Variability of the main sequence.

abstract：PURPOSE:The current study was done to determine the role of lipocalin-2 (LCN2) in the pathogenesis of demyelinating optic neuritis using an experimental autoimmune optic neuritis (EAON) model. METHODS:The EAON was induced by subcutaneous immunization with an emulsified mixture of myelin oligodendrocyte glycoprotein (M...

journal_title：Investigative ophthalmology & visual science

authors： Chun BY,Kim JH,Nam Y,Huh MI,Han S,Suk K

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:To investigate the effect of ABCA4 mutation status on lipofuscin-related quantitative autofluorescence (qAF) in humans and on bisretinoid accumulation in mice. METHODS:Genotyped parents (n = 26; age 37-64 years) of patients with biallelic ABCA4-related retinopathy underwent in-depth retinal phenotyping includi...

journal_title：Investigative ophthalmology & visual science

authors： Müller PL,Gliem M,Mangold E,Bolz HJ,Finger RP,McGuinness M,Betz C,Jiang Z,Weber BH,MacLaren RE,Holz FG,Radu RA,Charbel Issa P

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:To assess the effect of group B streptococcal (GBS) meningitis on retinal blood flow (RetBF) and choroidal blood flow (ChBF) autoregulation in sedated newborn piglets (1 to 5 days of age). METHODS:Fourteen study animals injected with 0.5 ml heat-killed GBS (10(9)) were compared to 10 control animals injected w...

journal_title：Investigative ophthalmology & visual science

authors： Bottoli I,Beharry K,Modanlou HD,Norris K,Ling E,Noya F,Amato MM,Aranda JV

更新日期：1995-06-01 00:00:00

abstract：:Increased vascular permeability, one of the characteristic features of immediate hypersensitivity (Type I), is mediated through a variety of compounds, including histamine and platelet-activating factor (PAF), a phospholipid inflammatory mediator. The effects on vascular permeability of histamine, PAF, and ethanol, th...

journal_title：Investigative ophthalmology & visual science

authors： Stock EL,Roth SI,Kim ED,Walsh MK,Thamman R

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:Human tear film stability decreases with increasing age. In this study, the changes in meibum composition were measured in search of markers of tear film instability. METHODS:(1)H NMR nuclear magnetic resonance (NMR) spectra of 43 normal donors aged 1 to 88 years were acquired. RESULTS:Compared with meibum fr...

journal_title：Investigative ophthalmology & visual science

authors： Borchman D,Foulks GN,Yappert MC,Milliner SE

更新日期：2012-01-31 00:00:00

abstract：:Pattern ERGs in response to pattern-reversal stimuli varying in spatial frequency (range: 0.2-9.03 cycles/deg) and contrast (range: 0.03-0.93) were recorded from two normal male subjects. At most spatial frequencies the response amplitude increased linearly up to the highest contrast without saturation. From the ampli...

journal_title：Investigative ophthalmology & visual science

authors： Korth M,Rix R,Sembritzki O

更新日期：1985-03-01 00:00:00

abstract：Purpose:To assess changes in Schlemm's canal (SC), intraocular pressure (IOP), and autonomic nervous system activity in healthy individuals after performing the water-drinking test (WDT). Methods:The SC area (SCAR), trabecular meshwork (TM) thickness, IOP, high frequency (HF) of heart rate variability (HRV), heart rat...

journal_title：Investigative ophthalmology & visual science

authors： Chen W,Chen L,Chen Z,Xiang Y,Liu S,Zhang H,Wang J

更新日期：2018-07-02 00:00:00

abstract：Purpose:During development, the corneal epithelium (CE) and the conjunctiva are derived from the surface ectoderm. Here we have examined how, during development, the cells of these two issues become isolated from each other. Methods:Epithelia from the anterior eyes of chicken embryos were labeled with the fluorescent,...

journal_title：Investigative ophthalmology & visual science

authors： Kubilus JK,Zapater I Morales C,Linsenmayer TF

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:To assess the impact of a novel visual field spatial filtering technique on the detection of glaucomatous progression. METHODS:One hundred ninety-eight ocular hypertensive (OHT) and 21 control subjects were examined prospectively (1994-2001) with regular full-threshold Humphrey visual field (VF) testing. VF pr...

journal_title：Investigative ophthalmology & visual science

authors： Strouthidis NG,Scott A,Viswanathan AC,Crabb DP,Garway-Heath DF

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Optic neuritis (ON) is a condition involving primary inflammation, demyelination, and axonal injury in the optic nerve and leads to apoptotic retinal ganglion cell (RGC) death, which contributes to the persistence of visual loss. Currently, ON has no effective treatment. The goal was to determine the effectiven...

