A longitudinal study of the relationship between intraocular and blood pressures.

abstract：:The corneas of 12 eye donors with maturity-onset diabetes were obtained, and the corneal epithelial basement membranes were studied by transmission electron microscopy. Similar tissue was obtained from 12 nondiabetic eye donors who were matched for age (within 2 years) and race. The mean thickness of the corneal epith...

journal_title：Investigative ophthalmology & visual science

authors： Taylor HR,Kimsey RA

更新日期：1981-04-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the effect of bovine lactoferrin (BLF) on human corneal epithelial wound healing using an in vitro alkali-induced wound model and to understand its role in promoting wound healing. METHODS:Confluent human corneal limbal epithelial (HCLE) cells wounded using 0.5 micr...

journal_title：Investigative ophthalmology & visual science

authors： Pattamatta U,Willcox M,Stapleton F,Cole N,Garrett Q

更新日期：2009-04-01 00:00:00

abstract：Purpose:To investigate diurnal variation in the length of mouse rod outer segments in vivo. Methods:The lengths of rod inner and outer segments (RIS, ROS) of dark-adapted albino mice maintained on a 12-hour dark:12-hour light cycle with light onset 7 AM were measured at prescribed times (6:30 AM, 11 AM, 3:30 PM) durin...

journal_title：Investigative ophthalmology & visual science

authors： Zhang P,Shibata B,Peinado G,Zawadzki RJ,FitzGerald P,Pugh EN Jr

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:The outcome of glaucoma filtration surgery is affected by subconjunctival wound healing. The effects of the antiglaucoma drug latanoprost on the contractility of human Tenon fibroblasts (HTFs) cultured in a three-dimensional collagen gel were investigated. METHODS:HTFs were cultured in a type I collagen gel wi...

journal_title：Investigative ophthalmology & visual science

authors： Liu Y,Ko JA,Yanai R,Kimura K,Chikama T,Sagara T,Nishida T

更新日期：2008-04-01 00:00:00

abstract：:Ocular ultraviolet radiation (UVR) exposure was assessed in three occupational groups: fisherman, landscape workers and construction workers. The ratio of ocular exposure to ambient exposure was determined by placing UV-sensitive film (295-320 nm) between the eyes of the subjects and in a nearby open field. The mean o...

journal_title：Investigative ophthalmology & visual science

authors： Rosenthal FS,Phoon C,Bakalian AE,Taylor HR

更新日期：1988-04-01 00:00:00

abstract：PURPOSE:α-Crystallins are small heat shock proteins that regulate cellular damage and cell survival. Expression of the proteins of the crystallin superfamily in the retina and their role in neuronal cell survival were investigated in two animal models of diabetes and retinal neurons in culture. METHODS:Crystallin expr...

journal_title：Investigative ophthalmology & visual science

authors： Losiewicz MK,Fort PE

更新日期：2011-08-24 00:00:00

abstract：PURPOSE:To investigate the role of intralysosomal redox-active iron in oxidative stress-induced damage in trabecular meshwork (TM) cells. METHODS:Chronic oxidative stress was applied using the hyperoxic model; acute oxidative stress was applied with H(2)O(2). Microarray analysis was performed using microarrays. mRNA a...

journal_title：Investigative ophthalmology & visual science

authors： Lin Y,Epstein DL,Liton PB

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To determine whether neural pathways for controlling goblet cell secretion are present in mouse and human conjunctiva. METHODS:Mouse conjunctiva was homogenized and subjected to electrophoresis and Western blotting to detect PGP 9.5 (indicates nerves), muscarinic receptor subtypes (indicates parasympathetic pa...

journal_title：Investigative ophthalmology & visual science

authors： Diebold Y,Ríos JD,Hodges RR,Rawe I,Dartt DA

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:People with limited literacy are at increased risks of chronic systemic conditions. The authors therefore investigated the independent contribution of limited literacy on visual impairment and visual function in a large eye survey in Singapore. METHODS:The authors undertook a population-based, cross-sectional ...

journal_title：Investigative ophthalmology & visual science

authors： Zheng Y,Lamoureux EL,Chiang PP,Cheng CY,Anuar AR,Saw SM,Aung T,Wong TY

更新日期：2011-09-29 00:00:00

abstract：PURPOSE:To characterize the pharmacology of the carbachol-induced changes of phospholipase C (PLC) activity and intracellular calcium concentration ([Ca2+]i) in cultured human ciliary muscle cells. METHODS:Changes in PLC activity of cultured human ciliary muscle cells were determined by production of inositol phosphat...

