Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes.

abstract：:The mitotic rate and goblet cell content of conjunctival epithelium following total or central corneal epithelial removal using n-heptanol was measured to determine how the conjunctival epithelium responds to injury and whether conjuctiva responds to central corneal epithelial loss. One day following a wound that remo...

journal_title：Investigative ophthalmology & visual science

authors： Danjo S,Friend J,Thoft RA

更新日期：1987-09-01 00:00:00

abstract：PURPOSE:To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI). METHODS:The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All s...

journal_title：Investigative ophthalmology & visual science

authors： Lee JY,Jeong HJ,Lee JH,Kim YJ,Kim EY,Kim YY,Ryu T,Cho ZH,Kim YB

更新日期：2014-04-10 00:00:00

abstract：PURPOSE:The purpose of this study was to identify target antigens of autoimmune keratitis with a disease-prone mouse model. METHODS:BALB/c nude mice grafted with embryonic rat thymi (TG nude mice) develop various organ-localized autoimmune lesions, including keratitis. A hybridoma producing a monoclonal antibody (OT-2...

journal_title：Investigative ophthalmology & visual science

authors： Hattori T,Takeuchi M,Ohno K,Ogawara M,Asatani T,Usui Y,Muramatsu R,Inagaki M,Usui M,Taguchi O

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:Reading a text requires vergence angle adjustments, so that the images in the two eyes fall on corresponding retinal areas. Vergence adjustments bring the two retinal images into Panum's fusional area and therefore, small remaining errors or regulations do not lead to double vision. The present study evaluated ...

journal_title：Investigative ophthalmology & visual science

authors： Jainta S,Dehnert A,Heinrich SP,Jaschinski W

更新日期：2011-12-09 00:00:00

abstract：PURPOSE:To investigate the role of nitric oxide synthase (NOS) in photoreceptor degeneration associated with photodynamic therapy (PDT) in a laser-induced model of choroidal neovascularization (CNV). METHODS:PDT was performed in monkey and Brown Norway rats with laser-induced CNV. L-NAME, a NOS inhibitor, or saline wa...

journal_title：Investigative ophthalmology & visual science

authors： She H,Nakazawa T,Matsubara A,Hisatomi T,Young TA,Michaud N,Connolly E,Hafezi-Moghadam A,Gragoudas ES,Miller JW

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:To explore factors affecting the glaucoma diagnostic capability of macular thickness and circumpapillary retinal nerve fiber layer (cRNFL) thickness as determined by spectral domain-optical coherence tomography. METHODS:Area under the curve (AUC) of the receiver operating characteristics (ROC) discriminating h...

journal_title：Investigative ophthalmology & visual science

authors： Na JH,Sung KR,Baek S,Sun JH,Lee Y

更新日期：2011-10-11 00:00:00

abstract：PURPOSE:To investigate spatial anisotropies in the peripheral visual field of axially myopic eyes, in an attempt to distinguish between models of isotropic and anisotropic ocular stretching. METHODS:Stimuli consisted of two high-contrast Gaussian patches presented in one of four orientations (90 degrees, 180 degrees, ...

journal_title：Investigative ophthalmology & visual science

authors： Vera-Diaz FA,McGraw PV,Strang NC,Whitaker D

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:To link psychophysical thresholds for blind spot awareness and filling-in with early neural components that underpin these perceptions. METHODS:Blind spot dimensions were quantified, after which an intrinsic stimulus (i.e., a rectangular bar of varying length centered within the blind spot) was used to determi...

journal_title：Investigative ophthalmology & visual science

authors： Abadi RV,Jeffery G,Murphy JS

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:To evaluate the expression of tissue inhibitor of metalloproteinases (TIMP) mRNA in corneal tissues before and at early time points (6 and 12 hours and 1, 3, and 5 days) after corneal infection with Pseudomonas aeruginosa. METHODS:Ribonuclease protection assays were used to detect and quantitate TIMP mRNA expr...

journal_title：Investigative ophthalmology & visual science

authors： Kernacki KA,Goebel DJ,Poosch MS,Hazlett LD

更新日期：1998-02-01 00:00:00

abstract：PURPOSE:Retinal ischemia/reperfusion (IR) is common in eye disorders. Pattern-recognition receptors (PRRs) are reported to initiate sterile inflammatory response. The role of PRRs in retinal IR injury is currently unknown. Thus, we investigated the expression and function of membrane and cytoplasmic PRRs during retinal...

journal_title：Investigative ophthalmology & visual science

authors： Qi Y,Zhao M,Bai Y,Huang L,Yu W,Bian Z,Zhao M,Li X

更新日期：2014-08-05 00:00:00

abstract：PURPOSE:To evaluate the immunosuppressive and antiangiogenic activities of an intraocular rapamycin (RAPA) drug delivery system (DDS) in a rabbit model of high-risk penetrating keratoplasty. METHODS:Forty New Zealand White rabbits with corneal neovascularization underwent allograft cornea transplantation and were rand...

