Intravitreal concentrations of a near-infrared fluorescence-labeled biotherapeutic determined in situ using confocal scanning laser ophthalmoscopy.

abstract：:Steady-state visual evoked potentials were elicited by the appearance/disappearance of sinusoidal gratings of varying spatial frequency for both eyes of amblyopic subjects. The amblyopic eyes showed reduced responses and a phase shift relative to the nonamblyopic eyes across a wide range of spatial frequencies. Both t...

journal_title：Investigative ophthalmology & visual science

authors： Levi DM,Harwerth RS

更新日期：1978-06-01 00:00:00

abstract：PURPOSE:DBA/2J mice are a standard preclinical glaucoma model, which spontaneously developed mutations resulting in chronic age-related pigmentary glaucoma. The goals of this study were to identify the degree of visual impairment in DBA/2J mice before and after disease onset by quantifying the optokinetic reflex respon...

journal_title：Investigative ophthalmology & visual science

authors： Burroughs SL,Kaja S,Koulen P

更新日期：2011-06-01 00:00:00

abstract：Purpose:We assessed changes in age-specific prevalence of refractive error at the time of starting school, by comparing preschool and school age cohorts in Shanghai, China. Methods:A cross-sectional study was done in Jiading District, Shanghai during November and December 2013. We randomly selected 7 kindergartens and...

journal_title：Investigative ophthalmology & visual science

authors： Ma Y,Qu X,Zhu X,Xu X,Zhu J,Sankaridurg P,Lin S,Lu L,Zhao R,Wang L,Shi H,Tan H,You X,Yuan H,Sun S,Wang M,He X,Zou H,Congdon N

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:To examine the signal transduction pathways involved in the activation of orbital fibroblast effector functions relevant to the pathogenesis of Graves' ophthalmopathy (GO). To determine, using antisense technology, whether the c-myc protooncogene is involved in cell proliferation and glycosaminoglycan (GAG) syn...

journal_title：Investigative ophthalmology & visual science

authors： Heufelder AE,Bahn RS

更新日期：1995-06-01 00:00:00

abstract：PURPOSE:To determine which components present in oxidized LDL are responsible for the cytotoxicity associated with its internalization by culture ARPE19 cells. METHODS:ARPE19 cells were grown in 24-well and 96-well plates. Cell viability was measured by MTT and/or adenosine triphosphate (ATP) content. LDL was oxidized...

journal_title：Investigative ophthalmology & visual science

authors： Rodriguez IR,Alam S,Lee JW

更新日期：2004-08-01 00:00:00

abstract：:The uveal absorption of aqueous humor at two different intraocular pressures was measured in rhesus monkeys by sampling vortex vein blood during anterior chamber perfusion of Ringer's solution containing both fluorescein and 125I albumin. At 20 mm. Hg, an excess of fluorescein equivalent in amount to 0.45 microliter/m...

journal_title：Investigative ophthalmology & visual science

authors： Pederson JE,Gaasterland DE,MacLellan HM

更新日期：1977-11-01 00:00:00

abstract：PURPOSE:To characterize the static blood flow autoregulation in the optic nerve head (ONH), and to investigate its role in hemodynamic changes in experimental glaucoma (EG). METHODS:Unilateral elevation of intraocular pressure (IOP) was induced in 15 adult rhesus macaques by laser treatment to the trabecular meshwork....

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Burgoyne CF,Cull G,Thompson S,Fortune B

更新日期：2014-02-10 00:00:00

abstract：PURPOSE:To describe an in vivo mouse model for the study of recurrent corneal erosion syndrome (RCES) in mice and to characterize the changes in alpha9 integrin expression during wound healing. METHODS:Corneal epithelial debridement wounds of two sizes (1.5 and 2.5 mm) were made on the ocular surface of BALB/c mice an...

journal_title：Investigative ophthalmology & visual science

authors： Pal-Ghosh S,Pajoohesh-Ganji A,Brown M,Stepp MA

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:The authors investigated whether trigeminal sensitization occurs in response to bright light with the retina disconnected from the rest of the central nervous system by optic nerve section. METHODS:In urethane-anesthetized rats, trigeminal reflex blinks were evoked with air puff stimuli directed at the cornea ...

journal_title：Investigative ophthalmology & visual science

authors： Dolgonos S,Ayyala H,Evinger C

更新日期：2011-10-04 00:00:00

abstract：Purpose:To investigate brain white matter pathways using magnetic resonance diffusion tensor imaging (DTI) and correlate the findings with developmental outcomes at 18 months of corrected age in preterm infants with and without retinopathy of prematurity (ROP). Methods:In this prospective cohort study, probabilistic m...

