Amplitude of accommodation and refractive error.

abstract：PURPOSE:Overloading of unfolded or misfolded proteins in the endoplasmic reticulum (ER) can cause ER stress and activate the unfolded protein response (UPR) in the cell. The authors tested whether transgene overexpression in the mouse lens would activate the UPR. METHODS:Transgenic mice expressing proteins that either...

journal_title：Investigative ophthalmology & visual science

authors： Reneker LW,Chen H,Overbeek PA

更新日期：2011-04-04 00:00:00

abstract：PURPOSE:To evaluate interictal visual dysfunction in persons with migraine in terms of spatiotemporal selectivity and location within the visual pathways. METHODS:The vision of a group of 15 persons who had experienced migraine with aura was compared with that of 15 normal age-matched control subjects. A range of thre...

journal_title：Investigative ophthalmology & visual science

authors： McKendrick AM,Vingrys AJ,Badcock DR,Heywood JT

更新日期：2001-03-01 00:00:00

abstract：PURPOSE:Evidence suggests that altered metabolism of amyloid precursor protein (APP) may play a role in the pathophysiology of retinal ganglion cell (RGC) death in the etiology of glaucoma. The authors sought to determine the distribution of APP and amyloid-beta (Abeta) in DBA/2J glaucomatous mouse retinas. METHODS:Th...

journal_title：Investigative ophthalmology & visual science

authors： Goldblum D,Kipfer-Kauer A,Sarra GM,Wolf S,Frueh BE

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:Lysophosphatidic acid (LPA) is a phospholipid growth factor that stimulates proliferation, chemotaxis, cation currents, and K(+) currents in retinal pigment epithelial (RPE) cells. LPA receptor transduction was analyzed in human and rat RPE cells. METHODS:Cells were cultured with standard methods, and signalin...

journal_title：Investigative ophthalmology & visual science

authors： Thoreson WB,Ryan JS,Shi C,Kelly ME,Bryson EJ,Toews ML,Ediger TL,Chacko DM

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:To identify the differently expressed micro (mi) RNAs in pterygium compared with normal conjunctiva and investigate the potential role of miRNAs in the pathogenesis of pterygium. METHODS:With microRNA microarray and quantitative RT-PCR, we identified that microRNA-122 (miR-122) was significantly decreased in p...

journal_title：Investigative ophthalmology & visual science

authors： Cui YH,Li HY,Gao ZX,Liang N,Ma SS,Meng FJ,Li ZJ,Pan HW

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:We characterized fluorescent bone marrow cells (YFP(+) BMCs) in the thy1-YFP mouse and determine if they promote trigeminal ganglion (TG) cell neurite growth. METHODS:Excimer laser annular keratectomy was performed in thy1-YFP mice, and corneas were imaged. BMCs were harvested from femur and tibia, and the exp...

journal_title：Investigative ophthalmology & visual science

authors： Sarkar J,Chaudhary S,Jassim SH,Ozturk O,Chamon W,Ganesh B,Tibrewal S,Gandhi S,Byun YS,Hallak J,Mahmud DL,Mahmud N,Rondelli D,Jain S

更新日期：2013-09-03 00:00:00

abstract：:On the assumption that myelin intrusion into the papilla and peripapillary region might occur with traumatic lesions of the optic nerve, a study was made of the clinical and histopathologic changes that might be expected. Nine monkey eyes were subjected to hemostat compression of the nerve close to the globe and studi...

journal_title：Investigative ophthalmology & visual science

authors： Cogan DG,Yee RD

更新日期：1977-05-01 00:00:00

abstract：PURPOSE:Visual sensations in patients with blindness and retinal degenerations may be restored by electrical stimulation of retinal neurons with implantable microelectrode arrays. A prospective trial was initiated to evaluate the safety and efficacy of a wireless intraocular retinal implant (EPIRET3) in six volunteers ...

journal_title：Investigative ophthalmology & visual science

authors： Roessler G,Laube T,Brockmann C,Kirschkamp T,Mazinani B,Goertz M,Koch C,Krisch I,Sellhaus B,Trieu HK,Weis J,Bornfeld N,Röthgen H,Messner A,Mokwa W,Walter P

更新日期：2009-06-01 00:00:00

abstract：:Purpose. Super-selective intra-ophthalmic artery chemotherapy (SSIOAC) is an eye-targeted drug-delivery strategy to treat retinoblastoma, the most prevalent primary ocular malignancy in children. Unfortunately, recent clinical reports associate adverse vascular toxicities with SSIOAC using melphalan, the most commonly...

journal_title：Investigative ophthalmology & visual science

authors： Steinle JJ,Zhang Q,Thompson KE,Toutounchian J,Yates CR,Soderland C,Wang F,Stewart CF,Haik BG,Williams JS,Jackson JS,Mandrell TD,Johnson D,Wilson MW

