Enzymatic disaggregation of the infected rat cornea.

abstract：:Iron is a potent generator of oxidative damage whose levels increase with age, potentially exacerbating age-related diseases. Several lines of evidence suggest that iron accumulation may be a factor in age-related macular degeneration (AMD). AMD retinas have more iron within the photoreceptors, RPE, and drusen than do...

journal_title：Investigative ophthalmology & visual science

authors： Dunaief JL

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:The purpose of the present study was to investigate metabolic changes in different compartments of the rat lens (anterior, nuclear, posterior, and equatorial) after exposure to an acute double threshold dose of ultraviolet-B radiation (UVR-B) by using high-resolution magic angle spinning (HR-MAS) (1)H nuclear m...

journal_title：Investigative ophthalmology & visual science

authors： Tessem MB,Bathen TF,Löfgren S,Saether O,Mody V,Meyer L,Dong X,Söderberg PG,Midelfart A

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:Heavy chain-hyaluronic acid (HC-HA)/PTX3 purified from human amniotic membrane (AM) was previously observed to suppress inflammatory responses in vitro. We now examine whether HC-HA/PTX3 is able to exert a similar effect in vivo, using murine models for keratitis and corneal allograft rejection. METHODS:The in...

journal_title：Investigative ophthalmology & visual science

authors： He H,Tan Y,Duffort S,Perez VL,Tseng SC

更新日期：2014-03-19 00:00:00

abstract：Purpose:Centripetal retinal degeneration in choroideremia (CHM) leads to early visual field restriction and late central vision loss. The latter marks an acute decline in quality of life but visual prognostication remains challenging. We investigated visual function in CHM by correlating best-corrected visual acuity (B...

journal_title：Investigative ophthalmology & visual science

authors： Jolly JK,Xue K,Edwards TL,Groppe M,MacLaren RE

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:To test the incidence of mutations in RPGR ORF15 in six families with X-linked progressive retinal degeneration (cone-rod dystrophy [XLCORD], macular or cone dystrophy) and to undertake a detailed phenotypic assessment of families in whom ORF15 mutations were identified. METHODS:To amplify and sequence ORF15 i...

journal_title：Investigative ophthalmology & visual science

authors： Ebenezer ND,Michaelides M,Jenkins SA,Audo I,Webster AR,Cheetham ME,Stockman A,Maher ER,Ainsworth JR,Yates JR,Bradshaw K,Holder GE,Moore AT,Hardcastle AJ

更新日期：2005-06-01 00:00:00

abstract：:Silicone oil (SiO) and fluorosilicone oil (FSiO) are used as vitreous substitutes during retinal detachment surgery. Emulsification of these oils causes complications in oil-injected eyes. One factor contributing to emulsification is interfacial tension (gamma i) of the oils. In general, the lower the gamma i, the mor...

journal_title：Investigative ophthalmology & visual science

authors： Nakamura K,Refojo MF,Crabtree DV

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function. METHODS:Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained...

journal_title：Investigative ophthalmology & visual science

authors： Feigl B,Mattes D,Thomas R,Zele AJ

更新日期：2011-06-21 00:00:00

abstract：Purpose:Our goal was to generate and characterize a new mouse model in which only angiogenesis- and glaucoma-relevant tissues would be naturally fluorescent. The Matrix Gla (MGP) gene is highly expressed in vascular smooth muscle cells (VSMC) and trabecular meshwork (TM). We sought to direct our Mgp-Cre.KI mouse recomb...

journal_title：Investigative ophthalmology & visual science

authors： Asokan P,Mitra RN,Periasamy R,Han Z,Borrás T

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Slow oscillatory eye movements (SOMs) occur simultaneously with tremor, drifts, and microsaccades during visual fixation. In a previous study, the amplitude of SOM was found to be affected by the visual characteristics of the stimuli. This indicates a perceptual influence on the control of the movement. However...

journal_title：Investigative ophthalmology & visual science

authors： Zhang B,Bolzani R,Öqvist Seimyr G,Ygge J,Pansell T

更新日期：2013-12-11 00:00:00

abstract：Purpose:Keratoconus (KTCN) is a complex eye disorder resulting in loss of visual function. Its development is affected by genetic and environmental components. The aim of this study was to unravel the role of epigenetic factors in KTCN. Methods:To verify if DNA methylation may play a role in KTCN development, reduced ...

journal_title：Investigative ophthalmology & visual science

authors： Kabza M,Karolak JA,Rydzanicz M,Udziela M,Gasperowicz P,Ploski R,Szaflik JP,Gajecka M

更新日期：2019-04-01 00:00:00

abstract：:Three monoclonal antibodies against lens crystallin have been used to study the accumulation of specific polypeptides during development of the human lens. One antibody which recognizes an antigen common to three polypeptides with molecular weights close to 31,000 reacted equally well to the human lens cortex and nucl...

