Biomarkers and Surrogate Endpoints in Drug Development: A European Regulatory View.

abstract：PURPOSE:Our prospective study was conducted to compare axial length elongation in myopic children receiving long-term overnight orthokeratology (OK) treatment to those wearing spectacles as controls. METHODS:There were 59 subjects enrolled in this study. The OK group comprised 29 subjects who matched the inclusion cri...

journal_title：Investigative ophthalmology & visual science

authors： Hiraoka T,Kakita T,Okamoto F,Takahashi H,Oshika T

更新日期：2012-06-22 00:00:00

abstract：PURPOSE:We examined if light induces changes in the retinal structure that can be observed using optical coherence tomography (OCT). METHODS:Normal C57BL/6J mice (age 3-6 months) adapted to either room light (15 minutes to ∼5 hours, 50-500 lux) or darkness (overnight) were imaged using a Bioptigen UHR-OCT system. Conf...

journal_title：Investigative ophthalmology & visual science

authors： Li Y,Fariss RN,Qian JW,Cohen ED,Qian H

更新日期：2016-07-01 00:00:00

abstract：:Topically applied dipivalyl epinephrine (DPE) and related compounds have been found to inhibit passive anaphylactic reaction in rat conjunctiva. The order of activity is as follows: isoproterenol greater than DPE greater than epinephrine greater than norepinephrine. The antianaphylactic effect of DPE was antagonized b...

journal_title：Investigative ophthalmology & visual science

authors： Iso T,Uda K,Yamauchi H,Nakajima N,Suda H

更新日期：1980-07-01 00:00:00

abstract：PURPOSE:To map the disease locus in a four-generation, consanguineous Pakistani family affected by autosomal dominant congenital nuclear cataract (adNCat). All affected individuals had early onset of bilateral nuclear cataract. METHODS:Genomic DNA from family members was typed for alleles at more than 300 known polymo...

journal_title：Investigative ophthalmology & visual science

authors： Khaliq S,Hameed A,Ismail M,Anwar K,Mehdi SQ

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:Age-related nuclear cataracts involve denaturation and aggregation of intracellular proteins. We have documented age-dependent changes in membrane transport in the mouse lens to see what might initiate changes in the intracellular milieu. METHODS:Microelectrode-based intracellular impedance studies of intact l...

journal_title：Investigative ophthalmology & visual science

authors： Gao J,Wang H,Sun X,Varadaraj K,Li L,White TW,Mathias RT

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:To explore differences in optic disc tilt and torsion between normal control and glaucoma subjects, and to determine whether the direction of optic disc tilt is consistent with the initial location of glaucomatous visual field (VF) defect. METHODS:Glaucoma patients with isolated superior or inferior hemifield ...

journal_title：Investigative ophthalmology & visual science

authors： Choi JA,Park HY,Shin HY,Park CK

更新日期：2014-07-01 00:00:00

abstract：:Male albino rats, injected intravenously or intracerebroventricularly with delta 1-tetrahydrocannabinol (THC), develop mudriasis. The median effective dose of the intravenous administration group was 5 mg/kg THC, whereas that for the intracerebroventricular route was 150 microgram/kg THC. Sympathectomy significantly d...

journal_title：Investigative ophthalmology & visual science

authors： Korczyn AD,Eshel Y

更新日期：1982-03-01 00:00:00

abstract：PURPOSE:Human blood contains low levels of protoporphyrin IX (PP IX), a photoactive compound that produces reactive oxygen species when exposed to light. It has been proposed that photoactivation of PP IX and subsequent generation of potentially tissue-damaging reactive oxygen may be a mechanism of retinal injury in re...

journal_title：Investigative ophthalmology & visual science

authors： Bynoe LA,Gottsch JD,Sadda SR,Panton RW,Haller EM,Gleason CA

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:To investigate the topographic relationship between ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) defects in open-angle glaucoma patients with localized RNFL defects, using spectral-domain optical coherence tomography (SD-OCT). METHODS:We analyzed 140 eyes of 1...

journal_title：Investigative ophthalmology & visual science

authors： Kim KE,Park KH,Yoo BW,Jeoung JW,Kim DM,Kim HC

更新日期：2014-05-06 00:00:00

abstract：:PURPOSE. To investigate the normative data of corneal and anterior segment biometric parameters and their associations in Chinese adults, for use in preoperative assessment for corneal and anterior segment surgery. METHODS. This cross-sectional, population-based study included 750 subjects aged > or =50 years. The sub...

journal_title：Investigative ophthalmology & visual science

authors： Yuen LH,He M,Aung T,Htoon HM,Tan DT,Mehta JS

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:To determine protective properties of recombinant TCR ligands (RTLs) as a new treatment for experimental autoimmune anterior uveitis (AU). RTLs comprise the rat RT1.B beta1alpha1 domains, linked either to the guinea pig MBP69-89 peptide (RTL201), to the corresponding rat MBP69-89 peptide (RTL200), or to the car...

