Nicotinamide Deficiency in Primary Open-Angle Glaucoma.

abstract：PURPOSE:To determine some of the mechanisms by which substance P (SP) induces contraction in the isolated rat iris. METHODS:Rings of rat iris were mounted in a 5-ml organ chamber containing Krebs solution at 37 degrees C under basal tension of 75 mg, and isometric tension was recorded. RESULTS:Substance P produced gr...

journal_title：Investigative ophthalmology & visual science

authors： Grumann-Júnior A,Dias MA,Alves RV,Boteon JE,Calixto JB

更新日期：2000-06-01 00:00:00

abstract：PURPOSE:Focal opacities are signs of early cataractogenesis in the human lens. They progress slowly over a lifetime and may be precursors of mature cataracts. The authors analyzed changes in proteins, phospholipids, and cholesterol in these opacities using in situ techniques: Raman microspectroscopy, filipin cytochemis...

journal_title：Investigative ophthalmology & visual science

authors： Duindam JJ,Vrensen GF,Otto C,Greve J

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:We investigated the response of retinal vessel diameters and oxygen saturation to flicker light stimulation of neuronal activity in patients with diabetic retinopathy. METHODS:We included 18 patients with nonproliferative diabetic retinopathy (mean age 62.2 ± 8.3 years, diabetes type 1 in 4 patients and type 2...

journal_title：Investigative ophthalmology & visual science

authors： Hammer M,Heller T,Jentsch S,Dawczynski J,Schweitzer D,Peters S,Schmidtke KU,Müller UA

更新日期：2012-06-26 00:00:00

abstract：:PURPOSE. To solve the shortage of donor corneas, a decellularizing method based on hypertonic saline treatment was introduced, and a favorable outcome was observed in pig-to-rabbit lamellar corneal transplantation. This study was an investigation of the efficacy of pig-to-nonhuman primate lamellar corneal transplantat...

journal_title：Investigative ophthalmology & visual science

authors： Choi HJ,Kim MK,Lee HJ,Ko JH,Jeong SH,Lee JI,Oh BC,Kang HJ,Wee WR

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a computerized optokinetic nystagmus (OKN) test in detecting visual acuity (VA) of >20/200. METHODS:This was a combined retrospective and prospective, noninterventional study. In phase I of the study, data from 168 eyes of 154 subjects who underwent the computerized objective VA tes...

journal_title：Investigative ophthalmology & visual science

authors： Han SB,Yang HK,Hyon JY,Seo JM,Lee JH,Lee IB,Hwang JM

更新日期：2011-09-27 00:00:00

abstract：PURPOSE:To develop a modified adenoassociated viral (AAV) vector capable of efficient transfection of retinal ganglion cells (RGCs) and to test the hypothesis that use of this vector to express brain-derived neurotrophic factor (BDNF) could be protective in experimental glaucoma. METHODS:Ninety-three rats received one...

journal_title：Investigative ophthalmology & visual science

authors： Martin KR,Quigley HA,Zack DJ,Levkovitch-Verbin H,Kielczewski J,Valenta D,Baumrind L,Pease ME,Klein RL,Hauswirth WW

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:To examine the cross-sectional relationship between blood pressure, perfusion pressure, and prevalence of open angle glaucoma (OAG) in an adult Latino population. METHODS:Participants aged 40 years and older (N = 6130) from the Los Angeles Latino Eye Study (LALES), a large, population-based study of self-ident...

journal_title：Investigative ophthalmology & visual science

authors： Memarzadeh F,Ying-Lai M,Chung J,Azen SP,Varma R,Los Angeles Latino Eye Study Group.

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:To evaluate symptoms, signs, and the levels of 16 tears inflammatory mediators of dry eye (DE) patients exposed to an environment simulating an in-flight air cabin in an environmental chamber. METHODS:Twenty DE patients were exposed to controlled environment simulating an in-flight airplane cabin (simulated in...

journal_title：Investigative ophthalmology & visual science

authors： Tesón M,González-García MJ,López-Miguel A,Enríquez-de-Salamanca A,Martín-Montañez V,Benito MJ,Mateo ME,Stern ME,Calonge M

更新日期：2013-03-01 00:00:00

abstract：:Liposomes 0.5 to 5 micron in diameter and of various phospholipid compositions were used as a simplified model of rod outer segment membranes to examine the phagocytic mechanism of cultured explants of retinal dystrophic Royal College of Surgeons (RCS) and normal Long-Evans (LE) rat pigment epithelium. RCS pigment epi...

journal_title：Investigative ophthalmology & visual science

authors： Effron JT,Szamier RB,Edwards RB

更新日期：1981-10-01 00:00:00

abstract：PURPOSE:Myopia (short sightedness) is a complex trait influenced by as yet unidentified genetic factors. To date, there have been four myopia susceptibility loci (MYP7 to -10) identified in twin studies, but these are yet to be independently verified. In an independent yet ethnically and phenotypically similar twin coh...

