Corneal endothelial cell survival in organ cultures under acute oxidative stress: effect of VIP.

abstract：Purpose:The purpose of this study was to evaluate the efficacy of new viscous cysteamine hydrochloride (CH) eye drops (vCH 0.55%) compared with standard CH 0.10% drops treatment. Methods:This was an open-label, phase III, randomized, two-arm multicenter trial conducted at two centers in France. Cystinosis patients ≥2 ...

journal_title：Investigative ophthalmology & visual science

authors： Liang H,Labbé A,Le Mouhaër J,Plisson C,Baudouin C

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function. METHODS:Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained...

journal_title：Investigative ophthalmology & visual science

authors： Feigl B,Mattes D,Thomas R,Zele AJ

更新日期：2011-06-21 00:00:00

abstract：Purpose:To investigate the application of optical coherence tomography angiography (OCT-A) in evaluation of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Methods:Patients with GA were prospectively enrolled and studied with blue fundus autofluorescence (FAF), en face structural OCT, and ...

journal_title：Investigative ophthalmology & visual science

authors： Corbelli E,Sacconi R,Rabiolo A,Mercuri S,Carnevali A,Querques L,Bandello F,Querques G

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to demonstrate the efficacy of the digital fluoroscopy system (DFS) for the in vivo assessment of pharmacologically induced posterior vitreous detachment (PVD) and vitreous liquefaction in a rabbit model. METHODS:Twenty eyes from 10 New Zealand white rabbits were divided into 5 gr...

journal_title：Investigative ophthalmology & visual science

authors： Bae JH,Park HS,Kim JM,Lee BR,Lee SC,Tandogan T,Auffarth GU,Koss MJ,Choi CY

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To determine the metrics of vertical saccades in elderly subjects for comparison in neurologic disease. METHODS:Sixteen elderly subjects, ten middle-aged subjects, and thirteen young subjects were examined using a magnetic search coil technique. Saccades were measured to predictable vertical target steps and m...

journal_title：Investigative ophthalmology & visual science

authors： Huaman AG,Sharpe JA

更新日期：1993-07-01 00:00:00

abstract：:Alloantigens placed into the anterior chamber of the eye elicit antigen-specific suppression of systemic delayed-type hypersensitivity (DTH) responses and severe impairment of skin allograft rejection. This pattern of immunologic alteration has been termed anterior chamber-associated immune deviation (ACAID) and is th...

journal_title：Investigative ophthalmology & visual science

authors： Benson JL,Niederkorn JY

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:To investigate the patterns of retinal nerve fiber layer (RNFL) defects in mean deviation-matched early glaucomatous eyes with either superior or inferior visual hemifield loss. METHODS:Seventy-five open-angle glaucoma patients with isolated parafoveal scotoma (PFS) within a central 10° of fixation, and 62 pat...

journal_title：Investigative ophthalmology & visual science

authors： Choi JA,Park HY,Jung KI,Hong KH,Park CK

更新日期：2013-10-23 00:00:00

abstract：PURPOSE:Juvenile monkeys being trained on smooth-pursuit tasks exhibit ocular oscillations resembling pendular nystagmus. The purpose of this study was to analyze these oscillations, the effects of gabapentin on them, and responses of cerebellar floccular neurons to understand possible neuronal mechanisms. METHODS:Fou...

journal_title：Investigative ophthalmology & visual science

authors： Shichinohe N,Barnes G,Akao T,Kurkin S,Fukushima J,Kase M,Leigh RJ,Belton T,Fukushima K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Tissues derived from immune-privileged sites sometimes possess special characteristics that promote their own survival when transplanted to a nonprivileged site. This study was undertaken to evaluate whether retinal pigment epithelium (RPE) behaves as an immune-privileged tissue when transplanted extraocularly....

journal_title：Investigative ophthalmology & visual science

authors： Wenkel H,Streilein JW

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To investigate the role of the gap junction protein connexin43 (Cx43), which is predominantly expressed in lens epithelial cells in the control of lens development and organization. METHODS:Newborn mice in which the Cx43 gene was disrupted by homologous recombination were used. Lenses from Cx43 (-/-) mice and ...

journal_title：Investigative ophthalmology & visual science

authors： Gao Y,Spray DC

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:To correlate retinal histopathology with functional changes caused by the rhodopsin Q64ter mutation. METHODS:A 50-year-old female heterozygote was evaluated clinically and with psychophysical and electroretinographic measurements of rod and cone function. The retinas obtained after death were examined microsco...

