Autoregulation of retinal circulation in response to decrease of perfusion pressure.

abstract：:The outer horizontal cell (OHC) of the frog Rana pipiens was studied by light and electron microscopy of Golgi-stained and horseradish peroxidase-injected cells. Responses of OHCs were recorded with intracellular electrodes. The OHCs are probably axonless cells. Their dendritic terminals are lateral processes at synap...

journal_title：Investigative ophthalmology & visual science

authors： Ogden TE,Mascetti GG,Pierantoni R

更新日期：1985-05-01 00:00:00

abstract：PURPOSE:To study relationships between glaucoma-sensitive components identified with frequency-domain analysis of global-flash multifocal electroretinogram (mfERG), regional retinal nerve fiber layer thickness (RNFLT), and local visual field sensitivity (VS). METHODS:Eleven macaque monkeys, including four controls and...

journal_title：Investigative ophthalmology & visual science

authors： Luo X,Patel NB,Harwerth RS,Frishman LJ

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Previous studies have demonstrated that in 129alpha3Cx46-/- mice, age-related nuclear cataract is formed. In the present study, a more in vivo-relevant model was generated to test the hypothesis that the calpain 3 gene is involved in age-related nuclear cataractogenesis in alpha3Cx46 knockout mice. METHODS:To ...

journal_title：Investigative ophthalmology & visual science

authors： Tang Y,Liu X,Zoltoski RK,Novak LA,Herrera RA,Richard I,Kuszak JR,Kumar NM

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:7-Ketocholesterol is a highly toxic oxysterol found in abundance in atherosclerotic plaques and is believed to play a critical role in atherosclerosis. The purpose of this study was to identify and localize 7-ketocholesterol (7kCh) in the primate retina and to examine the potential consequences of its presence ...

journal_title：Investigative ophthalmology & visual science

authors： Moreira EF,Larrayoz IM,Lee JW,Rodríguez IR

更新日期：2009-02-01 00:00:00

abstract：Purpose:We determine the feasibility of human conjunctival epithelial cells (hCjECs) on poly(lactic-co-glycolic) acid (PLGA) membranes for corneal epithelium regeneration. hCjECs on PLGA or polyester (PET) membranes with or without coculture of human Tenon's fibroblasts (hTFs) were compared in vitro, and to determine w...

journal_title：Investigative ophthalmology & visual science

authors： Hong S,Yun JH,Kim ES,Kim JS,Tchah H,Hwang C

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:Lacritin is a tear glycoprotein with prosecretory, prosurvival, and mitogenic properties. We examined lacritin levels in the tears of Sjögren's syndrome (SS) patients and explored the therapeutic potential of topical lacritin for the treatment of keratoconjunctivitis sicca. METHODS:Tears from healthy controls ...

journal_title：Investigative ophthalmology & visual science

authors： Vijmasi T,Chen FY,Balasubbu S,Gallup M,McKown RL,Laurie GW,McNamara NA

更新日期：2014-07-17 00:00:00

abstract：:Healing of corneal alkali injuries remains a severe clinical challenge. The authors evaluated the effect of a new synthetic inhibitor of matrix metalloproteinases (GM6001 or N-[2(R)-2-(hydroxamido carbonylmethyl)-4-methylpentanoyl]-L-tryptophane methylamide) on preventing ulceration of rabbit corneas after alkali inju...

journal_title：Investigative ophthalmology & visual science

authors： Schultz GS,Strelow S,Stern GA,Chegini N,Grant MB,Galardy RE,Grobelny D,Rowsey JJ,Stonecipher K,Parmley V

更新日期：1992-11-01 00:00:00

abstract：PURPOSE:To evaluate the developmental expression of Thy-1 in the retina. Thy-1, the most abundant mammalian neuronal surface glycoprotein, is likely to play a significant role in retinal development. In the mammalian retina, it is found predominantly, if not exclusively, on retinal ganglion cells. METHODS:Rat retinae ...

journal_title：Investigative ophthalmology & visual science

authors： Liu CJ,Chaturvedi N,Barnstable CJ,Dreyer EB

更新日期：1996-06-01 00:00:00

abstract：PURPOSE:The aim of the present study was to use an in vivo model of retinal excitotoxicity to investigate the neuroprotective effect of somatostatin (SRIF)-ergic agents. METHODS:Adult Sprague-Dawley rats (weight range, 250-300 g) intravitreally received (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hyd...

journal_title：Investigative ophthalmology & visual science

authors： Kiagiadaki F,Thermos K

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:Leber congenital amaurosis (LCA) is a group of childhood-onset retinal diseases characterized by severe visual impairment or blindness. One form is caused by mutations in the RPE65 gene, which encodes the retinal pigment epithelium (RPE) isomerase. In this study, the retinal structure and expression of molecula...

