Mechanisms mediating substance P-induced contraction in the rat iris in vitro.

abstract：Purpose:To investigate autophagy in the outflow pathway and ganglion cell layer in the aging and ocular hypertensive mouse. Methods:Both 4-month-old and 18-month-old C57BL/6J and GFP-LC3 mice were subjected to unilateral injection of hypertonic saline into a limbal vein, causing sclerosis of the outflow pathway and su...

journal_title：Investigative ophthalmology & visual science

authors： Nettesheim A,Dixon A,Shim MS,Coyne A,Walsh M,Liton PB

更新日期：2020-08-03 00:00:00

abstract：PURPOSE:Focal opacities are signs of early cataractogenesis in the human lens. They progress slowly over a lifetime and may be precursors of mature cataracts. The authors analyzed changes in proteins, phospholipids, and cholesterol in these opacities using in situ techniques: Raman microspectroscopy, filipin cytochemis...

journal_title：Investigative ophthalmology & visual science

authors： Duindam JJ,Vrensen GF,Otto C,Greve J

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:Currently, there are no definitive immunomarkers for epithelial stem cells (corneal and conjunctival) or their poorly understood niche microenvironment. The H2B-GFP/K5tTA mouse enables visualization of label-retaining cells (LRCs), which exhibit the functional marker of stem cell quiescence. We used immunofluor...

journal_title：Investigative ophthalmology & visual science

authors： Parfitt GJ,Kavianpour B,Wu KL,Xie Y,Brown DJ,Jester JV

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To investigate possible protective effects of lens epithelium-derived growth factor (LEDGF) against photoreceptor death in light-damaged, Royal College of Surgeons (RCS) and P23H rhodopsin transgenic rats. METHODS:Twelve-week-old Sprague-Dawley (SD), 6-week-old RCS, and 10-day-old P23H (line 1, heterozygote) r...

journal_title：Investigative ophthalmology & visual science

authors： Machida S,Chaudhry P,Shinohara T,Singh DP,Reddy VN,Chylack LT Jr,Sieving PA,Bush RA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:Videokeratography of early keratoconus may be difficult to distinguish from contact lens-induced corneal warpage, even by experienced examiners. Furthermore, topographic irregularity may be judged inconsistently if quantitative standards are not applied. Quantitative measures based on videokeratographic data we...

journal_title：Investigative ophthalmology & visual science

authors： Smolek MK,Klyce SD,Maeda N

更新日期：1994-12-01 00:00:00

abstract：PURPOSE:Genetic modification of cells before transplantation may allow the delivery of neuroprotective and other functional molecules to patients with neurodegenerative diseases. To avoid complications associated with virally transfected cells, we have explored the use of nonviral methods to insert genetic material int...

journal_title：Investigative ophthalmology & visual science

authors： Johnen S,Kazanskaya O,Armogan N,Stickelmann C,Stöcker M,Walter P,Thumann G

更新日期：2011-07-23 00:00:00

abstract：PURPOSE:To determine whether the size and configuration of the optic chiasm in humans with albinism is different from that in normal control subjects. METHODS:Seventeen patients and 15 control subjects underwent magnetic resonance imaging of the entire head. Images were reformatted to the chiasm region and analyzed wi...

journal_title：Investigative ophthalmology & visual science

authors： Schmitz B,Schaefer T,Krick CM,Reith W,Backens M,Käsmann-Kellner B

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:To examine the rate of retinal ganglion cell (RGC) layer and retinal nerve fiber layer (RNFL) changes in nonoptic neuritis (NON) eyes of relapsing remitting multiple sclerosis (RRMS) patients, and to find a specific imaging parameter useful for identifying disease progression. METHODS:Forty-five consecutive RR...

journal_title：Investigative ophthalmology & visual science

authors： Graham EC,You Y,Yiannikas C,Garrick R,Parratt J,Barnett MH,Klistorner A

更新日期：2016-04-01 00:00:00

abstract：:The effects of x-rays and three chemical agents, known to cause intraocular inflammation in mammalian eyes, were studied on the chicken eye because this species was reported to be insensitive to the cataractogenic effects of x-rays. Intravitreal injection of Shigella endotoxin and topical and/or intravitreal administr...

journal_title：Investigative ophthalmology & visual science

authors： Stetz DE,Bito LZ

更新日期：1978-05-01 00:00:00

abstract：PURPOSE:We characterized fluorescent bone marrow cells (YFP(+) BMCs) in the thy1-YFP mouse and determine if they promote trigeminal ganglion (TG) cell neurite growth. METHODS:Excimer laser annular keratectomy was performed in thy1-YFP mice, and corneas were imaged. BMCs were harvested from femur and tibia, and the exp...

