Role of Endothelium in Abnormal Cannabidiol-Induced Vasoactivity in Retinal Arterioles.

abstract：:The hydration of actin was studied by differential scanning calorimetry between -30 degrees C and 30 degrees C and by thermogravimetric analysis. The differential scanning calorimetry provided the freezable water content of G- and F-actin as a function of concentration, and the thermogravimetric analysis measured the ...

journal_title：Investigative ophthalmology & visual science

authors： Kakar S,Bettelheim FA

更新日期：1991-03-01 00:00:00

abstract：PURPOSE:To test the association between TCF4, a gene recently found to confer susceptibility to Fuchs' corneal dystrophy (FCD) in Caucasian populations, and Chinese patients with FCD. METHODS:Fifty-seven Chinese subjects with clinically diagnosed FCD and 121 normal control subjects were recruited. Genomic DNA was extr...

journal_title：Investigative ophthalmology & visual science

authors： Thalamuthu A,Khor CC,Venkataraman D,Koh LW,Tan DT,Aung T,Mehta JS,Vithana EN

更新日期：2011-07-29 00:00:00

abstract：PURPOSE:CD4(+)CD25(+)FoxP3(+) naturally occurring regulatory T cells (Tregs) maintain self-tolerance and function to suppress overly exuberant immune responses. However, it is unclear whether innate immune cells modulate Treg function. Here the authors examined the role of innate immunity in lymphomyeloid homeostasis. ...

journal_title：Investigative ophthalmology & visual science

authors： Mott KR,Gate D,Zandian M,Allen SJ,Rajasagi NK,van Rooijen N,Chen S,Arditi M,Rouse BT,Flavell RA,Town T,Ghiasi H

更新日期：2011-04-08 00:00:00

abstract：PURPOSE:Oxidative stress and metabolic dysregulation of the RPE have been implicated in AMD; however, the molecular regulation of RPE metabolism remains unclear. The transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) is a powerful mediator of mitochondrial function. Th...

journal_title：Investigative ophthalmology & visual science

authors： Iacovelli J,Rowe GC,Khadka A,Diaz-Aguilar D,Spencer C,Arany Z,Saint-Geniez M

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To determine whether a novel optical treatment using contact lenses to reduce relative peripheral hyperopia can slow the rate of progress of myopia. METHODS:Chinese children, aged 7 to 14 years, with baseline myopia from sphere -0.75 to -3.50 D and cylinder ≤1.00 D, were fitted with novel contact lenses (n = 4...

journal_title：Investigative ophthalmology & visual science

authors： Sankaridurg P,Holden B,Smith E 3rd,Naduvilath T,Chen X,de la Jara PL,Martinez A,Kwan J,Ho A,Frick K,Ge J

更新日期：2011-12-09 00:00:00

abstract：PURPOSE:To investigate the characteristics of the mononuclear cell infiltrate in murine experimental autoimmune uveoretinitis (EAU). METHODS:EAU was induced by immunization with bovine interphotoreceptor retinal binding protein (IRBP) in Freund's complete adjuvant (subcutaneous injection) and pertussis toxin (intraper...

journal_title：Investigative ophthalmology & visual science

authors： Jiang HR,Lumsden L,Forrester JV

更新日期：1999-12-01 00:00:00

abstract：Purpose:Applying CNGA3 gene augmentation therapy to cure a novel causative mutation underlying achromatopsia (ACHM) in sheep. Methods:Impaired vision that spontaneously appeared in newborn lambs was characterized by behavioral, electroretinographic (ERG), and histologic techniques. Deep-sequencing reads of an affected...

journal_title：Investigative ophthalmology & visual science

authors： Gootwine E,Abu-Siam M,Obolensky A,Rosov A,Honig H,Nitzan T,Shirak A,Ezra-Elia R,Yamin E,Banin E,Averbukh E,Hauswirth WW,Ofri R,Seroussi E

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To study the aggregation of bovine gamma-crystallins in aqueous solutions and the effect of gamma(s)-crystallin on the aggregation of other gamma-crystallins. METHODS:Aggregation in aqueous solutions of gamma(s)-, gammaII-, and gammaIVa-crystallin was monitored by quasielastic light scattering. Aggregation in ...

journal_title：Investigative ophthalmology & visual science

authors： Liu C,Pande J,Lomakin A,Ogun O,Benedek GB

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:This study was conducted to investigate metabolic changes in aqueous humor from rabbit eyes exposed to either UV-A or -B radiation, by using (1)H nuclear magnetic resonance (NMR) spectroscopy and unsupervised pattern recognition METHODS:methods. Both eyes of adult albino rabbits were irradiated with UV-A (366 ...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Cejková J,Midelfart A

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:To investigate functional abnormalities in mutations in the peripherin (RDS) gene leading to different clinical types of autosomal dominant retinal disease--macular degeneration and retinitis pigmentosa. METHODS:Patients from two families, one with a mutation in codon 167 (Gly167Asp) leading to macular degener...

