Retinomotor pigment migration in the teleost retinal pigment epithelium. II. Cyclic-3',5'-adenosine monophosphate induction of dark-adaptive movement in vitro.

abstract：PURPOSE:To provide a clinical and genetic description of a patient cohort with Stargardt disease (STGD1) with identifiable foveal sparing. METHODS:Patients with retinal atrophy (defined as an absence of autofluorescence) that surrounded the fovea by at least 180° and did not include the fovea were defined as having fo...

journal_title：Investigative ophthalmology & visual science

authors： van Huet RA,Bax NM,Westeneng-Van Haaften SC,Muhamad M,Zonneveld-Vrieling MN,Hoefsloot LH,Cremers FP,Boon CJ,Klevering BJ,Hoyng CB

更新日期：2014-10-16 00:00:00

abstract：Purpose:To quantify associations between microvascular density and retinal ganglion cell (RGC) axonal volume in the laminar compartments of the human optic nerve head (ONH). Methods:Eleven normal human ONHs were evaluated. Antibodies were used to label the vascular endothelium (factor VIII-related antigen/von Willebra...

journal_title：Investigative ophthalmology & visual science

authors： Kang MH,Suo M,Balaratnasingam C,Yu PK,Morgan WH,Yu DY

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:We examined changes of the central nervous system in patients with advanced primary open-angle glaucoma (POAG). METHODS:The clinical observational study included 15 patients with bilateral advanced POAG and 15 healthy normal control subjects, matched for age and sex with the study group. Retinal nerve fiber l...

journal_title：Investigative ophthalmology & visual science

authors： Chen WW,Wang N,Cai S,Fang Z,Yu M,Wu Q,Tang L,Guo B,Feng Y,Jonas JB,Chen X,Liu X,Gong Q

更新日期：2013-01-17 00:00:00

abstract：PURPOSE:To investigate effects of aging on endothelial nitric oxide synthase (eNOS) expression and signaling in angular aqueous plexus (AAP) (functional equivalent to human Schlemm's canal) cells subjected to shear stress. METHODS:The AAP cells were isolated differentially from porcine outflow tissues using puromycin ...

journal_title：Investigative ophthalmology & visual science

authors： Lei Y,Stamer WD,Wu J,Sun X

更新日期：2014-11-06 00:00:00

abstract：PURPOSE:To compare action spectra for visual discomfort in the fovea and the parafovea and to determine the effect of macular pigment (MP). METHODS:Visual discomfort thresholds to lights from 440 to 600 nm were obtained for six young (<35 y), visually normal subjects with a wide range of MP densities (0.10-0.71 at 30'...

journal_title：Investigative ophthalmology & visual science

authors： Stringham JM,Snodderly DM

更新日期：2013-09-19 00:00:00

abstract：:The binding of plasma fibronectin to the collagens I, II, and III was greater in a cohort of glaucoma patients. In contrast, binding of plasma fibronectin to collagen type IV was less in 39 glaucoma patients than in any of 3 other diagnostic categories, including 92 patients that were normal, cataract, and glaucoma su...

journal_title：Investigative ophthalmology & visual science

authors： Worthen DM,Cleveland PH,Slight JR,Abare J

更新日期：1985-12-01 00:00:00

abstract：PURPOSE:To characterize the possible role of transducin Gtβγ-complex in modulating the signaling properties of photoactivated rhodopsin and its lifetime in rod disc membranes and intact rods. METHODS:Rhodopsin photolysis was studied using UV-visible spectroscopy and rapid scanning spectroscopy in the presence of hydro...

journal_title：Investigative ophthalmology & visual science

authors： Lomonosova E,Kolesnikov AV,Kefalov VJ,Kisselev OG

更新日期：2012-03-09 00:00:00

abstract：:The extracellular matrix of retinal pigment epithelial (RPE) cells is an important component of the fibroelastic membranes formed in proliferative vitreoretinopathy (PVR). These membranes consist of cells intermingled with fibrillar proteins, such as elastin and collagen. Because RPE cells may be exposed to vitreous a...

journal_title：Investigative ophthalmology & visual science

authors： Martini B,Pandey R,Ogden TE,Ryan SJ

更新日期：1992-03-01 00:00:00

abstract：:Light and electron microscopic studies were done on 11 cynomolgus monkey eyes which had undergone total iris removal followed by surgical disinsertion of the ciliary muscle from the scleral spur 4.7 to 14.4 months earlier. Anterior chamber perfusion to measure gross outflow facility had been performed one to nine time...

journal_title：Investigative ophthalmology & visual science

authors： Lütjen-Drecoll E,Kaufman PL,Bárány EH

更新日期：1977-03-01 00:00:00

abstract：:Purpose. To establish a theoretical model to determine the relationship between retinal coverage and tamponade shape in relation to tamponade volume, for a variety of tamponades, and to test these relationships with a physical analogue of the human eye. Methods. The theoretical model was based on a static balance betw...

