Structural Change Can Be Detected in Advanced-Glaucoma Eyes.

abstract：PURPOSE:To create a binocular statistical eye model based on previously measured ocular biometric data. METHODS:Thirty-nine parameters were determined for a group of 127 healthy subjects (37 male, 90 female; 96.8% Caucasian) with an average age of 39.9 ± 12.2 years and spherical equivalent refraction of -0.98 ± 1.77 D...

journal_title：Investigative ophthalmology & visual science

authors： Rozema JJ,Atchison DA,Tassignon MJ

更新日期：2011-06-23 00:00:00

abstract：PURPOSE:To evaluate the dynamic changes in refraction during the accommodative facility test in myopes and emmetropes. METHODS:Ten myopes and 10 emmetropes participated in the study. All were young adults, and refractive error in the myopes was corrected with soft contact lenses. Monocular accommodative facility measu...

journal_title：Investigative ophthalmology & visual science

authors： Radhakrishnan H,Allen PM,Charman WN

更新日期：2007-09-01 00:00:00

abstract：PURPOSE:To determine the mechanisms underlying prostaglandin (PG) F(2)alpha-(,) carbachol (CCh)-, or latanoprost (a PGF(2)alpha analogue)-induced contraction of the pig iris sphincter muscle. METHODS:Effects of these agents on myofilament Ca(2+) sensitivity were evaluated and compared with the use of receptor-coupled ...

journal_title：Investigative ophthalmology & visual science

authors： Hasegawa Y,Nishimura J,Niiro N,Hirano K,Ishibashi T,Kanaide H

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Aquaporin (AQP) is a hexahelical integral membrane protein that functions as a constitutive channel for water and regulated channel for cations in fluid transporting tissues, including many in the eye. Although AQP1 has been cloned from a cDNA library prepared from cultures of retinal pigment epithelial (RPE) c...

journal_title：Investigative ophthalmology & visual science

authors： Stamer WD,Bok D,Hu J,Jaffe GJ,McKay BS

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:To explore changes in corneal sensitivity that develop in patients with dry eye and the relationship between sensibility and severity of the dry eye disease. METHODS:Experiments were performed in 44 patients with dry eye and 42 healthy individuals. Corneal sensitivity was measured with the Belmonte noncontact ...

journal_title：Investigative ophthalmology & visual science

authors： Bourcier T,Acosta MC,Borderie V,Borrás F,Gallar J,Bury T,Laroche L,Belmonte C

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:To optimize fixation, sectioning, and immunolabeling protocols to map the morphology of the human lens with confocal microscopy. METHODS:Transparent human lenses were fixed in 0.75% paraformaldehyde for 24 hours, cut in half, and fixed for another 24 hours. Lenses were cryoprotected, sectioned, and labeled wit...

journal_title：Investigative ophthalmology & visual science

authors： Lim JC,Walker KL,Sherwin T,Schey KL,Donaldson PJ

更新日期：2009-09-01 00:00:00

abstract：:Autophagy and macropinocytosis are processes that are vital for cellular homeostasis, and help cells respond to stress and take up large amounts of material, respectively. The limbal and corneal epithelia have the machinery necessary to carry out both processes; however, autophagy and macropinocytosis are relatively u...

journal_title：Investigative ophthalmology & visual science

authors： Peng H,Park JK,Lavker RM

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:The sense of vision in humans is robust, and visual flickering is rarely experienced. To investigate this mechanism, electrophysiological and molecular biological techniques were used on human cone and rod photoreceptors. METHODS:Voltage-gated currents were recorded using the patch-clamp technique on isolated ...

journal_title：Investigative ophthalmology & visual science

authors： Kawai F,Horiguchi M,Ichinose H,Ohkuma M,Isobe R,Miyachi E

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the PAR1 receptor. The authors recently showed that parstatin is a potent inhibitor of angiogenesis. The purpose of the present study was to evaluate the therapeutic effect of parstatin on ocular neovascularization. METHODS:Choroidal...

journal_title：Investigative ophthalmology & visual science

authors： Huang H,Vasilakis P,Zhong X,Shen JK,Geronatsiou K,Papadaki H,Maragoudakis ME,Gartaganis SP,Vinores SA,Tsopanoglou NE

更新日期：2010-11-01 00:00:00

abstract：Purpose:To determine the effects of narrowband light exposure on choroidal thickness and the pupil response in humans. Methods:Twenty subjects, ages 21 to 43 years, underwent 1 hour of exposure to broadband, short wavelength "blue," or long wavelength "red" light, or darkness. Choroidal thickness, imaged with spectral...

