The role of inflammation in CW Nd:YAG contact transscleral photocoagulation and cryopexy.

abstract：PURPOSE:To investigate the long-term effects of transient ligature of the ophthalmic vessels (LOV) on the inner and outer retina as well as on retinotectal projection, and whether brimonidine (BMD) has protective effects. METHODS:In adult rats, the left eye was subjected to 90 minutes of LOV. One hour before ischemia,...

journal_title：Investigative ophthalmology & visual science

authors： Mayor-Torroglosa S,De la Villa P,Rodríguez ME,López-Herrera MP,Avilés-Trigueros M,García-Avilés A,de Imperial JM,Villegas-Pérez MP,Vidal-Sanz M

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:The present study was undertaken to examine the relationship between choroidal permeability and scleral glycosaminoglycan synthesis rates during the development of and recovery from form deprivation myopia. METHODS:Form deprivation myopia was induced in chicks for 10 days and was followed by a period of unrest...

journal_title：Investigative ophthalmology & visual science

authors： Rada JA,Palmer L

更新日期：2007-07-01 00:00:00

abstract：:Greene's melanomas, implanted in the anterior chamber of 31 eyes of 19 Dutch rabbits, were treated with hyperthermia induced by high intensity focused ultrasound (HIFU). The percentage necrosis 24 hr after treatment (N) as a function of steady-state intratumor temperature (T) could be described with N(T) = -181.5 + 4....

journal_title：Investigative ophthalmology & visual science

authors： Braakman R,van der Valk P,van Delft JL,de Wolff-Rouendaal D,Oosterhuis JA

更新日期：1989-05-01 00:00:00

abstract：PURPOSE:When intraocular pressure (IOP) was monitored in supine healthy young adults throughout a 24-hour period, a diurnal-to-nocturnal elevation of IOP was observed. This study was undertaken to investigate whether a similar elevation of IOP can be detected when experimental subjects are in the sitting position. MET...

journal_title：Investigative ophthalmology & visual science

authors： Liu JH,Bouligny RP,Kripke DF,Weinreb RN

更新日期：2003-10-01 00:00:00

abstract：Purpose:To assess the presence of binocular gain in macular telangiectasia type 2 (MacTel) and its correlation to paracentral scotomas. Methods:Sixty-eight patients with MacTel were consecutively recruited for a cross-sectional analysis. Best-corrected visual acuity (BCVA), reading acuity, and reading speed were teste...

journal_title：Investigative ophthalmology & visual science

authors： Tzaridis S,Herrmann P,Charbel Issa P,Degli Esposti S,Wagner SK,Fruttiger M,Egan C,Rubin G,Holz FG,Heeren TFC

更新日期：2019-09-03 00:00:00

abstract：:Monoclonal antibody to HSV glycoprotein D was derivatized with palmitic acid and incorporated into liposomes. These immunoliposomes bound specifically to intact mouse corneas infected with HSV-1 in vitro. Furthermore, in yield reduction assays, anti-gD immunoliposomes loaded with acyclovir proved far more effective at...

journal_title：Investigative ophthalmology & visual science

authors： Norley SG,Sendele D,Huang L,Rouse BT

更新日期：1987-03-01 00:00:00

abstract：PURPOSE:Adeno-associated virus serotype 2 (AAV2) has been shown to be effective in transducing inner retinal neurons after intravitreal injection in several species. However, results in nonprimates may not be predictive of transduction in the human inner retina, because of differences in eye size and the specialized mo...

journal_title：Investigative ophthalmology & visual science

authors： Yin L,Greenberg K,Hunter JJ,Dalkara D,Kolstad KD,Masella BD,Wolfe R,Visel M,Stone D,Libby RT,Diloreto D Jr,Schaffer D,Flannery J,Williams DR,Merigan WH

更新日期：2011-04-25 00:00:00

abstract：PURPOSE:The chemokine receptor CX3CR1 is expressed by monocyte-derived dendritic cells (DCs) and macrophages. CX3CR1 mediates leukocyte migration and adhesion in homeostatic and inflammatory conditions. Mice lacking Cx3cr1 have altered distribution and function of DC subpopulations in some tissue microenvironments. The...

journal_title：Investigative ophthalmology & visual science

authors： Kezic J,Xu H,Chinnery HR,Murphy CC,McMenamin PG

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To obtain quantitative data on the optic disc excavation in children affected by cerebral visual impairment (CVI) by using the Heidelberg Retinal Tomograph (HRT)-II (Heidelberg Engineering, Heidelberg, Germany). METHODS:A total of 24 subjects affected by CVI (mean age, 7.28 years) were examined: 16 in alert co...

