Brain White Matter Maturation and Early Developmental Outcomes in Preterm Infants With Retinopathy of Prematurity.

Abstract:

Purpose:To investigate brain white matter pathways using magnetic resonance diffusion tensor imaging (DTI) and correlate the findings with developmental outcomes at 18 months of corrected age in preterm infants with and without retinopathy of prematurity (ROP). Methods:In this prospective cohort study, probabilistic maps of the 26 white matter pathways associated with motor, cognitive, visual, and limbic/language functions were generated in 84 preterm infants using DTI obtained at term-equivalent age. The mean fractional anisotropy (FA) and mean diffusivity (MD) values were compared between those with and without ROP. Developmental outcomes were assessed using the third edition of Bayley Scales of Infant and Toddler Development (BSID-III) at 18 months of corrected age. Multiple regression analyses were performed to confirm the association among developmental outcomes, white matter pathways, and ROP or severe ROP after adjusting for potential confounders. Results:The white matter pathways were insignificantly associated with ROP or severe ROP. There were no significant differences in the FA and MD values of the pathways between ROP infants treated with and without bevacizumab therapy. Furthermore, there were no significant differences in BSID-III scores between infants with and without ROP or severe ROP. The BSID-III scores at 18 months of age showed a significant association with FA or MD values in several pathways. Conclusions:ROP or severe ROP was insignificantly associated with maturation delay of the white matter pathways. Developmental outcomes were similar between preterm infants with and without ROP or severe ROP or between ROP infants with and without intravitreal bevacizumab therapy.

authors

Ahn SJ,Lee JY,Lee JY,Lee YJ,Lee JM,Lee BR,Kim J,Lee HJ

doi

10.1167/iovs.62.2.2

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

2

issue

2

eissn

0146-0404

issn

1552-5783

pii

2772236

journal_volume

62

pub_type

杂志文章
  • Volume flow across the isolated retinal pigment epithelium of cynomolgus monkey eyes.

    abstract::The retinal pigment epithelium (RPE)-choroid was isolated from cynomolgus monkey eyes with experimental retinal detachments and the volume flow was determined in vitro using Ussing-type chambers. With zero pressure difference across the membrane, retina-to-choroid volume flow was 5.0 microliter/hr/cm2 in eyes with sub...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Tsuboi S,Pederson JE

    更新日期:1988-11-01 00:00:00

  • Noninvasive measurement of rat intraocular pressure with the Tono-Pen.

    abstract:PURPOSE:The purpose of this study was to evaluate the Tono-Pen 2 tonometer for measuring intraocular pressure (IOP) in the living rat eye. METHODS:One eye from each of 20 adult, anesthetized brown Norway rats (group 1) was cannulated and simultaneously connected to a syringe and a pressure transducer with a chart reco...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Moore CG,Milne ST,Morrison JC

    更新日期:1993-02-01 00:00:00

  • Individual variation in size of the human red and green visual pigment gene array.

    abstract:PURPOSE:To determine the size variation of the X-chromosomal human red and green visual pigment gene array in the general population using pulsed field gel electrophoresis and Southern blotting. METHODS:Peripheral blood lymphocytes were prepared from 67 anonymous males. The cells were embedded in agarose and the genom...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Macke JP,Nathans J

    更新日期:1997-04-01 00:00:00

  • Role of vascular endothelial growth factor and placental growth factors during retinal vascular development and hyaloid regression.

    abstract:PURPOSE:Vascular endothelial growth factor (VEGF)-A and placental growth factor (PlGF) are members of a large group of homologous peptides identified as the VEGF family. Although VEGF-A is known to act as a potent angiogenic peptide in the retina, the vasoactive function of PlGF in this tissue is less well defined. Thi...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.02-0040

    authors: Feeney SA,Simpson DA,Gardiner TA,Boyle C,Jamison P,Stitt AW

    更新日期:2003-02-01 00:00:00

  • Long-term corneal morphology after PRK by in vivo confocal microscopy.

    abstract:PURPOSE:To examine human corneal morphology and nerve recovery 5 years after photorefractive keratectomy (PRK). METHODS:Fourteen eyes of 14 patients (ages, 27-53 years) who underwent 6-mm diameter PRK for low to moderate myopia (spherical equivalent [SE] -2.5 to -8.0 D) were examined once 5 years after surgery. Nine h...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.02-0247

    authors: Moilanen JA,Vesaluoma MH,Müller LJ,Tervo TM

    更新日期:2003-03-01 00:00:00

  • Correlation of high-definition optical coherence tomography and fluorescein angiography imaging in neovascular macular degeneration.

