Differentiation-dependent expression of alpha-2,3-sialyltransferase in rabbit corneal epithelium.

abstract：Purpose:To examine the coaggregation and cohesion between the commonly isolated bacteria from contact lens cases. Methods:Four or five strains each of commonly isolated bacteria from contact lens cases, Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Serratia marcescens, were grown, wash...

journal_title：Investigative ophthalmology & visual science

authors： Datta A,Stapleton F,Willcox MD

更新日期：2017-01-01 00:00:00

abstract：:The efficacy of intravitreally administered amphotericin B was evaluated. Experimental fungal infections were produced by inoculation of Candida albicans organisms into the vitreous cavities of 46 rabbit eyes. After 72 hr, eight eyes received intravitreal injections of 10 micrograms of free amphotericin B; and ten eye...

journal_title：Investigative ophthalmology & visual science

authors： Liu KR,Peyman GA,Khoobehi B

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:To investigate whether enzymatic collagen breakdown is an active process in the human vitreous. METHODS:Human donor eyes were used for immunohistochemistry to detect the possible presence of the matrix metalloproteinase (MMP)-induced type II collagen breakdown product col2-3/4C-short in the vitreous. Western b...

journal_title：Investigative ophthalmology & visual science

authors： van Deemter M,Pas HH,Kuijer R,van der Worp RJ,Hooymans JM,Los LI

更新日期：2009-10-01 00:00:00

abstract：PURPOSE:We evaluated whether UVA-riboflavin collagen cross-linking (CXL) increases transverse stromal shear moduli ex vivo, whether the shear moduli are greater in the anterior compared to the posterior stroma, and whether the shear moduli are affected by CXL. METHODS:The resistance to unidirectional transverse shear ...

journal_title：Investigative ophthalmology & visual science

authors： Søndergaard AP,Ivarsen A,Hjortdal J

更新日期：2013-07-26 00:00:00

abstract：PURPOSE:To evaluate age-related Meibomian gland (MG) changes by in vivo laser scanning confocal microscopy (LSCM). METHODS:Asymptomatic healthy subjects (n=100, age range 20-83 years) with an Ocular Surface Disease Index score of less than 13 were consecutively enrolled. Two additional groups, one composed of subjects...

journal_title：Investigative ophthalmology & visual science

authors： Villani E,Canton V,Magnani F,Viola F,Nucci P,Ratiglia R

更新日期：2013-07-16 00:00:00

abstract：PURPOSE:To compare anterior segment parameters, assessed by anterior segment optical coherence tomography (ASOCT), in subjects categorized as primary angle closure suspect (PACS), primary angle closure (PAC), primary angle closure glaucoma (PACG), and previous acute PAC (APAC); and to identify factors associated with A...

journal_title：Investigative ophthalmology & visual science

authors： Guzman CP,Gong T,Nongpiur ME,Perera SA,How AC,Lee HK,Cheng L,He M,Baskaran M,Aung T

更新日期：2013-08-07 00:00:00

abstract：Purpose:To assess changes in Schlemm's canal (SC), intraocular pressure (IOP), and autonomic nervous system activity in healthy individuals after performing the water-drinking test (WDT). Methods:The SC area (SCAR), trabecular meshwork (TM) thickness, IOP, high frequency (HF) of heart rate variability (HRV), heart rat...

journal_title：Investigative ophthalmology & visual science

authors： Chen W,Chen L,Chen Z,Xiang Y,Liu S,Zhang H,Wang J

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:As in human populations, in which founder mutations have been identified in groups of families, a number of founder mutations have been observed across strains in mice. In this report, we provide a phenotype and genotype survey of three common eye diseases in the collection of JAX mice strains at The Jackson La...

journal_title：Investigative ophthalmology & visual science

authors： Chang B,Hurd R,Wang J,Nishina P

更新日期：2013-07-24 00:00:00

abstract：:This paper investigates the amplitude of accommodation of early onset myopes, late onset myopes, emmetropes, and hyperopes. Eighty subjects were used, 41 women and 39 men, with an age range of 18-22 yr (mean = 19.82). All subjects wore an optimum refractive correction, giving visual acuities of 20/20 or better. Signif...

journal_title：Investigative ophthalmology & visual science

authors： McBrien NA,Millodot M

更新日期：1986-07-01 00:00:00

abstract：:Although the lens has been shown to have the capacity to respond to insulin in vitro, little is known concerning the biochemical relationships of insulin to the lens in vivo. Therefore we have measured insulin in the aqueous humor of rabbits by a sensitive radioimmunoassay after paracentesis and feeding. The insulin c...

