Abstract:
PURPOSE:To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI). METHODS:The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All subjects underwent imaging on a high-resolution 7.0-T MRI system. Bilateral LGNs were identified and manually delineated, and LGN volumes were compared. Peripapillary retinal nerve fiber layer (pRNFL) thickness, optic nerve head parameters (including optic disc size, rim area, and cup-to-disc ratio), and combined thickness of the ganglion cell layer and inner plexus layer (GC-IPL) were measured by Cirrus high-definition optical coherence tomography (OCT). Correlations between OCT parameters and LGN volume were investigated. RESULTS:Mean LGN volumes were significantly smaller in the POAG group than in the control group (right, glaucoma 83.97 mm(3) [SD ± 26.65] versus control 106.12 mm(3) [SD ± 24.32]; left, glaucoma 65.12 mm(3) [SD ± 29.41] versus control 92.70 mm(3) [SD ± 24.42], both P < 0.05). In the POAG group, average GC-IPL thickness was correlated with contralateral LGN volume (right LGN: r = 0.605, P = 0.008; left LGN: r = 0.471, P = 0.049). The correlation for right LGN volume remained significant after correction for multiple comparisons. However, there was no correlation between LGN volume and average pRNFL thickness or optic disc parameters in the POAG group. CONCLUSIONS:On high-resolution 7.0-T MRI, LGN volumes in POAG patients are significantly smaller than those of healthy subjects. Furthermore, in patients, LGN volume was found to be significantly correlated with GC-IPL thickness of the contralateral eye.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Lee JY,Jeong HJ,Lee JH,Kim YJ,Kim EY,Kim YY,Ryu T,Cho ZH,Kim YBdoi
10.1167/iovs.14-13902subject
Has Abstractpub_date
2014-04-10 00:00:00pages
3468-76issue
6eissn
0146-0404issn
1552-5783pii
iovs.14-13902journal_volume
55pub_type
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