journal_title：Investigative ophthalmology & visual science

authors： Milam AH,Li ZY,Cideciyan AV,Jacobson SG

更新日期：1996-04-01 00:00:00

abstract：PURPOSE:The production of proinflammatory cytokines and chemokines as well as the surface expression of intercellular adhesion molecule (ICAM)-1 by corneal fibroblasts contribute to corneal inflammation. The effects of triptolide on the expression of these proteins induced by lipopolysaccharide (LPS) in human corneal f...

journal_title：Investigative ophthalmology & visual science

authors： Lu Y,Liu Y,Fukuda K,Nakamura Y,Kumagai N,Nishida T

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:Endocannabinoids are important modulators of synaptic transmission and plasticity throughout the central nervous system. The cannabinoid receptor type 1 (CB1R) is extensively expressed in the adult retina of rodents, while CB2R mRNA and protein expression have been only recently demonstrated in retinal tissue. ...

journal_title：Investigative ophthalmology & visual science

authors： Cécyre B,Zabouri N,Huppé-Gourgues F,Bouchard JF,Casanova C

更新日期：2013-12-11 00:00:00

abstract：PURPOSE:To determine the impact of substratum compliance and latrunculin-B (Lat-B), both alone and together, on fundamental human trabecular meshwork (HTM) cell behavior. Lat-B is a reversible actin cytoskeleton disruptor that decreases resistance to aqueous humor outflow and decreases intraocular pressure. METHODS:HT...

journal_title：Investigative ophthalmology & visual science

authors： Wood JA,McKee CT,Thomasy SM,Fischer ME,Shah NM,Murphy CJ,Russell P

更新日期：2011-12-02 00:00:00

abstract：:Moiré fringes generated by two equal gratings in contact, looked at in Maxwellian view, are well suited for the assessment of retinal visual acuity. High-contrast fringes practically free from spatial harmonics (higher Fourier components) are obtained if, instead of the zero diffraction order, one first-order diffract...

journal_title：Investigative ophthalmology & visual science

authors： Lotmar W

更新日期：1980-04-01 00:00:00

abstract：Purpose:To evaluate the potential of lactoferrin (Lf) as a diagnostic biomarker for ocular diseases using a meta-analytic approach. Methods:All original studies reporting an estimate of the average Lf concentration in healthy subjects and those affected by ocular diseases were searched up to March 2020. The DerSimonia...

journal_title：Investigative ophthalmology & visual science

authors： Ponzini E,Scotti L,Grandori R,Tavazzi S,Zambon A

更新日期：2020-10-01 00:00:00

abstract：Purpose:To compare static rod function obtained with and without photobleach in control and intermediate age-related macular degeneration (iAMD) participants with and without subretinal drusenoid deposits (SDD). Methods:In this cross-sectional study, retinal sensitivities within the central 24° retina were obtained tw...

journal_title：Investigative ophthalmology & visual science

authors： Tan R,Guymer RH,Luu CD

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:We investigated the mechanism of tamoxifen (TAM) retinotoxicity using human retinal pigment epithelial (RPE)-derived (ARPE-19) and photoreceptor-derived (661W) cells. METHODS:Cultured ARPE-19 and 661W cells were treated with 5 to 10 μM TAM, and the resultant cell death was quantified using lactate dehydrogenas...

journal_title：Investigative ophthalmology & visual science

authors： Cho KS,Yoon YH,Choi JA,Lee SJ,Koh JY

更新日期：2012-08-09 00:00:00

abstract：PURPOSE:Increasing evidence indicates that the macular pigments (MP) protect the central retina and may retard macular disease. For that reason, a practical method for measuring MP that does not require elaborate optics and can be applied to diverse populations by operators with a modest amount of experience was develo...

journal_title：Investigative ophthalmology & visual science

authors： Wooten BR,Hammond BR Jr,Land RI,Snodderly DM

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:Given reports of corneal edema after endothelial exposure to platelet activating factor (PAF), the authors have investigated whether PAF can affect the function of corneal endothelium in vitro. METHODS:The endothelial side of deepithelialized rabbit corneas was perfused with BSS+ and test agents: PAF, its inac...

journal_title：Investigative ophthalmology & visual science

authors： Zhu Z,Kuang K,Kang F,Li J,Fischbarg J

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:To link psychophysical thresholds for blind spot awareness and filling-in with early neural components that underpin these perceptions. METHODS:Blind spot dimensions were quantified, after which an intrinsic stimulus (i.e., a rectangular bar of varying length centered within the blind spot) was used to determi...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Jeffery G,Murphy JS

