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Light and circadian modulation of teleost retinal tyrosine hydroxylase activity.

Abstract：

PURPOSE:The authors examined the effects of both light and circadian phase on the synthetic activity of the dopamine producing enzyme, tyrosine hydroxylase (TH), in the retina of the Midas cichlid (Cichlasoma citrinellum). METHODS:TH activity was assayed in the retina-retinal pigment epithelium (RPE) complex of fish entrained to cyclic light regimens. The animals were killed throughout cyclic light and continuous dark cycles and after light exposure following short-term dark adaptation to assess the effects of both diurnal and circadian phase and light exposure on TH activity. Variations in retina-RPE TH activity were compared with cone retinomotor position. RESULTS:The authors report that TH activity was influenced both by light and by circadian phase. In both cyclic light and continuous darkness, TH activity fluctuated in cyclic fashion, increasing to peak values at night, declining through dawn, and reaching minimal values at midday. In continuous dark-adapted retinae, the peak activity at night was approximately sixfold greater than the minimum activity during the day. In cyclic light-adapted retinae at midday, the TH activity was 2.4-fold higher than that determined at the same time point in continuous dark-adapted retinae. Light onset enhanced the TH activity in previously dark-adapted animals by 2.2-fold at midday and 1.7-fold at dusk. Thus, retinal TH activity exhibits fluctuations of approximately sixfold in response to circadian signals and is stimulated approximately twofold by light. CONCLUSIONS:These observations indicate that dopamine production in the retina is regulated both by light and by circadian phase and that there are cyclic changes in dopamine production during the 24-hr cycle both in normal light and dark cycles and under conditions of constant darkness.

journal_name

Invest Ophthalmol Vis Sci

journal_title

Investigative ophthalmology & visual science

authors

McCormack CA,Burnside B

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

1853-60

issue

5

eissn

0146-0404

issn

1552-5783

journal_volume

34

pub_type

杂志文章

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