journal_title：Investigative ophthalmology & visual science

authors： Hernández M,Pearce-Kelling SE,Rodriguez FD,Aguirre GD,Vecino E

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To decide whether the transitory coexpression of cone visual pigments described in the developing rat and gerbil retina is a universal feature of dichromatic mammalian species. METHODS:The rabbit, a species widely used in eye research, was selected for the study and a search made for the presence of cones that...

journal_title：Investigative ophthalmology & visual science

authors： Szepessy Z,Lukáts A,Fekete T,Barsi A,Röhlich P,Szél A

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:To determine the role of polyphosphate kinase 1 (PPK1) in the ocular virulence of Pseudomonas aeruginosa. METHODS:Using a mouse model of infection, P. aeruginosa strains PAO1, PAOM5 (an isogenic mutant of PAO1 deficient in PPK1), and PAOM5+PPK1 (the mutant complemented with PPK1 on plasmid pHEPAK11) were compa...

journal_title：Investigative ophthalmology & visual science

authors： Parks QM,Hobden JA

更新日期：2005-01-01 00:00:00

abstract：Purpose:The present study investigated retinal glia and choroidal vessels in flatmounts and sections from individuals with clinically diagnosed Stargardt disease (STGD). Methods:Eyes from three donors clinically diagnosed with STGD were obtained through the Foundation Fighting Blindness (FFB). Genetic testing was perf...

journal_title：Investigative ophthalmology & visual science

authors： Edwards MM,Bonilha VL,Bhutto IA,Bell BA,McLeod DS,Hollyfield JG,Lutty GA

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:To determine the effect of taxol and etoposide, hydrophobic drugs with antifibrosis activity, on the outcome of filtration surgery in glaucomatous monkeys. METHODS:Elevated intraocular pressure was produced bilaterally in eight cynomolgus monkeys by laser treatment of the trabecular meshwork. Four animals subc...

journal_title：Investigative ophthalmology & visual science

authors： Jampel HD,Thibault D,Leong KW,Uppal P,Quigley HA

更新日期：1993-10-01 00:00:00

abstract：PURPOSE:Mutations in the mitochondrial dynamin-related GTPase OPA1 cause autosomal dominant optic atrophy (ADOA), but the pathophysiology of this disease is unknown. As a first step in functional studies, this study was conducted to evaluate the expression of Opa1 in whole retina and in isolated retinal ganglion cells ...

journal_title：Investigative ophthalmology & visual science

authors： Kamei S,Chen-Kuo-Chang M,Cazevieille C,Lenaers G,Olichon A,Bélenguer P,Roussignol G,Renard N,Eybalin M,Michelin A,Delettre C,Brabet P,Hamel CP

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:The relative effect of simultaneously administered oxygen and carbon dioxide on the retinal and cerebral vessels is still controversial. The purpose of this study was to quantify and compare the superior-temporal retinal arteriole (RA) and middle cerebral artery (MCA) responses to hypercarbic and combined hyper...

journal_title：Investigative ophthalmology & visual science

authors： Kisilevsky M,Mardimae A,Slessarev M,Han J,Fisher J,Hudson C

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:To describe the psychometric characteristics of the Impact of Vision Impairment (IVI) Profile and evaluate its validity and reliability over time and between different forms of administration. METHODS:The IVI is a 32-item questionnaire developed to measure the impact of vision impairment on restriction of part...

journal_title：Investigative ophthalmology & visual science

authors： Weih LM,Hassell JB,Keeffe J

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:We sought to determine whether conjunctival ultraviolet autofluorescence (UVAF), a biomarker of outdoor light exposure, is associated with myopia. METHODS:We performed a cross-sectional study on Norfolk Island and recruited individuals aged ≥ 15 years. Participants completed a sun-exposure questionnaire and un...

journal_title：Investigative ophthalmology & visual science

authors： Sherwin JC,Hewitt AW,Coroneo MT,Kearns LS,Griffiths LR,Mackey DA

更新日期：2012-07-01 00:00:00

abstract：PURPOSE:Linkage intervals for erosive vitreoretinopathy (ERVR) and Wagner disease previously were found to overlap at 5q14.3. In a Japanese family with Wagner disease, a CSPG2/Versican splice site mutation (c.4004-2A-->G) was recently reported that resulted in a 39-nucleotide exon 8 in-frame deletion. We investigated w...

journal_title：Investigative ophthalmology & visual science

authors： Mukhopadhyay A,Nikopoulos K,Maugeri A,de Brouwer AP,van Nouhuys CE,Boon CJ,Perveen R,Zegers HA,Wittebol-Post D,van den Biesen PR,van der Velde-Visser SD,Brunner HG,Black GC,Hoyng CB,Cremers FP

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:Currently, the test for useful field of view (UFOV) typically relies on subjective feedback for detecting peripheral targets while attending to a central target. Steady-state visual evoked potential (SSVEP) recorded from the occipital region of the brain has been frequently used as an objective alternative to r...

