Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye.

abstract：PURPOSE:Although the presence of IgG autoantibodies in the vitreous of spontaneous cases of equine recurrent uveitis (ERU) has been demonstrated, the potential role of IgM reactivities during ERU pathogenesis remains unexplored. The purpose of this study was to examine the presence of IgM autoantibodies in vitreous spe...

journal_title：Investigative ophthalmology & visual science

authors： Swadzba ME,Hirmer S,Amann B,Hauck SM,Deeg CA

更新日期：2012-01-25 00:00:00

abstract：PURPOSE:To investigate the role of angiopoietin-1 (Ang1) in choroidal neovascularization (CNV) and vascular leakage. METHODS:We generated laser-induced CNV in mice and measured the size of CNV and vascular leakage after intravitreal administration of Ang1. The expressions and distributions of endothelial junctional pr...

journal_title：Investigative ophthalmology & visual science

authors： Lee J,Park DY,Park DY,Park I,Chang W,Nakaoka Y,Komuro I,Yoo OJ,Koh GY

更新日期：2014-04-07 00:00:00

abstract：PURPOSE:To investigate concentrations of growth factors and inflammatory cytokines in eyes with central (CRVO) and branch (BRVO) retinal vein occlusion before and during therapy with bevacizumab and to identify associations with disease activity. METHODS:In a prospective clinical trial, 13 eyes of patients with CRVO (...

journal_title：Investigative ophthalmology & visual science

authors： Funk M,Kriechbaum K,Prager F,Benesch T,Georgopoulos M,Zlabinger GJ,Schmidt-Erfurth U

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Sorsby fundus dystrophy (SFD) is a rare, late-onset macular dystrophy caused by mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) gene. The known mutations introduce potentially unpaired cysteine residues in the C terminus of the protein and result in the formation of higher-molecular-weight pro...

journal_title：Investigative ophthalmology & visual science

authors： Weber BH,Lin B,White K,Kohler K,Soboleva G,Herterich S,Seeliger MW,Jaissle GB,Grimm C,Reme C,Wenzel A,Asan E,Schrewe H

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:To assess dynamic interactions of eye and head movements during return-sweep saccades (RSS) when reading with single-vision (SVL) versus progressive-addition (PAL) lenses in a simulated computer-based business environment. METHODS:Horizontal eye and head movements were recorded objectively and simultaneously a...

journal_title：Investigative ophthalmology & visual science

authors： Han Y,Ciuffreda KJ,Selenow A,Ali SR

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:High intraocular pressure (IOP) is a major risk factor for glaucoma, one of the leading causes of blindness worldwide. Because it has been demonstrated that African populations are at increased risk for glaucoma, the authors investigated the genetic basis of IOP in a sample of West Africans with type 2 diabetes...

journal_title：Investigative ophthalmology & visual science

authors： Rotimi CN,Chen G,Adeyemo AA,Jones LS,Agyenim-Boateng K,Eghan BA Jr,Zhou J,Doumatey A,Lashley K,Huang H,Fasanmade O,Akinsola FB,Ezepue F,Amoah A,Akafo S,Chen Y,Oli J,Johnson T

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:The authors investigated the effect of brain-derived neurotrophic factor (BDNF) administration on the expression of Ca(2+)-binding proteins in the developing bdnf(-/-) mouse retina. METHODS:Intraocular injections of BDNF (0.5 microg) were applied on postnatal day (P) 11 bdnf(-/-) mice, and their effects were e...

journal_title：Investigative ophthalmology & visual science

authors： Arango-González B,Cellerino A,Kohler K

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To assess the comparative accuracy of potential screening tests for open angle glaucoma (OAG). METHODS:Medline, Embase, Biosis (to November 2005), Science Citation Index (to December 2005), and The Cochrane Library (Issue 4, 2005) were searched. Studies assessing candidate screening tests for detecting OAG in ...

journal_title：Investigative ophthalmology & visual science

authors： Mowatt G,Burr JM,Cook JA,Siddiqui MA,Ramsay C,Fraser C,Azuara-Blanco A,Deeks JJ,OAG Screening Project.