journal_title：Investigative ophthalmology & visual science

authors： Matsumoto S,Yorio T,DeSantis L,Pang IH

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:To study the vasorelaxing effect of calcitonin gene-related peptide (CGRP) and natriuretic peptides on isolated bovine retinal arteries (BRAs) and to evaluate the possibility of the unidentified retinal relaxing factor (RRF) being one of these peptides. METHODS:Retinal arteries were isolated from bovine eyes a...

journal_title：Investigative ophthalmology & visual science

authors： Boussery K,Delaey C,Van de Voorde J

更新日期：2005-04-01 00:00:00

abstract：Purpose:To investigate diabetic optic neuropathy (DON) prevalence and risk factors in Chinese diabetic retinopathy (DR) patients. Methods:This retrospective study included 1067 eyes (550 patients) that underwent ocular imaging. The diabetes duration, systolic blood pressure (SBP), hemoglobin A1c (HbA1c), and high-dens...

journal_title：Investigative ophthalmology & visual science

authors： Hua R,Qu L,Ma B,Yang P,Sun H,Liu L

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:We assessed whether partial occlusion of the nonamblyopic eye with Bangerter filters can immediately reduce suppression and promote binocular summation of contrast in observers with amblyopia. METHODS:In Experiment 1, suppression was measured for 22 observers (mean age, 20 years; range, 14-32 years; 10 females...

journal_title：Investigative ophthalmology & visual science

authors： Chen Z,Li J,Thompson B,Deng D,Yuan J,Chan L,Hess RF,Yu M

更新日期：2014-10-28 00:00:00

abstract：:Secretory component (SC) was studied by indirect immunofluorescence of the ocular surface epithelium. We find that conjunctival epithelium produces this component, and that it is absent in the corneal epithelium. Conjunctival epithelium loses its SC staining within 1 to 2 days as it grows over a denuded corneal stroma...

journal_title：Investigative ophthalmology & visual science

authors： Liu SH,Tagawa Y,Prendergast RA,Franklin RM,Silverstein AM

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To assess the impact of glaucoma-related vision loss on measures of out-loud reading, including time to say individual words, interval time between consecutive words, lexical errors, skipped words, and repetitions. METHODS:Glaucoma subjects (n = 63) with bilateral visual field loss and glaucoma suspect control...

journal_title：Investigative ophthalmology & visual science

authors： Mathews PM,Rubin GS,McCloskey M,Salek S,Ramulu PY

更新日期：2015-03-03 00:00:00

abstract：:PURPOSE. The purpose of the study was to investigate the effects of hyperglycemia on EGFR (epidermal growth factor receptor)-mediated wound response and signal transduction in the corneal epithelium of rats with type I diabetes mellitus (DM). METHODS. Corneal epithelia were removed from streptozotocin (STZ)- and weigh...

journal_title：Investigative ophthalmology & visual science

authors： Xu K,Yu FS

更新日期：2011-05-17 00:00:00

abstract：PURPOSE:Subcellular Ca2+ signaling patterns, such as Ca2+ waves, gradients, and oscillations, are an important aspect of cell regulation, but the molecular basis for these signaling patterns is not understood. Because Ca2+ release patterns differ among isoforms of the inositol 1,4,5-trisphosphate (InsP3) receptor, the ...

journal_title：Investigative ophthalmology & visual science

authors： Hirata K,Nathanson MH,Burgstahler AD,Okazaki K,Mattei E,Sears ML

更新日期：1999-08-01 00:00:00

abstract：Purpose:To discover novel therapies that lower IOP by increasing aqueous humor outflow facility, ex vivo ocular perfusion systems provide a valuable tool. However, currently available designs are limited by their throughput. Here we report the development of a compact, scalable perfusion system with improved throughput...

journal_title：Investigative ophthalmology & visual science

authors： Zhou EH,Paolucci M,Dryja TP,Manley T,Xiang C,Rice DS,Prasanna G,Chen A

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:To explore the susceptibilities of adult retinal neurons in dissociated culture to treatments with excitotoxic agonists and the mechanisms of the resultant retinal cell death. METHODS:C57B6 mice were used. Retinas were removed, dissociated, plated on a polylysine/laminin substrate, and maintained in vitro for ...

journal_title：Investigative ophthalmology & visual science

authors： Luo X,Baba A,Matsuda T,Romano C

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:This study explores variation in the axial location of Bruch's membrane opening (BMO) to determine if this reference plane varies with age and race. METHODS:There were 168 spectral-domain optical coherence tomography (SDOCT) optic nerve head volumes that were obtained from healthy subjects and manually delinea...