journal_title：Investigative ophthalmology & visual science

authors： Adamus G,Burrows GG,Vandenbark AA,Offner H

更新日期：2006-06-01 00:00:00

abstract：Purpose:To describe the phenotypic spectrum of retinal disease caused by the c.2991+1655A>G mutation in CEP290 and to compare disease severity between homozygous and compound heterozygous patients. Methods:Medical records were reviewed for best-corrected visual acuity (BCVA), age of onset, fundoscopy descriptions. Fov...

journal_title：Investigative ophthalmology & visual science

authors： Valkenburg D,van Cauwenbergh C,Lorenz B,van Genderen MM,Bertelsen M,Pott JR,Coppieters F,de Zaeytijd J,Thiadens AAHJ,Klaver CCW,Kroes HY,van Schooneveld MJ,Preising M,Hoyng CB,Leroy BP,van den Born LI,Collin RWJ

更新日期：2018-09-04 00:00:00

abstract：Purpose:To determine whether combining quantitative optical coherence tomography angiography (OCTA) parameters can achieve high sensitivity and specificity to distinguish eyes with nonproliferative diabetic retinopathy (NPDR) from those with proliferative diabetic retinopathy (PDR) as well as eyes with diabetes and no ...

journal_title：Investigative ophthalmology & visual science

authors： Ashraf M,Nesper PL,Jampol LM,Yu F,Fawzi AA

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:The relative effect of simultaneously administered oxygen and carbon dioxide on the retinal and cerebral vessels is still controversial. The purpose of this study was to quantify and compare the superior-temporal retinal arteriole (RA) and middle cerebral artery (MCA) responses to hypercarbic and combined hyper...

journal_title：Investigative ophthalmology & visual science

authors： Kisilevsky M,Mardimae A,Slessarev M,Han J,Fisher J,Hudson C

更新日期：2008-12-01 00:00:00

abstract：Purpose:To radiologically examine for the presence of bony remodeling of the orbit in thyroid eye disease (TED). Methods:Computed tomography (CT) scans of 248 orbits of 124 patients with TED and 185 orbits of 138 controls were retrospectively reviewed, and the following parameters measured: the angle of the inferomedi...

journal_title：Investigative ophthalmology & visual science

authors： Tan NYQ,Leong YY,Lang SS,Htoon ZM,Young SM,Sundar G

更新日期：2017-05-01 00:00:00

abstract：Purpose:The purpose of this study was to study the effect of minocycline and several neurotrophic factors, alone or in combination, on photoreceptor survival and macro/microglial reactivity in two rat models of retinal degeneration. Methods:P23H-1 (rhodopsin mutation), Royal College of Surgeon (RCS, pigment epithelium...

journal_title：Investigative ophthalmology & visual science

authors： Di Pierdomenico J,Scholz R,Valiente-Soriano FJ,Sánchez-Migallón MC,Vidal-Sanz M,Langmann T,Agudo-Barriuso M,García-Ayuso D,Villegas-Pérez MP

更新日期：2018-09-04 00:00:00

abstract：:A method for denuding Descemet's membrane by dissection of all overlying stroma, while preserving the corneal endothelial layer, was developed and evaluated. The technique consists in treating the stroma with trypsin and surgically removing the softened stromal layers. With an automated thickness-measuring technique, ...

journal_title：Investigative ophthalmology & visual science

authors： Soong H,Fischbarg J,Iwamoto T

更新日期：1978-11-01 00:00:00

abstract：:Chloride ion (Cl-) secretion by the rabbit corneal epithelium involves a catecholamine-stimulated Cl- conductance at the apical membrane, but the characteristics of the ion channel(s) responsible are unknown. A primary cell culture system was developed that induces stratified epithelial differentiation of rat and rabb...

journal_title：Investigative ophthalmology & visual science

authors： Marshall WS,Hanrahan JW

更新日期：1991-04-01 00:00:00

abstract：PURPOSE:This study investigated a novel motion-on-color paradigm to functionally isolate the magnocellular pathway and evaluate its diagnostic value in preperimetric glaucoma patients. METHODS:Thirty patients with preperimetric primary open-angle glaucoma and 30 controls participated in this study. They were tested in...

journal_title：Investigative ophthalmology & visual science

authors： Wen W,Zhang P,Liu T,Zhang T,Gao J,Sun X,He S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Vision restoration is a fast-approaching reality for some people with profound vision loss. In order to reliably determine treatment efficacy, accurate assessment of baseline residual visual function is critical. The purpose of this study was to compare residual function as detected on Goldman visual field (GVF...