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To describe the in vivo evolution of laser-induced choroidal neovascularization (CNV) in mice using spectral domain optical coherence tomography (SD-OCT). METHODS:Laser photocoagulation was applied to the mouse fundus using a 532-nm diode laser (100, 150, and 200 mW; 100-μm diameter, 0.1-second duration). SD-O...

journal_title：Investigative ophthalmology & visual science

authors： Giani A,Thanos A,Roh MI,Connolly E,Trichonas G,Kim I,Gragoudas E,Vavvas D,Miller JW

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:To determine the effect of continuous light exposure on ocular growth and emmetropization in infant monkeys. METHODS:Nine infant rhesus monkeys were reared with the normal vivarium lights on continuously. The 24-hour light cycle was initiated between 1 and 4 weeks of age and maintained for 6 months. The ocular...

journal_title：Investigative ophthalmology & visual science

authors： Smith EL 3rd,Bradley DV,Fernandes A,Hung LF,Boothe RG

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:Recent studies have suggested the hypothesis that quench-assisted 1/T1 magnetic resonance imaging (MRI) measures free radical production with laminar resolution in vivo without the need of a contrast agent. Here, we test this hypothesis further by examining the spatial and detection sensitivity of quench-assist...

journal_title：Investigative ophthalmology & visual science

authors： Berkowitz BA,Lewin AS,Biswal MR,Bredell BX,Davis C,Roberts R

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:To investigate the association of 25-hydroxyvitamin D with AMD. METHODS:A population-based, cross-sectional study using a nationwide, systemic-stratified, multistage-clustered sampling method involved a total of 17,045 subjects older than 40 years who participated in the Korean National Health and Nutrition Ex...

journal_title：Investigative ophthalmology & visual science

authors： Kim EC,Han K,Jee D

更新日期：2014-07-11 00:00:00

abstract：PURPOSE:TNFalpha is a strong modulator expression of trabecular meshwork (TM) matrix metalloproteinase (MMP) and tissue inhibitor (TIMP). Laser trabeculoplasty appears to rely on this process to restore normal aqueous humor outflow facility. Thus, studies were conducted to determine whether the extracellular signal-reg...

journal_title：Investigative ophthalmology & visual science

authors： Alexander JP,Acott TS

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Lectin studies have shown that in the rabbit corneal epithelium, alpha-2,3 sialylation of O-linked glycans differentiates limbal and corneal epithelial cell phenotypes. Because sialic acid can be regulated at the level of the expression of sialyltransferases (STs), the purpose of the present study was to analyz...

journal_title：Investigative ophthalmology & visual science

authors： Matic M,Petrov I,Stegman Z,Buku A,Wolosin JM

更新日期：1998-05-01 00:00:00

abstract：PURPOSE:Mutations in the CLN6 gene cause variant late-infantile neuronal ceroid lipofuscinosis, a lysosomal storage disorder clinically characterized by progressive loss of vision, dementia, seizures, and early death. Here, we analyzed the time course of photoreceptor loss and the role of lysosomes in nclf mice, an ani...

journal_title：Investigative ophthalmology & visual science

authors： Bartsch U,Galliciotti G,Jofre GF,Jankowiak W,Hagel C,Braulke T

更新日期：2013-10-23 00:00:00

abstract：PURPOSE:Fundus autofluorescence (FAF), as an index of lipofuscin accumulation in the retinal pigment epithelium (RPE), provides indirect information on the level of metabolic activity of the RPE and thus the integrity of the RPE/photoreceptor complex. To investigate whether the photoreceptor/RPE complex is still viable...

journal_title：Investigative ophthalmology & visual science

authors： Scholl HP,Chong NH,Robson AG,Holder GE,Moore AT,Bird AC

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:Bevacizumab eyedrops inhibit corneal neovascularization. The purpose of this study was to analyze the safety profile of VEGF-A neutralization at the ocular surface. METHODS:Bevacizumab eyedrops (5 mg/mL) and an antimurine VEGF-A antibody (250 microg/mL) were applied to normal murine corneas five times a day fo...

journal_title：Investigative ophthalmology & visual science

authors： Bock F,Onderka J,Rummelt C,Dietrich T,Bachmann B,Kruse FE,Schlötzer-Schrehardt U,Cursiefen C

更新日期：2009-05-01 00:00:00

abstract：:The acute effect of topical epinephrine HCl 2% on macular capillary blood flow was studied in 18 healthy human volunteers using the blue-field simulation technique. This technique provides a method for quantifying the velocity of leukocytes flowing in macular capillaries. Subjects adjusted the velocity of simulated le...

journal_title：Investigative ophthalmology & visual science

authors： Robinson F,Chen S,Petrig BL,Grunwald JE,Riva CE

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:BetaIG-H3 is a TGF-beta-induced cell adhesion molecule, the mutations of which are responsible for a group of 5q31-linked corneal dystrophies. The characteristic findings in these diseases are accumulation of protein deposits of different ultrastructures. To understand the mechanisms of protein deposits in 5q31...

journal_title：Investigative ophthalmology & visual science

authors： Kim JE,Park RW,Choi JY,Bae YC,Kim KS,Joo CK,Kim IS

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:To optimize a nonviral gene transfection system targeting the corneal limbal stem/progenitor cells. METHODS:A plasmid containing LacZ gene coding for beta-galactosidase (beta-gal) was transfected into human corneal epithelial cells (HCECs) and multilineage progenitor cells (MLPCs) with different transfection r...