journal_title：Investigative ophthalmology & visual science

authors： Ruberto G,Salati R,Milano G,Bertone C,Tinelli C,Fazzi E,Guagliano R,Signorini S,Borgatti R,Bianchi A,Bianchi PE

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To evaluate the utility of baseline Stratus optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA) retinal nerve fiber layer (RNFL) normative classification in the prediction of future visual field (VF) loss. METHODS:Eighty-eight eyes with suspected glaucoma with abnormal RNFL classification by Str...

journal_title：Investigative ophthalmology & visual science

authors： Sung KR,Kim S,Lee Y,Yun SC,Na JH

更新日期：2011-04-22 00:00:00

abstract：PURPOSE:Contact inhibition has been implicated as an important antiproliferative mechanism in developing and mature corneal endothelium. Although exogenous TGF-beta2 and TGF-beta2 in aqueous humor suppress S-phase entry in cultured rat corneal endothelial cells, it is not known whether TGF-beta2 contributes to the mito...

journal_title：Investigative ophthalmology & visual science

authors： Joyce NC,Harris DL,Mello DM

更新日期：2002-07-01 00:00:00

abstract：:Swollen rabbit corneas incubated in vitro with their posterior surfaces blocked with silicone oil maintained fairly constant thickness over an 11 hr. period. Increasing the simulated intraocular pressure from 10 to 30 mm. Hg did not produce stromal thinning. When theophylline was added to stimulate epithelial Cl secre...

journal_title：Investigative ophthalmology & visual science

authors： Klyce SD

更新日期：1977-10-01 00:00:00

abstract：PURPOSE:To characterize the pharmacology of the carbachol-induced changes of phospholipase C (PLC) activity and intracellular calcium concentration ([Ca2+]i) in cultured human ciliary muscle cells. METHODS:Changes in PLC activity of cultured human ciliary muscle cells were determined by production of inositol phosphat...

journal_title：Investigative ophthalmology & visual science

authors： Matsumoto S,Yorio T,DeSantis L,Pang IH

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:The endothelium produces nitric oxide and endothelin (ET). This study was designed to investigate the endothelium-dependent regulation of the porcine ophthalmic microcirculation. METHODS:Isolated porcine eyes were perfused with a modified Langendorff setup (Hugo Sachs Elektronik KG, Freiburg, Germany) at a per...

journal_title：Investigative ophthalmology & visual science

authors： Meyer P,Flammer J,Lüscher TF

更新日期：1993-12-01 00:00:00

abstract：Purpose:Dense deposit disease (DDD) is caused by dysregulation of the alternative pathway of the complement cascade and characterized by electron-dense deposits in the kidney glomerular basement membrane (GBM) and drusen in Bruch's membrane (BrM). Complement factor H (fH) and factor properdin (fP) regulate complement a...

journal_title：Investigative ophthalmology & visual science

authors： Song D,Mohammed I,Bhuyan R,Miwa T,Williams AL,Gullipalli D,Sato S,Song Y,Dunaief JL,Song WC

更新日期：2018-07-02 00:00:00

abstract：UNLABELLED:PURPOSE. Test the hypothesis that the developmental increases in rod photoreceptor sensitivity and rod-mediated visual sensitivity at 10 degrees, 20 degrees , and 30 degrees eccentric are concurrent. It is known that maturation of the parafoveal (10 degrees eccentric) rod outer segments and visual sensitivit...

journal_title：Investigative ophthalmology & visual science

authors： Fulton AB,Hansen RM

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:Vergence eye movements undergo adaptive recalibration in response to a training stimulus in which the initial disparity is changed just after vergence begins (the double-step paradigm). In the present study the changes in the dynamic properties of convergence, speed and acceleration, were examined by using this...

journal_title：Investigative ophthalmology & visual science

authors： Takagi M,Oyamada H,Abe H,Zee DS,Hasebe H,Miki A,Usui T,Hasegawa S,Bando T

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:Early visual defects in degenerative diseases such as retinitis pigmentosa (RP) may arise from phased remodeling of the neural retina. The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degenerat...

journal_title：Investigative ophthalmology & visual science

authors： Marc RE,Jones BW,Anderson JR,Kinard K,Marshak DW,Wilson JH,Wensel T,Lucas RJ

更新日期：2007-07-01 00:00:00

abstract：Purpose:Retinal damage in ocular toxoplasmosis reflects Toxoplasma gondii-induced cell lysis and reactive inflammation. Human retinal histopathology demonstrates the presence of neutrophils, but activities of this leukocyte subset are unstudied. We conducted in vitro experiments to evaluate roles for neutrophils as ret...

journal_title：Investigative ophthalmology & visual science

authors： Ashander LM,Lie S,Ma Y,Rochet E,Washington JM,Furtado JM,Appukuttan B,Smith JR