journal_title：Investigative ophthalmology & visual science

authors： Eames I,Angunawela RI,Aylward GW,Azarbadegan A

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:Amniotic membrane transplantation (AMT) reportedly improves herpetic stromal keratitis (HSK). Here we studied the role of the amniotic membrane (AM) on macrophages. METHODS:BALB/c mice with necrotizing HSK received an AMT or tarsorrhaphy (TAR) as control. Apoptosis of F4/80+ cells was determined using the anne...

journal_title：Investigative ophthalmology & visual science

authors： Bauer D,Hennig M,Wasmuth S,Baehler H,Busch M,Steuhl KP,Thanos S,Heiligenhaus A

更新日期：2012-02-21 00:00:00

abstract：PURPOSE:Mutations in the mitochondrial dynamin-related GTPase OPA1 cause autosomal dominant optic atrophy (ADOA), but the pathophysiology of this disease is unknown. As a first step in functional studies, this study was conducted to evaluate the expression of Opa1 in whole retina and in isolated retinal ganglion cells ...

journal_title：Investigative ophthalmology & visual science

authors： Kamei S,Chen-Kuo-Chang M,Cazevieille C,Lenaers G,Olichon A,Bélenguer P,Roussignol G,Renard N,Eybalin M,Michelin A,Delettre C,Brabet P,Hamel CP

更新日期：2005-11-01 00:00:00

abstract：PURPOSE:Rabbits are commonly used for the evaluation of drugs and surgery to lower intraocular pressure (IOP). The accuracy of intraocular pressure measurement is therefore critical in the analysis of data and subsequent extrapolation to humans. The purpose of this study was to establish the most reliable technique, fr...

journal_title：Investigative ophthalmology & visual science

authors： Lim KS,Wickremasinghe SS,Cordeiro MF,Bunce C,Khaw PT

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:To determine the disease course of retinal dystrophy caused by recessive variants in the DRAM2 (damage-regulated autophagy modulator 2) gene. METHODS:Sixteen individuals with DRAM2-retinopathy were examined (six families; age range, 19-56 years, includes one pre-symptomatic case). The change in visual acuity o...

journal_title：Investigative ophthalmology & visual science

authors： Sergouniotis PI,McKibbin M,Robson AG,Bolz HJ,De Baere E,Müller PL,Heller R,El-Asrag ME,Van Schil K,Plagnol V,Toomes C,Uk Inherited Retinal Disease Consortium.,Ali M,Holder GE,Charbel Issa P,Leroy BP,Inglehearn CF,Webste

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:The objective of this systematic review was to examine the evidence on zinc intake from foods and supplements in the primary prevention and treatment of AMD. METHODS:Randomized controlled trials (RCTs), prospective cohort, retrospective cohort, and case-control studies that investigated zinc intake from foods ...

journal_title：Investigative ophthalmology & visual science

authors： Vishwanathan R,Chung M,Johnson EJ

更新日期：2013-06-12 00:00:00

abstract：PURPOSE:To determine the concentration of group II phospholipase (PL) A(2), an antimicrobial molecule, in tears of normal subjects in different age and sex groups. METHODS:PLA(2) content of tears was measured in 122 healthy volunteers with ages ranging from 20 to 89 years (mean, 49.5 years) by a time-resolved fluoroim...

journal_title：Investigative ophthalmology & visual science

authors： Saari KM,Aho V,Paavilainen V,Nevalainen TJ

更新日期：2001-02-01 00:00:00

abstract：PURPOSE:Adipose-derived stem cells (ASCs) have gained importance due to their myriad potential clinical applications. We hypothesize that progenitor cells also exist besides those conventionally isolated from the stromal vascular fraction (SVF). METHOD:Central and medial orbital adipose tissues obtained from patients ...

journal_title：Investigative ophthalmology & visual science

authors： Chen SY,Mahabole M,Horesh E,Wester S,Goldberg JL,Tseng SC

更新日期：2014-07-03 00:00:00

abstract：PURPOSE:Bayesian estimators allow the frequency of visual field progression rates in the population (the prior distribution) to constrain rate estimates for individuals. We examined the benefits of a prior distribution accounting for one of progression's major risk factors--whether intraocular pressure is treated--to g...

journal_title：Investigative ophthalmology & visual science

authors： Anderson AJ,Johnson CA

更新日期：2013-03-01 00:00:00

abstract：:Recent work demonstrated that a mannose receptor is involved in the phagocytosis of rod outer segments by the rat retinal pigment epithelium (RPE). In this study the binding of soluble mannose-containing ligands by human RPE explants is described. In addition, the authors report the isolation of a mannose receptor fro...

journal_title：Investigative ophthalmology & visual science

authors： Shepherd VL,Tarnowski BI,McLaughlin BJ

更新日期：1991-05-01 00:00:00

abstract：PURPOSE:To mathematically analyze and to clinically describe specific anatomic foveal configurations predisposing to the formation of macular holes in comparison with normal foveal anatomy. METHODS:In a retrospective observational case-control series, a total of 3882 optical coherence tomography (OCT) foveal thickness...

