Abstract:
Purpose:To test the amblyopic suppression at mid to low spatial frequencies when compensating for signal attenuation. Methods:Eight amblyopes with (n = 5) or without (n = 3) strabismus and 10 normal controls with normal or corrected to normal visual acuity (≥20/20) and normal stereopsis (≤40 arcseconds) participated. Using a quick contrast sensitivity function approach, we measured individuals' monocular contrast sensitivity functions when the untested eye saw a mean luminance background and when the untested eye saw a bandpass filtered noise whose peak spatial frequency was matched to that of the test grating. Interocular suppression was quantified by the difference in thresholds occurring between these two conditions for each eye. The contrast of the noise mask was set at five times the threshold of the untested eye. Results:Selected spatial frequencies (0.67-1.31 cyc/deg) were identified where neither ceiling (five times the mask contrast threshold in the amblyopic eye <100%) nor floor (threshold of the amblyopic eye when there was a noise mask in the fellow eye <100%) effects occurred for all observers. Within this frequency range, we found no interocular suppressive imbalance in normal observers. However, in amblyopes, the amblyopic eye exerted significantly less suppression than the fellow eye, while the suppression from the fellow eye to the amblyopic eye was similar to that found in the normal controls. Conclusions:We conclude that the reduced dichoptic masking by the amblyopic eye, within the context of normally balanced interocular inhibition, produces the amblyopic suppression at mid to low frequencies.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Zhou J,Reynaud A,Yao Z,Liu R,Feng L,Zhou Y,Hess RFdoi
10.1167/iovs.18-24206subject
Has Abstractpub_date
2018-08-01 00:00:00pages
4190-4197issue
10eissn
0146-0404issn
1552-5783pii
2697756journal_volume
59pub_type
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