Histopathology of continuous wave neodymium: yttrium aluminum garnet and diode laser contact transscleral lesions in rabbit ciliary body. A comparative study.

abstract：PURPOSE:To examine the effects of methylcobalamin on glutamate-induced neurotoxicity in the cultured retinal neurons. METHODS:Primary cultures obtained from the fetal rat retina (gestation days 16 to 19) were used for the experiment. The neurotoxicity was assessed quantitatively using the trypan blue exclusion method....

journal_title：Investigative ophthalmology & visual science

authors： Kikuchi M,Kashii S,Honda Y,Tamura Y,Kaneda K,Akaike A

更新日期：1997-04-01 00:00:00

abstract：:Eight murine monoclonal antibodies to retinal S-antigen were found to recognize three antigenic clusters in competitive binding experiments. Variable patterns of immunohistochemical staining of retinal sections supported the competitive binding studies. Monoclonal antibodies to two of these three antigenic clusters on...

journal_title：Investigative ophthalmology & visual science

authors： Banga JP,LeRoy F,Suleyman S,Kasp E,Brown E,Dumonde D

更新日期：1988-01-01 00:00:00

abstract：:The laser Doppler technique was used to measure alterations in retinal blood flow in human subjects under dark-adapted conditions compared to light-adapted conditions. Retinal blood flow increased 40 to 70% after the transition from light to dark. We show quantitatively that the measured increases in retinal blood flo...

journal_title：Investigative ophthalmology & visual science

authors： Feke GT,Zuckerman R,Green GJ,Weiter JJ

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:To investigate concentrations of growth factors and inflammatory cytokines in eyes with central (CRVO) and branch (BRVO) retinal vein occlusion before and during therapy with bevacizumab and to identify associations with disease activity. METHODS:In a prospective clinical trial, 13 eyes of patients with CRVO (...

journal_title：Investigative ophthalmology & visual science

authors： Funk M,Kriechbaum K,Prager F,Benesch T,Georgopoulos M,Zlabinger GJ,Schmidt-Erfurth U

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Persistent hyperplastic primary vitreous (PHPV) is a developmental ocular malformation often associated with additional ocular abnormalities. This study involved a novel mouse model of PHPV, generated by a null mutation of the Ski proto-oncogene, that displays other anterior segment and retinal malformations of...

journal_title：Investigative ophthalmology & visual science

authors： McGannon P,Miyazaki Y,Gupta PC,Traboulsi EI,Colmenares C

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To evaluate the effect of chemical chaperones on the trafficking of secretion-incompetent primary open-angle glaucoma-associated mutant myocilin and the possibility to rescue cells coexpressing mutant and wild-type myocilin from endoplasmic reticulum (ER) stress and apoptosis. METHODS:CHO-K1, HEK293 and human ...

journal_title：Investigative ophthalmology & visual science

authors： Yam GH,Gaplovska-Kysela K,Zuber C,Roth J

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:Diabetes mellitus has been shown to be associated with and complicated by dry eye syndrome. We sought to examine and compare the tear film proteome of type 2 diabetic patients with or without dry eye syndrome and normal subjects using two-dimensional nano-liquid chromatography coupled with tandem mass spectrome...

journal_title：Investigative ophthalmology & visual science

authors： Li B,Sheng M,Xie L,Liu F,Yan G,Wang W,Lin A,Zhao F,Chen Y

更新日期：2014-01-09 00:00:00

abstract：PURPOSE:The authors recently reported that a severe inflammatory response resulting in substantial loss of acinar cells was induced by a single injection of interleukin-1alpha into the lacrimal gland and that this effect was reversible. The purpose of the present study was to determine the mechanisms involved in lacrim...

journal_title：Investigative ophthalmology & visual science

authors： Zoukhri D,Fix A,Alroy J,Kublin CL

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To assess photoreceptor morphology in patients with Stargardt's disease and fundus flavimaculatus using ultrahigh-resolution optical coherence tomography (UHR-OCT) and correlate it with visual acuity (VA). METHODS:This was a prospective observational case series. Fourteen patients with Stargardt's disease (nin...

journal_title：Investigative ophthalmology & visual science

authors： Ergun E,Hermann B,Wirtitsch M,Unterhuber A,Ko TH,Sattmann H,Scholda C,Fujimoto JG,Stur M,Drexler W

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Vitreoretinal disorders are frequently characterized by increased vitreous levels of cellular mediators, including cytokines, chemokines, and growth factors. The study was conducted to investigate whether multiplex bead analysis could identify disease-specific profiles of these mediators in a variety of vitreor...

journal_title：Investigative ophthalmology & visual science

authors： Banerjee S,Savant V,Scott RA,Curnow SJ,Wallace GR,Murray PI

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:The phenotype of specialized cells arises, in part, from their characteristic gene expression patterns. Retinal ganglion cells (RGCs) are of wide interest in neuroscience and die in glaucoma and other optic neuropathies. In this study the genes expressed by RGCs were profiled by expressed sequence tag (EST) ana...