journal_title：Investigative ophthalmology & visual science

authors： Barak Y,Sherman MP,Schaal S

更新日期：2011-10-21 00:00:00

abstract：PURPOSE:To describe and interpret "choroidal caverns," an unreported optical coherence tomography (OCT) finding in the choroid of patients with geographic atrophy (GA) secondary to atrophic AMD. METHODS:Retrospective analysis of patients with GA. Main outcomes measures included estimation of the prevalence of choroida...

journal_title：Investigative ophthalmology & visual science

authors： Querques G,Costanzo E,Miere A,Capuano V,Souied EH

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:To determine the roles of glial fibrillary acidic protein (GFAP) and vimentin in Müller cell reactivity. METHODS:Retinal detachments were created in mice deficient for GFAP and vimentin (GFAP(-/-)vim(-/-)) and age-matched wild-type (wt) mice. The reactivity of the retina was studied by immunofluorescence and e...

journal_title：Investigative ophthalmology & visual science

authors： Verardo MR,Lewis GP,Takeda M,Linberg KA,Byun J,Luna G,Wilhelmsson U,Pekny M,Chen DF,Fisher SK

更新日期：2008-08-01 00:00:00

abstract：:Adaptation of saccadic magnitude and vestibulo-ocular reflex gain (VOR) was examined in six monkeys that had undergone a tenectomy of the medial and lateral recti of one eye. After the tenectomy, when the normal eye was patched, a conjugate increase in saccadic magnitude and VOR was observed in both eyes. Subsequent u...

journal_title：Investigative ophthalmology & visual science

authors： Snow R,Hore J,Vilis T

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:To evaluate the potential role that FoxO transcription factors play in modulating resveratrol's protective effects against oxidative stress in lens epithelial cells. METHODS:Primary human or porcine lens epithelial cells (LECs) were treated with resveratrol (RES) 25 μM and incubated under either physiologic (5...

journal_title：Investigative ophthalmology & visual science

authors： Li G,Luna C,Navarro ID,Epstein DL,Huang W,Gonzalez P,Challa P

更新日期：2011-06-21 00:00:00

abstract：Purpose:To investigate brain white matter pathways using magnetic resonance diffusion tensor imaging (DTI) and correlate the findings with developmental outcomes at 18 months of corrected age in preterm infants with and without retinopathy of prematurity (ROP). Methods:In this prospective cohort study, probabilistic m...

journal_title：Investigative ophthalmology & visual science

authors： Ahn SJ,Lee JY,Lee JY,Lee YJ,Lee JM,Lee BR,Kim J,Lee HJ

更新日期：2021-02-01 00:00:00

abstract：Purpose:To examine the association between intraocular pressure (IOP) and the prevalence of glaucomatous optic neuropathy (GON) in high myopia. Methods:The hospital-based observational study consisted of patients treated in the Tokyo High Myopia Clinics and for whom fundus photographs and IOP readings were available. ...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Nagaoka N,Fang YX,Weber P,Ohno-Matsui K

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Inflammatory status of RPE cells induced by A2E is essential in the development of AMD. Recent research indicated T-cell immunity was involved in the pathological progression of AMD. This study was designed to investigate how A2E suppresses immunoregulatory function of RPE cells in T-cell immunity in vitro. ME...

journal_title：Investigative ophthalmology & visual science

authors： Shi Q,Wang Q,Li J,Zhou X,Fan H,Wang F,Liu H,Sun X,Sun X

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:The selective muscarinic antagonist pirenzepine inhibits experimentally induced myopia in avian and mammalian species, including nonhuman primates and adolescent humans. Transient positive lens defocus has a potent inhibitory effect on negative-lens-induced myopia in avian and mammalian models. The purpose of t...

journal_title：Investigative ophthalmology & visual science

authors： Metlapally S,McBrien NA

更新日期：2010-11-01 00:00:00

abstract：:Fibroblasts in the retroocular connective tissue appear to play a central role in the pathogenesis of Graves' ophthalmopathy (GO). We hypothesize that specific attributes, differentiating normal from GO retroocular fibroblasts, may render the latter more vulnerable to the ongoing immunopathological process in GO. We i...

journal_title：Investigative ophthalmology & visual science

authors： Heufelder AE,Wenzel BE,Bahn RS

更新日期：1992-02-01 00:00:00

abstract：PURPOSE:To screen polymorphisms in complement factor-H (CFH), toll-like receptor 4 (TLR4), and APOE genes as potential risk factors for age-related macular degeneration (AMD) in Indian patients. METHODS:One hundred patients with AMD and 120 normal control subjects were screened for the polymorphisms by restriction dig...

journal_title：Investigative ophthalmology & visual science

authors： Kaur I,Hussain A,Hussain N,Das T,Pathangay A,Mathai A,Hussain A,Nutheti R,Nirmalan PK,Chakrabarti S

更新日期：2006-09-01 00:00:00