当前位置： SCI文献检索 > INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE期刊下所有文献 > The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model.

The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model.

Abstract：

PURPOSE:To investigate whether oxygen stresses experienced in retinopathy of prematurity (ROP) trigger signaling through reactive oxygen species (ROS) and whether the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway lead to intravitreous neovascularization (IVNV) in an oxygen-induced retinopathy (OIR) rat model. METHODS:Newborn rat pups exposed to repeated fluctuations in oxygen and rescued in supplemental oxygen (28% O(2), 50/10 OIR+SO) were treated with apocynin, an NADPH oxidase and ROS inhibitor (10 mg/kg/d), AG490, a JAK2 inhibitor (5 mg/kg/d), or phosphate-buffered saline. Intraperitoneal injections were given from postnatal day (P)12 to P17 (apocynin), or from P3 to P17 (AG490). Outcomes were intravitreous neovascularization and avascular/total retinal areas, vascular endothelial growth factor, phosphorylated JAK2, and phosphorylated STAT3. RESULTS:Apocynin significantly reduced phosphorylated STAT3 in 50/10 OIR+SO (P = 0.04), in association with previously reported inhibition of the IVNV area. Inhibition of JAK with AG490 significantly reduced phosphorylated JAK2 (P < 0.001), phosphorylated STAT3 (P = 0.002), and IVNV area (P = 0.033) in the 50/10 OIR+SO model compared with control. CONCLUSIONS:Activation of NADPH oxidase from supplemental oxygen works through activated STAT3 to lead to IVNV. In addition, inhibition of the JAK/STAT pathway reduces IVNV. Further studies are needed to determine the effects and relationships of oxygen stresses on JAK/STAT and NAPDH oxidase signaling.

journal_name

Invest Ophthalmol Vis Sci

journal_title

Investigative ophthalmology & visual science

authors

Byfield G,Budd S,Hartnett ME

doi

10.1167/iovs.08-3256

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

3360-5

issue

7

eissn

0146-0404

issn

1552-5783

pii

iovs.08-3256

journal_volume

50

pub_type

杂志文章

相关文献

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE文献大全
  • Plasminogen activator activity in vitamin A-deficient rat corneas.

    abstract：:Plasminogen activator (PA) activity during epithelial wound healing in vitamin A-deficient rats was investigated to determine whether a relationship exists between corneal defect formation and PA activity. Uniform, central 3 mm diameter corneal epithelial wounds were made by scalpel debridement in vitamin A-deficient ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Hayashi K,Frangieh G,Kenyon KR,Berman M,Wolf G

    更新日期：1988-12-01 00:00:00

  • Selective binding of a 30-kilodalton protein to disposable hydrophilic contact lenses.

    abstract：:To investigate the accumulation of tear proteins on disposable extended-wear contact lenses (42% Etafilcon A and 58% hydration), a technique involving sodium dodecyl sulfate-polyacrylamide minigel electrophoresis combined with a sensitive silver-staining method was used. Besides the binding of large amounts of tear ly...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Cheng KH,Kok JH,van Mil C,Kijlstra A

    更新日期：1990-11-01 00:00:00

  • Effect of blur adaptation on blur sensitivity and discrimination in emmetropes and myopes.

    abstract：PURPOSE:To determine whether blur adaptation influences blur sensitivity and blur discrimination thresholds in young adult myopes and emmetropes. In addition, to determine whether there is a differential effect of blur adaptation on blur sensitivity and discrimination between refractive error groups. METHODS:Proximal ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.06-0836

    authors： Cufflin MP,Mankowska A,Mallen EA

    更新日期：2007-06-01 00:00:00

  • Ischemia results 3 months later in altered ERG, degeneration of inner layers, and deafferented tectum: neuroprotection with brimonidine.