journal_title：Investigative ophthalmology & visual science

authors： Shi W,Gao H,Xie L,Wang S

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:The sense of vision in humans is robust, and visual flickering is rarely experienced. To investigate this mechanism, electrophysiological and molecular biological techniques were used on human cone and rod photoreceptors. METHODS:Voltage-gated currents were recorded using the patch-clamp technique on isolated ...

journal_title：Investigative ophthalmology & visual science

authors： Kawai F,Horiguchi M,Ichinose H,Ohkuma M,Isobe R,Miyachi E

更新日期：2005-01-01 00:00:00

abstract：Purpose:We examined the pattern and extent of connective tissue distribution in the extraocular muscles (EOMs) and determined the ability of the interconnected connective tissues to disseminate force laterally. Methods:Human EOMs were examined for collagens I, III, IV, and VI; fibronectin; laminin; and elastin using i...

journal_title：Investigative ophthalmology & visual science

authors： McLoon LK,Vicente A,Fitzpatrick KR,Lindström M,Pedrosa Domellöf F

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:To define the phenotypes of retinal degenerations associated with mutations in the gene encoding CRX (cone-rod homeobox), a photoreceptor-specific transcription factor. METHODS:Heterozygotes with the E168 [delta1 bp], E168 [delta2 bp], or G217 [delta1 bp] CRXgene mutation were studied clinically, with visual f...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Cideciyan AV,Huang Y,Hanna DB,Freund CL,Affatigato LM,Carr RE,Zack DJ,Stone EM,McInnes RR

更新日期：1998-11-01 00:00:00

abstract：PURPOSE:Human leukocyte antigen (HLA) polymorphisms have been associated with the development of autoimmune diseases. In uveal melanoma, a high expression of HLA classes I and II, and infiltration with lymphocytes and macrophages are associated with a bad prognosis. Inflammation has an important role in this malignancy...

journal_title：Investigative ophthalmology & visual science

authors： van Essen TH,Bronkhorst IH,Maat W,Verduyn W,Roelen DL,Luyten GP,Jager MJ

更新日期：2012-05-04 00:00:00

abstract：PURPOSE:Refraction, as measured by spherical equivalent, is the need for an external lens to focus images on the retina. While genetic factors play an important role in the development of refractive errors, few susceptibility genes have been identified. However, several regions of linkage have been reported for myopia ...

journal_title：Investigative ophthalmology & visual science

authors： Klein AP,Duggal P,Lee KE,Cheng CY,Klein R,Bailey-Wilson JE,Klein BE

更新日期：2011-07-13 00:00:00

abstract：PURPOSE:Primary congenital glaucoma (PCG) is an autosomal recessive disorder that has been linked to CYP1B1 mutations. This study was conducted to explore the role of FOXC1, which is involved in anterior segment dysgenesis, in PCG. METHODS:An earlier screening for CYP1B1 in a clinically well-characterized PCG cohort (...

journal_title：Investigative ophthalmology & visual science

authors： Chakrabarti S,Kaur K,Rao KN,Mandal AK,Kaur I,Parikh RS,Thomas R

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:The aim of the present study was to use an in vivo model of retinal excitotoxicity to investigate the neuroprotective effect of somatostatin (SRIF)-ergic agents. METHODS:Adult Sprague-Dawley rats (weight range, 250-300 g) intravitreally received (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hyd...

journal_title：Investigative ophthalmology & visual science

authors： Kiagiadaki F,Thermos K

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To investigate mechanical properties of the human posterior lens capsule. METHODS:Twenty-five human donor eyes were obtained from an eye bank. The age of the donors ranged from 1 to 94 years. Test specimens were prepared as tissue rings from posterior lens capsules by means of excimer laser. Capsular thickness...

journal_title：Investigative ophthalmology & visual science

authors： Krag S,Andreassen TT

更新日期：2003-02-01 00:00:00

abstract：PURPOSE:FOXC1 mutations result in Axenfeld-Rieger syndrome, a disorder characterized by a broad spectrum of malformations of the anterior segment of the eye and an elevated risk for glaucoma. A novel FOXC1 W152G mutation was identified in a patient with aniridia. Molecular analysis was conducted to determine the functi...

journal_title：Investigative ophthalmology & visual science

authors： Ito YA,Footz TK,Berry FB,Mirzayans F,Yu M,Khan AO,Walter MA

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:To evaluate quantitatively the relationship between the displacement of anterior visual pathway structures by pituitary tumors and visual field damage with the goal of improving diagnosis and management. METHODS:Subjects had pituitary macroadenomas and both magnetic resonance imaging (MRI) and static perimetry...