journal_title：Investigative ophthalmology & visual science

authors： Adamus G,Brown L,Andrew S,Meza-Romero R,Burrows GG,Vandenbark AA

更新日期：2012-01-25 00:00:00

abstract：PURPOSE:The selective degeneration of pericytes and the proliferation of endothelial cells (ECs) appear to be associated with microaneurysm formation, an initial deficit in the early stage of diabetic retinopathy. The preventive effect of aldose reductase (AR) inhibitor (ARI) for high glucose-induced pericyte loss and ...

journal_title：Investigative ophthalmology & visual science

authors： Takamura Y,Tomomatsu T,Kubo E,Tsuzuki S,Akagi Y

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To assess the relationship between reduced vision and low self-rating of global health, after taking into account many other related factors. METHODS:The Blue Mountains Eye Study examined 3654 residents aged > or =49 years (82.4% response) in an area west of Sydney, Australia. Presenting and best-corrected vis...

journal_title：Investigative ophthalmology & visual science

authors： Wang JJ,Mitchell P,Smith W

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:Mucosa-associated lymphoid tissue (MALT) represents a part of the immune system located at mucosal surfaces. Its presence in the human eye is the point in question in the current study. Its occurrence, components, topography, and probable functional significance in the human conjunctiva and lacrimal drainage sy...

journal_title：Investigative ophthalmology & visual science

authors： Knop N,Knop E

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:Vergence eye movements undergo adaptive recalibration in response to a training stimulus in which the initial disparity is changed just after vergence begins (the double-step paradigm). In the present study the changes in the dynamic properties of convergence, speed and acceleration, were examined by using this...

journal_title：Investigative ophthalmology & visual science

authors： Takagi M,Oyamada H,Abe H,Zee DS,Hasebe H,Miki A,Usui T,Hasegawa S,Bando T

更新日期：2001-06-01 00:00:00

abstract：PURPOSE:To develop an imaging technique that maps the distribution of free cystine in the rat lens at subcellular resolution and enables cystine accumulation to be compared with the expression of the cystine-glutamate exchanger (Xc-). METHODS:Whole lenses were fixed, cryoprotected, and then cryosectioned in either an ...

journal_title：Investigative ophthalmology & visual science

authors： Li L,Lim J,Jacobs MD,Kistler J,Donaldson PJ

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:The anatomy of individual myofibers within the orbicularis oculi muscle was examined to determine individual myofiber lengths in the different regions of the muscle. A wide variety of eyelid conditions require eyelid surgery or drug injections directly into the eyelid. Knowledge of regional myofiber anatomy and...

journal_title：Investigative ophthalmology & visual science

authors： Lander T,Wirtschafter JD,McLoon LK

更新日期：1996-08-01 00:00:00

abstract：PURPOSE:Patients with typical clinical features of retinitis pigmentosa were found to have the atypical electroretinographic finding of a negative waveform to a bright flash in the dark-adapted state. The full-field electroretinogram (ERG) was studied in seven such patients to understand better the pathophysiology. ME...

journal_title：Investigative ophthalmology & visual science

authors： Cideciyan AV,Jacobson SG

更新日期：1993-11-01 00:00:00

abstract：PURPOSE:We tested variants in genes related to lutein and zeaxanthin status for association with age-related macular degeneration (AMD) in the Carotenoids in Age-Related Eye Disease Study (CAREDS). METHODS:Of 2005 CAREDS participants, 1663 were graded for AMD from fundus photography and genotyped for 424 single nucleo...

journal_title：Investigative ophthalmology & visual science

authors： Meyers KJ,Mares JA,Igo RP Jr,Truitt B,Liu Z,Millen AE,Klein M,Johnson EJ,Engelman CD,Karki CK,Blodi B,Gehrs K,Tinker L,Wallace R,Robinson J,LeBlanc ES,Sarto G,Bernstein PS,SanGiovanni JP,Iyengar SK

更新日期：2014-01-29 00:00:00

abstract：PURPOSE:The iron carrier transferrin is expressed at remarkably high levels in normal retinas and is upregulated during retinal degeneration. The authors characterized the consequences of genetically reduced retinal transferrin production on retinal structure and function. METHODS:Hypotransferrinemic (HPX⁻/⁻) mice tre...

journal_title：Investigative ophthalmology & visual science

authors： Lederman M,Obolensky A,Grunin M,Banin E,Chowers I

更新日期：2012-02-02 00:00:00

abstract：PURPOSE:To determine the cellular origin and the vascular endothelial growth factor (VEGF) immunoreactivity of the nonvascular stromal cells in surgically excised age-related macular degeneration (ARMD)-associated choroidal neovascular membranes (CNVMs). METHODS:Immunohistochemical analysis was performed on frozen sec...