更新日期：2012-04-30 00:00:00

abstract：Purpose:To give a European regulatory overview of the requirements on and the use of biomarkers or surrogate endpoints in the development of drugs for ocular disease. Methods:Definitions, methods to validate new markers, and circumstances where surrogate endpoints can be appropriate are summarized. Results:The key en...

journal_title：Investigative ophthalmology & visual science

authors： Wickström K,Moseley J

更新日期：2017-05-01 00:00:00

abstract：:The susceptibility of Candida albicans to topical amphotericin B and natamycin was evaluated in a model of stromal keratitis in Dutch-belted rabbits and compared with minimal inhibitory concentrations in vitro. Treatment was delayed 24 hr to allow invasive disease to occur and was then continued for 5 days. Ten strain...

journal_title：Investigative ophthalmology & visual science

authors： O'Day DM,Ray WA,Robinson RD,Head WS,Savage AM

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:One of the methods used in macular translocation (MT) surgery for subfoveal neovascularization is to create a temporary total retinal detachment followed by a 360 degrees retinotomy. The whole retina is then shifted from the original surface of the retinal pigment epithelium (RPE), resulting in an unusual retin...

journal_title：Investigative ophthalmology & visual science

authors： Terasaki H,Miyake Y,Suzuki T,Niwa T,Piao CH,Suzuki S,Nakamura M,Kondo M

更新日期：2002-02-01 00:00:00

abstract：PURPOSE:Corneal allografts placed in human eyes at high risk often fail, and immune rejection is thought to be a major pathogenic factor. To understand the immunologic factors responsible for rejection in this instance, the authors have created "high-risk" eyes in mice by inducing corneal neovascularization. The author...

journal_title：Investigative ophthalmology & visual science

authors： Sano Y,Ksander BR,Streilein JW

更新日期：1995-10-01 00:00:00

abstract：:Adaptation of saccadic magnitude and vestibulo-ocular reflex gain (VOR) was examined in six monkeys that had undergone a tenectomy of the medial and lateral recti of one eye. After the tenectomy, when the normal eye was patched, a conjugate increase in saccadic magnitude and VOR was observed in both eyes. Subsequent u...

journal_title：Investigative ophthalmology & visual science

authors： Snow R,Hore J,Vilis T

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:To determine whether the severity of glaucomatous damage in eyes with pseudoexfoliative (PEX) glaucoma is related to the amount of PEX material in the trabecular meshwork. METHODS:Trabecular meshwork and optic nerves from 19 eyes (11 donors) with PEX syndrome were studied. Eyes were chosen to represent all sta...

journal_title：Investigative ophthalmology & visual science

authors： Gottanka J,Flügel-Koch C,Martus P,Johnson DH,Lütjen-Drecoll E

更新日期：1997-11-01 00:00:00

abstract：PURPOSE:To investigate feasibility and potential uses of flow cytometry in impression cytology as a new procedure to assess and quantify conjunctival inflammation. METHODS:Specimens for cytology were collected by impression from 30 patients with various chronic ocular surface disorders and from 10 normal subjects. Two...

journal_title：Investigative ophthalmology & visual science

authors： Baudouin C,Brignole F,Becquet F,Pisella PJ,Goguel A

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:meso-Zeaxanthin is a carotenoid that is rarely encountered in nature outside of the vertebrate eye. It is not a constituent of a normal human diet, yet this carotenoid comprises one-third of the primate macular pigment. In the current study, we undertook a systematic approach to biochemically characterize the p...

journal_title：Investigative ophthalmology & visual science

authors： Gorusupudi A,Shyam R,Li B,Vachali P,Subhani YK,Nelson K,Bernstein PS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Cortical cataract in humans is associated with Ca2+ overload and protein loss, and although animal models of cataract have implicated Ca2+-activated proteases in this process, it remains to be determined whether the human lens responds in this manner to conditions of Ca2+ overload. The purpose of these experime...

journal_title：Investigative ophthalmology & visual science

authors： Sanderson J,Marcantonio JM,Duncan G

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:Dry eye disease (DED) produces ocular pain and irritation, yet a detailed characterization of ocular sensitivity in a preclinical model of DED is lacking. The aim of the present study was to assess nociceptive behaviors in an aqueous tear deficiency model of DED in the rat. METHODS:Spontaneous blinking, cornea...

journal_title：Investigative ophthalmology & visual science

authors： Meng ID,Barton ST,Mecum NE,Kurose M

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To determine the effects of topical dorzolamide (a carbonic anhydrase inhibitor) on choroidal and ciliary blood flow and the relationship between ciliary blood flow and aqueous flow. METHODS:The experiments were performed in four groups of pentobarbital-anesthetized rabbits treated with topical dorzolamide (2%...

journal_title：Investigative ophthalmology & visual science

authors： Reitsamer HA,Bogner B,Tockner B,Kiel JW

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:To provide a clinical and genetic description of a patient cohort with Stargardt disease (STGD1) with identifiable foveal sparing. METHODS:Patients with retinal atrophy (defined as an absence of autofluorescence) that surrounded the fovea by at least 180° and did not include the fovea were defined as having fo...