    abstract:PURPOSE:To correlate the morphologic characteristics of choroidal neovascular lesions (CNV) in age-related macular degeneration (AMD) using raster scanning high-definition optical coherence tomography (HD-OCT) and conventional fluorescein angiography (FA). METHODS:In this comparative clinical study, 37 consecutive pat...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.09-3610

    authors: Malamos P,Sacu S,Georgopoulos M,Kiss C,Pruente C,Schmidt-Erfurth U

    更新日期:2009-10-01 00:00:00

  • Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease.

    abstract:PURPOSE:Lacritin is a tear glycoprotein with prosecretory, prosurvival, and mitogenic properties. We examined lacritin levels in the tears of Sjögren's syndrome (SS) patients and explored the therapeutic potential of topical lacritin for the treatment of keratoconjunctivitis sicca. METHODS:Tears from healthy controls ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.14-13924

    authors: Vijmasi T,Chen FY,Balasubbu S,Gallup M,McKown RL,Laurie GW,McNamara NA

    更新日期:2014-07-17 00:00:00

  • Optic disc progression in glaucoma: comparison of confocal scanning laser tomography to optic disc photographs in a prospective study.

    abstract:PURPOSE:To compare confocal scanning laser tomography (CSLT) to optic disc photography for detecting progressive glaucomatous disc changes. METHODS:Four expert observers first examined a training set of 40 pairs of monoscopic disc photographs to help set a criterion for change. They then classified 44 pairs of monosco...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.08-2457

    authors: Chauhan BC,Hutchison DM,Artes PH,Caprioli J,Jonas JB,LeBlanc RP,Nicolela MT

    更新日期:2009-04-01 00:00:00

  • Definition and Diagnostic Criteria of Dry Eye Disease: Historical Overview and Future Directions.

    abstract::The definition and diagnostic criteria of dry eye disease (DED) proposed by the Japan Dry Eye Society and other countries are reviewed. The first definition and criteria of DED in Japan were proposed in 1995. In that report, DED was considered a disease of tears, which subsequently damaged ocular epithelia. The presen...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 历史文章,杂志文章,评审

    doi:10.1167/iovs.17-23475

    authors: Shimazaki J

    更新日期:2018-11-01 00:00:00

  • Human retinal pigment epithelium contains two distinct species of superoxide dismutase.

    abstract::Superoxide dismutase (SOD) molecules occur in all cells exposed to an oxygen-containing environment, including retinal pigment epithelial (RPE) cells. Previous studies of nonhuman RPE have either probed specifically for copper-zinc-containing SOD (CuZn-SOD) or have not distinguished between CuZn-SOD and the SOD molecu...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Newsome DA,Dobard EP,Liles MR,Oliver PD

    更新日期:1990-12-01 00:00:00

  • A novel experimental mouse model of retinal detachment: complete functional and histologic recovery of the retina.

    abstract:PURPOSE:To establish an experimental mouse model of retinal detachment (RD) created by corneal puncture (CP). METHODS:Mouse corneas were punctured with a 30.5-gauge beveled needle, and the anterior chamber was penetrated. Histologic and functional changes of the retina were examined by light microscopy and electroreti...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.11-8241

    authors: Zeng R,Zhang Y,Shi F,Kong F

    更新日期:2012-03-26 00:00:00

  • Long posterior ciliary arterial blood flow and systemic blood pressure.

    abstract::The purpose of the current study was to investigate the relationship between systemic blood pressure (BP) and long posterior ciliary arterial (LPCA) blood flow (BF) in response to autonomic drugs, and to determine the types of receptors involved. LPCA BF was measured in anesthetized rabbits at the retrobulbar region u...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Okubo H,Gherezhiher T,Koss MC

    更新日期:1990-05-01 00:00:00

  • Reduced accommodation in children with Down syndrome.

    abstract:PURPOSE:To examine the accommodative accuracy and amplitude in children with Down syndrome. Accommodation is usually assumed to be good in children and is rarely measured. METHODS:A dynamic retinoscopy technique was developed that allows rapid and reliable measures of accuracy and amplitude of accommodation in infants...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Woodhouse JM,Meades JS,Leat SJ,Saunders KJ

    更新日期:1993-06-01 00:00:00

  • Efficacy of liposome-bound amphotericin B for the treatment of experimental fungal endophthalmitis in rabbits.

    abstract::The efficacy of intravitreally administered amphotericin B was evaluated. Experimental fungal infections were produced by inoculation of Candida albicans organisms into the vitreous cavities of 46 rabbit eyes. After 72 hr, eight eyes received intravitreal injections of 10 micrograms of free amphotericin B; and ten eye...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Liu KR,Peyman GA,Khoobehi B

    更新日期:1989-07-01 00:00:00

  • The Effects of Aging on Corneal and Ocular Surface Homeostasis in Mice.

