Spatial contrast transfer functions of the pattern-evoked electroretinogram.

abstract：PURPOSE:The outcome of glaucoma filtration surgery is affected by subconjunctival wound healing. The effects of the antiglaucoma drug latanoprost on the contractility of human Tenon fibroblasts (HTFs) cultured in a three-dimensional collagen gel were investigated. METHODS:HTFs were cultured in a type I collagen gel wi...

journal_title：Investigative ophthalmology & visual science

authors： Liu Y,Ko JA,Yanai R,Kimura K,Chikama T,Sagara T,Nishida T

更新日期：2008-04-01 00:00:00

abstract：Purpose:IFT81, a core component of the IFT-B complex, involved in the bidirectional transport of ciliary proteins, has been recently implicated in syndromic ciliopathies. However, none of the IFT-B core complex proteins have been associated with nonsyndromic retinal dystrophies. Given the importance of ciliary transpor...

journal_title：Investigative ophthalmology & visual science

authors： Dharmat R,Liu W,Ge Z,Sun Z,Yang L,Li Y,Wang K,Thomas K,Sui R,Chen R

更新日期：2017-05-01 00:00:00

abstract：Purpose:Conventional full-field flash electroretinography (ERG) yields a single response waveform that can be useful in the early detection and diagnosis of many diseases affecting the retina. It is an objective measurement that probes the entire retina. However, localized areas of dysfunction have relatively small inf...

journal_title：Investigative ophthalmology & visual science

authors： Derafshi Z,Kunzer BE,Mugler EM,Rokhmanova N,Park DW,Tajalli H,Shetty K,Ma Z,Williams JC,Hetling JR

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:Parstatin is a 41-mer peptide formed by proteolytic cleavage on activation of the PAR1 receptor. The authors recently showed that parstatin is a potent inhibitor of angiogenesis. The purpose of the present study was to evaluate the therapeutic effect of parstatin on ocular neovascularization. METHODS:Choroidal...

journal_title：Investigative ophthalmology & visual science

authors： Huang H,Vasilakis P,Zhong X,Shen JK,Geronatsiou K,Papadaki H,Maragoudakis ME,Gartaganis SP,Vinores SA,Tsopanoglou NE

更新日期：2010-11-01 00:00:00

abstract：:The metabolism of the polyunsaturated fatty acid, arachidonic acid (20:4, n-6) in rabbit cornea with varying severities of herpes simplex viral infection was investigated. The results indicate an active synthesis of the lipoxygenase and cyclooxygenase reaction products of arachidonic acid in central cornea and corneal...

journal_title：Investigative ophthalmology & visual science

authors： Birkle DL,Sanitato JJ,Kaufman HE,Bazan NG

更新日期：1986-10-01 00:00:00

abstract：PURPOSE:To assess presbyopic spectacle coverage, willingness to pay, and the impact of correcting uncorrected presbyopia in individuals 40 years of age and older in Zanzibar and whether assessment of presbyopia can be incorporated into Rapid Assessment of Blindness (RAAB) surveys. METHODS:A cross-sectional, population...

journal_title：Investigative ophthalmology & visual science

authors： Laviers HR,Omar F,Jecha H,Kassim G,Gilbert C

更新日期：2010-02-01 00:00:00

abstract：PURPOSE:FOXC1 mutations result in Axenfeld-Rieger syndrome, a disorder characterized by a broad spectrum of malformations of the anterior segment of the eye and an elevated risk for glaucoma. A novel FOXC1 W152G mutation was identified in a patient with aniridia. Molecular analysis was conducted to determine the functi...

journal_title：Investigative ophthalmology & visual science

authors： Ito YA,Footz TK,Berry FB,Mirzayans F,Yu M,Khan AO,Walter MA

更新日期：2009-08-01 00:00:00

abstract：:In the retina from an eye enucleated for choroidal melanoma apposed rod outer segments were seen by transmission electron microscopy to be fusing together in groups by the confluence of their plasma membranes and the formation of cytoplasmic bridges between adjacent outer segments. These fusions were seen in areas dis...

journal_title：Investigative ophthalmology & visual science

authors： Borwein B,Medeiros JA,McGowan JW

更新日期：1977-07-01 00:00:00

abstract：PURPOSE:Oxidative stress and metabolic dysregulation of the RPE have been implicated in AMD; however, the molecular regulation of RPE metabolism remains unclear. The transcriptional coactivator, peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) is a powerful mediator of mitochondrial function. Th...

journal_title：Investigative ophthalmology & visual science

authors： Iacovelli J,Rowe GC,Khadka A,Diaz-Aguilar D,Spencer C,Arany Z,Saint-Geniez M

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To gain better understanding of the relationship between abnormalities detected by the multifocal VEP (mfVEP) compared with those detected by static achromatic, automated perimetry in patients with glaucoma. METHODS:Fifty patients were studied who had open-angle glaucoma that met the following criteria: (1) a ...