journal_title：Investigative ophthalmology & visual science

authors： Sarkar J,Chaudhary S,Jassim SH,Ozturk O,Chamon W,Ganesh B,Tibrewal S,Gandhi S,Byun YS,Hallak J,Mahmud DL,Mahmud N,Rondelli D,Jain S

更新日期：2013-09-03 00:00:00

abstract：PURPOSE:FOXC1 mutations result in Axenfeld-Rieger syndrome, a disorder characterized by a broad spectrum of malformations of the anterior segment of the eye and an elevated risk for glaucoma. A novel FOXC1 W152G mutation was identified in a patient with aniridia. Molecular analysis was conducted to determine the functi...

journal_title：Investigative ophthalmology & visual science

authors： Ito YA,Footz TK,Berry FB,Mirzayans F,Yu M,Khan AO,Walter MA

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Although the murine alphaA-crystallin promoter is the most commonly used promoter for achieving transgene expression in the developing lens, this promoter directs transgene expression efficiently only in lens fiber cells. The purpose of the present study was to generate promoters capable of directing transgene ...

journal_title：Investigative ophthalmology & visual science

authors： Zhao H,Yang Y,Rizo CM,Overbeek PA,Robinson ML

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:To investigate the optimal frequency of imaging during follow-up to detect glaucoma progression by characterizing variability (noise) in neuroretinal rim area (RA) measured by Heidelberg Retina Tomograph (HRT; Heidelberg Engineering, Heidelberg, Germany). METHODS:RA noise was estimated from patient data and ch...

journal_title：Investigative ophthalmology & visual science

authors： Owen VM,Strouthidis NG,Garway-Heath DF,Crabb DP

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:Glucocorticoid sensitivity in glaucoma has been attributed to differences in the expression of the two glucocorticoid receptors, GRalpha and GRbeta. GRalpha undergoes steroid-dependent nuclear translocation by associating with a heat shock protein (Hsp)90 multiprotein heterocomplex. The nuclear transport of the...

journal_title：Investigative ophthalmology & visual science

authors： Zhang X,Clark AF,Yorio T

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:We previously showed that pre-exposure of the cornea to Toll-like receptor (TLR)5 ligand flagellin induces strong protective innate defense against microbial pathogens and hypothesized that flagellin modulates gene expression at the transcriptional levels. Thus, we sought to determine the role of one transcript...

journal_title：Investigative ophthalmology & visual science

authors： Yoon GS,Dong C,Gao N,Kumar A,Standiford TJ,Yu FS

更新日期：2013-11-15 00:00:00

abstract：PURPOSE:To investigate whether tissue plasminogen activator (tPA) can prevent and/or reverse steroid-induced IOP elevation in an ovine model. METHODS:Three animal groups were subjected to bilateral steroid-induced IOP elevation using thrice daily topical ocular prednisolone administration. In the first group (N = 8), ...

journal_title：Investigative ophthalmology & visual science

authors： Gerometta R,Kumar S,Shah S,Alvarez L,Candia O,Danias J

更新日期：2013-12-03 00:00:00

abstract：PURPOSE:This study was performed to investigate motion perception in patients with glaucoma. METHODS:A random dot motion test was used to measure three aspects of central motion perception: minimum displacement threshold (Dmin), maximum displacement threshold (Dmax), and coherence threshold (signal to noise). Motion p...

journal_title：Investigative ophthalmology & visual science

authors： Bullimore MA,Wood JM,Swenson K

更新日期：1993-12-01 00:00:00

abstract：PURPOSE:To study binding of retinoids to human tear lipocalin (TL) to assess factors influencing ligand affinity and delivery. Mechanistic features of retinoid interactions with TL were investigated, including the influence of the retinoid functional group on ligand affinity, the relative affinity of retinol versus fat...

journal_title：Investigative ophthalmology & visual science

authors： Gasymov OK,Abduragimov AR,Yusifov TN,Glasgow BJ

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:To investigate the protective effects of cobalt protoporphyrin (CoPP), a potent heme oxygenase (HO)-1 inducer, in a rat model of ischemia-reperfusion injury and to document the possible antiapoptotic and anti-inflammatory mechanisms underlying the protection. METHODS:Rats pretreated with intraperitoneal inject...

journal_title：Investigative ophthalmology & visual science

authors： Sun MH,Pang JH,Chen SL,Han WH,Ho TC,Chen KJ,Kao LY,Lin KK,Tsao YP

更新日期：2010-09-01 00:00:00

abstract：Purpose:To improve the transparency of the acellular dermal matrix (ADM) and investigate the optical, mechanical and histologic properties and biocompatibility of transparent ADM (TADM) in lamellar keratoplasty. Methods:A stepwise sectioning strategy was applied to determine the transparency distribution of the ADM, a...

