Uveoscleral aqueous outflow in the rhesus monkey: importance of uveal reabsorption.

abstract：PURPOSE:Age-related macular degeneration (AMD), the most common cause of incurable blindness in the western world, is characterized by the dysfunction and eventual death of choroidal endothelial (CECs), RPE, and photoreceptor cells. Stem cell-based treatment strategies designed to replace photoreceptor and RPE cells cu...

journal_title：Investigative ophthalmology & visual science

authors： Songstad AE,Wiley LA,Duong K,Kaalberg E,Flamme-Wiese MJ,Cranston CM,Riker MJ,Levasseur D,Stone EM,Mullins RF,Tucker BA

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Stereoscopic displays challenge the neural cross-coupling between accommodation and vergence by inducing a constant accommodative demand and a varying vergence demand. Stereoscopic viewing calls for a decrease in the gain of vergence accommodation, which is the accommodation caused by vergence, quantified by us...

journal_title：Investigative ophthalmology & visual science

authors： Neveu P,Roumes C,Philippe M,Fuchs P,Priot AE

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Diabetic retinopathy (DR) is a major cause of visual impairment in developed countries. While DR has been described classically as a microvascular disease, recent evidence suggests that changes to retinal microglia are an early feature of retinopathy. In our study, we assessed changes in microglial distribution...

journal_title：Investigative ophthalmology & visual science

authors： Kezic JM,Chen X,Rakoczy EP,McMenamin PG

更新日期：2013-01-30 00:00:00

abstract：:The circulating renin-angiotensin system (RAS) is an important determinant in maintaining adequate systemic blood pressure, and it also may modify organ-specific blood flow. All recognized RAS components have been identified in the eye. In this study, angiotensinogen (ANG) was localized using an affinity-purified anti...

journal_title：Investigative ophthalmology & visual science

authors： Sramek SJ,Wallow IH,Tewksbury DA,Brandt CR,Poulsen GL

更新日期：1992-04-01 00:00:00

abstract：Purpose:Retinal damage in ocular toxoplasmosis reflects Toxoplasma gondii-induced cell lysis and reactive inflammation. Human retinal histopathology demonstrates the presence of neutrophils, but activities of this leukocyte subset are unstudied. We conducted in vitro experiments to evaluate roles for neutrophils as ret...

journal_title：Investigative ophthalmology & visual science

authors： Ashander LM,Lie S,Ma Y,Rochet E,Washington JM,Furtado JM,Appukuttan B,Smith JR

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:To examine the relationship between circulating inflammatory markers, hemostatic factors, and age-related maculopathy (ARM). METHODS:A population-based, cross-sectional case-control study drawn from the Blue Mountains Eye Study included 159 early and 38 late ARM cases, and 433 controls matched for age, gender,...

journal_title：Investigative ophthalmology & visual science

authors： Wu KH,Tan AG,Rochtchina E,Favaloro EJ,Williams A,Mitchell P,Wang JJ

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:FOXC1 mutations result in Axenfeld-Rieger syndrome, a disorder characterized by a broad spectrum of malformations of the anterior segment of the eye and an elevated risk for glaucoma. A novel FOXC1 W152G mutation was identified in a patient with aniridia. Molecular analysis was conducted to determine the functi...

journal_title：Investigative ophthalmology & visual science

authors： Ito YA,Footz TK,Berry FB,Mirzayans F,Yu M,Khan AO,Walter MA

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Evidence suggests that capillary degeneration in early diabetic retinopathy results from chronic inflammation, and leukotrienes have been implicated in this process. The authors investigated the cellular sources of leukotriene biosynthesis in diabetic retinas and the effects of hyperglycemia on leukotriene prod...

journal_title：Investigative ophthalmology & visual science

authors： Talahalli R,Zarini S,Sheibani N,Murphy RC,Gubitosi-Klug RA

更新日期：2010-03-01 00:00:00

abstract：PURPOSE:The anterior surface of the eye is covered by several physically contiguous but histologically distinguishable epithelial overlying the cornea, limbus, bulbar conjunctiva, fornix conjunctiva, and palpebral conjunctiva. It is important to determine whether the different phenotypes of these epithelia are the resu...

journal_title：Investigative ophthalmology & visual science

authors： Wei ZG,Wu RL,Lavker RM,Sun TT

更新日期：1993-04-01 00:00:00

abstract：PURPOSE:To demonstrate the effectiveness of Hierarchical Bayesian (HB) approach in a modeling framework for association effects that accounts for SEs of vision-specific latent traits assessed using Rasch analysis. METHODS:A systematic literature review was conducted in four major ophthalmic journals to evaluate Rasch ...