journal_title：Investigative ophthalmology & visual science

authors： Ahn SJ,Lee JY,Lee JY,Lee YJ,Lee JM,Lee BR,Kim J,Lee HJ

更新日期：2021-02-01 00:00:00

abstract：PURPOSE:To determine the profiles of soluble cytokine receptors and cytokines, including mostly their ligands, in the vitreous humor of patients with B-cell vitreoretinal lymphoma (VRL) and uveitis. METHODS:Vitreous samples were collected from immunocompetent patients with VRL (n = 21), uveitis (n = 20), and idiopathi...

journal_title：Investigative ophthalmology & visual science

authors： Takeda A,Yoshikawa H,Fukuhara T,Hikita S,Hijioka K,Otomo T,Arita R,Hisatomi T,Kimura K,Yoshida S,Kawano Y,Sonoda KH,Ishibashi T

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To identify cell types and extracellular matrix components in Molteno implant capsules. METHODS:Histologic features including cytology, distribution of apoptotic cells, cytoantigens, collagens, basement membranes, elastic fibers, and glycoproteins were examined by light microscopy. Findings were correlated wit...

journal_title：Investigative ophthalmology & visual science

authors： Molteno AC,Thompson AM,Bevin TH,Dempster AG

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To investigate effects of aging on endothelial nitric oxide synthase (eNOS) expression and signaling in angular aqueous plexus (AAP) (functional equivalent to human Schlemm's canal) cells subjected to shear stress. METHODS:The AAP cells were isolated differentially from porcine outflow tissues using puromycin ...

journal_title：Investigative ophthalmology & visual science

authors： Lei Y,Stamer WD,Wu J,Sun X

更新日期：2014-11-06 00:00:00

abstract：PURPOSE:This study examined the influence of stimulus chromaticity on simple reaction times (RTs) to determine the stage of chromatic processing that is most influential in their generation. METHODS:Simple RTs were measured in response to the cosinusoidally ramped onset of small, equiluminant, colored Gaussian spots. ...

journal_title：Investigative ophthalmology & visual science

authors： McKeefry DJ,Parry NR,Murray IJ

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:To examine the relative prevalence of ocular conditions among children who are unable to perform preschool vision screening tests and the impact on measures of screening test performance. METHODS:Trained nurse and lay screeners each administered a Lea Symbols visual acuity (VA) test (Good-Lite, Inc., Steamwood...

journal_title：Investigative ophthalmology & visual science

authors： Maguire MG,Vision in Preschoolers Study Group.

更新日期：2007-01-01 00:00:00

abstract：:Adaptation of saccadic magnitude and vestibulo-ocular reflex gain (VOR) was examined in six monkeys that had undergone a tenectomy of the medial and lateral recti of one eye. After the tenectomy, when the normal eye was patched, a conjugate increase in saccadic magnitude and VOR was observed in both eyes. Subsequent u...

journal_title：Investigative ophthalmology & visual science

authors： Snow R,Hore J,Vilis T

更新日期：1985-07-01 00:00:00

abstract：PURPOSE:Adipose-derived stem cells (ASCs) have gained importance due to their myriad potential clinical applications. We hypothesize that progenitor cells also exist besides those conventionally isolated from the stromal vascular fraction (SVF). METHOD:Central and medial orbital adipose tissues obtained from patients ...

journal_title：Investigative ophthalmology & visual science

authors： Chen SY,Mahabole M,Horesh E,Wester S,Goldberg JL,Tseng SC

更新日期：2014-07-03 00:00:00

abstract：PURPOSE:Glial cells are structurally and functionally linked to neuronal tissues. Pathologically, the cells may be activated and characterized by increased size and number and altered cellular properties. In glaucoma, pathologic mechanisms within the anterior optic nerve may include glial activation. This study examine...

journal_title：Investigative ophthalmology & visual science

authors： Wang L,Cioffi GA,Cull G,Dong J,Fortune B

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:Heavy chain-hyaluronic acid (HC-HA)/PTX3 purified from human amniotic membrane (AM) was previously observed to suppress inflammatory responses in vitro. We now examine whether HC-HA/PTX3 is able to exert a similar effect in vivo, using murine models for keratitis and corneal allograft rejection. METHODS:The in...

journal_title：Investigative ophthalmology & visual science

authors： He H,Tan Y,Duffort S,Perez VL,Tseng SC

更新日期：2014-03-19 00:00:00

abstract：PURPOSE:Vanishing optotypes (VOs) are pseudo high-pass letters whose mean luminance matches the background so that they "vanish" when the recognition acuity threshold is reached in the fovea. We determined the effect of increasing blur on acuity for these optotypes and conventional letters, in both foveal and extrafove...

