Immunolocalization of GQ1b and related gangliosides in human extraocular neuromuscular junctions and muscle spindles.

abstract：PURPOSE:To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI). METHODS:The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All s...

journal_title：Investigative ophthalmology & visual science

authors： Lee JY,Jeong HJ,Lee JH,Kim YJ,Kim EY,Kim YY,Ryu T,Cho ZH,Kim YB

更新日期：2014-04-10 00:00:00

abstract：:Monoclonal antibody to HSV glycoprotein D was derivatized with palmitic acid and incorporated into liposomes. These immunoliposomes bound specifically to intact mouse corneas infected with HSV-1 in vitro. Furthermore, in yield reduction assays, anti-gD immunoliposomes loaded with acyclovir proved far more effective at...

journal_title：Investigative ophthalmology & visual science

authors： Norley SG,Sendele D,Huang L,Rouse BT

更新日期：1987-03-01 00:00:00

abstract：PURPOSE:To evaluate the feasibility of introducing exogenous genes and phosphorothioate oligonucleotides into the anterior chamber tissues of rats and monkeys using the authors' fusogenic liposomes. METHODS:Hemagglutinating virus of Japan liposomes containing LacZ DNA-high-mobility group 1 complexes or fluorescein iso...

journal_title：Investigative ophthalmology & visual science

authors： Hangai M,Tanihara H,Honda Y,Kaneda Y

更新日期：1998-03-01 00:00:00

abstract：:Prism induced shift of fixation was measured in 12 cooperative patients utilizing electro-oculography. These recordings were compared with a voluntary shift in fixation of the same eye. No differences were noted when comparing voluntary movements with prism induced movements. Trial of the prism induced eye movement fo...

journal_title：Investigative ophthalmology & visual science

authors： Metz HS

更新日期：1984-10-01 00:00:00

abstract：PURPOSE:Th2 lymphocytes may play a key role in the development of allergic diseases such as vernal keratoconjunctivitis (VKC). Cytokine flow cytometry of tear samples was used to identify the phenotypical and functional properties of lymphocytes at the actual site of the allergic reaction. METHODS:Tear and blood sampl...

journal_title：Investigative ophthalmology & visual science

authors： Leonardi A,DeFranchis G,Zancanaro F,Crivellari G,De Paoli M,Plebani M,Secchi AG

更新日期：1999-11-01 00:00:00

abstract：:The retinal pigment epithelium (RPE) and photoreceptors of teleosts exhibit dramatic examples of cell motility (called retinomotor movements) in response to diurnal changes in lighting conditions. In darkness the pigment granules of the RPE migrate to the scleral base of the RPE cell and cone photoreceptors elongate. ...

journal_title：Investigative ophthalmology & visual science

authors： Burnside B,Basinger S

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:To investigate the human disease due to CRB1 mutations and compare results with the Crb1-mutant rd8 mouse. METHODS:Twenty-two patients with CRB1 mutations were studied. Function was assessed with perimetry and electroretinography (ERG) and retinal structure with optical coherence tomography (OCT). Cortical str...

journal_title：Investigative ophthalmology & visual science

authors： Aleman TS,Cideciyan AV,Aguirre GK,Huang WC,Mullins CL,Roman AJ,Sumaroka A,Olivares MB,Tsai FF,Schwartz SB,Vandenberghe LH,Limberis MP,Stone EM,Bell P,Wilson JM,Jacobson SG

更新日期：2011-08-29 00:00:00

abstract：PURPOSE:The purpose of this study was to elucidate the differentiated expression patterns and phagocytic activities of two subtypes of microglia. METHODS:A rat optic nerve crush model was used to identify the expression patterns of two subtypes of microglia. Primary microglia were isolated from rat mixed glial culture...

journal_title：Investigative ophthalmology & visual science

authors： Haga A,Takahashi E,Inomata Y,Kawahara K,Tanihara H

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:To characterize the thickness profile of the corneal epithelium and the Bowman's layer across the horizontal meridian. METHODS:Forty-four eyes of 22 healthy subjects were investigated in this study. Ultra-high resolution anterior segment spectral domain-optical coherence tomography (SD-OCT) was used to assess ...

journal_title：Investigative ophthalmology & visual science

authors： Tao A,Wang J,Chen Q,Shen M,Lu F,Dubovy SR,Shousha MA

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:To test a newly developed tear evaporimetry system that detects real-time changes in tear evaporation rates and shows the tear film stability in patients with obstructive meibomian gland dysfunction (MGD). METHODS:A ventilated chamber system with high-sensitivity microbalance sensor was used to evaluate tear e...

journal_title：Investigative ophthalmology & visual science

authors： Goto E,Endo K,Suzuki A,Fujikura Y,Matsumoto Y,Tsubota K

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:To determine the accuracy of a history of cataract and cataract surgery (self-report and for a sibling), and to determine which demographic, cognitive, and medical factors are predictive of an accurate history. METHODS:All participants in the Salisbury Eye Evaluation (SEE) project and their locally resident si...