journal_title：Investigative ophthalmology & visual science

authors： Boland MV,Lee IH,Zan E,Yousem DM,Miller NR

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:In normal eyes and in diseases such as age-related macular degeneration (AMD) and proliferative vitreoretinopathy (PVR), retinal pigment epithelial (RPE) cell survival is critically important. Bcl-x(L) has been shown to be among the most highly expressed survival factors in cultured human RPE cells. In the curr...

journal_title：Investigative ophthalmology & visual science

authors： Zhang N,Peairs JJ,Yang P,Tyrrell J,Roberts J,Kole R,Jaffe GJ

更新日期：2007-08-01 00:00:00

abstract：Purpose:It has been suggested that arteriolar annuli localized in retinal arterioles regulate retinal blood flow acting as sphincters. Here, the morphology and protein expression profile of arteriolar annuli have been analyzed under physiologic conditions in the retina of wild-type, β-actin-Egfp, and Nestin-gfp transge...

journal_title：Investigative ophthalmology & visual science

authors： Ramos D,Catita J,López-Luppo M,Valença A,Bonet A,Carretero A,Navarro M,Nacher V,Mendez-Ferrer S,Meseguer A,Casellas A,Mendes-Jorge L,Ruberte J

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:We explored the role of myeloid-related protein 8 and 14 (MRP8/14) in Pseudomonas aeruginosa (PA) keratitis. METHODS:MRP8/14 mRNA levels in human corneal scrapes and mouse corneas infected by PA were tested using real-time PCR. MRP8/14 protein expression in C57BL/6 (B6) corneas was confirmed using Western blot...

journal_title：Investigative ophthalmology & visual science

authors： Deng Q,Sun M,Yang K,Zhu M,Chen K,Yuan J,Wu M,Huang X

更新日期：2013-02-01 00:00:00

abstract：Purpose:Tumor necrosis factor (TNF)-α is upregulated in eyes following corneal alkali injury and contributes to corneal and also retinal damage. Prompt TNF-α inhibition by systemic infliximab ameliorates retinal damage and improves corneal wound healing. However, systemic administration of TNF-α inhibitors carries risk...

journal_title：Investigative ophthalmology & visual science

authors： Zhou C,Robert MC,Kapoulea V,Lei F,Stagner AM,Jakobiec FA,Dohlman CH,Paschalis EI

更新日期：2017-01-01 00:00:00

abstract：Purpose:The three-dimensional configurations of rod and cone bipolar cell (BC) dendrites and horizontal cell (HC) processes outside rod and cone synaptic terminals have not been fully elucidated. We reveal how these neurites are mutually arranged to coordinate formation and maintenance of the postsynaptic complex of ri...

journal_title：Investigative ophthalmology & visual science

authors： Tsukamoto Y,Iseki K,Omi N

更新日期：2021-01-04 00:00:00

abstract：PURPOSE:We evaluated whether UVA-riboflavin collagen cross-linking (CXL) increases transverse stromal shear moduli ex vivo, whether the shear moduli are greater in the anterior compared to the posterior stroma, and whether the shear moduli are affected by CXL. METHODS:The resistance to unidirectional transverse shear ...

journal_title：Investigative ophthalmology & visual science

authors： Søndergaard AP,Ivarsen A,Hjortdal J

更新日期：2013-07-26 00:00:00

abstract：Purpose:Examine associations between the vasculature at arteriovenous (AV) crossings and the onset of branch retinal vein occlusion (BRVO). Methods:We included 78 patients with major BRVO, 35 patients with macular BRVO, and 110 controls without BRVO and determined the vessel positions at AV crossings, where the first-...

journal_title：Investigative ophthalmology & visual science

authors： Kogo T,Muraoka Y,Iida Y,Ooto S,Murakami T,Kadomoto S,Iida-Miwa Y,Numa S,Miyake M,Miyata M,Uji A,Tsujikawa A

更新日期：2020-02-07 00:00:00

abstract：PURPOSE:To determine whether constitutive signal flow arising from defective rhodopsin shut-off causes photoreceptor cell death in arrestin knockout mice. METHODS:The retinas of cyclic-light-reared, pigmented arrestin knockout mice and wild-type littermate control mice were examined histologically for photoreceptor ce...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,Simon MI,Matthes MT,Yasumura D,LaVail MM

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:The S1 RNA binding domain 1 (SRBD1) and elongation of long-chain fatty acids family member 5 (ELOVL5) have been reported to be susceptibility genes for early-onset normal-tension glaucoma (NTG). The present study we conducted to assess whether these genes were associated with primary open-angle glaucoma (POAG),...

journal_title：Investigative ophthalmology & visual science

authors： Mabuchi F,Sakurada Y,Kashiwagi K,Yamagata Z,Iijima H,Tsukahara S

更新日期：2011-06-28 00:00:00