    abstract:Purpose:Aging is a risk factor for dry eye disease. The aim of this study was to investigate if aging is associated with a range of signs of dry eye disease, including tear hyperosmolarity, reduced nerve density, and increased dendritic cell number, in mice. Method:Healthy C57BL/6 female mice, aged 2 months (young, n ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.19-26631

    authors: De Silva MEH,Hill LJ,Downie LE,Chinnery HR

    更新日期:2019-06-03 00:00:00

  • Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder.

    abstract:PURPOSE:It has been suggested that early menopause increases the risk of aging-macula disorder (AMD), the major cause of incurable blindness with a dry and wet late subtype, and that exposure to endogenous or postmenopausal exogenous estrogens reduces this risk. This study was undertaken to investigate whether genetic ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.06-0577

    authors: Boekhoorn SS,Vingerling JR,Uitterlinden AG,Van Meurs JB,van Duijn CM,Pols HA,Hofman A,de Jong PT

    更新日期:2007-03-01 00:00:00

  • Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography.

    abstract:PURPOSE:To assess photoreceptor morphology in patients with Stargardt's disease and fundus flavimaculatus using ultrahigh-resolution optical coherence tomography (UHR-OCT) and correlate it with visual acuity (VA). METHODS:This was a prospective observational case series. Fourteen patients with Stargardt's disease (nin...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.04-0212

    authors: Ergun E,Hermann B,Wirtitsch M,Unterhuber A,Ko TH,Sattmann H,Scholda C,Fujimoto JG,Stur M,Drexler W

    更新日期:2005-01-01 00:00:00

  • The decline in attentional visual fields over time among older participants in the Salisbury Eye Evaluation Driving Study.

    abstract:PURPOSE:The loss of attentional visual field (AVF) has been linked to poor mobility and car crashes. We investigated the risk factors associated with a decrease in AVF over time among participants in the Salisbury Eye Evaluation Driving Study (SEEDS). METHODS:In a longitudinal cohort of 968 individuals ages 67 to 87, ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.11-8874

    authors: Rao P,Munoz B,Turano K,Munro C,West SK

    更新日期:2013-03-13 00:00:00

  • Reattachment of cultured human retinal pigment epithelium to extracellular matrix and human Bruch's membrane.

    abstract:PURPOSE:To determine the mechanism of reattachment of harvested human retinal pigment epithelium (RPE) to RPE-derived extracellular matrix and Bruch's membrane. METHODS:Confluent first-to third-passage human RPE were harvested from tissue culture and plated onto RPE-derived extracellular matrix or human Bruch's membra...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Ho TC,Del Priore LV

    更新日期:1997-05-01 00:00:00

  • Molecular polymorphism of lumican during corneal development.

    abstract:PURPOSE:To evaluate the expression of lumican and decorin, the major proteoglycans of the adult corneal stroma, during the acquisition of corneal transparency in developing chick embryos. METHODS:mRNA levels of decorin and lumican were measured in total RNA extracted from corneas of days 9 to 18 of development by Nort...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Cornuet PK,Blochberger TC,Hassell JR

    更新日期:1994-03-01 00:00:00

  • Induction of apoptosis in human corneal and HeLa cells by mutated BIGH3.

    abstract:PURPOSE:To determine the effects of overexpression of mutated BIGH3 in HeLa and human corneal epithelial (HCE) cells. METHODS:Six mutations known to be responsible for autosomal dominant corneal dystrophies linked to chromosome 5 were generated in a BIGH3 expression vector and transfected in HeLa and HCE cells. The ex...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.02-0661

    authors: Morand S,Buchillier V,Maurer F,Bonny C,Arsenijevic Y,Munier FL,Schorderet DF

    更新日期:2003-07-01 00:00:00

  • Vertical vergence adaptation produces an objective vertical deviation that changes with head tilt.

    abstract:PURPOSE:To document the cyclovertical ocular motor mechanism used for vertical fusion in healthy subjects, and to explore whether vertical vergence training in healthy individuals can produce objectively confirmed vertical deviations that change with head tilt, revealing a basic mechanism that can produce a pattern of ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.12-11368

    authors: Irsch K,Guyton DL,Ramey NA,Adyanthaya RS,Ying HS

    更新日期:2013-05-03 00:00:00

  • The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1.

    abstract:Purpose:Diabetes leads to the downregulation of the retinal Kir4.1 channels and Müller cell dysfunction. The insulin receptor substrate-1 (IRS-1) is a critical regulator of insulin signaling in Müller cells. Circadian rhythms play an integral role in normal physiology; however, diabetes leads to a circadian dysrhythmia...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.18-26045

    authors: Luo Q,Xiao Y,Alex A,Cummins TR,Bhatwadekar AD

    更新日期:2019-05-01 00:00:00

  • A mouse model for the study of recurrent corneal epithelial erosions: alpha9beta1 integrin implicated in progression of the disease.

