Recording the contralateral PERG: effect of different electrodes.

abstract：PURPOSE:To understand the involvement of the CYP1B1 gene in cases of primary open-angle (POAG) and primary angle-closure (PACG) glaucomas and obtain the haplotype background of these mutations. METHODS:The entire coding region of CYP1B1 was screened by resequencing in 224 unrelated cases of POAG (n = 134) and PACG (n ...

journal_title：Investigative ophthalmology & visual science

authors： Chakrabarti S,Devi KR,Komatireddy S,Kaur K,Parikh RS,Mandal AK,Chandrasekhar G,Thomas R

更新日期：2007-12-01 00:00:00

abstract：:The relationship of the ocular pressure to the anterior ciliary arterial pressure was studied by measuring the pressure of the anterior ciliary artery using a modified pressure chamber. Of the 40 subjects, 9 were normal, 16 were ocular hypertensive patients, and 15 were primary, open-angle, glaucoma patients. A signif...

journal_title：Investigative ophthalmology & visual science

authors： Sakimoto G,Schwartz B

更新日期：1984-08-01 00:00:00

abstract：:PURPOSE. To investigate the effects and possible mechanisms of rat bone marrow mesenchymal stem cell (BMSC) transplantation on the light-damaged retinal structure and the apoptosis of photoreceptors. METHODS. DAPI-labeled BMSCs were transplanted into the subretinal space of light-damaged Sprague-Dawley rats 10 days af...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Wang W

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Elimination of myofibroblasts after repair of corneal injury is essential for the maintenance of corneal transparency. In the current study, the role of platelet-activating factor (PAF) in combination with tumor necrosis factor (TNF)-alpha in corneal myofibroblast apoptosis was explored. METHODS:Porcine cornea...

journal_title：Investigative ophthalmology & visual science

authors： He J,Bazan HE

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:To determine whether transcorneal electrical stimulation (TES) has neuroprotective effects on the photoreceptors, and whether it slows the rate of decrease of the electroretinogram (ERG) in rhodopsin P347L transgenic (Tg) rabbits. METHODS:Six-week-old Tg rabbits received TES through a contact lens electrode on...

journal_title：Investigative ophthalmology & visual science

authors： Morimoto T,Kanda H,Kondo M,Terasaki H,Nishida K,Fujikado T

更新日期：2012-06-28 00:00:00

abstract：:PURPOSE. Simple sphingolipids control crucial cellular processes in several cell types. Previous work demonstrated that sphingolipids, such as ceramide, sphingosine, and sphingosine-1-phosphate, are key mediators in the regulation of survival, differentiation, and proliferation of retina photoreceptors. Ceramide-1-pho...

journal_title：Investigative ophthalmology & visual science

authors： Miranda GE,Abrahan CE,Agnolazza DL,Politi LE,Rotstein NP

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:To determine whether intraocular pressure (IOP) elevation alters OPA1 expression and triggers OPA1 release, as well as whether the uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist memantine blocks OPA1 release and subsequent apoptotic cell death in glaucomatous DBA/2J mouse retina. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Ju WK,Kim KY,Angert M,Duong-Polk KX,Lindsey JD,Ellisman MH,Weinreb RN

更新日期：2009-02-01 00:00:00

abstract：:Purpose. To establish a theoretical model to determine the relationship between retinal coverage and tamponade shape in relation to tamponade volume, for a variety of tamponades, and to test these relationships with a physical analogue of the human eye. Methods. The theoretical model was based on a static balance betw...

journal_title：Investigative ophthalmology & visual science

authors： Eames I,Angunawela RI,Aylward GW,Azarbadegan A

更新日期：2010-04-01 00:00:00

abstract：Purpose:To clarify the distinct molecular pathogenesis of central serous chorioretinopathy (CSC) and pachychoroid neovasculopathy (PNV). Methods:Aqueous humor (AH) was collected from 18 acute CSC, 20 chronic CSC, and 20 PNV patients. Concentrations of 30 cytokines in the AH were analyzed using a multiplex bead immunoa...

journal_title：Investigative ophthalmology & visual science

authors： Terao N,Koizumi H,Kojima K,Yamagishi T,Nagata K,Kitazawa K,Yamamoto Y,Yoshii K,Hiraga A,Toda M,Kinoshita S,Sotozono C,Hamuro J

更新日期：2018-12-03 00:00:00

abstract：:Application of devices that degrade the retinal image has been reported to produce enlargement of the ocular globe in young domestic chicks. Two such device types (domes and arches) were applied to 3-day-old chicks. The domes affected the entire visual field whereas the arches affected only the lateral field. A third ...

