Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes.

abstract：PURPOSE:To investigate the neural basis of contraction anisocoria and any implications for assessments using pupillary responses, through analysis of topographic variation in amplitudes of direct and consensual pupil responses. METHODS:Direct and consensual pupillary contraction amplitudes were analyzed from six studi...

journal_title：Investigative ophthalmology & visual science

authors： Carle CF,Maddess T,James AC

更新日期：2011-04-12 00:00:00

abstract：Purpose:Contrast agents applicable for optical coherence tomography (OCT) imaging are rare. The intrascleral aqueous drainage system would be a potential application for a contrast agent, because the aqueous veins are of small diameter and located deep inside the highly scattering sclera. We tested lipid emulsions (LEs...

journal_title：Investigative ophthalmology & visual science

authors： Gottschalk HM,Wecker T,Khattab MH,Fischer CV,Callizo J,Rehfeldt F,Lubjuhn R,Russmann C,Hoerauf H,van Oterendorp C

更新日期：2019-01-02 00:00:00

abstract：PURPOSE:To evaluate the efficiency of mitomycin C (MMC) in limiting the postoperative inflammatory response and scarring after strabismus surgery. METHODS:A prospective, two-stage, masked, controlled trial was conducted. In the first stage, the inflammatory response at the extraocular muscle reattachment site was incr...

journal_title：Investigative ophthalmology & visual science

authors： Minguini N,Monteiro de Carvalho KM,Akaishi PM,De Luca IM

更新日期：2000-10-01 00:00:00

abstract：PURPOSE:To examine the retinotoxic effect of naphthalene, a powerful oxidative agent and a well-known cataractogenic agent. METHODS:A 10% solution of naphthalene dissolved in paraffin oil was given every other day by gavage to 31 pigmented rabbits for 5 weeks, at a dose of 1 g/kg body weight. Four rabbits who received...

journal_title：Investigative ophthalmology & visual science

authors： Orzalesi N,Migliavacca L,Miglior S

更新日期：1994-02-01 00:00:00

abstract：PURPOSE:To compare macular pigment optical density (MPOD) in type 2 diabetic and nondiabetic patients by using dual-wavelength autofluorescence imaging and to investigate the correlation of MPOD with glycosylated hemoglobin (HbA1C) and serum lipid levels. METHODS:Forty-three patients were divided into groups 1 (contro...

journal_title：Investigative ophthalmology & visual science

authors： Lima VC,Rosen RB,Maia M,Prata TS,Dorairaj S,Farah ME,Sallum J

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Angiotensin-converting-enzyme (ACE) catalyses the formation of angiotensin II (ANGII), which presumably acts as a central neurotransmitter/modulator. ANGII-related effects have also been observed in the retina. Present in vivo experiments were designed to investigate further ANGII-related effects on retinal neu...

journal_title：Investigative ophthalmology & visual science

authors： Jacobi PC,Osswald H,Jurklies B,Zrenner E

更新日期：1994-03-01 00:00:00

abstract：PURPOSE:To isolate and characterize bovine lens endopeptidase activity that cleaves the Phe-Ser bond in peptide substrates. METHODS:The protease activity in young bovine lens homogenate was measured using the Mca-(Ala(7),Lys(Dnp)(9))-bradykinin substrate. Degradation of bradykinin and other unlabeled peptide substrate...

journal_title：Investigative ophthalmology & visual science

authors： Chaerkady R,Sharma KK

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:To assess the scene gist recognition in eyes with age-related macular degeneration (AMD) and to study the relationship between scene recognition and macular function. METHODS:Twenty-seven patients with age-related macular degeneration with a visual acuity lower than 20/50 and 17 age-matched controls were inclu...

journal_title：Investigative ophthalmology & visual science

authors： Tran TH,Rambaud C,Despretz P,Boucart M

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To determine the location of parasympathetic neurons that innervate the meibomian glands in rats. METHODS:The B subunit of cholera toxin (CTB), fast blue, and a retrograde transneuronal tracer, the Bartha strain of pseudorabies virus (PRV-Ba), were injected into the upper eyelids of adult Sprague-Dawley rats a...

journal_title：Investigative ophthalmology & visual science

authors： LeDoux MS,Zhou Q,Murphy RB,Greene ML,Ryan P

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:To determine the morphologic changes in the retina in the macula and around the optic disc in patients with autosomal dominant optic atrophy (ADOA) associated with a mutation in the OPA1 gene. METHODS:Cross-sectional images of the macular area of the retina were obtained by optical coherence tomography (OCT) i...