journal_title：Investigative ophthalmology & visual science

authors： Bowie H,Congdon NG,Lai H,West SK

更新日期：2003-07-01 00:00:00

abstract：:The first heritable model of retinoblastoma was established by retina-specific expression of simian virus 40 T-antigen (SV40 T-ag) in transgenic mice. Bilateral, multifocal ocular tumors were observed in 100% of transgene-bearing mice. Central nervous system neoplasms occurred at a lower rate (27%) and represented the...

journal_title：Investigative ophthalmology & visual science

authors： Marcus DM,Carpenter JL,O'Brien JM,Kivela T,Brauner E,Tarkkanen A,Virtanen I,Albert DM

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:Mutations in the mitochondrial dynamin-related GTPase OPA1 cause autosomal dominant optic atrophy (ADOA), but the pathophysiology of this disease is unknown. As a first step in functional studies, this study was conducted to evaluate the expression of Opa1 in whole retina and in isolated retinal ganglion cells ...

journal_title：Investigative ophthalmology & visual science

authors： Kamei S,Chen-Kuo-Chang M,Cazevieille C,Lenaers G,Olichon A,Bélenguer P,Roussignol G,Renard N,Eybalin M,Michelin A,Delettre C,Brabet P,Hamel CP

更新日期：2005-11-01 00:00:00

abstract：Purpose:A shortage of human corneal endothelial cells (HCEC) for transplant and current methods of differentiation induction require chemical compounds, which might cast further influences after differentiation induction. Therefore, we developed a simple and straightforward approach to endothelial cell differentiation ...

journal_title：Investigative ophthalmology & visual science

authors： Chen X,Wu L,Li Z,Dong Y,Pei X,Huang Y,Wang L

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To evaluate the short- and long-term changes of focal macular electroretinograms (fmERGs) after macular translocation with 360 degrees retinotomy. METHODS:This was a retrospective study. fmERGs were recorded in 19 eyes of 19 consecutive patients who underwent macular translocation with 360 degrees retinotomy f...

journal_title：Investigative ophthalmology & visual science

authors： Terasaki H,Ishikawa K,Niwa Y,Piao CH,Niwa T,Kondo M,Ito Y,Miyake Y

更新日期：2004-02-01 00:00:00

abstract：PURPOSE:To identify the underlying mechanisms by which lipid mediator lysophosphatidic acid (LPA) acts as a growth factor in stimulating extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3'-kinase (PI3K) during corneal epithelial wound healing. METHODS:Epithelial debridement wounds in cultured porci...

journal_title：Investigative ophthalmology & visual science

authors： Xu KP,Yin J,Yu FS

更新日期：2007-02-01 00:00:00

abstract：PURPOSE:Previous in vitro studies with transgenic and gene-knockout mice have shown that lenses with elevated levels of glutathione peroxidase (GPX)-1 activity are able to resist the cytotoxic effect of H(2)O(2), compared with normal lenses and lenses from GPX-1-deficient animals. The purpose of this study was to inves...

journal_title：Investigative ophthalmology & visual science

authors： Reddy VN,Giblin FJ,Lin LR,Dang L,Unakar NJ,Musch DC,Boyle DL,Takemoto LJ,Ho YS,Knoernschild T,Juenemann A,Lütjen-Drecoll E

更新日期：2001-12-01 00:00:00

abstract：PURPOSE:To compare three microkeratome-assisted techniques for the preparation of ultrathin (UT) grafts for Descemet stripping automated endothelial keratoplasty. METHODS:After dissection with a 300-μm microkeratome head in 40 donor tissues, a second cut was performed with a 130-μm head either after manual stromal hyd...

journal_title：Investigative ophthalmology & visual science

authors： Busin M,Patel AK,Scorcia V,Ponzin D

更新日期：2012-01-31 00:00:00

abstract：:Evoked potentials (EP's) in response to phase-alternating gratings were recorded from normal and stereoblind or stereodefective subjects (adults and children) under monocular and binocular viewing conditions. The amplitude of the binocular EP was found to exceed the larger monocular EP in normal but not in stereodefec...

journal_title：Investigative ophthalmology & visual science

authors： Amigo G,Fiorentini A,Pirchio M,Spinelli D

更新日期：1978-09-01 00:00:00

abstract：PURPOSE:Macular drusen are hallmarks of age-related maculopathy (ARM), but these focal extracellular lesions also appear with age in the peripheral retina. The present study was conducted to determine regional differences in morphology that contribute to the higher vulnerability of the macula to advanced disease. METH...

