The kinase inhibitor PKC412 suppresses epiretinal membrane formation and retinal detachment in mice with proliferative retinopathies.

abstract：Purpose:Single-cell RNA-sequencing (scRNA-seq) was used to interrogate the relatively rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia from wild-type and autophagy-compromised mice. Methods:We conducted scRNA-seq on ocular anterior segmental tissue from wild-type and beclin...

journal_title：Investigative ophthalmology & visual science

authors： Kaplan N,Wang J,Wray B,Patel P,Yang W,Peng H,Lavker RM

更新日期：2019-08-01 00:00:00

abstract：:A stimulus consisting of 96 red LEDs mounted in the rear of a ganzfeld bowl was used to elicit focal electroretinograms (FERG) from the central 9 degrees of the retina in human subjects. The luminance of the stimulus was driven sinusoidally at frequencies from 10-60 Hz. The temporal responsiveness and response phase l...

journal_title：Investigative ophthalmology & visual science

authors： Seiple WH,Siegel IM,Carr RE,Mayron C

更新日期：1986-07-01 00:00:00

abstract：PURPOSE:To engineer a knockin mouse model that can be used to monitor the effects of treatments on degradation and mislocalization of proline-to-histidine change at codon 23 (P23H) rhodopsin, a common cause of autosomal dominant retinitis pigmentosa (ADRP). The goal was to introduce a gene that expressed rhodopsin at l...

journal_title：Investigative ophthalmology & visual science

authors： Price BA,Sandoval IM,Chan F,Simons DL,Wu SM,Wensel TG,Wilson JH

更新日期：2011-12-28 00:00:00

abstract：PURPOSE:To assess the retinal macrophage response to cannulation of the anterior chamber (AC) and acute elevation of intraocular pressure (IOP) in adult mice. METHODS:Eyes from 12-month-old C57BL/6J WT mice were subject to IOP increase (50 mm Hg for 30 minutes) by direct cannulation of the AC. Fellow eyes were either ...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chrysostomou V,Trounce IA,McMenamin PG,Crowston JG

更新日期：2013-04-30 00:00:00

abstract：PURPOSE:Adipose-derived stem cells (ASCs) have gained importance due to their myriad potential clinical applications. We hypothesize that progenitor cells also exist besides those conventionally isolated from the stromal vascular fraction (SVF). METHOD:Central and medial orbital adipose tissues obtained from patients ...

journal_title：Investigative ophthalmology & visual science

authors： Chen SY,Mahabole M,Horesh E,Wester S,Goldberg JL,Tseng SC

更新日期：2014-07-03 00:00:00

abstract：PURPOSE:To determine the effect of interleukin (IL)-1alpha and tumor necrosis factor (TNF)-alpha on cytokine, chemokine, and receptor expression in corneal stromal cells; the effect of corneal scrape injury on monocyte chemotactic and activating factor (MCAF) expression and monocyte-macrophage influx into the stroma; a...

journal_title：Investigative ophthalmology & visual science

authors： Hong JW,Liu JJ,Lee JS,Mohan RR,Mohan RR,Woods DJ,He YG,Wilson SE

更新日期：2001-11-01 00:00:00

abstract：PURPOSE:Equine recurrent uveitis (ERU) is an incurable disease affecting the inner eye that leads to blindness, through activated T cells that pass the blood-retinal barrier and destroy the retina. Serum markers are a desirable choice for monitoring development of disease, as serum is easy accessible and the markers co...

journal_title：Investigative ophthalmology & visual science

authors： Zipplies JK,Hauck SM,Schoeffmann S,Amann B,van der Meijden CH,Stangassinger M,Ueffing M,Deeg CA

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To identify the underlying mechanisms by which lipid mediator lysophosphatidic acid (LPA) acts as a growth factor in stimulating extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3'-kinase (PI3K) during corneal epithelial wound healing. METHODS:Epithelial debridement wounds in cultured porci...

journal_title：Investigative ophthalmology & visual science

authors： Xu KP,Yin J,Yu FS

更新日期：2007-02-01 00:00:00

abstract：:Axonal transport studies were undertaken to determine the effect of chronic demyelination on axonal function in experimental allergic optic neuritis in the guinea pig, an animal model for multiple sclerosis. Fast and slow components of axonal transport over the prelaminar, laminar, and retrolaminar portions of the opt...

journal_title：Investigative ophthalmology & visual science

authors： Rao NA,Guy J,Sheffield PS

更新日期：1981-10-01 00:00:00

abstract：PURPOSE:Doxorubicin chemomyectomy presently represents the only permanent, nonsurgical treatment for blepharospasm and hemifacial spasm. The major deterrent to an otherwise extremely effective treatment protocol is the development in patients of localized inflammation, discomfort, and skin injury over the injection sit...

