Static blood flow autoregulation in the optic nerve head in normal and experimental glaucoma.

abstract：Purpose:To assess if ripasudil has a neuroprotective effect using mice with excitatory amino acid carrier 1 (EAAC1) deletion (EAAC1 knockout [KO] mice), a mouse model of normal tension glaucoma. Methods:Topical administration (5 μL/day) of two different concentrations of ripasudil (0.4% and 2%) were applied to EAAC1 K...

journal_title：Investigative ophthalmology & visual science

authors： Akaiwa K,Namekata K,Azuchi Y,Sano H,Guo X,Kimura A,Harada C,Mitamura Y,Harada T

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:To identify the risk factors for having advanced glaucomatous visual field loss on the first visit at three hospital eye services. METHODS:This was a hospital-based, case-control study involving patients newly diagnosed with glaucoma at first visit to one of three ophthalmic departments in the United Kingdom. ...

journal_title：Investigative ophthalmology & visual science

authors： Fraser S,Bunce C,Wormald R

更新日期：1999-09-01 00:00:00

abstract：Purpose:To give a European regulatory overview of the requirements on and the use of biomarkers or surrogate endpoints in the development of drugs for ocular disease. Methods:Definitions, methods to validate new markers, and circumstances where surrogate endpoints can be appropriate are summarized. Results:The key en...

journal_title：Investigative ophthalmology & visual science

authors： Wickström K,Moseley J

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Endothelin (ET)-1 is known to inhibit active NaK transport by as much as 50% in kidney tubule and other tissues. The presence of low levels of ET-1 in aqueous humor combined with the potential for release of ET-1 from ciliary processes suggests that the lens could be exposed to ET-1 in vivo. In this study, expe...

journal_title：Investigative ophthalmology & visual science

authors： Okafor MC,Delamere NA

更新日期：2001-04-01 00:00:00

abstract：PURPOSE:During fixation and saccades, human eye movements obey Listing's law, which specifies the torsional eye position for each combination of horizontal and vertical eye positions. To study the mechanisms that implement Listing's law, the authors measured whether the law was violated in peripheral and central unilat...

journal_title：Investigative ophthalmology & visual science

authors： Wong AM,Tweed D,Sharpe JA

更新日期：2002-01-01 00:00:00

abstract：:Selenium toxicity was investigated in cultured rabbit lenses to provide further information about the role of Ca++ in Se cataract. At a dose of 0.1 mM for 20 hr, Se induces a 10% change in Na levels within 6 hr, a 30% increase after 20 hr, and a three-fold increase within 48 hr of subsequent culture after removal of S...

journal_title：Investigative ophthalmology & visual science

authors： Hightower KR,McCready JP

更新日期：1989-01-01 00:00:00

abstract：:Acute laser injury to the tapetum of the feline retina produces thrombosis of the choriocapillaris. Early changes are characterized by the appearance of platelet-fibrin thrombi within capillary loops and disruption of endothelial integrity. By 4 days, thrombi have disappeared, and the endothelium shows regenerative ch...

journal_title：Investigative ophthalmology & visual science

authors： Perry DD,Reddick RL,Risco JM

更新日期：1984-09-01 00:00:00

abstract：PURPOSE:This study explores variation in the axial location of Bruch's membrane opening (BMO) to determine if this reference plane varies with age and race. METHODS:There were 168 spectral-domain optical coherence tomography (SDOCT) optic nerve head volumes that were obtained from healthy subjects and manually delinea...

journal_title：Investigative ophthalmology & visual science

authors： Johnstone J,Fazio M,Rojananuangnit K,Smith B,Clark M,Downs C,Owsley C,Girard MJ,Mari JM,Girkin CA

更新日期：2014-03-28 00:00:00

abstract：Purpose:Single-cell RNA-sequencing (scRNA-seq) was used to interrogate the relatively rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia from wild-type and autophagy-compromised mice. Methods:We conducted scRNA-seq on ocular anterior segmental tissue from wild-type and beclin...

journal_title：Investigative ophthalmology & visual science

authors： Kaplan N,Wang J,Wray B,Patel P,Yang W,Peng H,Lavker RM

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:To map the canine rcd2 retinal degeneration locus. Rod-cone dysplasia type 2 (rcd2), an early-onset autosomal recessive form of progressive retinal atrophy (PRA), is phenotypically similar to early-onset forms of retinitis pigmentosa collectively termed Leber congenital amaurosis and segregates naturally in the...

journal_title：Investigative ophthalmology & visual science

authors： Kukekova AV,Nelson J,Kuchtey RW,Lowe JK,Johnson JL,Ostrander EA,Aguirre GD,Acland GM

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:To investigate lateral geniculate nucleus (LGN) volume of primary open-angle glaucoma (POAG) patients compared with age- and sex-matched controls using ultra-high field 7.0-T magnetic resonance imaging (MRI). METHODS:The study included 18 patients with POAG and 18 age- and sex-matched healthy volunteers. All s...