journal_title：Investigative ophthalmology & visual science

authors： Wong WL,Li X,Li J,Wong TY,Cheng CY,Lamoureux EL

更新日期：2014-07-11 00:00:00

abstract：PURPOSE:Cilostazol, a selective inhibitor of phosphodiesterase 3, has antiplatelet aggregation and peripheral vasodilation effects. We examined the effects of cilostazol on the retinal microvascular diameter to determine its dependence on the endothelium and/or smooth muscle to reveal the signaling mechanisms involved ...

journal_title：Investigative ophthalmology & visual science

authors： Tanano I,Nagaoka T,Omae T,Ishibazawa A,Kamiya T,Ono S,Yoshida A

更新日期：2013-02-19 00:00:00

abstract：:This paper investigates the amplitude of accommodation of early onset myopes, late onset myopes, emmetropes, and hyperopes. Eighty subjects were used, 41 women and 39 men, with an age range of 18-22 yr (mean = 19.82). All subjects wore an optimum refractive correction, giving visual acuities of 20/20 or better. Signif...

journal_title：Investigative ophthalmology & visual science

authors： McBrien NA,Millodot M

更新日期：1986-07-01 00:00:00

abstract：Purpose:To investigate factors associated with visual field (VF) progression in treated myopic normal-tension glaucoma (NTG) using a novel posterior sclera reconstruction method involving swept-source optical coherence tomography (OCT). Methods:Fifty-six myopic patients on ocular hypotensive therapy with the diagnose ...

journal_title：Investigative ophthalmology & visual science

authors： Kim YC,Koo YH,Jung KI,Park CK

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To compare the magnification properties of four different indirect double aspheric fundus examination lenses for clinical disc biometry. METHODS:Experimental study in a model eye. The relationship between the true size of a fundus object and its image was calculated for each fundus lens for an ametropic range ...

journal_title：Investigative ophthalmology & visual science

authors： Ansari-Shahrezaei S,Maar N,Biowski R,Stur M

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:As in human populations, in which founder mutations have been identified in groups of families, a number of founder mutations have been observed across strains in mice. In this report, we provide a phenotype and genotype survey of three common eye diseases in the collection of JAX mice strains at The Jackson La...

journal_title：Investigative ophthalmology & visual science

authors： Chang B,Hurd R,Wang J,Nishina P

更新日期：2013-07-24 00:00:00

abstract：PURPOSE:Peripheral and limbal corneal stromal cells (PLCSCs), which contain keratocytes, have a complex phenotype. Knowledge of keratocyte cell properties, function, and origin is limited. Evidence available thus far has suggested both mesenchymal stromal and hematopoietic characteristics. Multipotent mesenchymal strom...

journal_title：Investigative ophthalmology & visual science

authors： Branch MJ,Hashmani K,Dhillon P,Jones DR,Dua HS,Hopkinson A

更新日期：2012-08-03 00:00:00

abstract：:The metabolic disorder in diabetics often results in progressive retinopathy with severe visual impairment. Changes in metabolism can influence corneal autofluorescence. This has led to speculation that diabetic retinopathy might be associated with changes in corneal autofluorescence. Corneal autofluorescence of both ...

journal_title：Investigative ophthalmology & visual science

authors： Stolwijk TR,van Best JA,Oosterhuis JA,Swart W

更新日期：1992-01-01 00:00:00

abstract：:In order to investigate the effect of traction of the vasculature on induction or acceleration of neovascularization, the chorioallantoic membranes (CAMs) of the developing chick embryo were placed under tension with 10-0 nylon sutures and subsequently examined histologically. In the initial phase of the study, CAMs f...

journal_title：Investigative ophthalmology & visual science

authors： Yamashita H,Hori S,Yamamoto T

更新日期：1989-04-01 00:00:00

abstract：PURPOSE:To determine whether poor fetal growth, as determined by size at birth, is associated with increased risk of age-related macular degeneration. METHODS:A total of 660 men and women born in Sheffield, United Kingdom, between 1922 and 1930 and whose size at birth was available were traced and invited to take part...

journal_title：Investigative ophthalmology & visual science

authors： Hall NF,Gale CR,Syddall H,Martyn CN,Phillips DI

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:To assess dynamic interactions of eye and head movements during return-sweep saccades (RSS) when reading with single-vision (SVL) versus progressive-addition (PAL) lenses in a simulated computer-based business environment. METHODS:Horizontal eye and head movements were recorded objectively and simultaneously a...

journal_title：Investigative ophthalmology & visual science

authors： Han Y,Ciuffreda KJ,Selenow A,Ali SR

更新日期：2003-04-01 00:00:00

abstract：PURPOSE:To investigate the pharmacologic effect of tetramethylpyrazine (TMP) on human Tenon's fibroblasts (HTFs), the cells implicated in scarring after filtration surgery. METHODS:Transforming growth factor-β2 (TGF-β2) was used to stimulate a fibrotic phenotype in primary HTFs, and the influence of TMP on the fibroti...

