Dark-adapted sensitivity, rhodopsin content, and background adaptation in pcd/pcd mice.

abstract：PURPOSE:Several nonsyndromic high-grade myopia loci have been mapped primarily by microsatellite markers and a limited number of pedigrees. In this study, whole-genome linkage scans were performed for high-grade myopia, using single nucleotide polymorphisms (SNPs) in 254 families from five independent sites. METHODS:G...

journal_title：Investigative ophthalmology & visual science

authors： Li YJ,Guggenheim JA,Bulusu A,Metlapally R,Abbott D,Malecaze F,Calvas P,Rosenberg T,Paget S,Creer RC,Kirov G,Owen MJ,Zhao B,White T,Mackey DA,Young TL

更新日期：2009-07-01 00:00:00

abstract：:Cone electroretinograms were elicited with a full-field red flash after-45 min of dark adaptation from 16 patients with retinitis pigmentosa and from 17 normal subjects. The average latency and implicit time of the cone a-waves recorded from the patients were each significantly delayed (p less than 0.005) compared wit...

journal_title：Investigative ophthalmology & visual science

authors： Sandberg MA,Sullivan PL,Berson EL

更新日期：1981-11-01 00:00:00

abstract：Purposes:Trabeculectomy is a surgical procedure for lowering intraocular pressure in glaucoma patients, in which excessive scarring leading to failure of the filtering bleb adversely affects the surgical outcome. Heightened Tenon's capsule fibroblast (TCF) proliferation and extracellular matrix (ECM) deposition are imp...

journal_title：Investigative ophthalmology & visual science

authors： Lei D,Dong C,Wu WK,Dong A,Li T,Chan MT,Zhou X,Yuan H

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To demonstrate the application of multiphoton fluorescence (MF) and second harmonic generation (SHG) microscopy for ex vivo characterization of the structural alterations of human corneas due to keratoconus. METHODS:Buttons of keratoconic corneas derived from penetrating keratoplasty were sent for structural a...

journal_title：Investigative ophthalmology & visual science

authors： Tan HY,Sun Y,Lo W,Lin SJ,Hsiao CH,Chen YF,Huang SC,Lin WC,Jee SH,Yu HS,Dong CY

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:To apply tissue-engineered cell sheet transplantation after excimer laser keratectomy as a novel approach for the reduction of postoperative corneal haze. METHODS:Limbal biopsy specimens were obtained, and epithelial cells were cultured on temperature-responsive culture inserts without the use of feeder cells....

journal_title：Investigative ophthalmology & visual science

authors： Hayashida Y,Nishida K,Yamato M,Yang J,Sugiyama H,Watanabe K,Hori Y,Maeda N,Kikuchi A,Okano T,Tano Y

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To investigate the foveal changes after repair of macula-off rhegmatogenous retinal detachment (RRD). METHODS:Prospective comparative case series. Twenty-four eyes of 24 patients with macula-off/fovea-on detachment (n = 9) and fovea-off detachment (n = 15) were studied. Serial optical coherence tomography (OCT...

journal_title：Investigative ophthalmology & visual science

authors： dell'Omo R,Viggiano D,Giorgio D,Filippelli M,Di Iorio R,Calo' R,Cardone M,Rinaldi M,dell'Omo E,Costagliola C

更新日期：2015-01-22 00:00:00

abstract：PURPOSE:To develop an eye-motion-tracking optical coherence tomographic (OCT) method and assess its effect on image registration and nerve fiber layer (NFL) thickness measurement reproducibility. METHODS:A system capable of tracking common fundus features based on reflectance changes was integrated into a commercial O...

journal_title：Investigative ophthalmology & visual science

authors： Ishikawa H,Gabriele ML,Wollstein G,Ferguson RD,Hammer DX,Paunescu LA,Beaton SA,Schuman JS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:To determine the mechanism by which basic fibroblast growth factor (bFGF) exerts its neuroprotective effects on degenerating or injured photoreceptors. METHODS:Confocal immunofluorescence microscopy was used to identify sites of bFGF and FGF receptor 1 (FGFR1) expression after focal injury or experimental reti...

journal_title：Investigative ophthalmology & visual science

authors： Ozaki S,Radeke MJ,Anderson DH

更新日期：2000-02-01 00:00:00

abstract：PURPOSE:To determine whether intraocular pressure (IOP) elevation alters OPA1 expression and triggers OPA1 release, as well as whether the uncompetitive N-methyl-d-aspartate (NMDA) glutamate receptor antagonist memantine blocks OPA1 release and subsequent apoptotic cell death in glaucomatous DBA/2J mouse retina. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Ju WK,Kim KY,Angert M,Duong-Polk KX,Lindsey JD,Ellisman MH,Weinreb RN

更新日期：2009-02-01 00:00:00

abstract：:Membrane-bound proteins in plasma membrane enriched fractions from cultured rat RPE were analyzed by two-dimensional gel electrophoresis. Membrane proteins were characterized on three increasingly specific levels. Total protein was visualized by silver staining. A maximum of 102 separate proteins were counted in silve...