journal_title：Investigative ophthalmology & visual science

authors： Lou L,Ostrin LA

更新日期：2020-08-03 00:00:00

abstract：PURPOSE:To investigate the use of topically applied FK506, a new immunosuppressive compound, systemic and ocular absorption was determined in serum and various ocular tissues. METHODS:Two drops of 20 microliters FK506 were applied using oil dissolved (OD-FK506) or liposome-bound (LIP-FK506) drug. FK506 concentrations ...

journal_title：Investigative ophthalmology & visual science

authors： Pleyer U,Lutz S,Jusko WJ,Nguyen KD,Narawane M,Rückert D,Mondino BJ,Lee VH,Nguyen K

更新日期：1993-08-01 00:00:00

abstract：:Retinal ultrastructure was examined at various intervals following a single intravitreal injection of 100-4,000 micrograms of gentamicin in rabbit eyes. Three days after injections of 100-500 micrograms, numerous abnormal lamellar lysosomal inclusions were observed in the retinal pigment epithelium (RPE) and in macrop...

journal_title：Investigative ophthalmology & visual science

authors： D'Amico DJ,Libert J,Kenyon KR,Hanninen LA,Caspers-Velu L

更新日期：1984-05-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) and d-ala2-methionine enkephalinamide (DALA, a long-lasting enkephalin analogue) were used to investigate the peptidergic control of lacrimal gland function. To characterize the mechanism by which VIP stimulates and DALA inhibits lacrimal peroxidase secretion, the effect of these pe...

journal_title：Investigative ophthalmology & visual science

authors： Cripps MM,Bennett DJ

更新日期：1990-10-01 00:00:00

abstract：PURPOSE:To examine the association between central corneal thickness (CCT) and glaucoma. METHODS:This was a nested case-control study using 1090 subjects from an eye disease population survey in Singapore and 243 participants from a hospital glaucoma surgery clinical trial in Singapore. RESULTS:Mean CCT in 938 commun...

journal_title：Investigative ophthalmology & visual science

authors： Day AC,Machin D,Aung T,Gazzard G,Husain R,Chew PT,Khaw PT,Seah SK,Foster PJ

更新日期：2011-10-28 00:00:00

abstract：PURPOSE:To study the spatial distribution of posterior pole choroidal thickness (CT) in healthy eyes using spectral domain optical coherence tomography (SD-OCT). METHODS:Fifty-nine eyes from 30 subjects with no retinal or choroidal disease were examined with high-definition (HD) OCT using macular volume cube scanning ...

journal_title：Investigative ophthalmology & visual science

authors： Ouyang Y,Heussen FM,Mokwa N,Walsh AC,Durbin MK,Keane PA,Sanchez PJ,Ruiz-Garcia H,Sadda SR

更新日期：2011-09-01 00:00:00

abstract：:Stevens-Johnson syndrome (SJS), and its more severe variant, toxic epidermal necrolysis (TEN), are life-threatening diseases of the skin and mucous membranes. After the acute-stage damage subsides, serious visual impairment and severe dry eye remains as ocular sequelae. At the acute stage, ocular complications occur i...

journal_title：Investigative ophthalmology & visual science

authors： Sotozono C,Ueta M,Yokoi N

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:StarGen is an equine infectious anemia virus (EIAV)-based lentiviral vector that expresses the photoreceptor-specific adenosine triphosphate (ATP)-binding cassette transporter (ABCA4) protein that is mutated in Stargardt disease (STGD1), a juvenile macular dystrophy. EIAV vectors are able to efficiently transdu...

journal_title：Investigative ophthalmology & visual science

authors： Binley K,Widdowson P,Loader J,Kelleher M,Iqball S,Ferrige G,de Belin J,Carlucci M,Angell-Manning D,Hurst F,Ellis S,Miskin J,Fernandes A,Wong P,Allikmets R,Bergstrom C,Aaberg T,Yan J,Kong J,Gouras P,Prefontaine A,

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:To determine whether ciliary neurotrophic factor (CNTF) or brain-derived neurotrophic factor (BDNF) treatment leads to long-term photoreceptor survival in hereditary retinal degeneration. METHODS:An autosomal dominant feline model of rod-cone dystrophy was used throughout the study with two normal animals. In ...

journal_title：Investigative ophthalmology & visual science

authors： Chong NH,Alexander RA,Waters L,Barnett KC,Bird AC,Luthert PJ

更新日期：1999-05-01 00:00:00

abstract：:Male albino rats, injected intravenously or intracerebroventricularly with delta 1-tetrahydrocannabinol (THC), develop mudriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 microgram/kg THC. Sympathectomy significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Korczyn AD,Eshel Y

更新日期：1982-03-01 00:00:00

abstract：PURPOSE:To determine the mechanism by which basic fibroblast growth factor (bFGF) exerts its neuroprotective effects on degenerating or injured photoreceptors. METHODS:Confocal immunofluorescence microscopy was used to identify sites of bFGF and FGF receptor 1 (FGFR1) expression after focal injury or experimental reti...