journal_title：Investigative ophthalmology & visual science

authors： Russell P,Carper DA,Chiogioji A,Reddy V

更新日期：1985-07-01 00:00:00

abstract：Purpose:We evaluate diabetic microaneurysm (MA) features on high-resolution adaptive optics scanning laser ophthalmoscopy (AOSLO) and their correlations with visual acuity (VA) and local retinal pathology on spectral domain optical coherence tomography (SDOCT). Methods:Diabetic participants underwent VA testing and AO...

journal_title：Investigative ophthalmology & visual science

authors： Lammer J,Karst SG,Lin MM,Cheney M,Silva PS,Burns SA,Aiello LP,Sun JK

更新日期：2018-11-01 00:00:00

abstract：:Dopamine, cis-flupenthixol, and dibutyryl cAMP affected the standing potential and light-evoked responses of the perfused cat eye in vitro. At micromolar concentrations, dopamine, a retinal neurotransmitter, increased the standing potential of the eye. At slightly higher concentrations, dopamine abolished the "light p...

journal_title：Investigative ophthalmology & visual science

authors： Dawis SM,Niemeyer G

更新日期：1986-03-01 00:00:00

abstract：PURPOSE:Tests for ocular Chlamydia trachomatis have not been well characterized, because there is no gold standard test. Latent class analysis (LCA) was performed to estimate the sensitivity and specificity of laboratory and clinical tests for trachoma in the absence of a gold standard. METHODS:Individual data from pr...

journal_title：Investigative ophthalmology & visual science

authors： See CW,Alemayehu W,Melese M,Zhou Z,Porco TC,Shiboski S,Gaynor BD,Eng J,Keenan JD,Lietman TM

更新日期：2011-08-03 00:00:00

abstract：:The relationship between intraocular and systemic blood pressures was investigated in a prospective study of 572 middle-aged men. There was no consistent relationship between intraocular pressure at first visit and age. Subjects with an intraocular pressure greater than 20 mm Hg had a significantly higher systolic blo...

journal_title：Investigative ophthalmology & visual science

authors： McLeod SD,West SK,Quigley HA,Fozard JL

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:Ischemic preconditioning (IPC) protects the rat retina against the injury that ordinarily follows prolonged ischemia. It has been shown that release of adenosine, de novo protein synthesis, and mediators, such as protein kinase C and K(ATP) channels, is required for IPC protection. However, the molecular mechan...

journal_title：Investigative ophthalmology & visual science

authors： Zhang C,Rosenbaum DM,Shaikh AR,Li Q,Rosenbaum PS,Pelham DJ,Roth S

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:Metabolism and transport of cysteine are critical for maintenance of the intracellular glutathione (GSH) level. In this study, transport mechanisms of L-cystine and regulation of GSH biosynthesis in the absence or presence of NO-induced oxidant stress were investigated in primary cultured rabbit conjunctival ep...

journal_title：Investigative ophthalmology & visual science

authors： Gukasyan HJ,Kannan R,Lee VH,Kim KJ

更新日期：2003-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to examine the test-retest repeatability of microperimetric sensitivity at the border of deep scotomas. METHODS:Thirty normal participants underwent two examinations, each on the Macular Integrity Assessment (MAIA) microperimeter and on the MP-1 microperimeter (four examinations i...

journal_title：Investigative ophthalmology & visual science

authors： Wu Z,Jung CJ,Ayton LN,Luu CD,Guymer RH

更新日期：2015-04-01 00:00:00

abstract：Purpose:To examine the impact of small pupils and light levels on reading performance of distance-corrected presbyopes. To determine whether small pupils would enable presbyopes to read at near even at low light levels. Methods:To establish the lower range of text luminances, we quantified the space-averaged luminance...

journal_title：Investigative ophthalmology & visual science

authors： Xu R,Gil D,Dibas M,Hare W,Bradley A

更新日期：2016-10-01 00:00:00

abstract：PURPOSE:To evaluate a photographic procedure for reflectometry of the topographic distribution of macular pigment density in normal pediatric subjects. METHODS:Digitized blue (480 nm) and green (540 nm) photographic images were aligned and subtracted to generate optical density difference maps. An 8 degrees x 8 degree...

journal_title：Investigative ophthalmology & visual science

authors： Bour LJ,Koo L,Delori FC,Apkarian P,Fulton AB

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:AIPL1 mutations cause the severe inherited blindness Leber congenital amaurosis (LCA). The similarity of AIPL1 to tetratricopeptide repeat (TPR) cochaperones that interact with the chaperone Hsp90 and the ability of AIPL1 to suppress the aggregation of NUB1 fragments in a chaperone-like manner suggest that AIPL...

