Abstract:
PURPOSE:Methylprednisolone (MP) is commonly used to treat traumatic optic neuropathy and optic neuritis, but its benefit in terms of neuronal survival remains controversial. The aim of this study was to investigate the effects of MP on retinal ganglion cell (RGC) survival and visual function after ischemia in rats. METHODS:Ocular ischemia was induced by elevated intraocular pressure. Rats were treated with NaCl, 1 mg/kg/d, or 30 mg/kg/d intraperitoneal MP over 3 days. RGCs were labeled retrogradely 4 days after ischemia and were quantified 6 days later. Post-ischemic retinal function was assessed by scotopic and photopic electroretinography (ERG). Optic nerve function was investigated on days 4 and 10 after ischemia by visual evoked potentials (VEPs). RESULTS:Compared with nonischemic eyes, ischemia reduced RGCs with NaCl to 47% +/- 3% (mean +/- SEM) and to 46% +/- 3% and 43% +/- 6% with 1 mg/kg/d and 30 mg/kg/d MP. ERG did not differ significantly for any parameter among the three groups. Four days after ischemia, the VEPs of rats receiving any dose of MP were significantly higher than the control. VEPs in both steroid groups fell to control levels 10 days after ischemia. CONCLUSIONS:Treatment with MP did not improve RGC survival or retinal function. The VEP showed a short-term benefit because of steroids.
journal_name
Invest Ophthalmol Vis Scijournal_title
Investigative ophthalmology & visual scienceauthors
Dimitriu C,Bach M,Lagrèze WA,Jehle Tdoi
10.1167/iovs.08-1869subject
Has Abstractpub_date
2008-11-01 00:00:00pages
5003-7issue
11eissn
0146-0404issn
1552-5783pii
iovs.08-1869journal_volume
49pub_type
杂志文章abstract::Nineteen hundred and seventy-six immature human cataracts extracted intracapsularly were classified according to the Cooperative Cataract Research Group (CCRG) method of cataract classification. Data on cataract location and extent, nuclear color, preoperative visual acuity, age, and sex were organized and stored in t...
journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
doi:
更新日期:1984-02-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
pub_type: 杂志文章
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journal_title:Investigative ophthalmology & visual science
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journal_title:Investigative ophthalmology & visual science
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更新日期:2014-04-21 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:2014-02-12 00:00:00
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journal_title:Investigative ophthalmology & visual science
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doi:
更新日期:1997-12-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
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更新日期:2007-04-01 00:00:00
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journal_title:Investigative ophthalmology & visual science
pub_type: 历史文章,杂志文章,评审
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更新日期:2018-11-01 00:00:00