journal_title：Investigative ophthalmology & visual science

authors： Zhao B,Allinson SL,Ma A,Bentley AJ,Martin FL,Fullwood NJ

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To examine the distribution of anti-GQ1b, -GT1a, and -GD1b antibody binding in human extraocular muscles (EOMs), axial and limb muscles, and muscle spindles and thereby test the hypothesis that their distinctive ganglioside composition provides the molecular basis for selective involvement of EOMs and muscle sp...

journal_title：Investigative ophthalmology & visual science

authors： Liu JX,Willison HJ,Pedrosa-Domellöf F

更新日期：2009-07-01 00:00:00

abstract：PURPOSE:It is well documented that grafting of cells in the subretinal space of Royal College of Surgeons (RCS) rats limits deterioration of vision and loss of photoreceptors if performed early in postnatal life. What is unclear is whether cells introduced later, when photoreceptor degeneration is already advanced, can...

journal_title：Investigative ophthalmology & visual science

authors： Wang S,Lu B,Girman S,Holmes T,Bischoff N,Lund RD

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:To compare three microkeratome-assisted techniques for the preparation of ultrathin (UT) grafts for Descemet stripping automated endothelial keratoplasty. METHODS:After dissection with a 300-μm microkeratome head in 40 donor tissues, a second cut was performed with a 130-μm head either after manual stromal hyd...

journal_title：Investigative ophthalmology & visual science

authors： Busin M,Patel AK,Scorcia V,Ponzin D

更新日期：2012-01-31 00:00:00

abstract：:Prostaglandins and other eicosanoids in the trabecular meshwork may play important physiological and pharmacological roles in the aqueous outflow pathway. In the present studies, we employed [14C]-arachidonic acid to explore potentially important pathways for the production of eicosanoids in cultured human trabecular ...

journal_title：Investigative ophthalmology & visual science

authors： Weinreb RN,Polansky JR,Alvarado JA,Mitchell MD

更新日期：1988-11-01 00:00:00

abstract：:A method for denuding Descemet's membrane by dissection of all overlying stroma, while preserving the corneal endothelial layer, was developed and evaluated. The technique consists in treating the stroma with trypsin and surgically removing the softened stromal layers. With an automated thickness-measuring technique, ...

journal_title：Investigative ophthalmology & visual science

authors： Soong H,Fischbarg J,Iwamoto T

更新日期：1978-11-01 00:00:00

abstract：PURPOSE:To assess RNA stability after death in a porcine model to simulate current human eye bank techniques. METHODS:Eye bank time interval data were collected from 191 donor specimens: death to refrigeration, enucleation, and tissue processing. A control porcine eye was enucleated, retina and RPE isolated, and speci...

journal_title：Investigative ophthalmology & visual science

authors： Malik KJ,Chen CD,Olsen TW

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:There is some evidence to suggest that thrombolysis has a beneficial effect in retinal vessel occlusion. However, there is concern that this therapeutic approach carries the risk of hemorrhage. Retrograde cannulation of the supraorbital arteries followed by irrigation with fibrinolytic agents may have the poten...

journal_title：Investigative ophthalmology & visual science

authors： Schwenn OK,Wüstenberg EG,Konerding MA,Hattenbach LO

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:This study explored the role of the left posterior parietal cortex (PPC) in saccades, vergence, and combined saccade-vergence movements by means of transcranial magnetic stimulation (TMS) in humans. METHODS:TMS was applied over the left PPC for 80, 90, or 100 ms after target onset. In a control experiment, TMS...

journal_title：Investigative ophthalmology & visual science

authors： Yang Q,Kapoula Z

更新日期：2004-07-01 00:00:00

abstract：:Drusen are small, yellowish deposits that form under the retinal pigment epithelium (RPE) with senescence or under certain pathological conditions. The present study examined these structures under the scanning electron microscope. Tissue came from four eyes of 66- and 75-year-old donors who demonstrated widespread dr...

journal_title：Investigative ophthalmology & visual science

authors： Ulshafer RJ,Allen CB,Nicolaissen B Jr,Rubin ML

更新日期：1987-04-01 00:00:00

abstract：PURPOSE:The Y402H polymorphism in the complement regulator factor H (fH) is strongly associated with age-related macular degeneration (AMD) across diverse populations. Persons homozygous for histidine at this position have up to 12-fold greater risk for AMD than those homozygous for tyrosine. Knowledge of fH-Y402H stat...

journal_title：Investigative ophthalmology & visual science

authors： Hakobyan S,Harris CL,Tortajada A,Goicochea de Jorge E,García-Layana A,Fernández-Robredo P,Rodríguez de Córdoba S,Morgan BP

更新日期：2008-05-01 00:00:00