Histologic effects of a new device for high-intensity focused ultrasound cyclocoagulation.

abstract：:Visual fixation of a small, stationary target was measured in 12 young observers (mean age = 22 yr) and in 12 older observers (mean age = 70 yr). The two groups' fixation behavior did not differ on various dimensions of fixation stability: mean fixation area, intra-subject variability, or changes in fixation over succ...

journal_title：Investigative ophthalmology & visual science

authors： Kosnik W,Fikre J,Sekuler R

更新日期：1986-12-01 00:00:00

abstract：PURPOSE:Vascular endothelial growth factor (VEGF) is required for vascular development and for ischemia-related tumor, iris, and retinal neovascularization. The role of VEGF in inflammatory corneal neovascularization is unknown and was investigated in these studies. METHODS:A rat model was used in which removal of the...

journal_title：Investigative ophthalmology & visual science

authors： Amano S,Rohan R,Kuroki M,Tolentino M,Adamis AP

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:To characterize the chemokines and chemokine receptors that mediate the effect of proinflammatory cytokines, interleukin (IL)-1 and tumor necrosis factor (TNF)-alpha, on the recruitment of MHC class II(+) Langerhans cells (LCs) in the corneal epithelium. METHODS:A standard model for corneal LC recruitment, app...

journal_title：Investigative ophthalmology & visual science

authors： Yamagami S,Hamrah P,Miyamoto K,Miyazaki D,Dekaris I,Dawson T,Lu B,Gerard C,Dana MR

更新日期：2005-04-01 00:00:00

abstract：:PURPOSE. To examine the biomechanical deformation of load bearing structures of the optic nerve head (ONH) resulting from raised intracranial pressure, using high definition optical coherence tomography (HD-OCT). The authors postulate that elevated intracranial pressure induces forces in the retrolaminar subarachnoid ...

journal_title：Investigative ophthalmology & visual science

authors： Kupersmith MJ,Sibony P,Mandel G,Durbin M,Kardon RH

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:To determine the effect of treatment with latanoprost on the tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in cultured human ciliary muscle (HCM) cells. METHODS:Confluent serum-starved HCM cells were exposed to increasing concentrations of latanoprost acid (LA, 1 nM to 10 micro M) for 6, 18, and 24 ho...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Weinreb RN

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:To investigate whether time outdoors and a range of other activities are associated with change in spherical equivalent (SE) and axial length in Chinese children over a period of 2 years. METHODS:A total of 1997 children aged 12.7 ± 0.5 (10.9-15.6) years in the Anyang Childhood Eye Study (ACES) were examined a...

journal_title：Investigative ophthalmology & visual science

authors： Li SM,Li H,Li SY,Liu LR,Kang MT,Wang YP,Zhang F,Zhan SY,Gopinath B,Mitchell P,Wang N,Anyang Childhood Eye Study Group.

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To study the aggregation of bovine gamma-crystallins in aqueous solutions and the effect of gamma(s)-crystallin on the aggregation of other gamma-crystallins. METHODS:Aggregation in aqueous solutions of gamma(s)-, gammaII-, and gammaIVa-crystallin was monitored by quasielastic light scattering. Aggregation in ...

journal_title：Investigative ophthalmology & visual science

authors： Liu C,Pande J,Lomakin A,Ogun O,Benedek GB

更新日期：1998-08-01 00:00:00

abstract：PURPOSE:To determine the distribution of invasive and cytotoxic genotypes among ocular isolates of P. aeruginosa and investigate the influence of the type III secretion system (T3SS) on adhesion to conventional, cosmetic, and silicone hydrogel contact lenses (CL). METHODS:Clinical isolates from 2001 to 2010 were analy...

journal_title：Investigative ophthalmology & visual science

authors： Shen EP,Tsay RY,Chia JS,Wu S,Lee JW,Hu FR

更新日期：2012-09-21 00:00:00

abstract：PURPOSE:China has among the lowest cataract surgical rates in Asia. This study was conducted to identify barriers to cataract surgery in rural China. METHODS:All subjects having undergone cataract surgery and persons with presenting visual acuity or=1 eye due to nons...

journal_title：Investigative ophthalmology & visual science

authors： Yin Q,Hu A,Liang Y,Zhang J,He M,Lam DS,Ge J,Wang N,Friedman DS,Zhao J,Congdon N

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To characterize the spectrum of mutations in the OPA1 gene in a large international panel of patients with autosomal dominant optic atrophy (adOA), to improve understanding of the range of functional deficits attributable to sequence variants in this gene, and to assess any genotype-phenotype correlations. MET...

journal_title：Investigative ophthalmology & visual science

authors： Thiselton DL,Alexander C,Taanman JW,Brooks S,Rosenberg T,Eiberg H,Andreasson S,Van Regemorter N,Munier FL,Moore AT,Bhattacharya SS,Votruba M