journal_title：Investigative ophthalmology & visual science

authors： Shah N,Dakin SC,Anderson RS

更新日期：2012-10-09 00:00:00

abstract：PURPOSE:We tested variants in genes related to lutein and zeaxanthin status for association with age-related macular degeneration (AMD) in the Carotenoids in Age-Related Eye Disease Study (CAREDS). METHODS:Of 2005 CAREDS participants, 1663 were graded for AMD from fundus photography and genotyped for 424 single nucleo...

journal_title：Investigative ophthalmology & visual science

authors： Meyers KJ,Mares JA,Igo RP Jr,Truitt B,Liu Z,Millen AE,Klein M,Johnson EJ,Engelman CD,Karki CK,Blodi B,Gehrs K,Tinker L,Wallace R,Robinson J,LeBlanc ES,Sarto G,Bernstein PS,SanGiovanni JP,Iyengar SK

更新日期：2014-01-29 00:00:00

abstract：:Iron is a potent generator of oxidative damage whose levels increase with age, potentially exacerbating age-related diseases. Several lines of evidence suggest that iron accumulation may be a factor in age-related macular degeneration (AMD). AMD retinas have more iron within the photoreceptors, RPE, and drusen than do...

journal_title：Investigative ophthalmology & visual science

authors： Dunaief JL

更新日期：2006-11-01 00:00:00

abstract：:A simple clinical method for measurement of light backscatter from defined regions of the lens in vivo is described. Light scattering was quantitated in 168 lenses of 85 "normal" subjects spanning 8 decades of life. The results indicate that light scatter from the anterior capsule does not change with age. The light s...

journal_title：Investigative ophthalmology & visual science

authors： Ben-Sira I,Weinberger D,Bodenheimer J,Yassur Y

更新日期：1980-04-01 00:00:00

abstract：PURPOSE:To document the cyclovertical ocular motor mechanism used for vertical fusion in healthy subjects, and to explore whether vertical vergence training in healthy individuals can produce objectively confirmed vertical deviations that change with head tilt, revealing a basic mechanism that can produce a pattern of ...

journal_title：Investigative ophthalmology & visual science

authors： Irsch K,Guyton DL,Ramey NA,Adyanthaya RS,Ying HS

更新日期：2013-05-03 00:00:00

abstract：PURPOSE:Stereoscopic displays challenge the neural cross-coupling between accommodation and vergence by inducing a constant accommodative demand and a varying vergence demand. Stereoscopic viewing calls for a decrease in the gain of vergence accommodation, which is the accommodation caused by vergence, quantified by us...

journal_title：Investigative ophthalmology & visual science

authors： Neveu P,Roumes C,Philippe M,Fuchs P,Priot AE

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To determine new referents, or cutoff levels for tear film hyperosmolarity in the diagnosis of keratoconjunctivitis sicca (KCS) and to assess their effectiveness in independent patient groups. METHOD:A meta-analysis was performed on published data for tear osmolarity in samples of normal eyes and various subty...

journal_title：Investigative ophthalmology & visual science

authors： Tomlinson A,Khanal S,Ramaesh K,Diaper C,McFadyen A

更新日期：2006-10-01 00:00:00

abstract：:The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNA...

journal_title：Investigative ophthalmology & visual science

authors： Ambati J

更新日期：2011-04-06 00:00:00

abstract：PURPOSE:To evaluate clinical, immunophenotypical, and cytogenetical characteristics of 116 patients with a diagnosis of extranodal marginal zone lymphoma (EMZL) presenting primarily in the ocular region. METHODS:Specimens from all patients with a diagnosis of ophthalmic lymphoma in Denmark during the period 1980 to 20...

journal_title：Investigative ophthalmology & visual science

authors： Sjö LD,Heegaard S,Prause JU,Petersen BL,Pedersen S,Ralfkiaer E

更新日期：2009-02-01 00:00:00

abstract：PURPOSE:To explore whether pointwise rates of visual field progression group together in patterns consistent with retinal nerve fiber layer (RNFL) bundles. METHODS:Three hundred eighty-nine eyes of 309 patients from the Advanced Glaucoma Intervention Study with ≥6 years of follow-up and ≥12 reliable visual field exams...

journal_title：Investigative ophthalmology & visual science

authors： Nouri-Mahdavi K,Mock D,Hosseini H,Bitrian E,Yu F,Afifi A,Coleman AL,Caprioli J

更新日期：2012-04-30 00:00:00

abstract：PURPOSE:The authors examine the effect of retinal branch vein occlusion (BVO), a common retinal vascular disorder, on protein tyrosine phosphorylation, production of angiogenic growth factors, and activation of signal proteins in the tyrosine kinase pathways in the retina. METHODS:Retinal branch vein occlusion was ind...

journal_title：Investigative ophthalmology & visual science

authors： Hayashi A,Imai K,Kim HC,de Juan E Jr

更新日期：1997-02-01 00:00:00