journal_title：Investigative ophthalmology & visual science

authors： Ayton LN,Apollo NV,Varsamidis M,Dimitrov PN,Guymer RH,Luu CD

更新日期：2014-03-06 00:00:00

abstract：PURPOSE:To determine the size variation of the X-chromosomal human red and green visual pigment gene array in the general population using pulsed field gel electrophoresis and Southern blotting. METHODS:Peripheral blood lymphocytes were prepared from 67 anonymous males. The cells were embedded in agarose and the genom...

journal_title：Investigative ophthalmology & visual science

authors： Macke JP,Nathans J

更新日期：1997-04-01 00:00:00

abstract：:Retinal ultrastructure was examined at various intervals following a single intravitreal injection of 100-4,000 micrograms of gentamicin in rabbit eyes. Three days after injections of 100-500 micrograms, numerous abnormal lamellar lysosomal inclusions were observed in the retinal pigment epithelium (RPE) and in macrop...

journal_title：Investigative ophthalmology & visual science

authors： D'Amico DJ,Libert J,Kenyon KR,Hanninen LA,Caspers-Velu L

更新日期：1984-05-01 00:00:00

abstract：PURPOSE:To examine the relative prevalence of ocular conditions among children who are unable to perform preschool vision screening tests and the impact on measures of screening test performance. METHODS:Trained nurse and lay screeners each administered a Lea Symbols visual acuity (VA) test (Good-Lite, Inc., Steamwood...

journal_title：Investigative ophthalmology & visual science

authors： Maguire MG,Vision in Preschoolers Study Group.

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:To determine the interaction of M3 muscarinic receptors (M3AChR) and P2X(7) receptors to increase intracellular [Ca2+] ([Ca2+]i) and stimulate protein secretion in rat lacrimal gland cells. METHODS:Exorbital lacrimal glands from male Sprague-Dawley rats were divided into pieces or digested with collagenase to ...

journal_title：Investigative ophthalmology & visual science

authors： Dartt DA,Hodges RR

更新日期：2011-05-01 00:00:00

abstract：PURPOSE:The presence of eosinophilic granulocytes in ocular tissue is a hallmark of the host response to environmental and parasite allergens. Using a mouse model of Onchocerca volvulus-mediated keratitis (river blindness), the present study examined the role of the cytokines interleukin (IL)-4 and IL-13 in regulating ...

journal_title：Investigative ophthalmology & visual science

authors： Berger RB,Blackwell NM,Lass JH,Diaconu E,Pearlman E

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:Erythropoietin (EPO) modulates erythropoiesis by inhibiting apoptosis in erythrocyte progenitors. Recently, EPO has been shown to be protective in experimental models of mechanical trauma, neuroinflammation, cerebral and retinal ischemia, and even in a human stroke trial. However, little is known about EPO sign...

journal_title：Investigative ophthalmology & visual science

authors： Weishaupt JH,Rohde G,Pölking E,Siren AL,Ehrenreich H,Bähr M

更新日期：2004-05-01 00:00:00

abstract：:The purpose of the current study was to investigate the relationship between systemic blood pressure (BP) and long posterior ciliary arterial (LPCA) blood flow (BF) in response to autonomic drugs, and to determine the types of receptors involved. LPCA BF was measured in anesthetized rabbits at the retrobulbar region u...

journal_title：Investigative ophthalmology & visual science

authors： Okubo H,Gherezhiher T,Koss MC

更新日期：1990-05-01 00:00:00

abstract：:The hypotensive effect of ascorbate on intraocular pressure has been reported following topical application, oral administration, or anterior chamber infusion in animals. The present report describes the correlation of aqueous humor ascorbate concentration with intraocular pressure as well as outflow facility in vivo....

journal_title：Investigative ophthalmology & visual science

authors： Lee PF,Fox R,Henrick I,Lam WK

更新日期：1978-08-01 00:00:00

abstract：PURPOSE:Previous reports indicated that pregnancy and corneal injury (CI) trigger alterations of lacrimal gland (LG) growth factor expression and redistributions of lymphocytes from periductal foci to acini. The purpose of this study was to test our hypothesis that pregnancy would exacerbate the changes induced by CI. ...

journal_title：Investigative ophthalmology & visual science

authors： Ding C,Chang N,Fong YC,Wang Y,Trousdale MD,Mircheff AK,Schechter JE

更新日期：2006-04-01 00:00:00

abstract：PURPOSE:In the studies of spatial integration an increase in the spatial extent of the stimulus usually results in a decrease in the spatial frequency bandwidth of the stimulus. The authors investigated separately the effects of these two factors on contrast detectability. METHODS:Efficiencies were measured for a circ...

journal_title：Investigative ophthalmology & visual science

authors： Kukkonen H,Näsänen R,Rovamo J

更新日期：1994-06-01 00:00:00