journal_title：Investigative ophthalmology & visual science

authors： Hodos W,Fitzke FW,Hayes BP,Holden AL

更新日期：1985-10-01 00:00:00

abstract：PURPOSE:Oxygen-induced retinopathy (OIR) is a model for human retinopathy of prematurity (ROP). In OIR mice, this study determined whether blockade of β-adrenergic receptors (β-ARs) with propranolol influences retinal levels of proangiogenic factors, retinal vascularization, and blood-retinal barrier (BRB) breakdown. ...

journal_title：Investigative ophthalmology & visual science

authors： Ristori C,Filippi L,Dal Monte M,Martini D,Cammalleri M,Fortunato P,la Marca G,Fiorini P,Bagnoli P

更新日期：2011-01-05 00:00:00

abstract：:The efficacy of intravitreally administered amphotericin B was evaluated. Experimental fungal infections were produced by inoculation of Candida albicans organisms into the vitreous cavities of 46 rabbit eyes. After 72 hr, eight eyes received intravitreal injections of 10 micrograms of free amphotericin B; and ten eye...

journal_title：Investigative ophthalmology & visual science

authors： Liu KR,Peyman GA,Khoobehi B

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:The transformed RGC-5 retinal ganglion cell line is used widely in glaucoma research. Increased resistance to glutamate was noted in published literature and led to the recharacterization of the RGC-5 cell line. METHODS:Characterization of the RGC-5 cell line was performed by sequencing of a region of the nucl...

journal_title：Investigative ophthalmology & visual science

authors： Van Bergen NJ,Wood JP,Chidlow G,Trounce IA,Casson RJ,Ju WK,Weinreb RN,Crowston JG

更新日期：2009-09-01 00:00:00

abstract：PURPOSE:To evaluate the change in ocular function by eye in patients with unilateral pigmentary retinopathy. METHODS:Longitudinal regression was used to estimate mean exponential rates of change in Goldmann visual field area (V4e white test light) and in full-field electroretinogram (ERG) amplitudes to 0.5- and 30-Hz ...

journal_title：Investigative ophthalmology & visual science

authors： Potsidis E,Berson EL,Sandberg MA

更新日期：2011-11-29 00:00:00

abstract：:An objective visual field can be mapped in terms of stimulus-induced eye movement. The authors used the scleral coil technique to record vergence and conjugate eye movements while stimulating different visual field locations with a 3 X 3 deg target whose image vergence was oscillated. For each of three subjects tested...

journal_title：Investigative ophthalmology & visual science

authors： Regan D,Erkelens CJ,Collewijn H

更新日期：1986-05-01 00:00:00

abstract：PURPOSE:The global or gross response index of visual performance measured from the eye does not necessarily translate to global responses measured from the brain. A better understanding of this relationship would facilitate the monitoring of disease models that affect the visual pathway. We consider whether rod- and co...

journal_title：Investigative ophthalmology & visual science

authors： Tsai TI,Bui BV,Vingrys AJ

更新日期：2014-02-20 00:00:00

abstract：PURPOSE:The selective degeneration of pericytes and the proliferation of endothelial cells (ECs) appear to be associated with microaneurysm formation, an initial deficit in the early stage of diabetic retinopathy. The preventive effect of aldose reductase (AR) inhibitor (ARI) for high glucose-induced pericyte loss and ...

journal_title：Investigative ophthalmology & visual science

authors： Takamura Y,Tomomatsu T,Kubo E,Tsuzuki S,Akagi Y

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To investigate the effects of lomerizine, a Ca2+ antagonist, on the ocular tissue circulation in rabbits and on the circulation in the optic nerve head (ONH) and choroid in healthy volunteers. METHODS:Lomerizine (0.1 [n=10] or 0.3 [n=11] mg/kg) or vehicle solution (n=11) was injected intravenously in urethane-...

journal_title：Investigative ophthalmology & visual science

authors： Tamaki Y,Araie M,Fukaya Y,Nagahara M,Imamura A,Honda M,Obata R,Tomita K

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:We compared the anti-fibrotic effects of single versus multiple postoperative injections of saratin following glaucoma filtration surgery (GFS) in the rabbit model. METHODS:The experiment was in two parts. To determine the optimal frequency for postoperative therapy, seven New Zealand White (NZW) rabbits recei...

journal_title：Investigative ophthalmology & visual science

authors： Min J,Lukowski ZL,Levine MA,Meyers CA,Beattie AR,Schultz GS,Samuelson DA,Sherwood MB

更新日期：2012-11-19 00:00:00

abstract：Purpose:We investigated the cross-sectional associations between macular pigment optical density (MPOD), plasma lutein (L), and zeaxanthin (Z) concentrations and cognitive function in 184 older adults of the 3-City-Bordeaux cohort. Methods:MPOD was measured using the two-wavelength autofluorescence method with a modif...