journal_title：Investigative ophthalmology & visual science

authors： Ozaki S,Radeke MJ,Anderson DH

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:This study was designed to examine whether retinal function can be rescued by allogeneic normal retinal pigment epithelial (RPE) grafts in Royal College of Surgeons (RCS) with retinal degeneration and, if so, whether this rescued function can be measured and followed by recording the corneal electroretinogram (...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Hamasaki D

更新日期：1994-12-01 00:00:00

abstract：PURPOSE:To determine the effects of X-linked and autosomal recessive Alport syndrome on retinal basement membranes and how these result in the characteristic perimacular dot-and-fleck retinopathy, lozenge, and macular hole. METHODS:The type IV collagen chains present in the normal retina were determined immunohistoche...

journal_title：Investigative ophthalmology & visual science

authors： Savige J,Liu J,DeBuc DC,Handa JT,Hageman GS,Wang YY,Parkin JD,Vote B,Fassett R,Sarks S,Colville D

更新日期：2010-03-01 00:00:00

abstract：Purpose:Little is known regarding the therapeutic effect of carbonic anhydrase inhibitors (CAIs) in the management of cystic macular lesions in children with X-linked juvenile retinoschisis (XLRS) despite the fact that this disease often manifests during childhood. Therefore, our goal was to determine the efficacy of C...

journal_title：Investigative ophthalmology & visual science

authors： Verbakel SK,van de Ven JP,Le Blanc LM,Groenewoud JM,de Jong EK,Klevering BJ,Hoyng CB

更新日期：2016-10-01 00:00:00

abstract：:This volume presents articles based on a workshop held June 14 to 16, 2013 in Rancho Palos Verde, CA sponsored by the Ocular Research Symposia Foundation (ORSF). The mission of the ORSF is to focus attention on unmet needs and current research opportunities in eye research with the objective of accelerating translatio...

journal_title：Investigative ophthalmology & visual science

authors： Chader GJ,Taylor A

更新日期：2013-12-13 00:00:00

abstract：PURPOSE:Fractal dimension of retinal vasculature is a global summary measure of retinal vascular network pattern and geometry. This study was conducted to examine the effect of variations in image color, brightness, focus, contrast, and format on the measurement of retinal vascular fractal dimension. METHODS:A set of ...

journal_title：Investigative ophthalmology & visual science

authors： Wainwright A,Liew G,Burlutsky G,Rochtchina E,Zhang YP,Hsu W,Lee JM,Wong TY,Mitchell P,Wang JJ

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To determine how the different stages of retinal processing change after photoreceptor degeneration in rabbits carrying the Pro347Leu rhodopsin mutation (Tg rabbits). METHODS:Cone electroretinograms (ERGs) were elicited by 150-ms duration stimuli from 13 Tg rabbits at 12 and 24 weeks of age. The ERG recordings...

journal_title：Investigative ophthalmology & visual science

authors： Nishimura T,Machida S,Kondo M,Terasaki H,Yokoyama D,Kurosaka D

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:To evaluate the histologic effects and clinical outcomes of high-intensity focused ultrasound (HIFU) delivered by miniaturized annular transducers for ciliary body coagulation in an animal study. METHODS:Eighteen eyes of 18 rabbits were insonified with a ring comprising a six-sector transducer, to produce a 12...

journal_title：Investigative ophthalmology & visual science

authors： Aptel F,Charrel T,Palazzi X,Chapelon JY,Denis P,Lafon C

更新日期：2010-10-01 00:00:00

abstract：:Rabbit corneas were treated in vitro and in vivo with cholera toxin (CTX), a specific and irreversible activator of adenylate cyclase. Tissue pieces incubated in vitro in the presence of 10 mug/ml CTX for 15 min continuously synthesized adenosine 3',5'-monophosphate (cyclic AMP) at an increased rate for 3 hr in the ab...

journal_title：Investigative ophthalmology & visual science

authors： Jumblatt MM,Fogle JA,Neufeld AH

更新日期：1980-11-01 00:00:00

abstract：Purpose:Global analyses using mean deviation (MD) assess visual field progression, but can miss localized changes. Pointwise analyses are more sensitive to localized progression, but more variable so require confirmation. This study assessed whether cluster trend analysis, averaging information across subsets of locati...

journal_title：Investigative ophthalmology & visual science

authors： Gardiner SK,Mansberger SL,Demirel S

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Subjects with macular disorders need longer time to plan and execute a reaching and grasping task compared with normally sighted controls. In everyday life it is normal to perform reaching and grasping movements while simultaneously carrying out a cognitively demanding task. We investigated whether a simultaneo...

journal_title：Investigative ophthalmology & visual science

authors： Pardhan S,Zuidhoek S

更新日期：2013-05-07 00:00:00