journal_title：Investigative ophthalmology & visual science

authors： Farkas RH,Qian J,Goldberg JL,Quigley HA,Zack DJ

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:To determine whether polyamines are present in corneal cells, whether corneal cell polyamines can be depleted by blocking the first rate-limiting enzyme in the polyamine synthesis pathway, ornithine decarboxylase (ODC), and whether polyamines are required for proliferation in all three corneal cell types. METH...

journal_title：Investigative ophthalmology & visual science

authors： Du H,Viar MJ,Johnson LR,Watsky MA

更新日期：2003-06-01 00:00:00

abstract：:Cellular retinol binding protein (CRBP) was localized in the rat retina by means of light and electron microscopic immunocytochemistry. The peroxidase-antiperoxidase (PAP) method employed at the light microscopic level showed that CRBP is sharply localized to the retinal pigment epithelium (RPE). None was detectable i...

journal_title：Investigative ophthalmology & visual science

authors： Bok D,Ong DE,Chytil F

更新日期：1984-08-01 00:00:00

abstract：PURPOSE:The Rd4/+ mouse inherits an autosomal dominant retinal degeneration that cosegregates with a large inversion spanning nearly all of mouse chromosome 4 (Chr 4). This inversion is homozygous lethal. The hypothesis for the study was that disruption of a gene at one of the two breakpoints in the Rd4 chromosome is r...

journal_title：Investigative ophthalmology & visual science

authors： Kitamura E,Danciger M,Yamashita C,Rao NP,Nusinowitz S,Chang B,Farber DB

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:To investigate the effect of high glucose on the proliferation of human retinal endothelial cells (HRECs) and to elucidate the possible mechanisms of antiangiogenic activity of curcumin, a diferuloylmethane. METHODS:Human retinal endothelial cells were isolated from the retinal tissue obtained from human donor...

journal_title：Investigative ophthalmology & visual science

authors： Premanand C,Rema M,Sameer MZ,Sujatha M,Balasubramanyam M

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:To develop a new test of activities of daily living (ADLs) appropriate for the low-vision population: the Melbourne Low-Vision ADL Index (MLVAI). METHODS:The MLVAI was designed as a desk-based clinical assessment, comprising 18 observed items on complex ADLs in part (a) and 9 questions on broad self-care ADLs ...

journal_title：Investigative ophthalmology & visual science

authors： Haymes SA,Johnston AW,Heyes AD

更新日期：2001-05-01 00:00:00

abstract：:A sensitive fluorometric assay for measuring permeability of liposomes containing bovine lens MIP26 has been developed and characterized. Lens membrane proteins were isolated and incorporated into artificial membranes composed of bovine brain phospholipids, sphingomyelin and the fluorescent probe, N-4-nitrobenzo-2-oxa...

journal_title：Investigative ophthalmology & visual science

authors： Scaglione BA,Rintoul DA

更新日期：1989-05-01 00:00:00

abstract：Purpose:This study investigated the expression of insulin-like growth factor binding protein-3 (IGFBP-3) in basal tears of patients with type 2 diabetes mellitus compared to nondiabetic controls; and correlated tear levels of IGFBP-3 with morphologic changes in the subbasal nerve plexus and density of basal corneal epi...

journal_title：Investigative ophthalmology & visual science

authors： Stuard WL,Titone R,Robertson DM

更新日期：2017-12-01 00:00:00

abstract：:Heightened interest in meibomian glands dysfunction prompted the authors to examine the ultrastructure of the glandular epithelium in specimens of surgical origin, by thin section and freeze-fracture electron microscopies. In meibomian glands, the morphology and ultrastructure of acinar cells varies considerably accor...

journal_title：Investigative ophthalmology & visual science

authors： Sirigu P,Shen RL,Pinto da Silva P

更新日期：1992-06-01 00:00:00

abstract：:Photoreceptors can segregate inner segment proteins from outer segment proteins. It is uncertain whether such a sorting process occurs during disc morphogenesis in rods, thereby resulting in an outer segment plasma membrane which differs compositionally from the discs. In this study, the plasma membranes of intact, pu...

journal_title：Investigative ophthalmology & visual science

authors： Polans AS,Burton MD

更新日期：1988-10-01 00:00:00

abstract：PURPOSE:An early injury response to retinal detachment is disruption of synaptic connectivity between photoreceptors and second-order neurons. Most dramatic is the retraction of rod cell axons and their terminals away from the outer synaptic layer and toward their cell bodies. This study tested whether axonal retractio...