journal_title：Investigative ophthalmology & visual science

authors： Ito Y,Nakamura M,Yamakoshi T,Lin J,Yatsuya H,Terasaki H

更新日期：2007-09-01 00:00:00

abstract：:The relationship of the ocular pressure to the anterior ciliary arterial pressure was studied by measuring the pressure of the anterior ciliary artery using a modified pressure chamber. Of the 40 subjects, 9 were normal, 16 were ocular hypertensive patients, and 15 were primary, open-angle, glaucoma patients. A signif...

journal_title：Investigative ophthalmology & visual science

authors： Sakimoto G,Schwartz B

更新日期：1984-08-01 00:00:00

abstract：:Light and electron microscopic studies were done on 11 cynomolgus monkey eyes which had undergone total iris removal followed by surgical disinsertion of the ciliary muscle from the scleral spur 4.7 to 14.4 months earlier. Anterior chamber perfusion to measure gross outflow facility had been performed one to nine time...

journal_title：Investigative ophthalmology & visual science

authors： Lütjen-Drecoll E,Kaufman PL,Bárány EH

更新日期：1977-03-01 00:00:00

abstract：:A method is presented for the rapid flow cytometric determination of epidermal growth factor (EGF) receptor densities on the surface of cultured ocular cells. The technique uses a biotinylated monoclonal antibody directed against the EGF receptor in conjunction with a streptavidin-bound fluorochrome and requires the s...

journal_title：Investigative ophthalmology & visual science

authors： Lopez JG,Chew SJ,Thompson HW,Malter JS,Insler MS,Beuerman RW

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine the optimal conditions for prolonging corneal allograft survival by inducing anergy with the superantigen staphylococcal enterotoxin B (SEB). METHODS:A rat model of penetrating keratoplasty, whereby Fisher344 donor corneas are implanted into Lewis recipients, was used...

journal_title：Investigative ophthalmology & visual science

authors： Pan Z,Chen Y,Zhang W,Jie Y,Li N,Wu Y

更新日期：2003-08-01 00:00:00

abstract：:Ultrastructural cytochemistry was used to localize a previously undescribed retinal enzyme activity, ie, "manganese-dependent pyrimidine 5'-nucleotidase" (MDPNase) activity in retinas from rats raised in cyclic light and killed at various times in the lighting cycle. In retinas fixed during the last 3 hr of darkness, ...

journal_title：Investigative ophthalmology & visual science

authors： Irons MJ

更新日期：1987-01-01 00:00:00

abstract：PURPOSE:To characterize the static blood flow autoregulation in the optic nerve head (ONH), and to investigate its role in hemodynamic changes in experimental glaucoma (EG). METHODS:Unilateral elevation of intraocular pressure (IOP) was induced in 15 adult rhesus macaques by laser treatment to the trabecular meshwork....

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Burgoyne CF,Cull G,Thompson S,Fortune B

更新日期：2014-02-10 00:00:00

abstract：PURPOSE:The purpose of this study was to develop a murine model of allergic conjunctivitis induced by house dust mite (HDM) extract from Dermatophagoides pteronyssinus, a major allergen in humans. METHODS:Forty BALB/c mice were divided into five groups, immunized with placebo, ovalbumin (10 μg), or HDM extract followi...

journal_title：Investigative ophthalmology & visual science

authors： Lee YJ,Han SJ,Lee H,Kim JS,Seo KY

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Chronic, subclinical inflammation contributes to the pathogenesis of several ocular diseases, including age-related macular degeneration. Proinflammatory cytokines affect tight junctions in epithelia that lack claudin-19, but in the retinal pigment epithelium claudin-19 predominates. We examined the effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Peng S,Gan G,Rao VS,Adelman RA,Rizzolo LJ

更新日期：2012-07-27 00:00:00

abstract：Purpose:To characterize the morphology of neovascularization at the disc (NVD) and neovascularization elsewhere (NVE) in treatment-naïve or previously treated proliferative diabetic retinopathy (PDR) patients using optical coherence tomography (OCT) angiography. Methods:En face OCT angiograms of NVD/NVE in 40 eyes of ...

journal_title：Investigative ophthalmology & visual science

authors： Ishibazawa A,Nagaoka T,Yokota H,Takahashi A,Omae T,Song YS,Takahashi T,Yoshida A

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To determine whether retinal progenitor cells in the inner nuclear layer give rise to regenerated cones after laser ablation of photoreceptors in adult goldfish retina. METHODS:Using a technique developed previously in this laboratory, photoreceptors in the retina of adult goldfish were ablated with an argon l...

journal_title：Investigative ophthalmology & visual science

authors： Wu DM,Schneiderman T,Burgett J,Gokhale P,Barthel L,Raymond PA

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:RPE cell activation is an important feature of autoimmune uveitis. This investigation focused on whether extracellular nucleotides could contribute to this activation, and the effects of ATPgammaS, UTP, and UDP on the production of IL-8 by RPE cells was studied in relation to their expression of functional P2Y ...