journal_title：Investigative ophthalmology & visual science

authors： Rudolf M,Clark ME,Chimento MF,Li CM,Medeiros NE,Curcio CA

更新日期：2008-03-01 00:00:00

abstract：:The level of oxygen at the anterior corneal surface beneath the closed eyelid is shown to be equivalent to an atmosphere of 7.7% oxygen. This finding is in good agreement with assumptions which have been based on the oxygen level at the palpebral conjunctiva. However, in some instances a significant amount of oxygen i...

journal_title：Investigative ophthalmology & visual science

authors： Efron N,Carney LG

更新日期：1979-01-01 00:00:00

abstract：:Scar formation and fibrosis are the most common causes of ultimate glaucoma filtration surgery failure. The authors used Coulter counter, hexosaminidase, and 3H-thymidine assays to evaluate the effects of mithramycin, mitomycin, daunorubicin, and bleomycin on human subconjunctival fibroblast growth in tissue culture. ...

journal_title：Investigative ophthalmology & visual science

authors： Lee DA,Lee TC,Cortes AE,Kitada S

更新日期：1990-10-01 00:00:00

abstract：Purpose:To investigate the plasma concentration of nicotinamide in primary open-angle glaucoma (POAG). Methods:Plasma of 34 POAG individuals was compared to that of 30 age- and sex-matched controls using a semiquantitative method based on liquid chromatography coupled to high-resolution mass spectrometry. Subsequently...

journal_title：Investigative ophthalmology & visual science

authors： Kouassi Nzoughet J,Chao de la Barca JM,Guehlouz K,Leruez S,Coulbault L,Allouche S,Bocca C,Muller J,Amati-Bonneau P,Gohier P,Bonneau D,Simard G,Milea D,Lenaers G,Procaccio V,Reynier P

更新日期：2019-06-03 00:00:00

abstract：PURPOSE:To identify specific site(s) on human ss4 molecule to which sera from ocular cicatricial pemphigoid (OCP) patients bind and to determine its role in the process of blister formation. METHODS:Clone the fragments representing the extracellular and intracellular domain of ss4 molecule from normal human conjunctiv...

journal_title：Investigative ophthalmology & visual science

authors： Kumari S,Bhol KC,Simmons RK,Razzaque MS,Letko E,Foster CS,Razzaque Ahmed A

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:This study investigated, using high-resolution magnetic resonance imaging (MRI), inferior oblique muscle (IO) position relative to the adnexa in normal controls, subjects with and without vertical strabismus following lower lid blepharoplasty, and subjects with other hypertropia. METHODS:Sagittal plane MRI was...

journal_title：Investigative ophthalmology & visual science

authors： Shin SY,Demer JL

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:To compare the Swedish interactive thresholding algorithm (SITA) with the full-threshold (FT) strategy for short-wavelength automated perimetry (SWAP). METHODS:One eye of 286 patients with glaucomatous optic neuropathy (GON) and 289 age-matched participants without GON from the Diagnostic Innovations in Glauco...

journal_title：Investigative ophthalmology & visual science

authors： Ng M,Racette L,Pascual JP,Liebmann JM,Girkin CA,Lovell SL,Zangwill LM,Weinreb RN,Sample PA

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:Fibroblast growth factor-10 (FGF10) can modulate extracellular matrix associated genes and, therefore, it could be a myopia susceptibility gene. This study used an animal model, single nucleotide polymorphisms (SNPs) association, and genetic functional assay to evaluate FGF10 gene for myopia. METHODS:The expre...

journal_title：Investigative ophthalmology & visual science

authors： Hsi E,Chen KC,Chang WS,Yu ML,Liang CL,Juo SH

更新日期：2013-05-07 00:00:00

abstract：:The effect of prostaglandin (PG) F2 alpha-isopropyl ester (IE), PGA2, or PGA2-IE on intraocular pressure (IOP) was tested in eight cynomolgus monkey eyes with argon laser-induced glaucoma. Dose-response testing and baseline IOP measurements were done. For multiple dose testing, 5 micrograms in 25 microliters (0.02%) o...

journal_title：Investigative ophthalmology & visual science

authors： Wang RF,Camras CB,Lee PY,Podos SM,Bito LZ

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:Juvenile monkeys being trained on smooth-pursuit tasks exhibit ocular oscillations resembling pendular nystagmus. The purpose of this study was to analyze these oscillations, the effects of gabapentin on them, and responses of cerebellar floccular neurons to understand possible neuronal mechanisms. METHODS:Fou...

journal_title：Investigative ophthalmology & visual science

authors： Shichinohe N,Barnes G,Akao T,Kurkin S,Fukushima J,Kase M,Leigh RJ,Belton T,Fukushima K

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:To assess the range of macular pigment optical density (MPOD) in a healthy group of young adults of South Asian origin; to investigate whether any dietary factors or personal characteristics were related to intersubject variations in MPOD; and to compare the mean MPOD of the South Asian group with the mean MPOD...

journal_title：Investigative ophthalmology & visual science

authors： Howells O,Eperjesi F,Bartlett H

更新日期：2013-04-17 00:00:00