journal_title：Investigative ophthalmology & visual science

authors： McLoon LK,Wirtschafter JD

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:We characterized fluorescent bone marrow cells (YFP(+) BMCs) in the thy1-YFP mouse and determine if they promote trigeminal ganglion (TG) cell neurite growth. METHODS:Excimer laser annular keratectomy was performed in thy1-YFP mice, and corneas were imaged. BMCs were harvested from femur and tibia, and the exp...

journal_title：Investigative ophthalmology & visual science

authors： Sarkar J,Chaudhary S,Jassim SH,Ozturk O,Chamon W,Ganesh B,Tibrewal S,Gandhi S,Byun YS,Hallak J,Mahmud DL,Mahmud N,Rondelli D,Jain S

更新日期：2013-09-03 00:00:00

abstract：:PURPOSE. To examine the biomechanical deformation of load bearing structures of the optic nerve head (ONH) resulting from raised intracranial pressure, using high definition optical coherence tomography (HD-OCT). The authors postulate that elevated intracranial pressure induces forces in the retrolaminar subarachnoid ...

journal_title：Investigative ophthalmology & visual science

authors： Kupersmith MJ,Sibony P,Mandel G,Durbin M,Kardon RH

更新日期：2011-08-22 00:00:00

abstract：PURPOSE:Dry eye disease (DED) produces ocular pain and irritation, yet a detailed characterization of ocular sensitivity in a preclinical model of DED is lacking. The aim of the present study was to assess nociceptive behaviors in an aqueous tear deficiency model of DED in the rat. METHODS:Spontaneous blinking, cornea...

journal_title：Investigative ophthalmology & visual science

authors： Meng ID,Barton ST,Mecum NE,Kurose M

更新日期：2015-05-01 00:00:00

abstract：Purpose:To investigate foveal avascular zone (FAZ) changes in the superficial (SCP) and deep (DCP) capillary plexuses in beta-thalassemia major (BTM) patients, as shown in optical coherence tomography angiography. Methods:Nonrandomized, comparative case series of 54 eyes of 27 BTM patients and 46 eyes of 23 healthy co...

journal_title：Investigative ophthalmology & visual science

authors： Georgalas I,Makris G,Papaconstantinou D,Petrou P,Chalkiadaki E,Droutsas K,Andreanos K,Kanakis M

更新日期：2019-09-03 00:00:00

abstract：PURPOSE:Looping patterns rich in laminin are present in tissue samples of primary aggressive human uveal melanomas and their metastases. Because these extravascular patterns connect to blood vessels and transmit fluid in vitro and in vivo, the three-dimensional configuration of these patterns has been the subject of co...

journal_title：Investigative ophthalmology & visual science

authors： Chen X,Ai Z,Rasmussen M,Bajcsy P,Auvil L,Welge M,Leach L,Vangveeravong S,Maniotis AJ,Folberg R

更新日期：2003-07-01 00:00:00

abstract：:Photoreceptor-mediated mechanisms were studied in patients with a recently identified retinopathy typified by night blindness, cystoid maculopathy, and similar scotopic and photopic electroretinograms (ERGs). Dark-adapted spectral sensitivity functions were only partly explained as composites of rod and cone curves sh...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Marmor MF,Kemp CM,Knighton RW

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:The authors' previous study showed that the expression of a Rho-associated serine/threonine kinase (ROCK) is regulated during cell cycle progression in corneal epithelial cells. The present study was conducted to determine whether and how Rho/ROCK signaling regulates cell cycle progression. METHODS:Rabbit corn...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,Guerriero E,Lathrop K,SundarRaj N

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:In addition to photoreceptor degeneration, excessive light causes degenerative alterations in the inner retina and ganglion cell death. A disturbance in osmohomeostasis may be one causative factor for the alterations in the inner retina. Because Müller cells mediate inner retinal osmohomeostasis (mainly through...

journal_title：Investigative ophthalmology & visual science

authors： Iandiev I,Wurm A,Hollborn M,Wiedemann P,Grimm C,Remé CE,Reichenbach A,Pannicke T,Bringmann A

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a biodegradable scleral plug containing ganciclovir (GCV) in a rabbit model of human cytomegalovirus (HCMV) retinitis. METHODS:To develop a rabbit model for HCMV retinitis, HCMV solution was injected once into the vitreous cavity of pigmented rabbits. The treated animals were divide...

journal_title：Investigative ophthalmology & visual science

authors： Sakurai E,Matsuda Y,Ozeki H,Kunou N,Nakajima K,Ogura Y

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:To examine the histologic and ultrastructural changes in Bruch's membrane (BM) in apolipoprotein E deficient [ApoE(-)] mice in comparison with age-matched control animals. METHODS:Two-month-old (group 1) and 8-month-old (group 2) normal control C57BL/6 mice and 2-month-old (group 3) and 8-month-old (group 4) A...