journal_title：Investigative ophthalmology & visual science

authors： Relvas LJ,Bouffioux C,Marcet B,Communi D,Makhoul M,Horckmans M,Blero D,Bruyns C,Caspers L,Boeynaems JM,Willermain F

更新日期：2009-03-01 00:00:00

abstract：Purpose:To use laser speckle flowgraphy (LSFG) to assess blood flow (BF) in the optic nerve head (ONH) tissue and choroid during elevated intraocular pressure (IOP). Methods:This prospective study included 20 eyes of 20 healthy volunteers. The testing protocol had a baseline phase, two elevated IOP phases (+10 and +20...

journal_title：Investigative ophthalmology & visual science

authors： Kiyota N,Shiga Y,Ichinohasama K,Yasuda M,Aizawa N,Omodaka K,Honda N,Kunikata H,Nakazawa T

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:To determine the toxicity of various doses of intravitreal amphotericin B deoxycholate, amphotericin B lipid complex (ABLC), and liposomal amphotericin B (L-AmB). METHODS:Fifty-two rabbits were divided into two treatment groups (groups A and B). Thirteen treatments were administered intravitreally to the 104 r...

journal_title：Investigative ophthalmology & visual science

authors： Cannon JP,Fiscella R,Pattharachayakul S,Garey KW,De Alba F,Piscitelli S,Edward DP,Danziger LH

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical coherence tomography (SD-OCT). METHODS:Images were captured on B...

journal_title：Investigative ophthalmology & visual science

authors： Lin P,Mettu PS,Pomerleau DL,Chiu SJ,Maldonado R,Stinnett S,Toth CA,Farsiu S,Mruthyunjaya P

更新日期：2012-04-06 00:00:00

abstract：PURPOSE:CD40 antigen is a membrane receptor that plays a role in the regulation of immune reactions. The expressions of CD40 and CD40 ligand (CD40L) were investigated ex vivo and in vitro in conjunctival epithelial cells, in correlation with HLA DR class H antigen, previously shown to be upregulated in conjunctival inf...

journal_title：Investigative ophthalmology & visual science

authors： Bourcier T,De Saint-Jean M,Brignole F,Goguel A,Baudouin C

更新日期：2000-01-01 00:00:00

abstract：:In order to determine the source of the retinol which has been identified in the tear fluid, the lacrimal gland ducts of rabbits and rats were cannulated and the collected lacrimal gland fluid was analyzed by high performance liquid chromatography. Retinol was identified in the lacrimal gland fluid of rabbits and rats...

journal_title：Investigative ophthalmology & visual science

authors： Ubels JL,Foley KM,Rismondo V

更新日期：1986-08-01 00:00:00

abstract：PURPOSE:To describe a software program developed to provide an objective assessment of the amount of posterior capsular opacification (PCO) in high-resolution digital images of the posterior capsule after cataract surgery. METHODS:Images are analyzed by a set protocol of defining the area of the posterior capsule, rem...

journal_title：Investigative ophthalmology & visual science

authors： Barman SA,Hollick EJ,Boyce JF,Spalton DJ,Uyyanonvara B,Sanguinetti G,Meacock W

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:To investigate in impression cytology (IC) specimens the expression of inflammatory and apoptosis-related markers by conjunctival epithelial cells from patients with dry eye as a rationale for treatment with topical cyclosporine. METHODS:Immunologic anomalies were identified at baseline, before treatment with ...

journal_title：Investigative ophthalmology & visual science

authors： Brignole F,Pisella PJ,Goldschild M,De Saint Jean M,Goguel A,Baudouin C

更新日期：2000-05-01 00:00:00

abstract：:Horseradish peroxidase has been injected into the dorsal lateral geniculate nucleus of macaque monkeys to label ganglion cells of the retina by retrograde axoplasmic transport. Displaced ganglion cells, with somata in the inner nuclear layer and dendrites in the inner plexiform layer, were detected by virtue of their ...

journal_title：Investigative ophthalmology & visual science

authors： Bunt AH,Minckler DS

更新日期：1977-01-01 00:00:00

abstract：PURPOSE:To examine the distribution of human heat shock proteins (HSPs) HSP90, inducible HSP70 (iHSP70), constitutive and inducible HSP70 (cHSP70), HSP65, and human HSP27 in conjunctival biopsy specimens of ocular cicatricial pemphigoid (OCP), atopic keratoconjunctivitis, and healthy persons with cataract. METHODS:Usi...

journal_title：Investigative ophthalmology & visual science

authors： Berra A,Dutt JE,Nouri M,Foster CS

更新日期：1994-02-01 00:00:00