Rapid upregulation of fibroblast growth factor receptor 1 (flg) by rat photoreceptor cells after injury.

abstract：PURPOSE:Evidence suggests that capillary degeneration in early diabetic retinopathy results from chronic inflammation, and leukotrienes have been implicated in this process. The authors investigated the cellular sources of leukotriene biosynthesis in diabetic retinas and the effects of hyperglycemia on leukotriene prod...

journal_title：Investigative ophthalmology & visual science

authors： Talahalli R,Zarini S,Sheibani N,Murphy RC,Gubitosi-Klug RA

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:To study relationships between glaucoma-sensitive components identified with frequency-domain analysis of global-flash multifocal electroretinogram (mfERG), regional retinal nerve fiber layer thickness (RNFLT), and local visual field sensitivity (VS). METHODS:Eleven macaque monkeys, including four controls and...

journal_title：Investigative ophthalmology & visual science

authors： Luo X,Patel NB,Harwerth RS,Frishman LJ

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Increasing evidence indicates that the macular pigments (MP) protect the central retina and may retard macular disease. For that reason, a practical method for measuring MP that does not require elaborate optics and can be applied to diverse populations by operators with a modest amount of experience was develo...

journal_title：Investigative ophthalmology & visual science

authors： Wooten BR,Hammond BR Jr,Land RI,Snodderly DM

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:During mammalian embryonic eyelid closure ADAM17 has been proposed to play a role as a transactivator of epidermal growth factor receptor (EGFR) signaling by shedding membrane bound EGFR ligands. However, ADAM17 also sheds numerous other ligands, thus implicating ADAM17 in additional molecular pathways. The goa...

journal_title：Investigative ophthalmology & visual science

authors： Hassemer EL,Endres B,Toonen JA,Ronchetti A,Dubielzig R,Sidjanin DJ

更新日期：2013-01-07 00:00:00

abstract：PURPOSE:Organized conjunctiva-associated lymphoid tissue (O-CALT) is constantly exposed to environmental antigens and plays a central role in the common mucosal immune system. This study was undertaken to investigate whether O-CALT in rabbit lymphoid tissue, as in other lymphoid tissue in other mammals, changes with ag...

journal_title：Investigative ophthalmology & visual science

authors： Cain C,Phillips TE

更新日期：2008-02-01 00:00:00

abstract：Purpose:To determine whether mitochondrial DNA haplogroups or rare variants associate with primary open-angle glaucoma in subjects of European descent. Methods:A case-control comparison of age- and sex-matched cohorts of 90 primary open-angle glaucoma patients and 95 population controls. Full mitochondrial DNA sequenc...

journal_title：Investigative ophthalmology & visual science

authors： Singh LN,Crowston JG,Lopez Sanchez MIG,Van Bergen NJ,Kearns LS,Hewitt AW,Yazar S,Mackey DA,Wallace DC,Trounce IA

更新日期：2018-09-04 00:00:00

abstract：:Three monoclonal antibodies against lens crystallin have been used to study the accumulation of specific polypeptides during development of the human lens. One antibody which recognizes an antigen common to three polypeptides with molecular weights close to 31,000 reacted equally well to the human lens cortex and nucl...

journal_title：Investigative ophthalmology & visual science

authors： Russell P,Carper DA,Chiogioji A,Reddy V

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:To characterize the static blood flow autoregulation in the optic nerve head (ONH), and to investigate its role in hemodynamic changes in experimental glaucoma (EG). METHODS:Unilateral elevation of intraocular pressure (IOP) was induced in 15 adult rhesus macaques by laser treatment to the trabecular meshwork....

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Burgoyne CF,Cull G,Thompson S,Fortune B

更新日期：2014-02-10 00:00:00

abstract：PURPOSE:To examine the correlation between corneal acoustic impedance and Young's modulus in a canine eye model. METHODS:Twenty canine globes were recovered from healthy animals. Corneal acoustic impedance was measured in the intact globes using two methods: a quantitative ultrasound spectroscopy method and the reflec...

journal_title：Investigative ophthalmology & visual science

authors： He X,Liu J

更新日期：2011-02-09 00:00:00

abstract：:Using aqueous and vitreous fluorophotometry, the authors examined the blood-aqueous and blood-retinal barrier functions in three groups of pigmented rabbits. Epinephrine (1.25%) was applied topically five times daily and indomethacin (0.5% sesame oil suspension) was applied topically three times daily to one eye of ea...

journal_title：Investigative ophthalmology & visual science

authors： Miyake K,Kayazawa F,Manabe R,Miyake Y

更新日期：1987-03-01 00:00:00

abstract：PURPOSE:Folic acid is essential for DNA, RNA, and protein synthesis, and deficiencies in folate can lead to nutritional amblyopia and optic neuropathy. The transport of folate from the choroidal blood supply to the retina is only now beginning to be understood. The reduced-folate transporter was reported recently to be...