journal_title：Investigative ophthalmology & visual science

authors： Kemp CM,Jacobson SG,Cideciyan AV,Kimura AE,Sheffield VC,Stone EM

更新日期：1994-07-01 00:00:00

abstract：:We studied the effect of topical timolol maleate 0.5% on the retinal circulation of eyes with ocular hypertension using laser Doppler velocimetry and monochromatic fundus photography. Patients with ocular hypertension had normal eye examinations and had documented elevated intraocular pressures of 23 mmHg or higher on...

journal_title：Investigative ophthalmology & visual science

authors： Grunwald JE

更新日期：1990-03-01 00:00:00

abstract：PURPOSE:The growth of ocular neovascularization is regulated by a balance between stimulating and inhibiting growth factors. Somatostatin affects angiogenesis by inhibiting the growth hormone-insulin-like growth factor axis and also has a direct antiproliferative effect on human retinal endothelial cells. The purpose o...

journal_title：Investigative ophthalmology & visual science

authors： Lambooij AC,Kuijpers RW,van Lichtenauer-Kaligis EG,Kliffen M,Baarsma GS,van Hagen PM,Mooy CM

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:To compare spectral-domain optical coherence tomography (SD-OCT) standard structural measures and a new three-dimensional (3D) volume optic nerve head (ONH) change detection method for detecting change over time in severely advanced-glaucoma (open-angle glaucoma [OAG]) patients. METHODS:Thirty-five eyes of 35 ...

journal_title：Investigative ophthalmology & visual science

authors： Belghith A,Medeiros FA,Bowd C,Liebmann JM,Girkin CA,Weinreb RN,Zangwill LM

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:To examine the association between central corneal thickness (CCT) and glaucoma. METHODS:This was a nested case-control study using 1090 subjects from an eye disease population survey in Singapore and 243 participants from a hospital glaucoma surgery clinical trial in Singapore. RESULTS:Mean CCT in 938 commun...

journal_title：Investigative ophthalmology & visual science

authors： Day AC,Machin D,Aung T,Gazzard G,Husain R,Chew PT,Khaw PT,Seah SK,Foster PJ

更新日期：2011-10-28 00:00:00

abstract：PURPOSE:Methionine-sulfoxide reductases are unique, in that their ability to repair oxidized proteins and MsrA, which reduces S-methionine sulfoxide, can protect lens cells against oxidative stress damage. To date, the roles of MsrB1, -B2 and -B3 which reduce R-methionine sulfoxide have not been established for any mam...

journal_title：Investigative ophthalmology & visual science

authors： Marchetti MA,Pizarro GO,Sagher D,Deamicis C,Brot N,Hejtmancik JF,Weissbach H,Kantorow M

更新日期：2005-06-01 00:00:00

abstract：PURPOSE:The S1 RNA binding domain 1 (SRBD1) and elongation of long-chain fatty acids family member 5 (ELOVL5) have been reported to be susceptibility genes for early-onset normal-tension glaucoma (NTG). The present study we conducted to assess whether these genes were associated with primary open-angle glaucoma (POAG),...

journal_title：Investigative ophthalmology & visual science

authors： Mabuchi F,Sakurada Y,Kashiwagi K,Yamagata Z,Iijima H,Tsukahara S

更新日期：2011-06-28 00:00:00

abstract：:Contrast sensitivity functions for sinusoidal gratings of different spatial frequencies and stimulus durations have been determined for both eyes of amblyopic subjects. For both long and short stimulus durations, the entire contrast sensitivity function of the amblyopic eyes is lower than that of the nonamblyopic eyes...

journal_title：Investigative ophthalmology & visual science

authors： Levi DM,Harwerth RS

更新日期：1977-01-01 00:00:00

abstract：PURPOSE:To test the effect of valacyclovir alone and with aspirin on the asymptomatic shedding of HSV-1 DNA in tears and saliva of healthy individuals. METHOD. The subjects (n = 45) were randomized into three groups without regard to age, sex, or race. Group 1 (n = 14) received the placebo, group 2 (n = 15) received a ...

journal_title：Investigative ophthalmology & visual science

authors： Kumar M,Hill JM,Clement C,Varnell ED,Thompson HW,Kaufman HE

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:To test the association between elevated proportions of CD1c+ myeloid dendritic cells (mDCs) and disease activation/reactivation in noninfectious uveitis. METHODS:Noninfectious uveitis patients (n = 89) and healthy controls (n = 111) were recruited. The proportion of CD1c+ mDCs in the total dendritic cell (DC)...

journal_title：Investigative ophthalmology & visual science

authors： Chen P,Urzua CA,Knickelbein JE,Kim JS,Li Z,Hannes S,Kuo D,Chaigne-Delalande B,Armbrust K,Tucker W,Liu B,Agrón E,Sen HN,Nussenblatt RB