journal_title：Investigative ophthalmology & visual science

authors： Wang Y,Ma J,Jiang X,Liu Z,Yang J,Li X

更新日期：2020-01-23 00:00:00

abstract：Purpose:To assess the effect of serous retinal detachment (SRD) on functional and anatomical outcomes in ranibizumab-treated patients with diabetic macular edema (DME). Methods:All consecutive ranibizumab-treated patients with SRD were included in this retrospective study. For each patient with SRD, a patient without ...

journal_title：Investigative ophthalmology & visual science

authors： Giocanti-Aurégan A,Hrarat L,Qu LM,Sarda V,Boubaya M,Levy V,Chaine G,Fajnkuchen F

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To determine whether blur adaptation influences blur sensitivity and blur discrimination thresholds in young adult myopes and emmetropes. In addition, to determine whether there is a differential effect of blur adaptation on blur sensitivity and discrimination between refractive error groups. METHODS:Proximal ...

journal_title：Investigative ophthalmology & visual science

authors： Cufflin MP,Mankowska A,Mallen EA

更新日期：2007-06-01 00:00:00

abstract：:Rabbit corneas were treated in vitro and in vivo with cholera toxin (CTX), a specific and irreversible activator of adenylate cyclase. Tissue pieces incubated in vitro in the presence of 10 mug/ml CTX for 15 min continuously synthesized adenosine 3',5'-monophosphate (cyclic AMP) at an increased rate for 3 hr in the ab...

journal_title：Investigative ophthalmology & visual science

authors： Jumblatt MM,Fogle JA,Neufeld AH

更新日期：1980-11-01 00:00:00

abstract：PURPOSE:The effects of adrenergic agonists and antagonists on Na+, K+, Cl- cotransport in fetal human nonpigmented ciliary epithelial (NPE) cells were investigated. METHODS:86Rb+ as a marker for K+ was used to study ouabain-insensitive, bumetanide-sensitive 86Rb+ uptake in cultured NPE monolayers. Cyclic adenosine mon...

journal_title：Investigative ophthalmology & visual science

authors： Crook RB,Riese K

更新日期：1996-05-01 00:00:00

abstract：Purpose:The purpose of this study was to describe the cellular architecture of normal human peripapillary sclera (PPS) and evaluate surface topography's role in fibroblast behavior. Methods:PPS cryosections from nonglaucomatous eyes were labelled for nuclei, fibrillar actin (FA), and alpha smooth muscle actin (αSMA) a...

journal_title：Investigative ophthalmology & visual science

authors： Szeto J,Chow A,McCrea L,Mozzer A,Nguyen TD,Quigley HA,Pitha I

更新日期：2021-01-04 00:00:00

abstract：:Eight murine monoclonal antibodies to retinal S-antigen were found to recognize three antigenic clusters in competitive binding experiments. Variable patterns of immunohistochemical staining of retinal sections supported the competitive binding studies. Monoclonal antibodies to two of these three antigenic clusters on...

journal_title：Investigative ophthalmology & visual science

authors： Banga JP,LeRoy F,Suleyman S,Kasp E,Brown E,Dumonde D

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:To evaluate whether β-zone parapapillary atrophy (PPA) is associated with the rate of retinal nerve fiber layer (RNFL) thickness change as assessed by trend-based analysis using time-domain optical coherence tomography (OCT). METHODS:This retrospective cohort study included 202 glaucomatous eyes that were obse...

journal_title：Investigative ophthalmology & visual science

authors： Lee EJ,Kim TW,Weinreb RN,Park KH,Kim SH,Kim DM

更新日期：2011-06-22 00:00:00

abstract：PURPOSE:Cannabinoids have been reported to mediate changes in vascular resistance through endothelial receptor targets. We examined involvement of the endothelium in cannabinoid-mediated vasoactive responses in resistance arterioles of the retina. METHODS:Vascular responses to both intraluminal (IL) and extraluminal (...

journal_title：Investigative ophthalmology & visual science

authors： Su EN,Kelly ME,Cringle SJ,Yu DY

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:To design a glucocorticoid-inducible virus vector overexpressing recombinant matrix metalloproteinase 1 (MMP1) and counteract extracellular matrix deposition in the trabecular meshwork only when steroid is present. METHODS:Endogenous MMP1 expression was measured in primary human trabecular meshwork cells (HTM)...

journal_title：Investigative ophthalmology & visual science

authors： Spiga MG,Borrás T

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Müller glia have multiple functions in the retina, including synthesis of neurotrophic factors, uptake and metabolism of neurotransmitters, spatial buffering of ions, maintenance of the blood-retinal barrier, and response to injury. A population of Müller glia has some stem cell-like characteristics both in viv...

journal_title：Investigative ophthalmology & visual science

authors： Otteson DC,Phillips MJ

更新日期：2010-11-01 00:00:00