    abstract:PURPOSE:To describe an in vivo mouse model for the study of recurrent corneal erosion syndrome (RCES) in mice and to characterize the changes in alpha9 integrin expression during wound healing. METHODS:Corneal epithelial debridement wounds of two sizes (1.5 and 2.5 mm) were made on the ocular surface of BALB/c mice an...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.03-1194

    authors: Pal-Ghosh S,Pajoohesh-Ganji A,Brown M,Stepp MA

    更新日期:2004-06-01 00:00:00

  • The balance between proteinases and inhibitors in a murine model of proliferative retinopathy.

    abstract:PURPOSE:To examine the expression of matrix metalloproteinases (MMPs) and their inhibitors during the development of retinal neovascularization (NV) in a mouse model. METHODS:A well-characterized murine model of retinal NV was used to study the expression of specific MMPs (MMP-2, MMP-9, and MT1-MMP) and tissue inhibit...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:

    authors: Majka S,McGuire P,Colombo S,Das A

    更新日期:2001-01-01 00:00:00

  • Gene Augmentation Therapy for a Missense Substitution in the cGMP-Binding Domain of Ovine CNGA3 Gene Restores Vision in Day-Blind Sheep.

    abstract:Purpose:Applying CNGA3 gene augmentation therapy to cure a novel causative mutation underlying achromatopsia (ACHM) in sheep. Methods:Impaired vision that spontaneously appeared in newborn lambs was characterized by behavioral, electroretinographic (ERG), and histologic techniques. Deep-sequencing reads of an affected...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.16-20986

    authors: Gootwine E,Abu-Siam M,Obolensky A,Rosov A,Honig H,Nitzan T,Shirak A,Ezra-Elia R,Yamin E,Banin E,Averbukh E,Hauswirth WW,Ofri R,Seroussi E

    更新日期:2017-03-01 00:00:00

  • Efficacy of pig-to-rhesus lamellar corneal xenotransplantation.

    abstract::PURPOSE. To solve the shortage of donor corneas, a decellularizing method based on hypertonic saline treatment was introduced, and a favorable outcome was observed in pig-to-rabbit lamellar corneal transplantation. This study was an investigation of the efficacy of pig-to-nonhuman primate lamellar corneal transplantat...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.11-7273

    authors: Choi HJ,Kim MK,Lee HJ,Ko JH,Jeong SH,Lee JI,Oh BC,Kang HJ,Wee WR

    更新日期:2011-08-22 00:00:00

  • Evaluation of Retinal Nerve Fiber Layer Thinning in Myopic Glaucoma: Impact of Optic Disc Morphology.

    abstract:Purpose:The purpose of this study was to investigate the role of optic disc torsion on the rate of progressive retinal nerve fiber layer (RNFL) thinning in patients with myopic open-angle glaucoma. Methods:We included 102 patients with myopic open-angle glaucoma accompanied by glaucomatous damage confined to a single ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.17-22534

    authors: Na KI,Lee WJ,Kim YK,Park KH,Jeoung JW

    更新日期:2017-12-01 00:00:00

  • Regional differences in cystine accumulation point to a sutural delivery pathway to the lens core.

    abstract:PURPOSE:To develop an imaging technique that maps the distribution of free cystine in the rat lens at subcellular resolution and enables cystine accumulation to be compared with the expression of the cystine-glutamate exchanger (Xc-). METHODS:Whole lenses were fixed, cryoprotected, and then cryosectioned in either an ...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.06-0861

    authors: Li L,Lim J,Jacobs MD,Kistler J,Donaldson PJ

    更新日期:2007-03-01 00:00:00

  • The Fate and Prognostic Implications of Hyperreflective Crystalline Deposits in Nonneovascular Age-Related Macular Degeneration.

    abstract:Purpose:To explore patterns of disease progression in nonneovascular age-related macular degeneration (AMD) associated with hyperreflective crystalline deposits (HCDs) in the sub-retinal pigment epithelium-basal laminar space. Methods:Retrospective review of medical records, multimodal imaging, and longitudinal eye-tr...

    journal_title:Investigative ophthalmology & visual science

    pub_type: 杂志文章

    doi:10.1167/iovs.19-26589

    authors: Fragiotta S,Fernández-Avellaneda P,Breazzano MP,Curcio CA,Leong BCS,Kato K,Yannuzzi LA,Freund KB

    更新日期:2019-07-01 00:00:00