journal_title：Investigative ophthalmology & visual science

authors： Hood DC,Thienprasiddhi P,Greenstein VC,Winn BJ,Ohri N,Liebmann JM,Ritch R

更新日期：2004-02-01 00:00:00

abstract：Purpose:Endophthalmitis models have reported the virulent role of Panton-Valentine leucocidin (PVL) secreted by Staphylococcus aureus on the retina. PVL targets retinal ganglion cells (RGCs), expressing PVL membrane receptor C5aR. Interactions between PVL and retinal cells lead to glial activation, retinal inflammation...

journal_title：Investigative ophthalmology & visual science

authors： Wurtz M,Ruhland E,Liu X,Namer IJ,Mazzoleni V,Lipsker D,Keller D,Prévost G,Gaucher D

更新日期：2021-01-04 00:00:00

abstract：PURPOSE:To compare the developmental sequences of two basic measures of pattern vision, Vernier acuity and grating acuity, using steady state visual-evoked potentials (VEPs) and an analysis designed to isolate pattern-specific responses from those due to motion in the Vernier stimulus. METHODS:The authors recorded VEP...

journal_title：Investigative ophthalmology & visual science

authors： Skoczenski AM,Norcia AM

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:To compare the Swedish interactive thresholding algorithm (SITA) with the full-threshold (FT) strategy for short-wavelength automated perimetry (SWAP). METHODS:One eye of 286 patients with glaucomatous optic neuropathy (GON) and 289 age-matched participants without GON from the Diagnostic Innovations in Glauco...

journal_title：Investigative ophthalmology & visual science

authors： Ng M,Racette L,Pascual JP,Liebmann JM,Girkin CA,Lovell SL,Zangwill LM,Weinreb RN,Sample PA

更新日期：2009-04-01 00:00:00

abstract：Purpose:To investigate brain white matter pathways using magnetic resonance diffusion tensor imaging (DTI) and correlate the findings with developmental outcomes at 18 months of corrected age in preterm infants with and without retinopathy of prematurity (ROP). Methods:In this prospective cohort study, probabilistic m...

journal_title：Investigative ophthalmology & visual science

authors： Ahn SJ,Lee JY,Lee JY,Lee YJ,Lee JM,Lee BR,Kim J,Lee HJ

更新日期：2021-02-01 00:00:00

abstract：:Adaptation to steady background lights has been investigated in pcd/pcd mice, a mutant strain with retinal degeneration. The hyperbolic stimulus/response functions of the scotopic b-wave of the electroretinogram show progressive changes. For the dark-adapted eyes the decrease in log sensitivity between ages 1 and 12 m...

journal_title：Investigative ophthalmology & visual science

authors： Fulton AB,Manning KA,Baker BN,Schukar SE,Bailey CJ

更新日期：1982-03-01 00:00:00

abstract：Purpose:Most of the inflammation in murine herpes simplex virus type 1 (HSV-1)-induced stromal keratitis (HSK) is due to exposure stress resulting from loss of corneal nerves and blink reflex. Corneal grafts often fail when placed on corneal beds with a history of HSK. We asked if corneal exposure contributes to the se...

journal_title：Investigative ophthalmology & visual science

authors： Rowe AM,Yun H,Hendricks RL

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:This study investigated the relationship between amplitude and peak velocity of saccadic eye movements (the so-called main sequence) and the intra-individual variability of the main sequence. METHODS:Saccadic amplitudes and peak velocities were measured twice in 58 healthy subjects with an infrared reflection ...

journal_title：Investigative ophthalmology & visual science

authors： Bollen E,Bax J,van Dijk JG,Koning M,Bos JE,Kramer CG,van der Velde EA

更新日期：1993-12-01 00:00:00

abstract：PURPOSE:The objective of this study was to investigate whether leakage of aquaporin 5 (AQP5) in tear is associated with damage of lacrimal glands (LGs) in dacryoadenitis models. METHODS:Female MRL/lpr (24-week-old), male NOD/Shi Jci (5-, 8-, and 10-week-old), female NFS/s-TX (10-week-old), and lipopolysaccharide (LPS)...

journal_title：Investigative ophthalmology & visual science

authors： Hirai S,Ishida N,Watanabe K,Mita S

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:In the rabbit iris sphincter muscle, sodium nitroprusside (SNP), a nitric oxide (NO) donor, inhibits cholinergic contraction but does not affect tachykinergic contraction in vitro. The objectives of the current study were to clarify the mechanism for the different responsiveness to NO in cholinergic and tachyki...

journal_title：Investigative ophthalmology & visual science

authors： Chuman H,Chuman T,Nao-i N,Sawada A,Yamamoto R,Kobayashi H,Wada A

更新日期：1997-08-01 00:00:00

abstract：PURPOSE:To assess the diagnostic validity of a fully automated image analysis algorithm of in vivo confocal microscopy images in quantifying corneal subbasal nerves to diagnose diabetic neuropathy. METHODS:One hundred eighty-six patients with type 1 and type 2 diabetes mellitus (T1/T2DM) and 55 age-matched controls un...