journal_title：Investigative ophthalmology & visual science

authors： Dithmar S,Curcio CA,Le NA,Brown S,Grossniklaus HE

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:Classic studies have demonstrated that corneal epithelial cell density in culture can alter the balance of stimulatory and inhibitory cytokines controlling the elaboration of collagenolytic activity by co-cultured stromal cells. The current study attempts to bring the understanding of this mechanism to a molecu...

journal_title：Investigative ophthalmology & visual science

authors： Strissel KJ,Rinehart WB,Fini ME

更新日期：1997-02-01 00:00:00

abstract：PURPOSE:This study sought to examine the acute effects of ocular ischemia and reperfusion on retinal function and determine the extent to which recovery during reperfusion is improved by allopurinol (AP), a blocker of xanthine oxidase (XO). The latter is presumed to be a major factor in the formation of free radicals a...

journal_title：Investigative ophthalmology & visual science

authors： Peachey NS,Green DJ,Ripps H

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Somatostatin (SST) analogues have been used to treat proliferative diabetic retinopathy, pseudotumor cerebri, thyroid orbitopathy, and cystoid macular edema. There is a paucity of published data in regards to cell-specific distribution of SST receptors (SSTR) in normal human eye tissues. Gene expression for all...

journal_title：Investigative ophthalmology & visual science

authors： Klisovic DD,O'Dorisio MS,Katz SE,Sall JW,Balster D,O'Dorisio TM,Craig E,Lubow M

更新日期：2001-09-01 00:00:00

abstract：PURPOSE:To evaluate the immunosuppressive and antiangiogenic activities of an intraocular rapamycin (RAPA) drug delivery system (DDS) in a rabbit model of high-risk penetrating keratoplasty. METHODS:Forty New Zealand White rabbits with corneal neovascularization underwent allograft cornea transplantation and were rand...

journal_title：Investigative ophthalmology & visual science

authors： Shi W,Gao H,Xie L,Wang S

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:To clarify the functions of a specific subtype of thyroid hormone receptor (TR), TRbeta2, and photoreceptor cell-specific nuclear receptor (PNR) in the development of cone photoreceptors. METHODS:The expression of short (S)- and medium (M)-wavelength cone opsins was analyzed by reverse transcription polymerase...

journal_title：Investigative ophthalmology & visual science

authors： Yanagi Y,Takezawa S,Kato S

更新日期：2002-11-01 00:00:00

abstract：:One eye of each of eight subjects was exposed to gases containing oxygen concentrations of 1.0%, 2.5%, 4.9%, 7.5%, 10.1%, and 21.4% (oxygen partial pressures ranging from 8 to 158 mmHg) for 8 hr. The precorneal oxygen concentration required to avoid corneal edema for the group as a whole was 10.1% (an oxygen tension o...

journal_title：Investigative ophthalmology & visual science

authors： Holden BA,Sweeney DF,Sanderson G

更新日期：1984-04-01 00:00:00

abstract：Purpose:Uveitis is a major cause of sight loss across the world. The reliable assessment of intraocular inflammation in uveitis ('disease activity') is essential in order to score disease severity and response to treatment. In this review, we describe how 'quantitative imaging', the approach of using automated analysis...

journal_title：Investigative ophthalmology & visual science

authors： Denniston AK,Keane PA,Srivastava SK

更新日期：2017-05-01 00:00:00

abstract：:The color matches of 46 retinitis pigmentosa (RP) patients were found to differ significantly from those of 55 unaffected observers. The color matches of group I (trichromatic) RP observers were more protanomalous (i.e., required a greater red/green mixture ratio) than those of unaffected observers. The matches of gro...

journal_title：Investigative ophthalmology & visual science

authors： Young RS,Fishman GA

更新日期：1980-08-01 00:00:00

abstract：PURPOSE:Viral conjunctivitis is a highly contagious infection often causing major epidemics. A safe broad-spectrum antiviral agent is needed to treat this unmet medical need. The purpose of this study is to demonstrate that in vitro NVC-422 is a safe, broad-spectrum topical virucidal agent with activity against ophthal...

journal_title：Investigative ophthalmology & visual science

authors： Jekle A,Abdul Rani S,Celeri C,Zuck M,Xu P,Wang L,Najafi-Tagol K,Anderson M,Stroman D,Debabov D

更新日期：2013-02-19 00:00:00

abstract：PURPOSE:To investigate the hypothesis that tumor-infiltrating macrophages contribute to prognosis of uveal melanoma and to study their association with tumor characteristics, especially microvessels. METHODS:This was a retrospective, population-based cohort study of 167 consecutive patients who had had an eye with cho...

journal_title：Investigative ophthalmology & visual science

authors： Mäkitie T,Summanen P,Tarkkanen A,Kivelä T

更新日期：2001-06-01 00:00:00