    abstract：PURPOSE:To investigate the long-term effects of transient ligature of the ophthalmic vessels (LOV) on the inner and outer retina as well as on retinotectal projection, and whether brimonidine (BMD) has protective effects. METHODS:In adult rats, the left eye was subjected to 90 minutes of LOV. One hour before ischemia,...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.05-0392

    authors： Mayor-Torroglosa S,De la Villa P,Rodríguez ME,López-Herrera MP,Avilés-Trigueros M,García-Avilés A,de Imperial JM,Villegas-Pérez MP,Vidal-Sanz M

    更新日期：2005-10-01 00:00:00

  • Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats.

    abstract：:PURPOSE. The purpose of the study was to investigate the effects of hyperglycemia on EGFR (epidermal growth factor receptor)-mediated wound response and signal transduction in the corneal epithelium of rats with type I diabetes mellitus (DM). METHODS. Corneal epithelia were removed from streptozotocin (STZ)- and weigh...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.10-5670

    authors： Xu K,Yu FS

    更新日期：2011-05-17 00:00:00

  • Variation of the axial location of Bruch's membrane opening with age, choroidal thickness, and race.

    abstract：PURPOSE:This study explores variation in the axial location of Bruch's membrane opening (BMO) to determine if this reference plane varies with age and race. METHODS:There were 168 spectral-domain optical coherence tomography (SDOCT) optic nerve head volumes that were obtained from healthy subjects and manually delinea...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,多中心研究

    doi：10.1167/iovs.13-12937

    authors： Johnstone J,Fazio M,Rojananuangnit K,Smith B,Clark M,Downs C,Owsley C,Girard MJ,Mari JM,Girkin CA

    更新日期：2014-03-28 00:00:00

  • Tear lipocalins: potential lipid scavengers for the corneal surface.

    abstract：PURPOSE:To investigate the dynamic effect of tear lipocalins (TLs), the major lipid-binding protein in tears, at aqueous-cornea and lipid-aqueous interfaces, and their potential contribution to surface tension in the tear film. METHODS:Human apo- and holo-TLs were applied to the aqueous subphase in a Langmuir trough, ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Glasgow BJ,Marshall G,Gasymov OK,Abduragimov AR,Yusifov TN,Knobler CM

    更新日期：1999-12-01 00:00:00

  • Oxygen levels beneath the closed eyelid.

    abstract：:The level of oxygen at the anterior corneal surface beneath the closed eyelid is shown to be equivalent to an atmosphere of 7.7% oxygen. This finding is in good agreement with assumptions which have been based on the oxygen level at the palpebral conjunctiva. However, in some instances a significant amount of oxygen i...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Efron N,Carney LG

    更新日期：1979-01-01 00:00:00

  • Lens lactate dehydrogenase inactivation after UV-B irradiation: an in vivo measure of UVR-B penetration.

    abstract：PURPOSE:To elucidate the spatial distribution of inactivation of lactate dehydrogenase (LDH) in ultraviolet-B radiation (UVR-B)-exposed eyes. To determine the in vivo penetration depth of UVR-B in the lens. METHODS:LDH activity in cornea and lens was investigated with an enzyme histochemical technique. Thirty rats wer...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Löfgren S,Söderberg PG

    更新日期：2001-07-01 00:00:00

  • Effect of group B streptococcal meningitis on retinal and choroidal blood flow in newborn pigs.

    abstract：PURPOSE:To assess the effect of group B streptococcal (GBS) meningitis on retinal blood flow (RetBF) and choroidal blood flow (ChBF) autoregulation in sedated newborn piglets (1 to 5 days of age). METHODS:Fourteen study animals injected with 0.5 ml heat-killed GBS (10(9)) were compared to 10 control animals injected w...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Bottoli I,Beharry K,Modanlou HD,Norris K,Ling E,Noya F,Amato MM,Aranda JV

    更新日期：1995-06-01 00:00:00

  • An investigation of lateral geniculate nucleus volume in patients with primary open-angle glaucoma using 7 tesla magnetic resonance imaging.

