Targeted cornea limbal stem/progenitor cell transfection in an organ culture model.

abstract：PURPOSE:Angiotensin-converting-enzyme (ACE) catalyses the formation of angiotensin II (ANGII), which presumably acts as a central neurotransmitter/modulator. ANGII-related effects have also been observed in the retina. Present in vivo experiments were designed to investigate further ANGII-related effects on retinal neu...

journal_title：Investigative ophthalmology & visual science

authors： Jacobi PC,Osswald H,Jurklies B,Zrenner E

更新日期：1994-03-01 00:00:00

abstract：:A group of 32 patients with low vision who were considered clinically appropriate candidates for visual rehabilitation with telescopic spectacles were prospectively studied before the first attempted use of these visual aids. Laboratory measurements were made of: (1) rotational head stability in pitch and yaw during q...

journal_title：Investigative ophthalmology & visual science

authors： Demer JL,Goldberg J,Porter FI,Schmidt K

更新日期：1991-09-01 00:00:00

abstract：PURPOSE:Human corneal endothelium, a neural crest-derived tissue, has a very limited regenerative capacity and may depend on trophic factors for its survival throughout life, as well as after injury and during storage before transplantation. The purpose of this study was to determine whether vasoactive intestinal pepti...

journal_title：Investigative ophthalmology & visual science

authors： Koh SW,Waschek JA

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:Fundus autofluorescence (FAF), as an index of lipofuscin accumulation in the retinal pigment epithelium (RPE), provides indirect information on the level of metabolic activity of the RPE and thus the integrity of the RPE/photoreceptor complex. To investigate whether the photoreceptor/RPE complex is still viable...

journal_title：Investigative ophthalmology & visual science

authors： Scholl HP,Chong NH,Robson AG,Holder GE,Moore AT,Bird AC

更新日期：2004-08-01 00:00:00

abstract：:Determination of intraocular antibody synthesis against certain microorganisms is a diagnostic aid in identifying the causative agent in clinical uveitis. Little is known, however, concerning the kinetics and specificity of antibodies produced during intraocular inflammation. To investigate this subject we induced uve...

journal_title：Investigative ophthalmology & visual science

authors： van der Voet JC,Liem A,Otto AJ,Kijlstra A

更新日期：1989-02-01 00:00:00

abstract：PURPOSE:To describe hereditary macular degeneration observed in the cynomolgus monkey (Macaca fascicularis), which shares phenotypic features with age-related macular degeneration in humans, and to test the involvement of candidate gene loci by mutation screening and linkage analysis. METHODS:Ophthalmic examinations w...

journal_title：Investigative ophthalmology & visual science

authors： Umeda S,Ayyagari R,Allikmets R,Suzuki MT,Karoukis AJ,Ambasudhan R,Zernant J,Okamoto H,Ono F,Terao K,Mizota A,Yoshikawa Y,Tanaka Y,Iwata T

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:To evaluate changes of levels of erythropoietin (EPO) and VEGF in aqueous humor before and after an intravitreal injection of bevacizumab (IVB) and determine the underlying correlation between them. METHODS:This prospective study involved 21 eyes of 21 patients with surgery-required advanced neovascular glauco...

journal_title：Investigative ophthalmology & visual science

authors： Zhou M,Chen S,Wang W,Huang W,Cheng B,Ding X,Zhang X

更新日期：2013-06-04 00:00:00

abstract：:Chloroquine was administered intramuscularly 5 days a week to rhesus monkeys for as long as 4 1/2 years. No clinical, fluorescein angiographic, or electrophysiological evidence of retinal damage was observed. Yet chloroquine/chloroquine byproduct analysis of the ocular tissues revealed an enormous binding capacity of ...

journal_title：Investigative ophthalmology & visual science

authors： Rosenthal AR,Kolb H,Bergsma D,Huxsoll D,Hopkins JL

更新日期：1978-12-01 00:00:00

abstract：:PURPOSE. To examine the biomechanical deformation of load bearing structures of the optic nerve head (ONH) resulting from raised intracranial pressure, using high definition optical coherence tomography (HD-OCT). The authors postulate that elevated intracranial pressure induces forces in the retrolaminar subarachnoid ...

journal_title：Investigative ophthalmology & visual science

authors： Kupersmith MJ,Sibony P,Mandel G,Durbin M,Kardon RH

更新日期：2011-08-22 00:00:00

abstract：:Intracameral perfusion with 4 to 6 mM Na2EDTA or 4 mM EGTA for 40 to 80 min caused a very large increase in gross outflow facility. This effect was partly reversible when followed by perfusion with mock aqueous humor. Eyes perfused with Na2EDTA were studied morphologically. In the trabecular meshwork the cells separat...