journal_title：Investigative ophthalmology & visual science

authors： van Huet RA,Bax NM,Westeneng-Van Haaften SC,Muhamad M,Zonneveld-Vrieling MN,Hoefsloot LH,Cremers FP,Boon CJ,Klevering BJ,Hoyng CB

更新日期：2014-10-16 00:00:00

abstract：Purpose:To examine the association between intraocular pressure (IOP) and the prevalence of glaucomatous optic neuropathy (GON) in high myopia. Methods:The hospital-based observational study consisted of patients treated in the Tokyo High Myopia Clinics and for whom fundus photographs and IOP readings were available. ...

journal_title：Investigative ophthalmology & visual science

authors： Jonas JB,Nagaoka N,Fang YX,Weber P,Ohno-Matsui K

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:Multidrug resistance protein 4 (MRP4) effluxes a wide variety of endogenous compounds, including cyclic adenosine monophosphate (cAMP), and is exclusively expressed in vascular endothelial cells (ECs) of the retina. This study aimed to investigate the role of MRP4 in retinal vascular development. METHODS:The r...

journal_title：Investigative ophthalmology & visual science

authors： Matsumiya W,Kusuhara S,Hayashibe K,Maruyama K,Kusuhara H,Tagami M,Schuetz JD,Negi A

更新日期：2012-12-07 00:00:00

abstract：Purpose:The purpose of this study was to evaluate the antiangiogenic effect of gold nanoparticles (AuNPs) on experimental choroidal neovascularization (CNV) in mice. Methods:Choroidal neovascularization was induced by rupturing the Bruch's membrane using laser photocoagulation in C57BL/6 mice. The following day, intra...

journal_title：Investigative ophthalmology & visual science

authors： Roh YJ,Rho CR,Cho WK,Kang S

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To examine the relationship between short-wavelength-sensitive (SWS) resolution acuity and epidemiologically defined stages of early age-related maculopathy (ARM). METHODS:Subjects consisted of 88 adults aged 51 to 87 years. Psychophysical testing was undertaken in only one eye of each subject (the study eye)....

journal_title：Investigative ophthalmology & visual science

authors： Beirne RO,Hogg RE,Stevenson MR,Zlatkova MB,Chakravarthy U,Anderson RS

更新日期：2006-10-01 00:00:00

abstract：PURPOSE:To compare visual evoked potentials (VEPs) and contrast sensitivity in adults with early- or late-onset strabismic amblyopia. METHODS:Twelve adults with early- and 12 with late-onset strabismic amblyopia with similar ranges of visual acuity were studied. Pattern-onset VEPs to 30-minute checks were recorded at ...

journal_title：Investigative ophthalmology & visual science

authors： Davis AR,Sloper JJ,Neveu MM,Hogg CR,Morgan MJ,Holder GE

更新日期：2003-02-01 00:00:00

abstract：:This volume presents articles based on a workshop held June 14 to 16, 2013 in Rancho Palos Verde, CA sponsored by the Ocular Research Symposia Foundation (ORSF). The mission of the ORSF is to focus attention on unmet needs and current research opportunities in eye research with the objective of accelerating translatio...

journal_title：Investigative ophthalmology & visual science

authors： Chader GJ,Taylor A

更新日期：2013-12-13 00:00:00

abstract：Purpose:We investigated whether fundus autofluorescence (FAF) lifetimes in patients with retinitis pigmentosa display a disease-specific lifetime pattern. Methods:Fundus autofluorescence lifetime imaging ophthalmoscopy (FLIO) was performed in two spectral channels (498-560 and 560-720 nm) after excitation with a 473 n...

journal_title：Investigative ophthalmology & visual science

authors： Dysli C,Schuerch K,Escher P,Wolf S,Zinkernagel MS

更新日期：2018-04-01 00:00:00

abstract：Purpose:Treatment success in clinical trials for AMD would ideally be aligned to measurable performance in visual tasks rather than imperceptible changes on clinical charts. We test the hypothesis that patients with dry AMD perform worse than visually healthy peers on computer-based surrogates of "real-world" visual se...

journal_title：Investigative ophthalmology & visual science

authors： Taylor DJ,Smith ND,Crabb DP

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Methionine-sulfoxide reductases are unique, in that their ability to repair oxidized proteins and MsrA, which reduces S-methionine sulfoxide, can protect lens cells against oxidative stress damage. To date, the roles of MsrB1, -B2 and -B3 which reduce R-methionine sulfoxide have not been established for any mam...

journal_title：Investigative ophthalmology & visual science

authors： Marchetti MA,Pizarro GO,Sagher D,Deamicis C,Brot N,Hejtmancik JF,Weissbach H,Kantorow M

更新日期：2005-06-01 00:00:00