更新日期：2002-06-01 00:00:00

abstract：PURPOSE:To examine the relationship between retinal vascular geometric parameters with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL) parameters in nonglaucomatous subjects. METHODS:Study subjects were identified from the Singapore Chinese Eye Study (SCES), a population-based survey ...

journal_title：Investigative ophthalmology & visual science

authors： Tham YC,Cheng CY,Zheng Y,Aung T,Wong TY,Cheung CY

更新日期：2013-11-05 00:00:00

abstract：PURPOSE:To evaluate the expression of tissue inhibitor of metalloproteinases (TIMP) mRNA in corneal tissues before and at early time points (6 and 12 hours and 1, 3, and 5 days) after corneal infection with Pseudomonas aeruginosa. METHODS:Ribonuclease protection assays were used to detect and quantitate TIMP mRNA expr...

journal_title：Investigative ophthalmology & visual science

authors： Kernacki KA,Goebel DJ,Poosch MS,Hazlett LD

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:To improve the interpretation of Heidelberg Retina Flowmeter (HRF; Heidelberg Engineering GmBH, Dosselheim, Germany) flow maps by examining the influence of specific vascular structures and focus depth in the presence and absence of retinal blood flow. METHODS:HRF flow maps were recorded from the inferior reti...

journal_title：Investigative ophthalmology & visual science

authors： Yu DY,Townsend R,Cringle SJ,Chauhan BC,Morgan WH

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:As efforts to noninvasively measure intracranial pressure (ICP) increase, we thought it important to investigate the timing of retinal venous pulsation in relation to the intraocular and intracranial pressure pulses. METHODS:Neurosurgical patients undergoing continuous direct ICP monitoring had video recording...

journal_title：Investigative ophthalmology & visual science

authors： Morgan WH,Lind CR,Kain S,Fatehee N,Bala A,Yu DY

更新日期：2012-07-10 00:00:00

abstract：PURPOSE:Methylprednisolone (MP) is commonly used to treat traumatic optic neuropathy and optic neuritis, but its benefit in terms of neuronal survival remains controversial. The aim of this study was to investigate the effects of MP on retinal ganglion cell (RGC) survival and visual function after ischemia in rats. ME...

journal_title：Investigative ophthalmology & visual science

authors： Dimitriu C,Bach M,Lagrèze WA,Jehle T

更新日期：2008-11-01 00:00:00

abstract：PURPOSE:Sildenafil (Viagra; Pfizer, New York, NY), a selective phosphodiesterase type-5 (PDE5) inhibitor, is widely used to treat impotence by improving penile blood flow via elevation of cGMP. However, its effect on ocular circulation is controversial and whether retinal arterioles are responsive to this drug remains ...

journal_title：Investigative ophthalmology & visual science

authors： Yuan Z,Hein TW,Rosa RH Jr,Kuo L

更新日期：2008-02-01 00:00:00

abstract：:A monoclonal antibody, 4G10.3, was developed that preferentially binds limbal basal cells in adult rat, rabbit, and human corneas. These cells were hypothesized to be the stem cells for the corneal epithelium. The antibody 4G10.3 was localized by immunofluorescence microscopy in rats 1 d and 1, 1.5, 2, 3, 4, and 6 wk ...

journal_title：Investigative ophthalmology & visual science

authors： Chung EH,Bukusoglu G,Zieske JD

更新日期：1992-06-01 00:00:00

abstract：PURPOSE:To investigate the induction of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) gene expression by prostaglandin E2 (PGE2) in cultured rat Müller cells and to study the mechanism of the induction. METHODS:Müller cells were obtained from neonatal Sprague-Dawley rat retinas an...

journal_title：Investigative ophthalmology & visual science

authors： Cheng T,Cao W,Wen R,Steinberg RH,LaVail MM

更新日期：1998-03-01 00:00:00

abstract：PURPOSE:To determine the distribution of perceived visual ability for functional vision performance among persons with low vision in the Indian state of Andhra Pradesh. METHODS:As part of a population-based epidemiologic study, the Andhra Pradesh Eye Disease Study (APEDS), a 16-item visual function questionnaire was d...

journal_title：Investigative ophthalmology & visual science

authors： Nutheti R,Shamanna BR,Krishnaiah S,Gothwal VK,Thomas R,Rao GN

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:To determine the effect of pyrrolidine dithiocarbamate (PDTC), a nuclear factor (NF)-kappaB inhibitor, on chemokine and chemokine receptor expression and thus elucidate the role of NF-kappaB in the pathogenesis of experimental autoimmune anterior uveitis (EAAU). METHODS:Uveitis was induced in Lewis rats with t...