journal_title：Investigative ophthalmology & visual science

authors： Lee JY,Jeong HJ,Lee JH,Kim YJ,Kim EY,Kim YY,Ryu T,Cho ZH,Kim YB

更新日期：2014-04-10 00:00:00

abstract：Purpose:Keratoconus (KTCN) is a complex eye disorder resulting in loss of visual function. Its development is affected by genetic and environmental components. The aim of this study was to unravel the role of epigenetic factors in KTCN. Methods:To verify if DNA methylation may play a role in KTCN development, reduced ...

journal_title：Investigative ophthalmology & visual science

authors： Kabza M,Karolak JA,Rydzanicz M,Udziela M,Gasperowicz P,Ploski R,Szaflik JP,Gajecka M

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Adipose-derived stem cells (ASCs) have gained importance due to their myriad potential clinical applications. We hypothesize that progenitor cells also exist besides those conventionally isolated from the stromal vascular fraction (SVF). METHOD:Central and medial orbital adipose tissues obtained from patients ...

journal_title：Investigative ophthalmology & visual science

authors： Chen SY,Mahabole M,Horesh E,Wester S,Goldberg JL,Tseng SC

更新日期：2014-07-03 00:00:00

abstract：PURPOSE:To determine whether a variational Bayesian independent component analysis mixture model (vB-ICA-mm), a form of unsupervised machine learning, can be used to identify and quantify areas of progression in standard automated perimetry fields. METHODS:In an earlier study, it was shown that a model using vB-ICA-mm...

journal_title：Investigative ophthalmology & visual science

authors： Sample PA,Boden C,Zhang Z,Pascual J,Lee TW,Zangwill LM,Weinreb RN,Crowston JG,Hoffmann EM,Medeiros FA,Sejnowski T,Goldbaum M

更新日期：2005-10-01 00:00:00

abstract：PURPOSE:To explore the role in the eye of tenomodulin (TeM), a chondromodulin (ChM)-I-related glycoprotein, the expression, localization, and antiangiogenic potential of TeM were investigated. METHODS:Gene expression and protein localization of TeM in mouse eyes were examined by Northern blot analysis, in situ hybridi...

journal_title：Investigative ophthalmology & visual science

authors： Oshima Y,Shukunami C,Honda J,Nishida K,Tashiro F,Miyazaki J,Hiraki Y,Tano Y

更新日期：2003-05-01 00:00:00

abstract：:Effects of substance P (SP) and vasoactive intestinal peptide (VIP) on motor function of bovine sphincter, dilator, and ciliary muscles were investigated pharmacologically, with and without field stimulation. SP contracted the sphincter and the maximum response was only about 25% of that in the presence of equimolar d...

journal_title：Investigative ophthalmology & visual science

authors： Suzuki R,Kobayashi S

更新日期：1983-12-01 00:00:00

abstract：PURPOSE:To develop models for assessing the differential growth of the fetal face along its horizontal and vertical axes, as well as of the orbit and the eye. METHODS:Normal human fetuses (n = 205), whose gestational ages ranged from 15.5 to 41 weeks of amenorrhea, were examined. Orbitofacial parameters were as follow...

journal_title：Investigative ophthalmology & visual science

authors： Denis D,Burguière O,Burillon C

更新日期：1998-11-01 00:00:00

abstract：PURPOSE:To determine the levels of free UV filters and selected amino acids in cataract lenses compared with normal lenses. METHODS:Indian cataract lenses (n=39) and normal lenses (n=6) were examined by HPLC to quantify levels of UV filter compounds, the UV filter precursor amino acid tryptophan (Trp), as well as tyro...

journal_title：Investigative ophthalmology & visual science

authors： Streete IM,Jamie JF,Truscott RJ

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:To assess vascular endothelial function in patients with normal pressure glaucoma using forearm blood flow responses to intra-arterial infusions of endothelial-dependent and -independent vasoactive agents. METHODS:Eight patients with newly diagnosed and untreated normal pressure glaucoma and eight healthy age-...

journal_title：Investigative ophthalmology & visual science

authors： Henry E,Newby DE,Webb DJ,O'Brien C

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Retinitis pigmentosa is a clinically and genetically heterogeneous disorder. It is characterized by progressive degeneration of the peripheral retina, leading to night blindness and loss of the peripheral visual field. PRPF31 is one of four pre-mRNA splicing factors identified as causing autosomal dominant reti...

journal_title：Investigative ophthalmology & visual science

authors： Waseem NH,Vaclavik V,Webster A,Jenkins SA,Bird AC,Bhattacharya SS

更新日期：2007-03-01 00:00:00

abstract：PURPOSE:Sarcoidosis is a heterogeneous and multisystem granulomatous disorder. The etiology still is uncertain, but the disease currently is thought to be triggered by various genetic as well as environmental factors. Recently, an association between sarcoidosis and the butyrophilin-like 2 (BTNL2) gene located in close...