journal_title：Investigative ophthalmology & visual science

authors： Bill A,Lütjen-Drecoll E,Svedbergh B

更新日期：1980-05-01 00:00:00

abstract：PURPOSE:To apply tissue-engineered cell sheet transplantation after excimer laser keratectomy as a novel approach for the reduction of postoperative corneal haze. METHODS:Limbal biopsy specimens were obtained, and epithelial cells were cultured on temperature-responsive culture inserts without the use of feeder cells....

journal_title：Investigative ophthalmology & visual science

authors： Hayashida Y,Nishida K,Yamato M,Yang J,Sugiyama H,Watanabe K,Hori Y,Maeda N,Kikuchi A,Okano T,Tano Y

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To investigate the effect of TNF-alpha on leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis (EIU) in the rat. METHODS:EIU was induced in Long-Evans rats by a single footpad injection of lipopolysaccharide (LPS; 350 microg/kg) from Salmonella typhimurium. A single injec...

journal_title：Investigative ophthalmology & visual science

authors： Koizumi K,Poulaki V,Doehmen S,Welsandt G,Radetzky S,Lappas A,Kociok N,Kirchhof B,Joussen AM

更新日期：2003-05-01 00:00:00

abstract：:A sensitive fluorometric assay for measuring permeability of liposomes containing bovine lens MIP26 has been developed and characterized. Lens membrane proteins were isolated and incorporated into artificial membranes composed of bovine brain phospholipids, sphingomyelin and the fluorescent probe, N-4-nitrobenzo-2-oxa...

journal_title：Investigative ophthalmology & visual science

authors： Scaglione BA,Rintoul DA

更新日期：1989-05-01 00:00:00

abstract：PURPOSE:To characterize the molecular properties, cellular distribution, and subcellular distribution of bovine rom-1 and its interaction with peripherin/rds in photoreceptor cells as an important step toward elucidating the role of rom-1 in photoreceptor outer segment structure-function relationships and in inherited ...

journal_title：Investigative ophthalmology & visual science

authors： Moritz OL,Molday RS

更新日期：1996-02-01 00:00:00

abstract：:Stiles-Crawford functions were obtained from the maculas of 22 patients with different genetic types of retinitis pigmentosa and visual acuity of 20/40 or better. Reduced cone directional sensitivity was seen in the fovea with both focal cone electroretinographic testing and psychophysical testing. Functions from the ...

journal_title：Investigative ophthalmology & visual science

authors： Birch DG,Sandberg MA,Berson EL

更新日期：1982-02-01 00:00:00

abstract：Purpose:To identify potentially pathogenic variants (PPVs) in Chinese familial exudative vitreoretinopathy (FEVR) patients in FZD4, LRP5, NDP, TSPAN12, ZNF408, and KIF11 genes. Methods:Blood samples were collected from probands and their parent(s). Genomic DNA was analyzed by next-generation sequencing, and the sequen...

journal_title：Investigative ophthalmology & visual science

authors： Li JK,Li Y,Zhang X,Chen CL,Rao YQ,Fei P,Zhang Q,Zhao P,Li J

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Research to restore some degree of vision to patients suffering from retinal degeneration is becoming increasingly more promising. Several groups have chosen electrical stimulation of the remaining network of a degenerate retina as a means to generate discrete light percepts (phosphenes). Approaches vary signif...

journal_title：Investigative ophthalmology & visual science

authors： Matteucci PB,Chen SC,Tsai D,Dodds CW,Dokos S,Morley JW,Lovell NH,Suaning GJ

更新日期：2013-06-21 00:00:00

abstract：PURPOSE:To investigate whether the detection of apoptosing retinal cells (DARC) could detect cells undergoing apoptosis in a laser model of retinal damage. METHODS:Laser lesions were placed, with the use of a frequency-doubled Nd:YAG laser, on the retina in 34 eyes of anesthetized Dark Agouti rats. Lesion size and las...

journal_title：Investigative ophthalmology & visual science

authors： Schmitz-Valckenberg S,Guo L,Maass A,Cheung W,Vugler A,Moss SE,Munro PM,Fitzke FW,Cordeiro MF

更新日期：2008-06-01 00:00:00

abstract：Purpose:We examined the pattern and extent of connective tissue distribution in the extraocular muscles (EOMs) and determined the ability of the interconnected connective tissues to disseminate force laterally. Methods:Human EOMs were examined for collagens I, III, IV, and VI; fibronectin; laminin; and elastin using i...

journal_title：Investigative ophthalmology & visual science

authors： McLoon LK,Vicente A,Fitzpatrick KR,Lindström M,Pedrosa Domellöf F

更新日期：2018-01-01 00:00:00

abstract：:Evidence for a population of acetylcholine (ACh) receptors in the human retina is presented. The authors have used the irreversible ligand 3H-propylbenzilylcholine mustard (3H-PrBCM) to label muscarinic receptors. 3H- or 125I-alpha-bungarotoxin (alpha-BTx) was used to label putative nicotinic receptors. Muscarinic rec...