    abstract：PURPOSE:To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI). METHODS:The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All s...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.14-13902

    authors： Lee JY,Jeong HJ,Lee JH,Kim YJ,Kim EY,Kim YY,Ryu T,Cho ZH,Kim YB

    更新日期：2014-04-10 00:00:00

  • Confocal microscopy reveals zones of membrane remodeling in the outer cortex of the human lens.

    abstract：PURPOSE:To optimize fixation, sectioning, and immunolabeling protocols to map the morphology of the human lens with confocal microscopy. METHODS:Transparent human lenses were fixed in 0.75% paraformaldehyde for 24 hours, cut in half, and fixed for another 24 hours. Lenses were cryoprotected, sectioned, and labeled wit...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.09-3435

    authors： Lim JC,Walker KL,Sherwin T,Schey KL,Donaldson PJ

    更新日期：2009-09-01 00:00:00

  • The retina of Spalax ehrenbergi: novel histologic features supportive of a modified photosensory role.

    abstract：PURPOSE:The retina of the blind mole rat Spalax ehrenbergi was compared with other vertebrate photosensitive organs in an attempt to correlate its histologic organization with a presumptive nonvisual photoreceptor role. METHODS:The eyes of eight adult animals were analyzed by light and electron microscopy, using conve...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Cernuda-Cernuda R,DeGrip WJ,Cooper HM,Nevo E,García-Fernández JM

    更新日期：2002-07-01 00:00:00

  • Mechanisms of mitotic inhibition in corneal endothelium: contact inhibition and TGF-beta2.

    abstract：PURPOSE:Contact inhibition has been implicated as an important antiproliferative mechanism in developing and mature corneal endothelium. Although exogenous TGF-beta2 and TGF-beta2 in aqueous humor suppress S-phase entry in cultured rat corneal endothelial cells, it is not known whether TGF-beta2 contributes to the mito...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Joyce NC,Harris DL,Mello DM

    更新日期：2002-07-01 00:00:00

  • Genetic Association at the 9p21 Glaucoma Locus Contributes to Sex Bias in Normal-Tension Glaucoma.

    abstract：PURPOSE:Many genome-wide association studies have identified common single nucleotide polymorphisms (SNPs) at the 9p21 glaucoma locus (CDKN2B/CDKN2B-AS1) to be significantly associated with primary open-angle glaucoma (POAG), with association being stronger in normal tension glaucoma (NTG) and advanced glaucoma. We aim...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-19401

    authors： Ng SK,Burdon KP,Fitzgerald JT,Zhou T,Fogarty R,Souzeau E,Landers J,Mills RA,Casson RJ,Ridge B,Graham SL,Hewitt AW,Mackey DA,Healey PR,Wang JJ,Mitchell P,MacGregor S,Craig JE

    更新日期：2016-06-01 00:00:00

  • Distinct functions of photoreceptor cell-specific nuclear receptor, thyroid hormone receptor beta2 and CRX in one photoreceptor development.

    abstract：PURPOSE:To clarify the functions of a specific subtype of thyroid hormone receptor (TR), TRbeta2, and photoreceptor cell-specific nuclear receptor (PNR) in the development of cone photoreceptors. METHODS:The expression of short (S)- and medium (M)-wavelength cone opsins was analyzed by reverse transcription polymerase...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Yanagi Y,Takezawa S,Kato S

    更新日期：2002-11-01 00:00:00

  • Effects of chronic demyelination on axonal transport in experimental allergic optic neuritis.

    abstract：:Axonal transport studies were undertaken to determine the effect of chronic demyelination on axonal function in experimental allergic optic neuritis in the guinea pig, an animal model for multiple sclerosis. Fast and slow components of axonal transport over the prelaminar, laminar, and retrolaminar portions of the opt...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Rao NA,Guy J,Sheffield PS

    更新日期：1981-10-01 00:00:00

  • Literacy is an independent risk factor for vision impairment and poor visual functioning.