journal_title：Investigative ophthalmology & visual science

authors： Cai X,Yang Y,Chen P,Ye Y,Liu X,Wu K,Yu M

更新日期：2016-09-01 00:00:00

abstract：Purpose:To investigate the effect of short-wavelength light (SL) on guinea pigs with lens-induced myopia (LIM) and the possible retinoic acid (RA)-related mechanisms. Methods:Two-week-old guinea pigs (n = 60) with monocular -5D lenses were reared under white light (WL, 580 lux) or SL (440 nm, 500 lux). The left eyes w...

journal_title：Investigative ophthalmology & visual science

authors： Yu M,Liu W,Wang B,Dai J

更新日期：2021-01-04 00:00:00

abstract：:Dog corneas were studied by indirect immunofluorescence with antibodies specific for pemphigus and pemphigoid antigens, laminin, and type IV collagen. The distribution of these antigens was similar to that observed in other squamous epithelia and skin. This study provides further evidence for close immunochemical simi...

journal_title：Investigative ophthalmology & visual science

authors： Cowen SJ,Anhalt GJ,Wicha MS,Sugar A,Labib RS,Diaz LA

更新日期：1981-12-01 00:00:00

abstract：Purpose:Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine that initiates allergic inflammatory reaction between epithelial and dendritic cells (DCs). miR-19b was reported to suppress TSLP expression. The present study aimed to examine miR-19b expression, regulation, and function in allergic conjunctivitis ...

journal_title：Investigative ophthalmology & visual science

authors： Guo C,Liu J,Hao P,Wang Y,Sui S,Li L,Ying M,Han R,Wang L,Li X

更新日期：2020-03-09 00:00:00

abstract：PURPOSE:The retrograde transport of wheat germ agglutinin-horseradish peroxidase (WGA/HRP) was used to study the localization of the neurons that innervate the superior tarsal muscle in the cynomolgus monkey. METHODS:A 5-10% WGA-HRP solution was applied to the medial part of the superior tarsal muscle. Seventy-two hou...

journal_title：Investigative ophthalmology & visual science

authors： van der Werf F,Baljet B,Prins M,Timmerman A,Otto JA

更新日期：1993-06-01 00:00:00

abstract：Purpose:The purpose of this study was to establish and analyze a cell model of Leber congenital amaurosis type 16 (LCA16), which is caused by mutations in the KCNJ13 gene encoding Kir7.1, an inward-rectifying potassium ion channel. Methods:The two guide RNAs specific to the target sites in the KCNJ13 gene were designe...

journal_title：Investigative ophthalmology & visual science

authors： Kanzaki Y,Fujita H,Sato K,Hosokawa M,Matsumae H,Shiraga F,Morizane Y,Ohuchi H

更新日期：2020-05-11 00:00:00

abstract：:Visual acuity of infants and young children with ophthalmologic disorders was assessed by adapting a transformed up-down staircase to preferential looking (PL) procedures. Eighty-five percent of pediatric patients between 11 days and 5 years of age were tested successfully. Acuity of infants and young children with no...

journal_title：Investigative ophthalmology & visual science

authors： Mayer DL,Fulton AB,Hansen RM

更新日期：1982-10-01 00:00:00

abstract：PURPOSE:To determine whether glaucoma alters intrinsically photosensitive retinal ganglion cell (ipRGC) function. METHODS:Forty-one patients (25 with glaucoma and 16 healthy age-matched control participants) were tested. Intrinsically photosensitive retinal ganglion cell function was directly measured by the sustained...

journal_title：Investigative ophthalmology & visual science

authors： Feigl B,Mattes D,Thomas R,Zele AJ

更新日期：2011-06-21 00:00:00

abstract：:Bovine corneal endothelial cells in culture synthesize predominantly type III collagen, unlike rabbit corneal endothelial cultures which synthesize type IV collagen. In an attempt to document whether this type III collagen synthesis by bovine cells is a tissue culture-specific phenomenon, collagens synthesized by orga...

journal_title：Investigative ophthalmology & visual science

authors： Kay EP,Oh S

更新日期：1988-02-01 00:00:00

abstract：PURPOSE:Retinopathy of prematurity (ROP) is a major cause of visual handicap in the pediatric population. To date, this disorder is thought to stem from deficient retinal vascularization. Intriguingly, functional electrophysiological studies in patients with mild or moderate ROP and in the oxygen-induced retinopathy (O...

journal_title：Investigative ophthalmology & visual science

authors： Shao Z,Dorfman AL,Seshadri S,Djavari M,Kermorvant-Duchemin E,Sennlaub F,Blais M,Polosa A,Varma DR,Joyal JS,Lachapelle P,Hardy P,Sitaras N,Picard E,Mancini J,Sapieha P,Chemtob S

更新日期：2011-08-05 00:00:00