journal_title：Investigative ophthalmology & visual science

authors： Smith SB,Kekuda R,Gu X,Chancy C,Conway SJ,Ganapathy V

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:Dry eye syndrome (DES) is characterized by an increase in tear osmolarity and induction of the expression and nuclear localization of an osmoprotective transcription factor (nuclear factor of activated T-cells 5 [NFAT5]) that plays an important role in providing protection against hyperosmotic tears. In this st...

journal_title：Investigative ophthalmology & visual science

authors： Sawazaki R,Ishihara T,Usui S,Hayashi E,Tahara K,Hoshino T,Higuchi A,Nakamura S,Tsubota K,Mizushima T

更新日期：2014-04-21 00:00:00

abstract：PURPOSE:To evaluate the antilymphangiogenic potential of multi-target tyrosine kinase inhibitor sunitinib in corneal neovascularization (NV). METHODS:Inflammatory corneal NV was induced by thermal cauterization applied in the central cornea of mice, to which sunitinib malate was daily administered by gavage or not. At...

journal_title：Investigative ophthalmology & visual science

authors： Detry B,Blacher S,Erpicum C,Paupert J,Maertens L,Maillard C,Munaut C,Sounni NE,Lambert V,Foidart JM,Rakic JM,Cataldo D,Noël A

更新日期：2013-05-03 00:00:00

abstract：PURPOSE:Lymphatic research has progressed rapidly in recent years. Lymphatic dysfunction has been found in myriad disorders from cancer metastasis to transplant rejection; however, effective treatment for lymphatic disorders is still limited. This study investigates the role of angiopoietin-2 (Ang-2) in corneal inflamm...

journal_title：Investigative ophthalmology & visual science

authors： Yuen D,Grimaldo S,Sessa R,Ecoiffier T,Truong T,Huang E,Bernas M,Daley S,Witte M,Chen L

更新日期：2014-04-29 00:00:00

abstract：:Two-dimensional electrophoretic maps of extracts from eleven normal and eleven keratoconus corneas were compared. Of the eleven corneas analyzed, eight were pooled and the remaining three were analyzed individually. Several differences were demonstrated between electrophoretic patterns of normal and keratoconus cornea...

journal_title：Investigative ophthalmology & visual science

authors： Panjwani N,Drysdale J,Clark B,Alberta J,Baum J

更新日期：1989-12-01 00:00:00

abstract：PURPOSE:To biochemically characterize the receptor for connective tissue growth factor (CTGF) of human corneal fibroblasts (HCF). METHODS:Radiolabeled recombinant human CTGF was used to determine the specificity and time course of binding to low-passage cultures of HCF. The affinity and number of receptors present wer...

journal_title：Investigative ophthalmology & visual science

authors： Blalock TD,Gibson DJ,Duncan MR,Tuli SS,Grotendorst GR,Schultz GS

更新日期：2012-06-05 00:00:00

abstract：Purpose:We investigate morphologic and physiologic alterations of ganglion cells (GCs) in a streptozocin (STZ)-induced diabetic mouse model. Methods:Experiments were conducted in flat-mount retinas of mice 3 months after the induction of diabetes. Changes in morphology of four subtypes of GCs (ON-type RGA2 [ON-RGA2], ...

journal_title：Investigative ophthalmology & visual science

authors： Cui RZ,Wang L,Qiao SN,Wang YC,Wang X,Yuan F,Weng SJ,Yang XL,Zhong YM

更新日期：2019-04-01 00:00:00

abstract：:An animal model has been developed to study the effects of various prophylaxis agents on acquisition of chlamydial conjunctivitis. When Hartley strain newborn guinea pigs received ocular inoculations of Chlamydia psittaci followed by the instillation of various agents, 1% AgNO3 significantly lowered the risk of develo...

journal_title：Investigative ophthalmology & visual science

authors： Sandstrom IK,Cummings M,Johnson P,Schachter J,Chandler JW

更新日期：1987-09-01 00:00:00

abstract：PURPOSE:Phakic intraocular lenses (pIOLs) are used for correcting vision; in this paper we investigate the fluid dynamical effects of an iris-fixated lens in the anterior chamber. In particular, we focus on changes in the wall shear stress (WSS) on the cornea and iris, which could be responsible for endothelial and pig...

journal_title：Investigative ophthalmology & visual science

authors： Repetto R,Pralits JO,Siggers JH,Soleri P

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:The objective of this study was to characterize the morphology of the anterior opacities formed during recovery from posterior subcapsular cataract (PSC) in Royal College of Surgeons (RCS) rats. METHODS:Lenses from RCS rats at 8 and 12 weeks postnatal (n = 14 and 12, respectively) were examined under a dissect...

journal_title：Investigative ophthalmology & visual science

authors： Al-Ghoul KJ,Kuszak JR

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:To evaluate the effect of chemical chaperones on the trafficking of secretion-incompetent primary open-angle glaucoma-associated mutant myocilin and the possibility to rescue cells coexpressing mutant and wild-type myocilin from endoplasmic reticulum (ER) stress and apoptosis. METHODS:CHO-K1, HEK293 and human ...