journal_title：Investigative ophthalmology & visual science

authors： Schäche M,Richardson AJ,Pertile KK,Dirani M,Scurrah K,Baird PN

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To make the first quantitative assessment of the rate of oxygen consumption in high oxygen-consuming layers of both the outer and inner retina of the rat in vivo. METHODS:Oxygen-sensitive microelectrodes were used to measure the oxygen tension as a function of depth through the retina in anesthetized rats. Ind...

journal_title：Investigative ophthalmology & visual science

authors： Cringle SJ,Yu DY,Yu PK,Su EN

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:We assessed whether partial occlusion of the nonamblyopic eye with Bangerter filters can immediately reduce suppression and promote binocular summation of contrast in observers with amblyopia. METHODS:In Experiment 1, suppression was measured for 22 observers (mean age, 20 years; range, 14-32 years; 10 females...

journal_title：Investigative ophthalmology & visual science

authors： Chen Z,Li J,Thompson B,Deng D,Yuan J,Chan L,Hess RF,Yu M

更新日期：2014-10-28 00:00:00

abstract：:Cyclodialysis was performed in both eyes of five cynomolgus monkeys. Two days later the intraocular pressure (IOP) had fallen from 17.7 +/- 0.8 to 7.1 +/- 1.4 mm Hg (P less than 0.001). At that time, both eyes were perfused for 30 min with fluorescein-isothiocyanate (FITC) dextran (MW 70,000), one at 35 mm Hg and the ...

journal_title：Investigative ophthalmology & visual science

authors： Toris CB,Pederson JE

更新日期：1985-12-01 00:00:00

abstract：PURPOSE:To investigate the effect of Fas and Fas ligand (FasL) deficiency on the development of herpes stromal keratitis and on the von Szily model of herpes retinitis in C57BL/6 mice, which are ordinarily resistant to development of both of these herpetic diseases. METHODS:Anterior chamber inoculation of the right ey...

journal_title：Investigative ophthalmology & visual science

authors： Nguyen QD,Uy HS,Merchant A,Medina CA,Baltatzis S,Zhao T,Zhao ZS,Cantor H,Foster CS

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:To test the hypothesis that subnormal retinal oxygenation response (DeltaPo2) found at 3 months of experimental diabetes is associated with cellular swelling and increased retinal thickness. METHODS:Two groups of animals were studied: control rats injected intraperitoneally with either 15% body weight of salin...

journal_title：Investigative ophthalmology & visual science

authors： Luan H,Roberts R,Sniegowski M,Goebel DJ,Berkowitz BA

更新日期：2006-01-01 00:00:00

abstract：Purpose:Corneal endothelial cells (CECs) are critical in maintaining clarity of the cornea. This study was initiated to develop peripheral blood mononuclear cell (PBMC)-originated, induced pluripotent stem cell (iPSC)-derived CECs. Methods:We isolated PBMCs and programmed the mononuclear cells to generate iPSCs, which...

journal_title：Investigative ophthalmology & visual science

authors： Ali M,Khan SY,Vasanth S,Ahmed MR,Chen R,Na CH,Thomson JJ,Qiu C,Gottsch JD,Riazuddin SA

更新日期：2018-05-01 00:00:00

abstract：PURPOSE:To quantify the role of anterior zonular tension on the optomechanical lens response during simulation of accommodation in primates. METHODS:Postmortem cynomolgus monkey eyes (n = 14; age range, 3.0-11.5 years) were dissected leaving intact the lens, zonules, ciliary body, hyaloid membrane, anterior vitreous, ...

journal_title：Investigative ophthalmology & visual science

authors： Nankivil D,Manns F,Arrieta-Quintero E,Ziebarth N,Borja D,Amelinckx A,Bernal A,Ho A,Parel JM

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Cilostazol, a selective inhibitor of phosphodiesterase 3, has antiplatelet aggregation and peripheral vasodilation effects. We examined the effects of cilostazol on the retinal microvascular diameter to determine its dependence on the endothelium and/or smooth muscle to reveal the signaling mechanisms involved ...

journal_title：Investigative ophthalmology & visual science

authors： Tanano I,Nagaoka T,Omae T,Ishibazawa A,Kamiya T,Ono S,Yoshida A

更新日期：2013-02-19 00:00:00

abstract：PURPOSE:A great deal of information about functionally significant domains of a protein may be obtained by comparison of primary sequences of gene homologues over a broad phylogenetic base. This study was designed to identify evolutionarily conserved domains of the photoreceptor disc membrane protein peripherin/rds by ...