journal_title：Investigative ophthalmology & visual science

authors： Suzuki H,Ota M,Meguro A,Katsuyama Y,Kawagoe T,Ishihara M,Asukata Y,Takeuchi M,Ito N,Shibuya E,Nomura E,Uemoto R,Nishide T,Namba K,Kitaichi N,Morimoto S,Kaburaki T,Ando Y,Takenaka S,Nakamura J,Saeki K,Ohno S,In

更新日期：2012-10-11 00:00:00

abstract：Purpose:To compare blood pressure and urine albumin-creatinine ratio over time for participants receiving aflibercept, bevacizumab, or ranibizumab. Methods:Preplanned secondary analyses from a randomized trial comparing aflibercept, bevacizumab, and ranibizumab for diabetic macular edema (DME). The Diabetic Retinopath...

journal_title：Investigative ophthalmology & visual science

authors： Glassman AR,Liu D,Jampol LM,Sun JK,Diabetic Retinopathy Clinical Research Network.

更新日期：2018-03-01 00:00:00

abstract：:Tendon and cornea of 17-day-old chick embryos primarily synthesize type I collagen as the major collagenous component nd type V collagen as a minor collagenous component. Matrix-free cells isolated from cornea and tendon synthesize and secrete mainly type I procollagen. A short lag period for the secretion of collagen...

journal_title：Investigative ophthalmology & visual science

authors： Kao WW,Mai SH,Chou KL

更新日期：1982-12-01 00:00:00

abstract：PURPOSE:To search for proprioceptive nerve terminals in human ciliary muscle. METHODS:In 48 human donor eyes, histologic and ultrathin sections cut in different planes and wholemounts of the ciliary muscle were studied. Immunohistochemical staining with antibodies against pan-neuronal antigens and antigens reported as...

journal_title：Investigative ophthalmology & visual science

authors： Flügel-Koch C,Neuhuber WL,Kaufman PL,Lütjen-Drecoll E

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:Our prospective study was conducted to compare axial length elongation in myopic children receiving long-term overnight orthokeratology (OK) treatment to those wearing spectacles as controls. METHODS:There were 59 subjects enrolled in this study. The OK group comprised 29 subjects who matched the inclusion cri...

journal_title：Investigative ophthalmology & visual science

authors： Hiraoka T,Kakita T,Okamoto F,Takahashi H,Oshika T

更新日期：2012-06-22 00:00:00

abstract：Purpose:Vision decline with healthy aging is a major public health concern with the unceasing growth of the aged population. In order to prevent or remedy the age-related visual loss, a better understanding of the underlying causes is needed. The current psychophysical study used a novel noise paradigm to investigate t...

journal_title：Investigative ophthalmology & visual science

authors： Silvestre D,Arleo A,Allard R

更新日期：2019-02-01 00:00:00

abstract：Purpose:High-mobility group box-1 (HMGB1) is a nonhistone DNA-binding nuclear protein released from necrotic cells, which is also secreted by activated leukocytes and acts as a primary proinflammatory cytokine. In this study, we compared vitreous HMGB1 levels in ocular sarcoidosis with those in noninflammatory vitreore...

journal_title：Investigative ophthalmology & visual science

authors： Takeuchi M,Taguchi M,Sato T,Karasawa K,Sakurai Y,Harimoto K,Ito M

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:To investigate the effect of TNF-alpha on leukocyte adhesion, vascular leakage, and apoptotic cell death in endotoxin-induced uveitis (EIU) in the rat. METHODS:EIU was induced in Long-Evans rats by a single footpad injection of lipopolysaccharide (LPS; 350 microg/kg) from Salmonella typhimurium. A single injec...

journal_title：Investigative ophthalmology & visual science

authors： Koizumi K,Poulaki V,Doehmen S,Welsandt G,Radetzky S,Lappas A,Kociok N,Kirchhof B,Joussen AM

更新日期：2003-05-01 00:00:00

abstract：PURPOSE:By their control of membrane potential and intracellular free Ca(2+) ([Ca(2+)](i)), K(+) currents are pivotal in the regulation of arterial smooth muscle tone. The goal of the present study was to identify and characterize the A-type K(+) current in retinal microvascular smooth muscle (MVSM) and to examine its ...

journal_title：Investigative ophthalmology & visual science

authors： McGahon MK,Dawicki JM,Scholfield CN,McGeown JG,Curtis TM

更新日期：2005-09-01 00:00:00

abstract：Purpose:Dry eye disease (DED) is a multifactorial disease associated with ocular surface inflammation. Toll-like receptors (TLRs) are integral in the initiation of inflammatory signaling. Therefore, we evaluated the effect of TLR-deficiency on dry eye-related ocular surface damage and inflammation using a mouse model o...

journal_title：Investigative ophthalmology & visual science

authors： Reins RY,Lema C,Courson J,Kunnen CME,Redfern RL

更新日期：2018-06-01 00:00:00