journal_title：Investigative ophthalmology & visual science

authors： Hutchins JB,Hollyfield JG

更新日期：1985-11-01 00:00:00

abstract：:The first heritable model of retinoblastoma was established by retina-specific expression of simian virus 40 T-antigen (SV40 T-ag) in transgenic mice. Bilateral, multifocal ocular tumors were observed in 100% of transgene-bearing mice. Central nervous system neoplasms occurred at a lower rate (27%) and represented the...

journal_title：Investigative ophthalmology & visual science

authors： Marcus DM,Carpenter JL,O'Brien JM,Kivela T,Brauner E,Tarkkanen A,Virtanen I,Albert DM

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:To evaluate the role of manganese superoxide dismutase (Mn-SOD) and copper/zinc superoxide dismutase (Cu/Zn-SOD) in cellular protection of the optic nerve against the oxidative injury that contributes to demyelination in experimental allergic encephalomyelitis (EAE). METHODS:Immunocytochemistry for Mn-SOD and ...

journal_title：Investigative ophthalmology & visual science

authors： Qi X,Guy J,Nick H,Valentine J,Rao N

更新日期：1997-05-01 00:00:00

abstract：:The ability of human and rabbit ocular tissues to degrade prostaglandins (PGs) was compared by following the metabolic fate of PGF2 alpha. No metabolism was observed in vitro after 5.0 hr incubation with human cornea, iris/ciliary body, or sclera, as indicated by the absence of a decrease in [3H]-PGF2 alpha concentrat...

journal_title：Investigative ophthalmology & visual science

authors： Cheng-Bennett A,Poyer J,Weinkam RJ,Woodward DF

更新日期：1990-07-01 00:00:00

abstract：PURPOSE:To evaluate the refractive status and optical components in school age children born prematurely and to examine the risk factors associated with refractive errors. METHODS:The participants were a cohort of children aged 7 to 9 years with gestational age less than 35 weeks or birth weight less than 1500 g. The ...

journal_title：Investigative ophthalmology & visual science

authors： Chen TC,Tsai TH,Shih YF,Yeh PT,Yang CH,Hu FC,Lin LL,Yang CM

更新日期：2010-12-01 00:00:00

abstract：:We present results from 64 glaucoma patients and glaucoma suspects followed up for a median period of 7.4 yr who had a median of seven examinations using Program 31 on the Octopus perimeter. The patients also had manual visual fields recorded on either the Tübinger or Goldmann perimeter during the same period. By exam...

journal_title：Investigative ophthalmology & visual science

authors： Chauhan BC,Drance SM,Douglas GR

更新日期：1990-03-01 00:00:00

abstract：PURPOSE:To describe the evolution of retinal thickness in eyes affected with acute anterior uveitis (AAU) in the course of follow-up and to assess its correlation with severity of inflammatory activity in the anterior chamber. METHODS:72 eyes (affected and fellow eyes) of 36 patients presenting with HLA-B27-related ac...

journal_title：Investigative ophthalmology & visual science

authors： Balaskas K,Ballabeni P,Guex-Crosier Y

更新日期：2012-09-14 00:00:00

abstract：PURPOSE:To characterize the features and possible mechanism of plus disease in the mouse oxygen-induced retinopathy (OIR) model for retinopathy of prematurity. METHODS:Wild-type and Adam (A Disintegrin And Metalloproteinase) knockout mice were exposed to 75% oxygen from postnatal day 7 to 12 (P7 to P12) (hyperoxia), t...

journal_title：Investigative ophthalmology & visual science

authors： Guaiquil VH,Hewing NJ,Chiang MF,Rosenblatt MI,Chan RV,Blobel CP

更新日期：2013-08-07 00:00:00

abstract：Purpose:To investigate the relationship between lens power and age as well as the relationship between lens power and axial length (AL) in Chinese children and adolescents. Methods:The participants underwent a comprehensive ophthalmic examination that included AL, cycloplegic refraction, and Pentacam measurements. The...

journal_title：Investigative ophthalmology & visual science

authors： Xiong S,Zhang B,Hong Y,He X,Zhu J,Zou H,Xu X

更新日期：2017-11-01 00:00:00

abstract：:An ultrasonic pachometer was used to measure the central, mid-peripheral, and peripheral thickness in 17 locations across the corneas of 12 adult New Zealand Albino rabbit eyes. The mean thickness at each location was entered into a microcomputer to generate a three-dimensional plot of corneal thickness. The rabbit co...

journal_title：Investigative ophthalmology & visual science

authors： Chan T,Payor S,Holden BA

更新日期：1983-10-01 00:00:00

abstract：:A pattern electroretinogram (PERG) can be recorded when the eye wearing the electrode is occluded and the stimulus is viewed with the other eye. We find that this phenomenon occurs when an Arden gold foil electrode is used, but not when either an ERG-Jet lens or a scleral lens electrode is used. Therefore, a corneal-t...

journal_title：Investigative ophthalmology & visual science

authors： Peachey NS,Sokol S,Moskowitz A

更新日期：1983-11-01 00:00:00