Dynamic patterns of histone lysine methylation in the developing retina.

abstract：PURPOSE:Recently, a segregation study in families with uveal and cutaneous melanoma identified 9q21 as a potential locus harboring a tumor-suppressor gene (TSG). One of the genes in this area, RASEF, was then analyzed as a candidate TSG, but lack of point mutations and copy number changes could not confirm this. In thi...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,Beiboer SH,Jager MJ,Luyten GP,Gruis NA,van der Velden PA

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:Age and advanced disease in the fellow eye are the two most important risk factors for age-related macular degeneration (AMD). In this study, the authors investigated the relationship between these variables and the optical density of macular pigment (MP) in a group of subjects from a northern European populati...

journal_title：Investigative ophthalmology & visual science

authors： Beatty S,Murray IJ,Henson DB,Carden D,Koh H,Boulton ME

更新日期：2001-02-01 00:00:00

abstract：Purpose:To assess the effect of serous retinal detachment (SRD) on functional and anatomical outcomes in ranibizumab-treated patients with diabetic macular edema (DME). Methods:All consecutive ranibizumab-treated patients with SRD were included in this retrospective study. For each patient with SRD, a patient without ...

journal_title：Investigative ophthalmology & visual science

authors： Giocanti-Aurégan A,Hrarat L,Qu LM,Sarda V,Boubaya M,Levy V,Chaine G,Fajnkuchen F

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To examine gain, speed, and temporal characteristics of initial and closed-loop components of vergence eye movements in young and elderly subjects. METHODS:Vergence eye movements in 13 elderly and 10 young adults were examined. A table with light-emitting diodes was used to elicit vergence starting from near (...

journal_title：Investigative ophthalmology & visual science

authors： Yang Q,Le TT,Kapoula Z

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To identify genes and molecular mechanisms associated with photoreceptor degeneration in a canine model of XLRP caused by an RPGR exon ORF15 microdeletion. Methods. Expression profiles of mutant and normal retinas were compared by using canine retinal custom cDNA microarrays. qRT-PCR, Western blot analysis, and...

journal_title：Investigative ophthalmology & visual science

authors： Genini S,Zangerl B,Slavik J,Acland GM,Beltran WA,Aguirre GD

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:A prior study showed that Toll-like receptor (TLR)-5 recognizes Pseudomonas aeruginosa flagellin and triggers the production of proinflammatory cytokines in human corneal epithelial cells (HCECs). The present study was conducted to determine how the inflammatory response is modulated after TLR activation in HCE...

journal_title：Investigative ophthalmology & visual science

authors： Kumar A,Yin J,Zhang J,Yu FS

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:MicroRNAs (miRNAs) are small, stable, noncoding RNA molecules with regulatory function and marked tissue specificity that posttranscriptionally regulate gene expression. However, their role in fungal keratitis remains unknown. The purpose of this study was to identify the miRNA profile and its regulatory role i...

journal_title：Investigative ophthalmology & visual science

authors： Boomiraj H,Mohankumar V,Lalitha P,Devarajan B

更新日期：2015-12-01 00:00:00

abstract：:We describe an instrument called a scanning ocular spectrofluorophotometer (SOSF) that measures fluorescence in a two-dimensional cross-section through the anterior chamber and cornea and provides the ability to change excitation and emission wavelengths rapidly. The output of a xenon arc lamp is filtered by a diffrac...

journal_title：Investigative ophthalmology & visual science

authors： McLaren JW,Brubaker RF

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:In glaucoma, the optic nerve head (ONH) is the principal site of initial axonal injury, and elevated intraocular pressure (IOP) is the predominant risk factor. However, the initial responses of the ONH to elevated IOP are unknown. Here the authors use a rat glaucoma model to characterize ONH gene expression cha...

journal_title：Investigative ophthalmology & visual science

authors： Johnson EC,Doser TA,Cepurna WO,Dyck JA,Jia L,Guo Y,Lambert WS,Morrison JC

更新日期：2011-01-25 00:00:00

abstract：:Ocular adenoviral infections occur worldwide, and currently, there is no ocular animal model for evaluating new antivirals or studying pathogenesis. With a paired-eye design, an ocular model was developed in 32 New Zealand rabbits following topical and intrastromal inoculation with a clinical isolate of adenovirus typ...

journal_title：Investigative ophthalmology & visual science

authors： Gordon YJ,Romanowski E,Araullo-Cruz T

更新日期：1992-03-01 00:00:00

abstract：PURPOSE:The objective of this study was to investigate whether leakage of aquaporin 5 (AQP5) in tear is associated with damage of lacrimal glands (LGs) in dacryoadenitis models. METHODS:Female MRL/lpr (24-week-old), male NOD/Shi Jci (5-, 8-, and 10-week-old), female NFS/s-TX (10-week-old), and lipopolysaccharide (LPS)...