journal_title：Investigative ophthalmology & visual science

authors： Johnstone J,Fazio M,Rojananuangnit K,Smith B,Clark M,Downs C,Owsley C,Girard MJ,Mari JM,Girkin CA

更新日期：2014-03-28 00:00:00

abstract：PURPOSE:Age-related cataract (ARC) is one of the most common causes of severe visual impairment among the elderly worldwide with four subtypes, such as cortical, nuclear, subcapsular, and mixed types. DNA damage and malfunction of DNA repair are believed to contribute to the pathogenesis of ARC. This study examined the...

journal_title：Investigative ophthalmology & visual science

authors： Su S,Yao Y,Zhu R,Liang C,Jiang S,Hu N,Zhou J,Yang M,Xing Q,Guan H

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:T cells play an important role in the pathogenesis of uveitis. Recent studies have indicated that the TNFSF15 gene that encodes the TL1A protein can regulate the differentiation and activation of T cells. TNFSF15 gene polymorphisms have been found to be associated with several autoimmune disorders. A possible a...

journal_title：Investigative ophthalmology & visual science

authors： Li H,Hou S,Yu H,Zheng M,Zhang L,Zhang J,Zhang Q,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:We tested the hypotheses that the mismatch between the clinical disc margin (CDM) and Bruch's membrane opening (BMO) is a function of BMO area (BMOA) and is affected by the presence of glaucoma. METHODS:A total of 45 normal eyes (45 subjects) and 53 glaucomatous eyes (53 patients) were enrolled and underwent r...

journal_title：Investigative ophthalmology & visual science

authors： Amini N,Miraftabi A,Henry S,Chung N,Nowroozizadeh S,Caprioli J,Nouri-Mahdavi K

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:To characterize the thickness profile of the corneal epithelium and the Bowman's layer across the horizontal meridian. METHODS:Forty-four eyes of 22 healthy subjects were investigated in this study. Ultra-high resolution anterior segment spectral domain-optical coherence tomography (SD-OCT) was used to assess ...

journal_title：Investigative ophthalmology & visual science

authors： Tao A,Wang J,Chen Q,Shen M,Lu F,Dubovy SR,Shousha MA

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:One of the difficulties in modeling visual field (VF) data is the sometimes large and correlated measurement errors in the point-wise sensitivity estimates. As these errors affect all locations of the same VF, we propose to model them as global visit effects (GVE). We evaluate this model and show the effect it ...

journal_title：Investigative ophthalmology & visual science

authors： Bryan SR,Eilers PH,Lesaffre EM,Lemij HG,Vermeer KA

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:The primary purpose of this study was to characterize photoreceptor apoptosis in the rd mouse. Given that apoptosis is the final common pathway in many cases of retinal degeneration, the ability to retard or even arrest this process may ameliorate retinal disorders such as retinitis pigmentosa (RP). The absence...

journal_title：Investigative ophthalmology & visual science

authors： Doonan F,Donovan M,Cotter TG

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:The influence of genetic and prenatal environmental factors on characteristics of saccadic performance were evaluated in young monozygotic (MZ) twins (8-19 years old) of known chorion type. METHODS:Saccadic eye movements were recorded using an infrared system. Saccadic latency, accuracy, and parameters of ampl...

journal_title：Investigative ophthalmology & visual science

authors： Blekher T,Christian JC,Abel LA,Yee RD

更新日期：1998-10-01 00:00:00

abstract：Purpose:Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness worldwide in the working-age population, and the incidence is rising. Until now it has been difficult to define initiating events and disease progression at the molecular level, as available diabetic rodent models do not present the...

journal_title：Investigative ophthalmology & visual science

authors： Ali Z,Zang J,Lagali N,Schmitner N,Salvenmoser W,Mukwaya A,Neuhauss SCF,Jensen LD,Kimmel RA

更新日期：2020-02-07 00:00:00

abstract：:The short-term fluctuation in regular grid threshold static fields is commonly determined from repeated observations of a number of threshold points. In this study we estimated the short-term fluctuation from a single determination of the field. Sixty-two eyes of 62 patients were tested, using three consecutive repeti...

journal_title：Investigative ophthalmology & visual science

authors： Schulzer M,Mills RP,Hopp RH,Lau W,Drance SM

更新日期：1990-04-01 00:00:00

abstract：:Herpetic stromal disease often is treated with combinations of antiviral agents and corticosteroids. The addition of steroids to the antiviral treatment regimen frequently increases the efficacy of therapy in patients; however, many complications may arise as a result of corticosteroid therapy. Using a rabbit model, t...

journal_title：Investigative ophthalmology & visual science

authors： O'Brien WJ,Taylor JL

更新日期：1991-08-01 00:00:00