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:To compare in vitro, on the human reconstituted corneal epithelial SkinEthics model, and in vivo, using an acute rabbit toxicological model, the effects of a benzalkonium chloride (BAK)-preserved solution of latanoprost and a preservative-free (PF) latanoprost solution. METHODS:In vitro, the three-dimensional ...

journal_title：Investigative ophthalmology & visual science

authors： Pauly A,Roubeix C,Liang H,Brignole-Baudouin F,Baudouin C

更新日期：2012-12-13 00:00:00

abstract：PURPOSE:To characterize age-related changes of retinal ganglion cell (RGC) function, IOP, and anatomical markers of axon/glia integrity in a transgenic mouse expressing Tyr437His mutant of human myocilin protein. METHODS:Retinal ganglion cell electrical responsiveness was tested with pattern electroretinogram (PERG) i...

journal_title：Investigative ophthalmology & visual science

authors： Chou TH,Tomarev S,Porciatti V

更新日期：2014-08-14 00:00:00

abstract：PURPOSE:To create a binocular statistical eye model based on previously measured ocular biometric data. METHODS:Thirty-nine parameters were determined for a group of 127 healthy subjects (37 male, 90 female; 96.8% Caucasian) with an average age of 39.9 ± 12.2 years and spherical equivalent refraction of -0.98 ± 1.77 D...

journal_title：Investigative ophthalmology & visual science

authors： Rozema JJ,Atchison DA,Tassignon MJ

更新日期：2011-06-23 00:00:00

abstract：PURPOSE:To image and analyze anatomical differences at the temporal raphe between normal and glaucomatous eyes using adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography (OCT), and to relate these differences to visual field measurements. METHODS:Nine glaucomatous eyes of 9 patients (...

journal_title：Investigative ophthalmology & visual science

authors： Huang G,Luo T,Gast TJ,Burns SA,Malinovsky VE,Swanson WH

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:To design a contact lens to treat and prevent fungal ocular infections. METHODS:Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in p...

journal_title：Investigative ophthalmology & visual science

authors： Ciolino JB,Hudson SP,Mobbs AN,Hoare TR,Iwata NG,Fink GR,Kohane DS

更新日期：2011-08-09 00:00:00

abstract：PURPOSE:To assess the strength of the association between retinal nerve fiber layer (RNFL) thickness and optic disc topography measured with confocal retinal tomography (HRT II; Heidelberg Engineering, Dossenheim, Germany), optical coherence tomography (StratusOCT; Carl Zeiss Meditec, Inc., Dublin, CA), and scanning la...

journal_title：Investigative ophthalmology & visual science

authors： Bowd C,Zangwill LM,Medeiros FA,Tavares IM,Hoffmann EM,Bourne RR,Sample PA,Weinreb RN

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To determine whether basic fibroblast growth factor (bFGF) and transforming growth factor-beta 2 (TGF-beta 2) influence the contractile activity and the expression of alpha-smooth muscle actin (alpha-SMA) in bovine lens epithelial cells (LECs). To examine whether modulation of contractile activity by these grow...

journal_title：Investigative ophthalmology & visual science

authors： Kurosaka D,Kato K,Nagamoto T,Negishi K

更新日期：1995-07-01 00:00:00

abstract：Purpose:It has been suggested that arteriolar annuli localized in retinal arterioles regulate retinal blood flow acting as sphincters. Here, the morphology and protein expression profile of arteriolar annuli have been analyzed under physiologic conditions in the retina of wild-type, β-actin-Egfp, and Nestin-gfp transge...

journal_title：Investigative ophthalmology & visual science

authors： Ramos D,Catita J,López-Luppo M,Valença A,Bonet A,Carretero A,Navarro M,Nacher V,Mendez-Ferrer S,Meseguer A,Casellas A,Mendes-Jorge L,Ruberte J

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Previous sequence analyses of hemidesmosomal BP 180/collagen XVII cDNA from human skin and of a similar chicken corneal cDNA showed some similarities, but major differences as well. The authors examined whether, in one species, the same mRNA is present in cornea and skin. They also studied the developmental exp...

journal_title：Investigative ophthalmology & visual science

authors： Gordon MK,Fitch JM,Foley JW,Gerecke DR,Linsenmayer C,Birk DE,Linsenmayer TF

更新日期：1997-01-01 00:00:00