journal_title：Investigative ophthalmology & visual science

authors： Hirai S,Ishida N,Watanabe K,Mita S

更新日期：2000-08-01 00:00:00

abstract：:The mouse retina has been used extensively over the past decades to study both physiologic and pathologic angiogenesis. Over time, various mouse retina models have evolved into well-characterized and robust tools for in vivo angiogenesis research. This article is a review of the angiogenic development of the mouse ret...

journal_title：Investigative ophthalmology & visual science

authors： Stahl A,Connor KM,Sapieha P,Chen J,Dennison RJ,Krah NM,Seaward MR,Willett KL,Aderman CM,Guerin KI,Hua J,Löfqvist C,Hellström A,Smith LE

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:The potential of stem cells (SCs) as a source for cell-based therapy on a wide range of degenerative diseases and damaged tissues such as retinal degeneration has been recognized. Generation of a high number of retinal stem cells (RSCs) in vitro would thus be beneficial for transplantation in the retina. Howeve...

journal_title：Investigative ophthalmology & visual science

authors： Djojosubroto M,Bollotte F,Wirapati P,Radtke F,Stamenkovic I,Arsenijevic Y

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Scleral proteoglycans were characterized from human donor eyes aged 2 months to 94 years to identify age-related changes in the synthesis and/or accumulation of these extracellular matrix components. METHODS:Newly synthesized proteoglycans (previously radiolabeled with 35SO4) and total accumulated scleral prot...

journal_title：Investigative ophthalmology & visual science

authors： Rada JA,Achen VR,Penugonda S,Schmidt RW,Mount BA

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:To investigate the impact of ambient room lighting on the magnitude of flicker light-induced retinal vasodilations in healthy individuals. METHODS:Twenty healthy nonsmokers participated in a balanced 2 × 2 crossover study. Retinal vascular imaging was performed with the dynamic vessel analyzer under reduced or...

journal_title：Investigative ophthalmology & visual science

authors： Noonan JE,Dusting GJ,Nguyen TT,Man RE,Best WJ,Lamoureux EL

更新日期：2014-08-07 00:00:00

abstract：PURPOSE:Tissues derived from immune-privileged sites sometimes possess special characteristics that promote their own survival when transplanted to a nonprivileged site. This study was undertaken to evaluate whether retinal pigment epithelium (RPE) behaves as an immune-privileged tissue when transplanted extraocularly....

journal_title：Investigative ophthalmology & visual science

authors： Wenkel H,Streilein JW

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To evaluate the role of TIMP-1 in inherited retinal degeneration. METHODS:The genomic structure of the TIMP-1 gene was established and male patients with x-linked retinitis pigmentosa 2 from five families were screened for sequence alterations by direct sequencing in all exons, exon-intron boundaries, and the ...

journal_title：Investigative ophthalmology & visual science

authors： Hardcastle AJ,Thiselton DL,Nayudu M,Hampson RM,Bhattacharya SS

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:Persistent hyperplastic primary vitreous (PHPV) is a developmental ocular malformation often associated with additional ocular abnormalities. This study involved a novel mouse model of PHPV, generated by a null mutation of the Ski proto-oncogene, that displays other anterior segment and retinal malformations of...

journal_title：Investigative ophthalmology & visual science

authors： McGannon P,Miyazaki Y,Gupta PC,Traboulsi EI,Colmenares C

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:Gangliosides are normal components of cell membranes, contribute to structural rigidity and membrane function, and have been shown to protect against various insults to the brain. This study evaluates the effect of exogenously administered monosialoganglioside GM1 on retinal damage induced by transient retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Weber M,Mohand-Said S,Hicks D,Dreyfus H,Sahel JA

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:Recent studies have shown that a decrease of regulatory T (Treg) cells may contribute to the activity of acute anterior uveitis (AAU) and ankylosing spondylitis (AS). A number of immunogenetic factors including IL2RA, miR-27a, miR-182, and FoxO1 are associated with Treg cell function. In this study, we investig...

journal_title：Investigative ophthalmology & visual science

authors： Yu H,Liu Y,Zhang L,Wu L,Zheng M,Cheng L,Luo L,Kijlstra A,Yang P

更新日期：2014-11-20 00:00:00

abstract：PURPOSE:Currently, there are no definitive immunomarkers for epithelial stem cells (corneal and conjunctival) or their poorly understood niche microenvironment. The H2B-GFP/K5tTA mouse enables visualization of label-retaining cells (LRCs), which exhibit the functional marker of stem cell quiescence. We used immunofluor...