journal_title：Investigative ophthalmology & visual science

authors： Yang CH,Fang IM,Lin CP,Yang CM,Chen MS

更新日期：2005-04-01 00:00:00

abstract：:The secretion of the aqueous humor has been proposed to occur as the result of active Na+ transport by a ouabain-sensitive Na-K ATPase. We have examined the localization of this enzyme in the epithelium of rabbit ciliary body pars plicata using [3H]ouabain autoradiography. Single ciliary processes were isolated and in...

journal_title：Investigative ophthalmology & visual science

authors： Usukura J,Fain GL,Bok D

更新日期：1988-04-01 00:00:00

abstract：:Autoregulation of the retinal circulation in response to an acute elevation of intraocular pressure was investigated in 17 subjects (23 eyes) with no ocular abnormalities, by means of the blue field entoptic phenomenon. This phenomenon allows a person to observe leukocytes flowing in his own macular capillaries. Subje...

journal_title：Investigative ophthalmology & visual science

authors： Riva CE,Sinclair SH,Grunwald JE

更新日期：1981-07-01 00:00:00

abstract：PURPOSE:Fluorescein and rose bengal are dyes used routinely in the examination of the ocular surface. As part of an ongoing search for a superior ophthalmic dye with optimal specificity and sensitivity and a lack of interference with subsequent viral cultures, and as part of studies that use chemical dyes to understand...

journal_title：Investigative ophthalmology & visual science

authors： Chodosh J,Dix RD,Howell RC,Stroop WG,Tseng SC

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:The adult lacrimal gland (LG) is highly regenerative and is able to repair itself even after substantial damage; however, this ability to regenerate is lost with the development of dry eye conditions in chronically inflamed LGs.This study compares changes in the cell adhesion and cell matrix molecules and stem ...

journal_title：Investigative ophthalmology & visual science

authors： Umazume T,Thomas WM,Campbell S,Aluri H,Thotakura S,Zoukhri D,Makarenkova HP

更新日期：2015-12-01 00:00:00

abstract：:Pattern ERGs in response to pattern-reversal stimuli varying in spatial frequency (range: 0.2-9.03 cycles/deg) and contrast (range: 0.03-0.93) were recorded from two normal male subjects. At most spatial frequencies the response amplitude increased linearly up to the highest contrast without saturation. From the ampli...

journal_title：Investigative ophthalmology & visual science

authors： Korth M,Rix R,Sembritzki O

更新日期：1985-03-01 00:00:00

abstract：:Accurate assessment of ocular alignment in monkeys is difficult because typical clinical methods require extensive cooperation by the subject or provide only a rough estimate of the misalignment. Recently, Brodie derived a geometrical model for determining the Hirschberg ratio in humans, and validated it photographica...

journal_title：Investigative ophthalmology & visual science

authors： Quick MW,Boothe RG

更新日期：1989-06-01 00:00:00

abstract：PURPOSE:Neovascularization of the avascular cornea is a significant problem associated with many corneal diseases. Because Fas ligand (FasL) is highly expressed in the cornea, the role of this molecule in controlling corneal neovascularization was examined in this study. METHODS:C57BL/6(B6), FasL (CD95L)-deficient B6-...

journal_title：Investigative ophthalmology & visual science

authors： Stuart PM,Pan F,Plambeck S,Ferguson TA

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:To explore differences in optic disc tilt and torsion between normal control and glaucoma subjects, and to determine whether the direction of optic disc tilt is consistent with the initial location of glaucomatous visual field (VF) defect. METHODS:Glaucoma patients with isolated superior or inferior hemifield ...

journal_title：Investigative ophthalmology & visual science

authors： Choi JA,Park HY,Shin HY,Park CK

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:To determine the disease course of retinal dystrophy caused by recessive variants in the DRAM2 (damage-regulated autophagy modulator 2) gene. METHODS:Sixteen individuals with DRAM2-retinopathy were examined (six families; age range, 19-56 years, includes one pre-symptomatic case). The change in visual acuity o...

journal_title：Investigative ophthalmology & visual science

authors： Sergouniotis PI,McKibbin M,Robson AG,Bolz HJ,De Baere E,Müller PL,Heller R,El-Asrag ME,Van Schil K,Plagnol V,Toomes C,Uk Inherited Retinal Disease Consortium.,Ali M,Holder GE,Charbel Issa P,Leroy BP,Inglehearn CF,Webste

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To investigate the role of anti-vascular endothelial growth factor (VEGF)-C therapy in corneal graft survival and concomitant suppression of hem- and lymph-angiogenesis. METHODS:Corneal suture model in BALB/c mice was placed and immunohistochemical staining was performed with CD31/PECAM-1 and LYVE-1 to quantif...

journal_title：Investigative ophthalmology & visual science

authors： Hajrasouliha AR,Funaki T,Sadrai Z,Hattori T,Chauhan SK,Dana R

更新日期：2012-03-09 00:00:00