journal_title：Investigative ophthalmology & visual science

authors： Li C,Ding XQ,O'Brien J,Al-Ubaidi MR,Naash MI

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:To assess whether tonometric measurements of the drop in intraocular pressure (IOP) induced by 0.005% latanoprost are modified after photorefractive keratectomy (PRK). METHODS:Data from 24 randomly selected eyes of 24 patients (12 men and 12 women, mean age +/- SD: 31.7 +/- 6.2 years) who were undergoing bilat...

journal_title：Investigative ophthalmology & visual science

authors： Tamburrelli C,Vaiano AS,Salgarello T,Caputo CG,Scullica L

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical coherence tomography (SD-OCT). METHODS:Images were captured on B...

journal_title：Investigative ophthalmology & visual science

authors： Lin P,Mettu PS,Pomerleau DL,Chiu SJ,Maldonado R,Stinnett S,Toth CA,Farsiu S,Mruthyunjaya P

更新日期：2012-04-06 00:00:00

abstract：PURPOSE:Angiotensin-converting-enzyme (ACE) catalyses the formation of angiotensin II (ANGII), which presumably acts as a central neurotransmitter/modulator. ANGII-related effects have also been observed in the retina. Present in vivo experiments were designed to investigate further ANGII-related effects on retinal neu...

journal_title：Investigative ophthalmology & visual science

authors： Jacobi PC,Osswald H,Jurklies B,Zrenner E

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:Recently, it has been found that form deprivation myopia can be induced in fish (tilapia). This study examined the sensitivity of the tilapia eye to positive and negative lenses. It further investigated the sensitivity of the fish eye to form deprivation by examining the effect of fish weight. METHODS:Twenty-f...

journal_title：Investigative ophthalmology & visual science

authors： Shen W,Sivak JG

更新日期：2007-10-01 00:00:00

abstract：:Evidence for a population of acetylcholine (ACh) receptors in the human retina is presented. The authors have used the irreversible ligand 3H-propylbenzilylcholine mustard (3H-PrBCM) to label muscarinic receptors. 3H- or 125I-alpha-bungarotoxin (alpha-BTx) was used to label putative nicotinic receptors. Muscarinic rec...

journal_title：Investigative ophthalmology & visual science

authors： Hutchins JB,Hollyfield JG

更新日期：1985-11-01 00:00:00

abstract：PURPOSE:The authors' previous models predicted local formation of diabetic retinopathy (DR) in adults with diabetes and existing retinopathy. Here they derived a multivariate model for local prediction of DR onset in patients with no previous retinopathy. METHODS:Seventy-eight eyes from 41 diabetes patients were teste...

journal_title：Investigative ophthalmology & visual science

authors： Harrison WW,Bearse MA Jr,Ng JS,Jewell NP,Barez S,Burger D,Schneck ME,Adams AJ

更新日期：2011-02-09 00:00:00

abstract：:Heightened interest in meibomian glands dysfunction prompted the authors to examine the ultrastructure of the glandular epithelium in specimens of surgical origin, by thin section and freeze-fracture electron microscopies. In meibomian glands, the morphology and ultrastructure of acinar cells varies considerably accor...

journal_title：Investigative ophthalmology & visual science

authors： Sirigu P,Shen RL,Pinto da Silva P

更新日期：1992-06-01 00:00:00

abstract：PURPOSE:Intrastromal inlays for refractive correction of presbyopia are being adopted into clinical practice. An important concern is the effect of the inlay on the long-term health of the cornea due to disturbances in the concentration profiles of metabolic species. A three-dimensional metabolic model for the cornea i...

journal_title：Investigative ophthalmology & visual science

authors： Pinsky PM

更新日期：2014-05-15 00:00:00

abstract：PURPOSE:To examine changes in spherical equivalent over a 5-year period in persons 43 to 84 years of age. METHODS:All people 43 to 84 years of age and living in Beaver Dam, Wisconsin, in 1988 were invited for a baseline examination (1988-1990) and a 5-year follow-up examination (1993-1995). Refractions were determined...

journal_title：Investigative ophthalmology & visual science

authors： Lee KE,Klein BE,Klein R

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:To test the hypothesis that human choroidal blood flow (ChBF) may depend, not only on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). METHODS:There were two study days in an open design. On the first day, OPP was varied by elevating IOP during ...

journal_title：Investigative ophthalmology & visual science

authors： Polska E,Simader C,Weigert G,Doelemeyer A,Kolodjaschna J,Scharmann O,Schmetterer L

更新日期：2007-08-01 00:00:00

abstract：:The short-term fluctuation in regular grid threshold static fields is commonly determined from repeated observations of a number of threshold points. In this study we estimated the short-term fluctuation from a single determination of the field. Sixty-two eyes of 62 patients were tested, using three consecutive repeti...

journal_title：Investigative ophthalmology & visual science

authors： Schulzer M,Mills RP,Hopp RH,Lau W,Drance SM

更新日期：1990-04-01 00:00:00