journal_title：Investigative ophthalmology & visual science

authors： Coulter JB 3rd,Engelke JA,Eaton DK

更新日期：1980-12-01 00:00:00

abstract：:Chloride ion (Cl-) secretion by the rabbit corneal epithelium involves a catecholamine-stimulated Cl- conductance at the apical membrane, but the characteristics of the ion channel(s) responsible are unknown. A primary cell culture system was developed that induces stratified epithelial differentiation of rat and rabb...

journal_title：Investigative ophthalmology & visual science

authors： Marshall WS,Hanrahan JW

更新日期：1991-04-01 00:00:00

abstract：PURPOSE:To investigate the relationship between ornithine-delta-aminotransferase (OAT) deficiency and ornithine accumulation and the specific degeneration of retinal pigment epithelial (RPE) cells in gyrate atrophy. METHODS:Human RPE cells, human hepatoma cells, and human fibroblast cells were treated with 5-fluoromet...

journal_title：Investigative ophthalmology & visual science

authors： Ueda M,Masu Y,Ando A,Maeda H,Del Monte MA,Uyama M,Ito S

更新日期：1998-04-01 00:00:00

abstract：:In order to determine whether a possible barrier exists to diffusion of tracer into the optic nerve during development and to provide a basis for later studies of retrograde axonal transport in embryonic nerves, we studied the diffusion of horseradish peroxidase (HRP) into the nerve after vitreal injections in chicks ...

journal_title：Investigative ophthalmology & visual science

authors： Kistler HB Jr,LaVail JH

更新日期：1981-06-01 00:00:00

abstract：Purpose:To investigate the effect of reducing high glucose (HG)-induced lysyl oxidase (LOX) overexpression and increased activity on retinal endothelial cell apoptosis. Methods:Rat retinal endothelial cells (RRECs) were grown in normal (N) or HG (30 mM glucose) medium for 7 days. In parallel, RRECs were grown in HG me...

journal_title：Investigative ophthalmology & visual science

authors： Kim D,Mecham RP,Trackman PC,Roy S

更新日期：2017-05-01 00:00:00

abstract：Purpose:Extremely preterm infants are at increased risk for retinopathy of prematurity (ROP). We previously identified several inflammatory proteins that were expressed early in life and are associated with an increased risk of ROP and several angiogenic and neurotrophic growth factors in the neonatal systemic circulat...

journal_title：Investigative ophthalmology & visual science

authors： Bulka CM,Dammann O,Santos HP Jr,VanderVeen DK,Smeester L,Fichorova R,O'Shea TM,Fry RC

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To characterize the phagocytosis of extracellular matrix components by retinal pigment epithelial cells and to determine which receptors and signal transduction pathways are involved. METHODS:Fluorescent latex beads were coated with fibronectin (FN), collagen type I or IV, or thrombospondin and incubated with ...

journal_title：Investigative ophthalmology & visual science

authors： Zhao MW,Jin ML,He S,Spee C,Ryan SJ,Hinton DR

更新日期：1999-10-01 00:00:00

abstract：:Increased vascular permeability, one of the characteristic features of immediate hypersensitivity (Type I), is mediated through a variety of compounds, including histamine and platelet-activating factor (PAF), a phospholipid inflammatory mediator. The effects on vascular permeability of histamine, PAF, and ethanol, th...

journal_title：Investigative ophthalmology & visual science

authors： Stock EL,Roth SI,Kim ED,Walsh MK,Thamman R

更新日期：1990-05-01 00:00:00

abstract：PURPOSE:Optic neuritis (ON) is a condition involving primary inflammation, demyelination, and axonal injury in the optic nerve and leads to apoptotic retinal ganglion cell (RGC) death, which contributes to the persistence of visual loss. Currently, ON has no effective treatment. The goal was to determine the effectiven...

journal_title：Investigative ophthalmology & visual science

authors： Adamus G,Brown L,Andrew S,Meza-Romero R,Burrows GG,Vandenbark AA

更新日期：2012-01-25 00:00:00

abstract：PURPOSE:To quantitate in vivo retinal ganglion cell (RGC) survival after transient periods of pressure-induced ischemia of the rat retina and after different survival intervals. METHODS:In adult rats, RGCs were labeled with fluorogold applied to their main targets in the brain. Seven days later, in several groups of r...

journal_title：Investigative ophthalmology & visual science

authors： Sellés-Navarro I,Villegas-Pérez MP,Salvador-Silva M,Ruiz-Gómez JM,Vidal-Sanz M

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:To determine the mechanism by which basic fibroblast growth factor (bFGF) exerts its neuroprotective effects on degenerating or injured photoreceptors. METHODS:Confocal immunofluorescence microscopy was used to identify sites of bFGF and FGF receptor 1 (FGFR1) expression after focal injury or experimental reti...