journal_title：Investigative ophthalmology & visual science

authors： Parfitt GJ,Kavianpour B,Wu KL,Xie Y,Brown DJ,Jester JV

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To evaluate the consequences of altering retinal sterol metabolism and composition on the development, histologic organization, and electrophysiological function of the retina, under conditions that mimic the biochemical hallmarks of the Smith-Lemli-Opitz (SLO) syndrome. METHODS:Pregnant Sprague-Dawley rats we...

journal_title：Investigative ophthalmology & visual science

authors： Fliesler SJ,Richards MJ,Miller C,Peachey NS

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Adult salamander photoreceptors retract existing axons and extend new neuritic processes in vitro. In mammalian retina, similar forms of structural plasticity occur in injury and disease. The authors asked whether RhoA is present in photoreceptor axon terminals and whether activity in the RhoA-ROCK pathway cont...

journal_title：Investigative ophthalmology & visual science

authors： Fontainhas AM,Townes-Anderson E

更新日期：2008-09-01 00:00:00

abstract：Purpose:Our goal was to describe the clinical and molecular genetic findings in Thai patients with Leber congenital amaurosis (LCA). Methods:Whole exome sequencing (WES) was performed in eight unrelated patients. All genes responsible for inherited retinal diseases (IRDs) based on RetNet were selected for analysis. Po...

journal_title：Investigative ophthalmology & visual science

authors： Jinda W,Taylor TD,Suzuki Y,Thongnoppakhun W,Limwongse C,Lertrit P,Trinavarat A,Atchaneeyasakul LO

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:Recently, RAP1 (Telomeric Repeat Binding Factor 2, Interacting Protein [TERF2IP]) was discovered as a modulator that selectively regulates nuclear factor light chain kappa enhancer of activated B cells (NFκB) signaling. The roles of RAP1 in regulation of inflammation and angiogenesis for corneal recovery follow...

journal_title：Investigative ophthalmology & visual science

authors： Poon MW,Yan L,Jiang D,Qin P,Tse HF,Wong IY,Wong DS,Tergaonkar V,Lian Q

更新日期：2015-01-08 00:00:00

abstract：PURPOSE:The retrograde transport of wheat germ agglutinin-horseradish peroxidase (WGA/HRP) was used to study the localization of the neurons that innervate the superior tarsal muscle in the cynomolgus monkey. METHODS:A 5-10% WGA-HRP solution was applied to the medial part of the superior tarsal muscle. Seventy-two hou...

journal_title：Investigative ophthalmology & visual science

authors： van der Werf F,Baljet B,Prins M,Timmerman A,Otto JA

更新日期：1993-06-01 00:00:00

abstract：PURPOSE:To assess if the in vivo mechanical displacement of the anterior laminar cribrosa surface (ALCS) as a response of an acute elevation in intraocular pressure (IOP) differs in individuals of European (ED) and African descent (AD). METHODS:Spectral-domain optical coherence tomography (SDOCT) scans were obtained f...

journal_title：Investigative ophthalmology & visual science

authors： Fazio MA,Johnstone JK,Smith B,Wang L,Girkin CA

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Ca(2+) is a major regulator of cell function. In the retinal pigment epithelium (RPE), intracellular free Ca(2+) concentration ([Ca(2+)](i)) is essential for the maintenance of normal retinal function. Therefore, accurate control of [Ca(2+)](i) is vital in these cells. Because Ca(2+) is permanently extruded fro...

journal_title：Investigative ophthalmology & visual science

authors： Wimmers S,Strauss O

更新日期：2007-12-01 00:00:00

abstract：:Determination of intraocular antibody synthesis against certain microorganisms is a diagnostic aid in identifying the causative agent in clinical uveitis. Little is known, however, concerning the kinetics and specificity of antibodies produced during intraocular inflammation. To investigate this subject we induced uve...

journal_title：Investigative ophthalmology & visual science

authors： van der Voet JC,Liem A,Otto AJ,Kijlstra A

更新日期：1989-02-01 00:00:00

abstract：:Recently protease inhibitors were used to treat corneal ulceration and persistent epithelial defect. An organ culture system was used in this study to examine the effect of four protease inhibitors on rat corneal epithelial migration and on incorporation of 3H-leucine into trichloroacetic acid-precipitable material as...

journal_title：Investigative ophthalmology & visual science

authors： Zieske JD,Bukusoglu G

更新日期：1991-06-01 00:00:00