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:The stratified squamous epithelial covering of the cornea provides one of the first physical and immunological lines of defense. A breach in its integrity results in a wound healing response that resolves quickly. However, under certain conditions-for example, when migrating cells are unable to adhere to the ba...

journal_title：Investigative ophthalmology & visual science

authors： Chow S,Di Girolamo N

更新日期：2014-09-18 00:00:00

abstract：PURPOSE:To determine the effect of bimatoprost on intraocular pressure in the prostaglandin FP receptor knockout mouse. METHODS:The IOP response to a single 1.2-microg (4 microL) dose of bimatoprost was measured in the treated and untreated fellow eyes of homozygote (FP+/+, n = 9) and heterozygote (FP+/-, n = 10) FP-k...

journal_title：Investigative ophthalmology & visual science

authors： Crowston JG,Lindsey JD,Morris CA,Wheeler L,Medeiros FA,Weinreb RN

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:A recent study identified single nucleotide polymorphisms (SNPs) within the IL-1 gene cluster at chromosomal locus 2q13 that were associated with reduced risk for primary open-angle glaucoma (POAG) in whites. The purpose of this study was to investigate the association between IL-1 SNPs and glaucoma in Chinese ...

journal_title：Investigative ophthalmology & visual science

authors： How AC,Aung T,Chew X,Yong VH,Lim MC,Lee KY,Toh JY,Li Y,Liu J,Vithana EN

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:The authors examined the effects of both light and circadian phase on the synthetic activity of the dopamine producing enzyme, tyrosine hydroxylase (TH), in the retina of the Midas cichlid (Cichlasoma citrinellum). METHODS:TH activity was assayed in the retina-retinal pigment epithelium (RPE) complex of fish e...

journal_title：Investigative ophthalmology & visual science

authors： McCormack CA,Burnside B

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:Conjunctiva-associated lymphoid tissue (CALT) is assumed to be a key location for the generation of adaptive immune mechanisms of the ocular surface, but functional studies of CALT are still lacking. The purpose of this study was to establish an animal model that enables functional analysis of immune mechanisms...

journal_title：Investigative ophthalmology & visual science

authors： Steven P,Rupp J,Hüttmann G,Koop N,Lensing C,Laqua H,Gebert A

更新日期：2008-04-01 00:00:00

abstract：Purpose:To investigate the role of mitogen-activated protein kinase-activated protein kinase-2 (MK2) in ocular surface damage of dry eye. Methods:MK2 inhibition was performed in mice subjected to desiccating stress (DS) by topical application of MK2 inhibitor (MK2i) or vehicle eye drops. The total and phosphorylated M...

journal_title：Investigative ophthalmology & visual science

authors： Wu Y,Bu J,Yang Y,Lin X,Cai X,Huang C,Zheng X,Ouyang W,Li W,Zhang X,Liu Z

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Activity in regions of the visual cortex corresponding to central scotomas in subjects with macular degeneration (MD) is considered evidence for functional reorganization in the brain. Three unresolved issues related to cortical activity in subjects with MD were addressed: Is the cortical response to stimuli pr...

journal_title：Investigative ophthalmology & visual science

authors： Liu T,Cheung SH,Schuchard RA,Glielmi CB,Hu X,He S,Legge GE

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Gangliosides are normal components of cell membranes, contribute to structural rigidity and membrane function, and have been shown to protect against various insults to the brain. This study evaluates the effect of exogenously administered monosialoganglioside GM1 on retinal damage induced by transient retinal ...

journal_title：Investigative ophthalmology & visual science

authors： Weber M,Mohand-Said S,Hicks D,Dreyfus H,Sahel JA

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:Retinal pigment epithelial (RPE) cells play important roles in ophthalmologic diseases such as proliferative vitreoretinopathy, AMD, and diabetic retinopathy. MicroRNA-34a (miR-34a) has been reported to be important in the regulation of cell proliferation, migration, differentiation, and apoptosis. In this stud...

journal_title：Investigative ophthalmology & visual science

authors： Hou Q,Tang J,Wang Z,Wang C,Chen X,Hou L,Dong XD,Tu L

更新日期：2013-10-03 00:00:00

abstract：:PURPOSE. To define the role of the serine protease HTRA1 in age-related macular degeneration (AMD) by examining its expression level and identifying its potential substrates in the context of primary RPE cell extracellular milieu. METHODS. Primary RPE cell cultures were established from human donor eyes and screened f...

journal_title：Investigative ophthalmology & visual science

authors： An E,Sen S,Park SK,Gordish-Dressman H,Hathout Y

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The use of patient-reported outcome (PRO) measures to assess self-reported difficulty in visual activities is common in patients with impaired vision. This study determines the visual and psychosocial factors influencing patients' responses to self-report measures, to aid in understanding what is being measured...

journal_title：Investigative ophthalmology & visual science

authors： Tabrett DR,Latham K

更新日期：2011-07-15 00:00:00