journal_title：Investigative ophthalmology & visual science

authors： Clark VM,Hall MO

更新日期：1986-02-01 00:00:00

abstract：PURPOSE:The hypothesis in the study was that androgens control meibomian gland function, regulate the quality and/or quantity of lipids produced by this tissue, and promote the formation of the tear film's lipid layer. To test this hypothesis, a study was conducted to determine whether androgen receptor protein exists ...

journal_title：Investigative ophthalmology & visual science

authors： Sullivan DA,Sullivan BD,Ullman MD,Rocha EM,Krenzer KL,Cermak JM,Toda I,Doane MG,Evans JE,Wickham LA

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:Age-related cataract (ARC) is one of the most common causes of severe visual impairment among the elderly worldwide with four subtypes, such as cortical, nuclear, subcapsular, and mixed types. DNA damage and malfunction of DNA repair are believed to contribute to the pathogenesis of ARC. This study examined the...

journal_title：Investigative ophthalmology & visual science

authors： Su S,Yao Y,Zhu R,Liang C,Jiang S,Hu N,Zhou J,Yang M,Xing Q,Guan H

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Oxidative stress in the human lens leads to a wide range of damage including DNA strand breaks, which are likely to contribute to cataract formation. The protein Ku80 is a fundamental component of the nonhomologous end-joining pathway that repairs DNA double strand breaks. This study investigates the putative i...

journal_title：Investigative ophthalmology & visual science

authors： Smith AJ,Ball SS,Manzar K,Bowater RP,Wormstone IM

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Dry eye disease (DED) is associated with ocular surface inflammation that is thought to be mediated primarily by CD4 T cells. The purpose of this study was to investigate whether this T cell-mediated immune response is generated in the lymphoid compartment and to characterize the functional phenotype of the T c...

journal_title：Investigative ophthalmology & visual science

authors： El Annan J,Chauhan SK,Ecoiffier T,Zhang Q,Saban DR,Dana R

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To investigate the long-term effects of transient ligature of the ophthalmic vessels (LOV) on the inner and outer retina as well as on retinotectal projection, and whether brimonidine (BMD) has protective effects. METHODS:In adult rats, the left eye was subjected to 90 minutes of LOV. One hour before ischemia,...

journal_title：Investigative ophthalmology & visual science

authors： Mayor-Torroglosa S,De la Villa P,Rodríguez ME,López-Herrera MP,Avilés-Trigueros M,García-Avilés A,de Imperial JM,Villegas-Pérez MP,Vidal-Sanz M

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:Ischemic preconditioning (IPC) protects the rat retina against the injury that ordinarily follows prolonged ischemia. It has been shown that release of adenosine, de novo protein synthesis, and mediators, such as protein kinase C and K(ATP) channels, is required for IPC protection. However, the molecular mechan...

journal_title：Investigative ophthalmology & visual science

authors： Zhang C,Rosenbaum DM,Shaikh AR,Li Q,Rosenbaum PS,Pelham DJ,Roth S

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:Compensatory eye movements (CEM) maintain a stable image on the retina by minimizing retinal slip. The optokinetic reflex (OKR) and vestibulo-ocular reflex (VOR) compensate for low and high velocity stimuli, respectively. The OKR system is known to be highly nonlinear. The VOR is generally modeled as a linear s...

journal_title：Investigative ophthalmology & visual science

authors： Sibindi TM,Holland PJ,van der Geest JN,Donchin O,Frens MA

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Oxygen-induced retinopathy (OIR) is a model for human retinopathy of prematurity (ROP). In OIR mice, this study determined whether blockade of β-adrenergic receptors (β-ARs) with propranolol influences retinal levels of proangiogenic factors, retinal vascularization, and blood-retinal barrier (BRB) breakdown. ...

journal_title：Investigative ophthalmology & visual science

authors： Ristori C,Filippi L,Dal Monte M,Martini D,Cammalleri M,Fortunato P,la Marca G,Fiorini P,Bagnoli P

更新日期：2011-01-05 00:00:00

abstract：:Analysis of cell populations in the cornea may be performed rapidly and accurately employing the technique of enzymatic disaggregation. To illustrate this method normal rat corneas and corneas infected 24 and 48 hours previously with Staphylococcus aureus were disaggregated in a solution containing pancreatin and coll...

journal_title：Investigative ophthalmology & visual science

authors： Badenoch PR,Finlay-Jones JJ,Coster DJ

更新日期：1983-02-01 00:00:00

abstract：Purpose:Mutations in the retinitis pigmentosa-1-like-1 (RP1L1) gene are the major cause of autosomal dominant occult macular dystrophy (OCMD), while recessive mutations have been linked to autosomal recessive retinitis pigmentosa (arRP). We present the clinical phenotype of a large German OCMD cohort, as well as four R...