journal_title：Investigative ophthalmology & visual science

authors： Lopez PF,Sippy BD,Lambert HM,Thach AB,Hinton DR

更新日期：1996-04-01 00:00:00

abstract：PURPOSE:Focal opacities are signs of early cataractogenesis in the human lens. They progress slowly over a lifetime and may be precursors of mature cataracts. The authors analyzed changes in proteins, phospholipids, and cholesterol in these opacities using in situ techniques: Raman microspectroscopy, filipin cytochemis...

journal_title：Investigative ophthalmology & visual science

authors： Duindam JJ,Vrensen GF,Otto C,Greve J

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:Human brain generates miniature eye movements, such as microsaccades, to counteract image fading due to visual adaptation. Generation of microsaccade relies on the amount of retinal error or acuity demand for a desired visual task. The goal of this study was to assess the influence of visual blur, induced by un...

journal_title：Investigative ophthalmology & visual science

authors： Ghasia FF,Shaikh AG

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:To determine the location of parasympathetic neurons that innervate the meibomian glands in rats. METHODS:The B subunit of cholera toxin (CTB), fast blue, and a retrograde transneuronal tracer, the Bartha strain of pseudorabies virus (PRV-Ba), were injected into the upper eyelids of adult Sprague-Dawley rats a...

journal_title：Investigative ophthalmology & visual science

authors： LeDoux MS,Zhou Q,Murphy RB,Greene ML,Ryan P

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:To describe a software program developed to provide an objective assessment of the amount of posterior capsular opacification (PCO) in high-resolution digital images of the posterior capsule after cataract surgery. METHODS:Images are analyzed by a set protocol of defining the area of the posterior capsule, rem...

journal_title：Investigative ophthalmology & visual science

authors： Barman SA,Hollick EJ,Boyce JF,Spalton DJ,Uyyanonvara B,Sanguinetti G,Meacock W

更新日期：2000-11-01 00:00:00

abstract：:Determination of intraocular antibody synthesis against certain microorganisms is a diagnostic aid in identifying the causative agent in clinical uveitis. Little is known, however, concerning the kinetics and specificity of antibodies produced during intraocular inflammation. To investigate this subject we induced uve...

journal_title：Investigative ophthalmology & visual science

authors： van der Voet JC,Liem A,Otto AJ,Kijlstra A

更新日期：1989-02-01 00:00:00

abstract：:A single injection of 20 mumol sodium selenite/kg body weight in 10-day-old rats caused severe nuclear cataract within 4 days. By 4 days postselenite injection, nuclear calcium levels increased from 0.4 to 6.8 mmol/kg lens dry weight. The purpose of these experiments was to determine if this calcium increase was assoc...

journal_title：Investigative ophthalmology & visual science

authors： David LL,Shearer TR

更新日期：1984-11-01 00:00:00

abstract：PURPOSE:Orbital eye position and vestibular sensitivity have both been postulated to influence vestibulo-ocular reflex (VOR) axis direction. The interaction of these factors in unilateral vestibular deafferentation (UVD) was examined. METHODS:Initial VOR direction and magnitude were examined in six normal human subjec...

journal_title：Investigative ophthalmology & visual science

authors： Crane BT,Tian J,Ishiyama A,Demer JL

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:To evaluate how aging alters 24-hour measurements of intraocular pressure (IOP) in the sitting and supine body positions. METHODS:Fifteen older volunteers with healthy eyes (ages, 53-71 years) were each housed for 1 day in a sleep laboratory. An 8-hour accustomed sleep period was assigned to each subject. Ever...

journal_title：Investigative ophthalmology & visual science

authors： Mansouri K,Weinreb RN,Liu JH

更新日期：2012-01-10 00:00:00

abstract：PURPOSE:To present a detailed phenotypic and molecular study of a series of 18 patients from 11 families with retinal dystrophies consequent on mutations in the cone-rod homeobox (CRX) gene and to report a novel phenotype. METHODS:Families were ascertained from a tertiary clinic in the United Kingdom and enrolled into...

journal_title：Investigative ophthalmology & visual science

authors： Hull S,Arno G,Plagnol V,Chamney S,Russell-Eggitt I,Thompson D,Ramsden SC,Black GC,Robson A,Holder GE,Moore AT,Webster AR

更新日期：2014-09-30 00:00:00

abstract：:The extracellular matrix of retinal pigment epithelial (RPE) cells is an important component of the fibroelastic membranes formed in proliferative vitreoretinopathy (PVR). These membranes consist of cells intermingled with fibrillar proteins, such as elastin and collagen. Because RPE cells may be exposed to vitreous a...

journal_title：Investigative ophthalmology & visual science

authors： Martini B,Pandey R,Ogden TE,Ryan SJ

更新日期：1992-03-01 00:00:00