    abstract：PURPOSE:People with limited literacy are at increased risks of chronic systemic conditions. The authors therefore investigated the independent contribution of limited literacy on visual impairment and visual function in a large eye survey in Singapore. METHODS:The authors undertook a population-based, cross-sectional ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-7725

    authors： Zheng Y,Lamoureux EL,Chiang PP,Cheng CY,Anuar AR,Saw SM,Aung T,Wong TY

    更新日期：2011-09-29 00:00:00

  • Autophagy and Macropinocytosis: Keeping an Eye on the Corneal/Limbal Epithelia.

    abstract：:Autophagy and macropinocytosis are processes that are vital for cellular homeostasis, and help cells respond to stress and take up large amounts of material, respectively. The limbal and corneal epithelia have the machinery necessary to carry out both processes; however, autophagy and macropinocytosis are relatively u...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,评审

    doi：10.1167/iovs.16-21111

    authors： Peng H,Park JK,Lavker RM

    更新日期：2017-01-01 00:00:00

  • Extranodal marginal zone lymphoma in the ocular region: clinical, immunophenotypical, and cytogenetical characteristics.

    abstract：PURPOSE:To evaluate clinical, immunophenotypical, and cytogenetical characteristics of 116 patients with a diagnosis of extranodal marginal zone lymphoma (EMZL) presenting primarily in the ocular region. METHODS:Specimens from all patients with a diagnosis of ophthalmic lymphoma in Denmark during the period 1980 to 20...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.08-2539

    authors： Sjö LD,Heegaard S,Prause JU,Petersen BL,Pedersen S,Ralfkiaer E

    更新日期：2009-02-01 00:00:00

  • Association of Upregulated Angiogenic Cytokines With Choroidal Abnormalities in Chronic Central Serous Chorioretinopathy.

    abstract：Purpose:To clarify the distinct molecular pathogenesis of central serous chorioretinopathy (CSC) and pachychoroid neovasculopathy (PNV). Methods:Aqueous humor (AH) was collected from 18 acute CSC, 20 chronic CSC, and 20 PNV patients. Concentrations of 30 cytokines in the AH were analyzed using a multiplex bead immunoa...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.18-25517

    authors： Terao N,Koizumi H,Kojima K,Yamagishi T,Nagata K,Kitazawa K,Yamamoto Y,Yoshii K,Hiraga A,Toda M,Kinoshita S,Sotozono C,Hamuro J

    更新日期：2018-12-03 00:00:00

  • Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects.

    abstract：PURPOSE:We studied the correlation between outer nuclear layer (ONL) thickness and cone density in normal eyes and eyes with retinitis pigmentosa (RP). METHODS:Spectral-domain optical coherence tomography (SD-OCT) scans were acquired using a displaced pupil entry position of the scanning beam to distinguish Henle's fi...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章,随机对照试验

    doi：10.1167/iovs.14-15521

    authors： Menghini M,Lujan BJ,Zayit-Soudry S,Syed R,Porco TC,Bayabo K,Carroll J,Roorda A,Duncan JL

    更新日期：2014-12-16 00:00:00

  • Acceleration of age-related changes in the retina in alpha-tocopherol transfer protein null mice fed a Vitamin E-deficient diet.

    abstract：PURPOSE:To assess the role of vitamin E (VE) in age-related changes in the retinal tissues by using a mouse model of severe VE deficiency. METHODS:Pups of alpha-tocopherol transfer protein null (a-TTP(-)(/)(-)) mice were fed a VE-deficient diet for 4 or 18 months (VE (-) group). Wild-type C57BL/6 mice were fed a 0.002...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.06-0872

    authors： Tanito M,Yoshida Y,Kaidzu S,Chen ZH,Cynshi O,Jishage K,Niki E,Ohira A

    更新日期：2007-01-01 00:00:00

  • Effects of aging on 24-hour intraocular pressure measurements in sitting and supine body positions.

