scans were performed for high-grade myopia, using single nucleotide polymorphisms (SNPs) in 254 families from five independent sites. METHODS:G...

journal_title：Investigative ophthalmology & visual science

authors： Li YJ,Guggenheim JA,Bulusu A,Metlapally R,Abbott D,Malecaze F,Calvas P,Rosenberg T,Paget S,Creer RC,Kirov G,Owen MJ,Zhao B,White T,Mackey DA,Young TL

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:To investigate the association of 25-hydroxyvitamin D with AMD. METHODS:A population-based, cross-sectional study using a nationwide, systemic-stratified, multistage-clustered sampling method involved a total of 17,045 subjects older than 40 years who participated in the Korean National Health and Nutrition Ex...

journal_title：Investigative ophthalmology & visual science

authors： Kim EC,Han K,Jee D

更新日期：2014-07-11 00:00:00

abstract：PURPOSE:To assess the relationship between reduced vision and low self-rating of global health, after taking into account many other related factors. METHODS:The Blue Mountains Eye Study examined 3654 residents aged > or =49 years (82.4% response) in an area west of Sydney, Australia. Presenting and best-corrected vis...

journal_title：Investigative ophthalmology & visual science

authors： Wang JJ,Mitchell P,Smith W

更新日期：2000-01-01 00:00:00

abstract：Purpose:To assess interocular delays in amblyopes with stereopsis and to evaluate the relationship between interocular delays and the clinical characteristics. Methods:Twenty amblyopes with stereopsis (median, 400 arcseconds) and 20 controls with normal or corrected to normal visual acuity (≤0 logMAR) and normal stere...

journal_title：Investigative ophthalmology & visual science

authors： Wu Y,Reynaud A,Tao C,Mao Y,He Z,Zhou J,Hess RF

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:Refraction, as measured by spherical equivalent, is the need for an external lens to focus images on the retina. While genetic factors play an important role in the development of refractive errors, few susceptibility genes have been identified. However, several regions of linkage have been reported for myopia ...

journal_title：Investigative ophthalmology & visual science

authors： Klein AP,Duggal P,Lee KE,Cheng CY,Klein R,Bailey-Wilson JE,Klein BE

更新日期：2011-07-13 00:00:00

abstract：PURPOSE:The hypothesis in the study was that androgens control meibomian gland function, regulate the quality and/or quantity of lipids produced by this tissue, and promote the formation of the tear film's lipid layer. To test this hypothesis, a study was conducted to determine whether androgen receptor protein exists ...

journal_title：Investigative ophthalmology & visual science

authors： Sullivan DA,Sullivan BD,Ullman MD,Rocha EM,Krenzer KL,Cermak JM,Toda I,Doane MG,Evans JE,Wickham LA

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:To compare the mydriatic effect and the short-term corneal endothelial safety of intracamerally injected N-methyl-3,4-dihydroxyphenylamine (epinine) to phenylephrine in a porcine eye model. METHODS:One hundred twelve eyes from newly slaughtered pigs were used in this study. After pretreatment with 20 mg intrac...

journal_title：Investigative ophthalmology & visual science

authors： Lundberg B,Behndig A

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:To investigate whether enzymatic collagen breakdown is an active process in the human vitreous. METHODS:Human donor eyes were used for immunohistochemistry to detect the possible presence of the matrix metalloproteinase (MMP)-induced type II collagen breakdown product col2-3/4C-short in the vitreous. Western b...

journal_title：Investigative ophthalmology & visual science

authors： van Deemter M,Pas HH,Kuijer R,van der Worp RJ,Hooymans JM,Los LI

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:Adipogenesis contributes to the pathogenesis of thyroid eye disease (TED). Thyrotropin receptor (TSHR) transcripts are present in orbital fat. This study was conducted to determine whether they are expressed as functional protein, and if so, whether this is restricted to TED orbits or to a particular stage in a...

journal_title：Investigative ophthalmology & visual science

authors： Crisp M,Starkey KJ,Lane C,Ham J,Ludgate M

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:Adipose-derived stem cells (ASCs) have gained importance due to their myriad potential clinical applications. We hypothesize that progenitor cells also exist besides those conventionally isolated from the stromal vascular fraction (SVF). METHOD:Central and medial orbital adipose tissues obtained from patients ...

journal_title：Investigative ophthalmology & visual science

authors： Chen SY,Mahabole M,Horesh E,Wester S,Goldberg JL,Tseng SC

更新日期：2014-07-03 00:00:00

abstract：PURPOSE:To investigate the expression of humanin (HN) in human retinal pigment epithelial (hRPE) cells and its effect on oxidative stress-induced cell death, mitochondrial bioenergetics, and senescence. METHODS:Humanin localization in RPE cells and polarized RPE monolayers was assessed by confocal microscopy. Human RP...

journal_title：Investigative ophthalmology & visual science

authors： Sreekumar PG,Ishikawa K,Spee C,Mehta HH,Wan J,Yen K,Cohen P,Kannan R,Hinton DR

更新日期：2016-03-01 00:00:00

abstract：Purpose:Aging is a critical risk factor for the development of retinal diseases, but how aging perturbs ocular homeostasis and contributes to disease is unknown. We identified transmembrane protein 135 (Tmem135) as a gene important for regulating retinal aging and mitochondrial dynamics in mice. Overexpression of Tmem1...

journal_title：Investigative ophthalmology & visual science

authors： Landowski M,Grindel S,Shahi PK,Johnson A,Western D,Race A,Shi F,Benson J,Gao M,Santoirre E,Lee WH,Ikeda S,Pattnaik BR,Ikeda A

更新日期：2020-10-01 00:00:00

abstract：:Determination of intraocular antibody synthesis against certain microorganisms is a diagnostic aid in identifying the causative agent in clinical uveitis. Little is known, however, concerning the kinetics and specificity of antibodies produced during intraocular inflammation. To investigate this subject we induced uve...

journal_title：Investigative ophthalmology & visual science

authors： van der Voet JC,Liem A,Otto AJ,Kijlstra A

更新日期：1989-02-01 00:00:00

abstract：:Secretory component (SC) was studied by indirect immunofluorescence of the ocular surface epithelium. We find that conjunctival epithelium produces this component, and that it is absent in the corneal epithelium. Conjunctival epithelium loses its SC staining within 1 to 2 days as it grows over a denuded corneal stroma...

journal_title：Investigative ophthalmology & visual science

authors： Liu SH,Tagawa Y,Prendergast RA,Franklin RM,Silverstein AM

更新日期：1981-01-01 00:00:00