journal_title：Investigative ophthalmology & visual science

authors： Ajana S,Weber D,Helmer C,Merle BM,Stuetz W,Dartigues JF,Rougier MB,Korobelnik JF,Grune T,Delcourt C,Féart C

更新日期：2018-04-01 00:00:00

abstract：:Increased saccadic latencies were measured in the amblyopic eyes of subjects having amblyopia without strabismus, constant strabismus amblyopia, and intermittent strabismus. The subjects tracked a small, bright spot of light moving with random, horizontal step displacements of 0.25 to 8.5 degrees over the central reti...

journal_title：Investigative ophthalmology & visual science

authors： Ciuffreda KJ,Kenyon RV,Stark L

更新日期：1978-07-01 00:00:00

abstract：PURPOSE:To compare accommodative facility in eyes with myopia to that in eyes with emmetropia or hyperopia and to determine whether accommodative facility can be used to predict an association with myopia. METHODS:In the Sydney Myopia Study, year-1 school children (6.7 +/- 0.4 years) were assessed for accommodative fa...

journal_title：Investigative ophthalmology & visual science

authors： Pandian A,Sankaridurg PR,Naduvilath T,O'Leary D,Sweeney DF,Rose K,Mitchell P

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:To test the hypothesis that human choroidal blood flow (ChBF) may depend, not only on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). METHODS:There were two study days in an open design. On the first day, OPP was varied by elevating IOP during ...

journal_title：Investigative ophthalmology & visual science

authors： Polska E,Simader C,Weigert G,Doelemeyer A,Kolodjaschna J,Scharmann O,Schmetterer L

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:The flavonoids have potent antioxidant and free-radical scavenging properties and are beneficial in the prevention and treatment of ocular diseases including glaucoma. The authors have previously reported that antiglaucoma agents could transcriptionally activate the antioxidant protein peroxiredoxin (PRDX)2. Th...

journal_title：Investigative ophthalmology & visual science

authors： Miyamoto N,Izumi H,Miyamoto R,Kondo H,Tawara A,Sasaguri Y,Kohno K

更新日期：2011-02-22 00:00:00

abstract：PURPOSE:The lipid layer of the tear film forms a barrier to evaporation. Evaporation is a major cause of tear thinning between blinks and tear breakup. The purpose of this study was to investigate the relation between tear film thinning and lipid layer thickness before and after instillation of an emulsion eye drop. M...

journal_title：Investigative ophthalmology & visual science

authors： King-Smith PE,Hinel EA,Nichols JJ

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:To investigate the characteristics of retinal nerve fiber layer (RNFL) defects associated with type II diabetes. METHODS:Forty nonglaucomatous eyes with type II diabetes and 54 eyes with early open angle glaucoma that exhibited a localized RNFL defect and 42 eyes from age- and sex-matched nondiabetic, nonglauc...

journal_title：Investigative ophthalmology & visual science

authors： Jeon SJ,Kwon JW,La TY,Park CK,Choi JA

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:In ischemic proliferative retinopathies, Müller glial cells (MGCs) acquire migratory abilities. However, the mechanisms that regulate this migration remain poorly understood. In addition, proliferative disorders associated with enhanced activities of matrix metalloproteinases (MMPs) also involve insulin-like gr...

journal_title：Investigative ophthalmology & visual science

authors： Lorenc VE,Jaldín-Fincati JR,Luna JD,Chiabrando GA,Sánchez MC

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Severe ocular allergic diseases are characterized by pronounced conjunctival inflammation triggered by T helper 2 (Th2) cells and corneal epithelial damage induced by eosinophils. To examine the role of alarmins released by damaged corneal epithelial cells in tissue eosinophilia, we investigated the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Fukuda K,Ishida W,Tanaka H,Harada Y,Matsuda A,Ebihara N,Fukushima A

更新日期：2013-08-27 00:00:00

abstract：PURPOSE:To evaluate interictal visual dysfunction in persons with migraine in terms of spatiotemporal selectivity and location within the visual pathways. METHODS:The vision of a group of 15 persons who had experienced migraine with aura was compared with that of 15 normal age-matched control subjects. A range of thre...

journal_title：Investigative ophthalmology & visual science

authors： McKendrick AM,Vingrys AJ,Badcock DR,Heywood JT

更新日期：2001-03-01 00:00:00

abstract：:Accurate assessment of ocular alignment in monkeys is difficult because typical clinical methods require extensive cooperation by the subject or provide only a rough estimate of the misalignment. Recently, Brodie derived a geometrical model for determining the Hirschberg ratio in humans, and validated it photographica...

journal_title：Investigative ophthalmology & visual science

authors： Quick MW,Boothe RG

更新日期：1989-06-01 00:00:00