journal_title：Investigative ophthalmology & visual science

authors： Yam GH,Gaplovska-Kysela K,Zuber C,Roth J

更新日期：2007-04-01 00:00:00

abstract：PURPOSE:The objective of this study was to determine whether alteration in mucins could be detected in patients with dry eye symptoms by using the monoclonal antibody H185, which recognizes carbohydrate epitopes on mucin molecules. METHODS:Immunohistochemistry and immunoelectron microscopy was used to examine binding ...

journal_title：Investigative ophthalmology & visual science

authors： Danjo Y,Watanabe H,Tisdale AS,George M,Tsumura T,Abelson MB,Gipson IK

更新日期：1998-12-01 00:00:00

abstract：PURPOSE:Endotoxin-induced uveitis (EIU) is a model that mimics human acute anterior uveitis. Cyclooxygenase (COX)-2 is an enzyme that initiates the conversion of arachidonic acid (AA) into prostaglandins (PGs), whereas 5-lipoxygenase (5-LO) generates leukotrienes (LT). The purpose of this study was to delineate the rol...

journal_title：Investigative ophthalmology & visual science

authors： Tuo J,Tuaillon N,Shen D,Chan CC

更新日期：2004-07-01 00:00:00

abstract：Purpose:The purpose of this study was to clarify the interactions between macrophages (MPs) and RPE cells in coculture systems to investigate the functional plasticity of RPE cells. Methods:Adherent peritoneal cells or murine MP cell line Raw 264.7 was cocultured with primary RPE cells taken from C57BL/6 mice, with or...

journal_title：Investigative ophthalmology & visual science

authors： Yamawaki T,Ito E,Mukai A,Ueno M,Yamada J,Sotozono C,Kinoshita S,Hamuro J

更新日期：2016-11-01 00:00:00

abstract：Purpose:This study quantified the thickness and depth of the lamina cribrosa (LC) and peripapillary scleral thickness in high-resolution three-dimensional (3D) fluorescent reconstructions of the optic nerve head (ONH) in eyes from donors of African (AD) and European descent (ED). Methods:A total of 64 eyes (45 ED, 19 ...

journal_title：Investigative ophthalmology & visual science

authors： Girkin CA,Fazio MA,Yang H,Reynaud J,Burgoyne CF,Smith B,Wang L,Downs JC

更新日期：2017-07-01 00:00:00

abstract：PURPOSE:Mutations of the CHM gene underlie the X-linked chorioretinal degeneration choroideremia (CHM). The affected gene product, Rab Escort Protein (REP)1, mediates the posttranslational prenyl modification of Rab GTPases. In patients with CHM, the related REP2 partially compensates for the loss of function of REP1. ...

journal_title：Investigative ophthalmology & visual science

authors： Moosajee M,Tulloch M,Baron RA,Gregory-Evans CY,Pereira-Leal JB,Seabra MC

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:Hormone diseases induce changes in the lacrimal gland (LG) and ocular surface (OS). Thyroid hormone (TH) induces cell proliferation and lipid metabolism through the activation of TH receptors. The aim of the present study was to evaluate the location and comparative expression of TH receptor beta-1 (Thrb) in LG...

journal_title：Investigative ophthalmology & visual science

authors： Dias AC,Módulo CM,Jorge AG,Braz AM,Jordão AA Jr,Filho RB,de Paula JS,Rocha EM

更新日期：2007-07-01 00:00:00

abstract：:Interactions between direction-selective mechanisms for motion were examined in strabismic and anisometropic amblyopia. Amblyopes were found to have a marked reduction in sensitivity to flicker or movement when the amblyopic eye was presented with a combination of two gratings drifting in opposite directions at the sa...

journal_title：Investigative ophthalmology & visual science

authors： Schor CM,Levi DM

更新日期：1980-09-01 00:00:00

abstract：:The authors created a new rabbit model for keratoconjunctivitis sicca by cauterizing the lacrimal gland excretory duct and surgically removing the nictitating membrane and harderian gland. Although the slit-lamp examination findings remained normal for the first 8 wk postoperatively, tear-film osmolarity was elevated ...

journal_title：Investigative ophthalmology & visual science

authors： Gilbard JP,Rossi SR,Gray KL

更新日期：1987-02-01 00:00:00

abstract：PURPOSE:To report the impact of intravitreous bevacizumab therapy on contrast sensitivity in patients with neovascular age-related macular degeneration (nAMD). METHODS:This was a prospective, multicenter, double-masked, randomized, controlled trial of 131 patients with nAMD. The patients with nAMD had received intravi...

journal_title：Investigative ophthalmology & visual science

authors： Patel PJ,Chen FK,Da Cruz L,Rubin GS,Tufail A,ABC Trial Study Group.

更新日期：2011-05-11 00:00:00