journal_title：Investigative ophthalmology & visual science

authors： Lin ST,Tey LK

更新日期：2016-06-01 00:00:00

abstract：:Assays of cortisol-metabolizing enzymes in homogenates of human trabecular meshwork cells under optimal conditions revealed two defects in primary open-angle glaucoma (POAG): one is a marked increase in delta 4-reductase and the other is a decrease in 3-oxidoreductase. Experiments indicated that the differences in enz...

journal_title：Investigative ophthalmology & visual science

authors： Weinstein BI,Munnangi P,Gordon GG,Southren AL

更新日期：1985-06-01 00:00:00

abstract：PURPOSE:We explored the role of myeloid-related protein 8 and 14 (MRP8/14) in Pseudomonas aeruginosa (PA) keratitis. METHODS:MRP8/14 mRNA levels in human corneal scrapes and mouse corneas infected by PA were tested using real-time PCR. MRP8/14 protein expression in C57BL/6 (B6) corneas was confirmed using Western blot...

journal_title：Investigative ophthalmology & visual science

authors： Deng Q,Sun M,Yang K,Zhu M,Chen K,Yuan J,Wu M,Huang X

更新日期：2013-02-01 00:00:00

abstract：Purpose:To test the amblyopic suppression at mid to low spatial frequencies when compensating for signal attenuation. Methods:Eight amblyopes with (n = 5) or without (n = 3) strabismus and 10 normal controls with normal or corrected to normal visual acuity (≥20/20) and normal stereopsis (≤40 arcseconds) participated. ...

journal_title：Investigative ophthalmology & visual science

authors： Zhou J,Reynaud A,Yao Z,Liu R,Feng L,Zhou Y,Hess RF

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:Müller cells support retinal neurons with essential functions. Here, we aim to examine the impact of starvation and oxidative stress on glutamate uptake and mitochondrial function in Müller cells. METHODS:Cultured human retinal Müller cells (MIO-M1) were exposed to H2O2 and additional starvation for 24 hours. ...

journal_title：Investigative ophthalmology & visual science

authors： Toft-Kehler AK,Gurubaran IS,Desler C,Rasmussen LJ,Skytt DM,Kolko M

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:Human blood contains low levels of protoporphyrin IX (PP IX), a photoactive compound that produces reactive oxygen species when exposed to light. It has been proposed that photoactivation of PP IX and subsequent generation of potentially tissue-damaging reactive oxygen may be a mechanism of retinal injury in re...

journal_title：Investigative ophthalmology & visual science

authors： Bynoe LA,Gottsch JD,Sadda SR,Panton RW,Haller EM,Gleason CA

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical coherence tomography (SD-OCT). METHODS:Images were captured on B...

journal_title：Investigative ophthalmology & visual science

authors： Lin P,Mettu PS,Pomerleau DL,Chiu SJ,Maldonado R,Stinnett S,Toth CA,Farsiu S,Mruthyunjaya P

更新日期：2012-04-06 00:00:00

abstract：PURPOSE:We compared the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect glaucoma. METHODS:We enrolled 87 normal eyes and 145 glaucomatous eyes (75 early glaucomatous eyes (EGs), ...

journal_title：Investigative ophthalmology & visual science

authors： Akashi A,Kanamori A,Nakamura M,Fujihara M,Yamada Y,Negi A

更新日期：2013-07-10 00:00:00

abstract：PURPOSE:The primary purpose of this study was to characterize photoreceptor apoptosis in the rd mouse. Given that apoptosis is the final common pathway in many cases of retinal degeneration, the ability to retard or even arrest this process may ameliorate retinal disorders such as retinitis pigmentosa (RP). The absence...

journal_title：Investigative ophthalmology & visual science

authors： Doonan F,Donovan M,Cotter TG

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine whether human corneal epithelial cells and keratocytes synthesize both the soluble and membrane forms of the type II IL-1 receptor (IL-1RII). METHODS:Primary cell cultures of human corneal epithelial cells and keratocytes were established from human corneas. RT-PCR wa...

journal_title：Investigative ophthalmology & visual science

authors： Cubitt CL,Lausch RN,Oakes JE

更新日期：2001-03-01 00:00:00

abstract：Purpose:To determine if variation in anterior lamina cribrosa surface depth (ALCSD) differs between glaucoma patients of African (AD) and European descent (ED). Methods:A total of 178 eyes from 123 glaucoma patients in the African Descent and Glaucoma Evaluation Study (ADAGES) and Diagnostic Innovations in Glaucoma St...

journal_title：Investigative ophthalmology & visual science

authors： Girkin CA,Fazio MA,Bowd C,Medeiros FA,Weinreb RN,Liebmann JM,Proudfoot J,Zangwill LM,Belghith A

更新日期：2019-10-01 00:00:00