    abstract：PURPOSE:To evaluate how aging alters 24-hour measurements of intraocular pressure (IOP) in the sitting and supine body positions. METHODS:Fifteen older volunteers with healthy eyes (ages, 53-71 years) were each housed for 1 day in a sleep laboratory. An 8-hour accustomed sleep period was assigned to each subject. Ever...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-8763

    authors： Mansouri K,Weinreb RN,Liu JH

    更新日期：2012-01-10 00:00:00

  • Saccade adaptation in Williams-Beuren Syndrome.

    abstract：PURPOSE:To investigate the capacity for rapid saccade adaptation in Williams-Beuren Syndrome (WBS), a genetic neurodevelopmental disorder, in which it has been observed that saccadic accuracy is severely reduced. METHODS:Saccade amplitude modification was elicited by backward steps (30% of target eccentricity) during ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.05-0617

    authors： van der Geest JN,Haselen GC,Frens MA

    更新日期：2006-04-01 00:00:00

  • Neutrophil Activities in Human Ocular Toxoplasmosis: An In Vitro Study With Human Cells.

    abstract：Purpose:Retinal damage in ocular toxoplasmosis reflects Toxoplasma gondii-induced cell lysis and reactive inflammation. Human retinal histopathology demonstrates the presence of neutrophils, but activities of this leukocyte subset are unstudied. We conducted in vitro experiments to evaluate roles for neutrophils as ret...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.19-28306

    authors： Ashander LM,Lie S,Ma Y,Rochet E,Washington JM,Furtado JM,Appukuttan B,Smith JR

    更新日期：2019-11-01 00:00:00

  • Comparative Anatomy of the Mammalian Corneal Subbasal Nerve Plexus.

    abstract：Purpose:The subbasal nerve plexus (SNP) is the densest and most recognizable component of the mammalian corneal innervation; however, the anatomical configuration of the SNP in most animal models remains incompletely described. The purpose of the current study is to describe in detail the SNP architecture in eight diff...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.19-28519

    authors： Marfurt C,Anokwute MC,Fetcko K,Mahony-Perez E,Farooq H,Ross E,Baumanis MM,Weinberg RL,McCarron ME,Mankowski JL

    更新日期：2019-12-02 00:00:00

  • Retinal and Choroidal Microvasculature in Nonarteritic Anterior Ischemic Optic Neuropathy: An Optical Coherence Tomography Angiography Study.

    abstract：Purpose:To analyze retinal and choroidal microvasculature in patients with nonarteritic anterior ischemic optic neuropathy (NAION) by using optical coherence tomography angiography (OCT-A). Methods:In this case-control retrospective observational study, patients with atrophic NAION (at least 3 months after onset of sy...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.17-22996

    authors： Augstburger E,Zéboulon P,Keilani C,Baudouin C,Labbé A

    更新日期：2018-02-01 00:00:00

  • Intravitreal concentrations of a near-infrared fluorescence-labeled biotherapeutic determined in situ using confocal scanning laser ophthalmoscopy.

    abstract：PURPOSE:The pharmacokinetics of ophthalmic biotherapeutics are difficult to determine in human vitreous humor. Because of the high transparency of living tissue to near-infrared (NIR) light, the temporal changes in vitreous concentrations of a biomolecule labeled with an NIR fluorescent probe can be monitored in situ w...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-7790

    authors： Basile AS,Glazier G,Lee A,Jiang LY,Johnson TR,Shields MJ,Vezina M,Doppalapudi VR

    更新日期：2011-09-01 00:00:00

  • BBSome Component BBS5 Is Required for Cone Photoreceptor Protein Trafficking and Outer Segment Maintenance.

    abstract：Purpose:To identify the role of the BBSome protein Bardet-Biedl syndrome 5 (BBS5) in photoreceptor function, protein trafficking, and structure using a congenital mutant mouse model. Methods:Bbs5-/- mice (2 and 9 months old) were used to assess retinal function and morphology. Hematoxylin and eosin staining of retinal...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.61.10.17

    authors： Bales KL,Bentley MR,Croyle MJ,Kesterson RA,Yoder BK,Gross AK

    更新日期：2020-08-03 00:00:00