journal_title：Investigative ophthalmology & visual science

authors： Fontainhas AM,Townes-Anderson E

更新日期：2011-02-01 00:00:00

abstract：Purpose:To clarify the distinct molecular pathogenesis of central serous chorioretinopathy (CSC) and pachychoroid neovasculopathy (PNV). Methods:Aqueous humor (AH) was collected from 18 acute CSC, 20 chronic CSC, and 20 PNV patients. Concentrations of 30 cytokines in the AH were analyzed using a multiplex bead immunoa...

journal_title：Investigative ophthalmology & visual science

authors： Terao N,Koizumi H,Kojima K,Yamagishi T,Nagata K,Kitazawa K,Yamamoto Y,Yoshii K,Hiraga A,Toda M,Kinoshita S,Sotozono C,Hamuro J

更新日期：2018-12-03 00:00:00

abstract：PURPOSE:Macrophages are thought to be the first line of defense in many infectious diseases and are present in high numbers in corneas with Acanthamoeba keratitis. Conjunctival macrophage depletion was performed in an animal model of Acanthamoeba infection to determine the importance of macrophages in this disease. ME...

journal_title：Investigative ophthalmology & visual science

authors： van Klink F,Taylor WM,Alizadeh H,Jager MJ,van Rooijen N,Niederkorn JY

更新日期：1996-06-01 00:00:00

abstract：Purpose:To investigate the optimal procedures for multichannel visually evoked potentials (VEPs) to detect misrouting in albinism subjects. Methods:Investigations were done in a phenotypically heterogeneous group of 180 albinism subjects and 187 controls with and without ocular pathology. We retrospectively compared s...

journal_title：Investigative ophthalmology & visual science

authors： Kruijt CC,de Wit GC,Talsma HE,Schalij-Delfos NE,van Genderen MM

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:To determine whether the atmospheric pressure (ATM) change experienced during diving can induce changes in the intraocular pressure (IOP) of eyes in a normal population. METHODS:The IOP of 27 healthy volunteers (ages, 23.8 +/- 4.9 years; range, 18-44) was measured with a Perkins applanation tonometer by two in...

journal_title：Investigative ophthalmology & visual science

authors： Van de Veire S,Germonpre P,Renier C,Stalmans I,Zeyen T

更新日期：2008-12-01 00:00:00

abstract：PURPOSE:Large copy number variations (CNV) can contribute to increased burden for neurodegenerative diseases. In this study, we analyzed the genome-wide burden of large CNVs > 100 kb in primary open angle glaucoma (POAG), a neurodegenerative disease of the eye that is the largest cause of irreversible blindness. METHO...

journal_title：Investigative ophthalmology & visual science

authors： Kaurani L,Vishal M,Kumar D,Sharma A,Mehani B,Sharma C,Chakraborty S,Jha P,Ray J,Sen A,Dash D,Ray K,Mukhopadhyay A

更新日期：2014-04-24 00:00:00

abstract：PURPOSE:To identify matrix metalloproteinases (MMPs) released by ciliary smooth muscle cells in vitro and to determine whether MMP release is altered by exposure to prostaglandins (PGs). METHODS:Human ciliary smooth muscle cells were grown to confluence in monolayer cultures and treated with PGF2 alpha, 11-deoxy-PGE1,...

journal_title：Investigative ophthalmology & visual science

authors： Weinreb RN,Kashiwagi K,Kashiwagi F,Tsukahara S,Lindsey JD

更新日期：1997-12-01 00:00:00

abstract：PURPOSE:To investigate the effects of an imaginary and a visual target on torsional optokinetic nystagmus (tOKN) and directional symmetry of tOKN. METHODS:Torsional OKN was induced by a rotating random dot pattern (52 degrees in diameter, constant angular velocity: +/-30 deg/sec to +/-52 deg/sec) with an imaginary or ...

journal_title：Investigative ophthalmology & visual science

authors： Suzuki Y,Shinmei Y,Nara H,Ifukube T

更新日期：2000-09-01 00:00:00

abstract：:Three methods of corneal epithelial preparation for subsequent analysis of epithelial glycogen and DNA content were compared: scraping, lamellar stripping, and in situ freezing. All three methods gave good recovery of these substances. However, there was incomplete recovery of the sample using the in situ freezing met...

journal_title：Investigative ophthalmology & visual science

authors： Friend J,Kiorpes T,Kinoshita S

更新日期：1983-02-01 00:00:00

abstract：:Although the lens has been shown to have the capacity to respond to insulin in vitro, little is known concerning the biochemical relationships of insulin to the lens in vivo. Therefore we have measured insulin in the aqueous humor of rabbits by a sensitive radioimmunoassay after paracentesis and feeding. The insulin c...

journal_title：Investigative ophthalmology & visual science

authors： Coulter JB 3rd,Engelke JA,Eaton DK

更新日期：1980-12-01 00:00:00