journal_title：Investigative ophthalmology & visual science

authors： Hidalgo-de-Quintana J,Evans RJ,Cheetham ME,van der Spuy J

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:The aim of this study was to use Raman spectra of tears to differentiate between infectious and noninfectious ulcerative keratitis. METHODS:Raman microspectroscopy was applied using the drop-coating deposition method on Ti/Au-coated glass slides to obtain sample spectra from different human tear groups, includ...

journal_title：Investigative ophthalmology & visual science

authors： Kuo MT,Lin CC,Liu HY,Yang MY,Chang HC

更新日期：2012-03-15 00:00:00

abstract：Purpose:We assessed changes in age-specific prevalence of refractive error at the time of starting school, by comparing preschool and school age cohorts in Shanghai, China. Methods:A cross-sectional study was done in Jiading District, Shanghai during November and December 2013. We randomly selected 7 kindergartens and...

journal_title：Investigative ophthalmology & visual science

authors： Ma Y,Qu X,Zhu X,Xu X,Zhu J,Sankaridurg P,Lin S,Lu L,Zhao R,Wang L,Shi H,Tan H,You X,Yuan H,Sun S,Wang M,He X,Zou H,Congdon N

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Microsaccades could indicate the place where our mind is unconsciously focusing, although our gaze is directed elsewhere. Many studies report the importance of microsaccades in visual scene perception, but none of them has addressed their relationship with the perception of a dynamic action and the prediction o...

journal_title：Investigative ophthalmology & visual science

authors： Piras A,Raffi M,Lanzoni IM,Persiani M,Squatrito S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:DBA/2J mice are a standard preclinical glaucoma model, which spontaneously developed mutations resulting in chronic age-related pigmentary glaucoma. The goals of this study were to identify the degree of visual impairment in DBA/2J mice before and after disease onset by quantifying the optokinetic reflex respon...

journal_title：Investigative ophthalmology & visual science

authors： Burroughs SL,Kaja S,Koulen P

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:We investigated whether the tear interferometric pattern was able to identify differences in tear film kinetics among clinical subtypes of dry eye. METHODS:A total of 138 eyes of 76 subjects (38 men and 38 women; mean age ± SD, 61.6 ± 16.2 years) with or without dry eye who visited Itoh Clinic from May to Augu...

journal_title：Investigative ophthalmology & visual science

authors： Arita R,Morishige N,Fujii T,Fukuoka S,Chung JL,Seo KY,Itoh K

更新日期：2016-07-01 00:00:00

abstract：:Two distinct patterns of delayed-onset, cell-mediated hypersensitivity have been induced in the guinea pig eye with the same soluble protein antigen and two different methods of immunization. The predominant histologic feature of these reactions was the large number of eosinophils which infiltrated the uveal tract and...

journal_title：Investigative ophthalmology & visual science

authors： Friedlaender MH,Howes EL Jr,Hall JM,Krasnobrod H,Wormstead MA

更新日期：1978-04-01 00:00:00

abstract：PURPOSE:To evaluate somatic mitochondrial (mt)DNA mutations in the macula during ageing. METHODS:Ten 30-microm cryostat sections from the macula (foveal and perifoveal regions) and peripheral retina of 14 donors (aged 14-94 years) were cut for cytochrome c oxidase cytochemistry. The photoreceptor layer was microdissec...

journal_title：Investigative ophthalmology & visual science

authors： Barron MJ,Johnson MA,Andrews RM,Clarke MP,Griffiths PG,Bristow E,He LP,Durham S,Turnbull DM

更新日期：2001-11-01 00:00:00

abstract：Purpose:To accelerate the development of new therapies, an inherited retinal degeneration model in a nonhuman primate would be useful to confirm the efficacy in preclinical studies. In this study, we describe the discovery of retinitis pigmentosa in a cynomolgus monkey (Macaca fascicularis) pedigree. Methods:First, sc...

journal_title：Investigative ophthalmology & visual science

authors： Ikeda Y,Nishiguchi KM,Miya F,Shimozawa N,Funatsu J,Nakatake S,Fujiwara K,Tachibana T,Murakami Y,Hisatomi T,Yoshida S,Yasutomi Y,Tsunoda T,Nakazawa T,Ishibashi T,Sonoda KH

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:To evaluate the visual and refractive outcome for four wavefront-guided surface ablation (WGSA) techniques (LASEK, LASEK flap-off [LASEK FO], Epi-LASIK, and Epi-LASIK flap-off [Epi-LASIK FO]) in a large myopic population. METHODS:This retrospective review included 1000 myopic eyes (spherical equivalent [SE] -1...

journal_title：Investigative ophthalmology & visual science

authors： Kulkarni SV,AlMahmoud T,Priest D,Taylor SE,Mintsioulis G,Jackson WB

更新日期：2013-01-21 00:00:00