journal_title：Investigative ophthalmology & visual science

authors： Ozaki S,Radeke MJ,Anderson DH

更新日期：2000-02-01 00:00:00

abstract：:The short-term fluctuation in regular grid threshold static fields is commonly determined from repeated observations of a number of threshold points. In this study we estimated the short-term fluctuation from a single determination of the field. Sixty-two eyes of 62 patients were tested, using three consecutive repeti...

journal_title：Investigative ophthalmology & visual science

authors： Schulzer M,Mills RP,Hopp RH,Lau W,Drance SM

更新日期：1990-04-01 00:00:00

abstract：Purpose:To define the nature and extent of temporal frequency abnormalities in diabetics who have mild or no nonproliferative diabetic retinopathy (NPDR) by using the flicker electroretinogram (ERG). Methods:Light-adapted flicker ERGs were recorded from 20 diabetics who have no clinically apparent retinopathy, 20 diab...

journal_title：Investigative ophthalmology & visual science

authors： McAnany JJ,Park JC

更新日期：2018-10-01 00:00:00

abstract：:Advanced macular degeneration is an important cause of vision loss in the United States with over 2 million people affected by the disease. Despite substantial progress in the development of new therapies for wet AMD, the severe visual impairment associated with geographic atrophy in dry AMD or Stargardt disease remai...

journal_title：Investigative ophthalmology & visual science

authors： Schwartz SD,Tan G,Hosseini H,Nagiel A

更新日期：2016-04-01 00:00:00

abstract：Purpose:Epithelial to mesenchymal transition (EMT) is a cause of anterior and posterior subcapsular cataracts. Central to EMT is the formation of actin stress fibers. Selective targeting of actin stress fiber-associated tropomyosin (Tpm) in epithelial cells may be a means to prevent stress fiber formation and repress l...

journal_title：Investigative ophthalmology & visual science

authors： Parreno J,Amadeo MB,Kwon EH,Fowler VM

更新日期：2020-06-03 00:00:00

abstract：PURPOSE:Sorsby fundus dystrophy (SFD) is a rare, late-onset macular dystrophy caused by mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) gene. The known mutations introduce potentially unpaired cysteine residues in the C terminus of the protein and result in the formation of higher-molecular-weight pro...

journal_title：Investigative ophthalmology & visual science

authors： Weber BH,Lin B,White K,Kohler K,Soboleva G,Herterich S,Seeliger MW,Jaissle GB,Grimm C,Reme C,Wenzel A,Asan E,Schrewe H

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:We tested the hypothesis that retinal blood flow has a postocclusive reactive hyperemia response modulated by occlusion duration and metabolic activity, and that choroidal blood flow does not. METHODS:Anesthetized and paralyzed rats (n = 34) were studied. Retinal and choroidal blood flow was measured by laser ...

journal_title：Investigative ophthalmology & visual science

authors： Li G,Kiel JW,Cardenas DP,De La Garza BH,Duong TQ

更新日期：2013-07-30 00:00:00

abstract：PURPOSE:To investigate whether a recently described retinal ganglion cell (RGC) marker Rbpms (RNA binding protein with multiple splicing) could be used for RGC quantification in various models of RGC degeneration. METHODS:Optic nerve crush, excitotoxicity, and elevated intraocular pressure (IOP) rat models were used. ...

journal_title：Investigative ophthalmology & visual science

authors： Kwong JM,Quan A,Kyung H,Piri N,Caprioli J

更新日期：2011-12-28 00:00:00

abstract：:Retinoblastoma patients have cellular and humoral reactivity towards antigens expressed on retinoblastoma cells. We report the ultrastructural, cytogenetic, and immunologic features of four new retinoblastoma derived tissue culture cell lines. Studies with hybridoma produced monoclonal antibodies demonstrate that thes...

journal_title：Investigative ophthalmology & visual science

authors： Char DH,Wood IS,Huhta K,Rand N,Morita CT,Howes EL Jr

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:To develop a new test of activities of daily living (ADLs) appropriate for the low-vision population: the Melbourne Low-Vision ADL Index (MLVAI). METHODS:The MLVAI was designed as a desk-based clinical assessment, comprising 18 observed items on complex ADLs in part (a) and 9 questions on broad self-care ADLs ...

journal_title：Investigative ophthalmology & visual science

authors： Haymes SA,Johnston AW,Heyes AD

更新日期：2001-05-01 00:00:00

abstract：PURPOSE:Lens epithelial cells transdifferentiate to myofibroblasts during the formation of anterior subcapsular cataracts and secondary cataracts. One of the defining characteristics of myofibroblasts is the expression of alpha-smooth muscle actin (alpha-SMA). This study investigated some of the factors that influence ...

journal_title：Investigative ophthalmology & visual science

authors： Nagamoto T,Eguchi G,Beebe DC

更新日期：2000-04-01 00:00:00