journal_title：Investigative ophthalmology & visual science

authors： Zobor D,Zobor G,Hipp S,Baumann B,Weisschuh N,Biskup S,Sliesoraityte I,Zrenner E,Kohl S

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:To assess the neuroprotective effects of different glutamate modulation strategies, with a nonselective (MK801) and a selective (ifenprodil) NMDA receptor antagonist and a metabotropic glutamate receptor agonist (mGluR Group II, LY354740), in glaucoma-related in vivo rat models of retinal ganglion cell (RGC) ap...

journal_title：Investigative ophthalmology & visual science

authors： Guo L,Salt TE,Maass A,Luong V,Moss SE,Fitzke FW,Cordeiro MF

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:Recent studies suggest that photoreceptor cells regulate local inflammation in the retina in diabetes. The purpose of this study was to determine if photoreceptor cells themselves produce inflammatory proteins in diabetes and if soluble factors released by photoreceptors in elevated glucose induce inflammatory ...

journal_title：Investigative ophthalmology & visual science

authors： Tonade D,Liu H,Kern TS

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To determine whether human retinal pigment epithelial (hRPE) cells produce activin, a growth factor in the transforming growth factor beta family, and to characterize growth regulatory effects of activin on retinal pigment epithelium. METHODS:mRNA expression was examined using polymerase chain reaction with pr...

journal_title：Investigative ophthalmology & visual science

authors： Jaffe GJ,Harrison CE,Lui GM,Roberts WL,Goldsmith PC,Mesiano S,Jaffe RB

更新日期：1994-06-01 00:00:00

abstract：PURPOSE:High concentrations of unconjugated bilirubin are neurotoxic and cause brain damage in newborn infants. However, the exact level of bilirubin that may be neurotoxic in a given infant is unknown. The aim of this study was to use a quantitative measure of neural activity, the swept parameter visual evoked potenti...

journal_title：Investigative ophthalmology & visual science

authors： Hou C,Norcia AM,Madan A,Good WV

更新日期：2014-09-02 00:00:00

abstract：:Neodymium: yttrium aluminum garnet (Nd:YAG) laser transscleral cyclophotocoagulation has been shown to be an effective method of lowering intraocular pressure (IOP). Transmission and absorption features of diode laser radiation (810 nm) make these new laser sources suitable for production of transscleral thermal lesio...

journal_title：Investigative ophthalmology & visual science

authors： Brancato R,Leoni G,Trabucchi G,Cappellini A

更新日期：1991-04-01 00:00:00

abstract：PURPOSE:In the Gbeta5(-/-) mouse, the electroretinogram (ERG) b-wave is absent, and the R7 subfamily of regulators of G protein signaling (RGS), which includes RGS6, -7, -9, and -11, is downregulated. Mutant mouse strains deficient in RGS7 or -11 were characterized, and the SG711 strain which is deficient in both prote...

journal_title：Investigative ophthalmology & visual science

authors： Chen FS,Shim H,Morhardt D,Dallman R,Krahn E,McWhinney L,Rao A,Gold SJ,Chen CK

更新日期：2010-02-01 00:00:00

abstract：:Chinese hamster ovarian (CHO) cells in culture were used to evaluate the relative antiproliferative potential of drugs. These agents have been used to improve the clinical response after glaucoma filtering surgery. The following drugs were evaluated: 5-fluorouracil (5-FU) as the benchmark, 5-fluorouridine (FUR), 5-flu...

journal_title：Investigative ophthalmology & visual science

authors： Senderoff RI,Weber PA,Smith DR,Sokoloski TD

更新日期：1990-12-01 00:00:00

abstract：:In order to determine the source of the retinol which has been identified in the tear fluid, the lacrimal gland ducts of rabbits and rats were cannulated and the collected lacrimal gland fluid was analyzed by high performance liquid chromatography. Retinol was identified in the lacrimal gland fluid of rabbits and rats...

journal_title：Investigative ophthalmology & visual science

authors： Ubels JL,Foley KM,Rismondo V

更新日期：1986-08-01 00:00:00

abstract：PURPOSE:To examine the influence of reticular pseudodrusen (RPD) on retinal and visual function in intermediate AMD using multifocal electroretinography (mfERG) and microperimetry. METHODS:In a prospective cross-sectional study, microperimetry and mfERG testing, followed by color fundus photography, near-infrared refl...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Ayton LN,Makeyeva G,Guymer RH,Luu CD

更新日期：2015-03-03 00:00:00

abstract：PURPOSE:The objective of this study was to investigate whether leakage of aquaporin 5 (AQP5) in tear is associated with damage of lacrimal glands (LGs) in dacryoadenitis models. METHODS:Female MRL/lpr (24-week-old), male NOD/Shi Jci (5-, 8-, and 10-week-old), female NFS/s-TX (10-week-old), and lipopolysaccharide (LPS)...

journal_title：Investigative ophthalmology & visual science

authors： Hirai S,Ishida N,Watanabe K,Mita S

更新日期：2000-08-01 00:00:00