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:α-Crystallins are small heat shock proteins that regulate cellular damage and cell survival. Expression of the proteins of the crystallin superfamily in the retina and their role in neuronal cell survival were investigated in two animal models of diabetes and retinal neurons in culture. METHODS:Crystallin expr...

journal_title：Investigative ophthalmology & visual science

authors： Losiewicz MK,Fort PE

更新日期：2011-08-24 00:00:00

abstract：PURPOSE:To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head. METHODS:This experimental study included nine monkeys that underwent implantation of a lumbar-peritoneal cerebrospinal fluid (C...

journal_title：Investigative ophthalmology & visual science

authors： Yang D,Fu J,Hou R,Liu K,Jonas JB,Wang H,Chen W,Li Z,Sang J,Zhang Z,Liu S,Cao Y,Xie X,Ren R,Lu Q,Weinreb RN,Wang N

更新日期：2014-04-15 00:00:00

abstract：PURPOSE:To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI). METHODS:The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All s...

journal_title：Investigative ophthalmology & visual science

authors： Lee JY,Jeong HJ,Lee JH,Kim YJ,Kim EY,Kim YY,Ryu T,Cho ZH,Kim YB

更新日期：2014-04-10 00:00:00

abstract：PURPOSE:To biochemically characterize the receptor for connective tissue growth factor (CTGF) of human corneal fibroblasts (HCF). METHODS:Radiolabeled recombinant human CTGF was used to determine the specificity and time course of binding to low-passage cultures of HCF. The affinity and number of receptors present wer...

journal_title：Investigative ophthalmology & visual science

authors： Blalock TD,Gibson DJ,Duncan MR,Tuli SS,Grotendorst GR,Schultz GS

更新日期：2012-06-05 00:00:00

abstract：Purpose:Evidence from animals and blind humans suggests that early visual experience influences the developmental calibration of auditory localization. Hypothesizing that unilateral amblyopia may involve cross-modal deficits in spatial hearing, we measured the precision and accuracy of sound localization in humans with...

journal_title：Investigative ophthalmology & visual science

authors： Richards MD,Goltz HC,Wong AMF

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To determine the effect of taxol and etoposide, hydrophobic drugs with antifibrosis activity, on the outcome of filtration surgery in glaucomatous monkeys. METHODS:Elevated intraocular pressure was produced bilaterally in eight cynomolgus monkeys by laser treatment of the trabecular meshwork. Four animals subc...

journal_title：Investigative ophthalmology & visual science

authors： Jampel HD,Thibault D,Leong KW,Uppal P,Quigley HA

更新日期：1993-10-01 00:00:00

abstract：PURPOSE:To better understand the cellular contributions to the human multifocal ERG (mfERG), rhesus monkey and human mfERGs were recorded using the same stimulus conditions. The monkey mfERGs were recorded before and after injections of pharmacologic agents known to selectively block activity of particular cells and ci...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Frishman LJ,Saszik S,Viswanathan S

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible blindness. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Kaurani L,Vishal M,Kumar D,Sharma A,Mehani B,Sharma C,Chakraborty S,Jha P,Ray J,Sen A,Dash D,Ray K,Mukhopadhyay A

更新日期：2014-04-24 00:00:00

abstract：:Experimental detachments were made in Dutch rabbit eyes by injecting autologous serum or Hanks' solution into the subretinal space through a glass micropipette. The serum was resorbed at a rate of 0.064 +/- 0.023 microliter/mm2/hr, which is approximately half as fast as Hanks' solution. Both cyclic GMP and dibutyryl c...

journal_title：Investigative ophthalmology & visual science

authors： Kawano S,Marmor MF

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:Patients with typical clinical features of retinitis pigmentosa were found to have the atypical electroretinographic finding of a negative waveform to a bright flash in the dark-adapted state. The full-field electroretinogram (ERG) was studied in seven such patients to understand better the pathophysiology. ME...

journal_title：Investigative ophthalmology & visual science

authors： Cideciyan AV,Jacobson SG

更新日期：1993-11-01 00:00:00

abstract：Purpose:We investigated the relationship between inflammation, neuronal loss, and expression of indoleamine 2, 3-dioxygenase (IDO) and quinolinic acid (QUIN) in the retina of subjects with type 1 diabetes (T1D) and type 2 diabetes (T2D) and in the retina of rats with T1D. Methods:Retinas from T1D (n = 7), T2D (n = 13)...

journal_title：Investigative ophthalmology & visual science

authors： Hu P,Hunt NH,Arfuso F,Shaw LC,Uddin MN,Zhu M,Devasahayam R,Adamson SJ,Benson VL,Chan-Ling T,Grant MB

更新日期：2017-10-01 00:00:00