journal_title：Investigative ophthalmology & visual science

authors： Petropoulos IN,Alam U,Fadavi H,Marshall A,Asghar O,Dabbah MA,Chen X,Graham J,Ponirakis G,Boulton AJ,Tavakoli M,Malik RA

更新日期：2014-04-03 00:00:00

abstract：PURPOSE:Using transient ischemia followed by reperfusion (IR) to model ischemic retinal disease, this study compares the effects of ischemic preconditioning (IPC) and therapies targeting vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF)-α on retinal apoptosis, vascular permeability, and mRNA exp...

journal_title：Investigative ophthalmology & visual science

authors： Abcouwer SF,Lin CM,Wolpert EB,Shanmugam S,Schaefer EW,Freeman WM,Barber AJ,Antonetti DA

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:To determine if there is endothelin-mediated regulation of cell signaling and proliferation in rabbit corneal epithelium. METHODS:Endothelin-1 (ET-1) gene and protein expression by the rabbit corneal epithelial (RCE) cells were analyzed by polymerase chain reaction, sequence analysis, and enzyme immunoassay. D...

journal_title：Investigative ophthalmology & visual science

authors： Takagi H,Reinach PS,Tachado SD,Yoshimura N

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To isolate tissue-specific gene products that contribute to corneal integrity. METHODS:A cDNA library was constructed and differentially hybridized. Cornea-specific clones were purified and further characterized. RESULTS:In this study cornea-specific gene products were isolated by differential cDNA hybridizat...

journal_title：Investigative ophthalmology & visual science

authors： Peek R,van Gelderen BE,Bruinenberg M,Kijlstra A

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:We explored the role of myeloid-related protein 8 and 14 (MRP8/14) in Pseudomonas aeruginosa (PA) keratitis. METHODS:MRP8/14 mRNA levels in human corneal scrapes and mouse corneas infected by PA were tested using real-time PCR. MRP8/14 protein expression in C57BL/6 (B6) corneas was confirmed using Western blot...

journal_title：Investigative ophthalmology & visual science

authors： Deng Q,Sun M,Yang K,Zhu M,Chen K,Yuan J,Wu M,Huang X

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Perinatal inflammatory stress in preterm babies is associated with increased rates of severe retinopathy of prematurity (ROP) and adverse neurological dysfunction. In this study, we set out to determine the consequences of severe systemic inflammatory stress on developmental retinal vascularization and evaluate...

journal_title：Investigative ophthalmology & visual science

authors： Tremblay S,Miloudi K,Chaychi S,Favret S,Binet F,Polosa A,Lachapelle P,Chemtob S,Sapieha P

更新日期：2013-12-17 00:00:00

abstract：:Greene's melanomas, implanted in the anterior chamber of 31 eyes of 19 Dutch rabbits, were treated with hyperthermia induced by high intensity focused ultrasound (HIFU). The percentage necrosis 24 hr after treatment (N) as a function of steady-state intratumor temperature (T) could be described with N(T) = -181.5 + 4....

journal_title：Investigative ophthalmology & visual science

authors： Braakman R,van der Valk P,van Delft JL,de Wolff-Rouendaal D,Oosterhuis JA

更新日期：1989-05-01 00:00:00

abstract：Purpose:The purpose of this study was to investigate the disease-causing mutations for retinitis pigmentosa (RP) patients and function of mutations. Methods:We recruited RP families and sporadic RP patients, and performed whole-exome sequencing (WES) to screen for sequence variations. Subsequently, we investigated the...

journal_title：Investigative ophthalmology & visual science

authors： Xiao X,Cao Y,Zhang Z,Xu Y,Zheng Y,Chen LJ,Pang CP,Chen H

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible blindness. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Kaurani L,Vishal M,Kumar D,Sharma A,Mehani B,Sharma C,Chakraborty S,Jha P,Ray J,Sen A,Dash D,Ray K,Mukhopadhyay A

更新日期：2014-04-24 00:00:00

abstract：PURPOSE:To determine whether a novel optical treatment using contact lenses to reduce relative peripheral hyperopia can slow the rate of progress of myopia. METHODS:Chinese children, aged 7 to 14 years, with baseline myopia from sphere -0.75 to -3.50 D and cylinder ≤1.00 D, were fitted with novel contact lenses (n = 4...

journal_title：Investigative ophthalmology & visual science

authors： Sankaridurg P,Holden B,Smith E 3rd,Naduvilath T,Chen X,de la Jara PL,Martinez A,Kwan J,Ho A,Frick K,Ge J

更新日期：2011-12-09 00:00:00

abstract：PURPOSE:Müller glia play crucial roles in retinal homeostasis and function. Genetic modification of Müller cells by viral gene delivery would be valuable for studies of their normal physiology and roles in retinal disease states. However, stable and efficient transgene expression in Müller cells after delivery of gene ...

journal_title：Investigative ophthalmology & visual science

authors： Greenberg KP,Geller SF,Schaffer DV,Flannery JG

更新日期：2007-04-01 00:00:00