Changes in Blood Pressure and Urine Albumin-Creatinine Ratio in a Randomized Clinical Trial Comparing Aflibercept, Bevacizumab, and Ranibizumab for Diabetic Macular Edema.

abstract：PURPOSE:To describe the clinical findings and to identify the genetic locus in a Dutch family with autosomal dominant benign concentric annular macular dystrophy (BCAMD). METHODS:All family members underwent ophthalmic examination. Linkage analysis of candidate retinal dystrophy loci and a whole genome scan were perfo...

journal_title：Investigative ophthalmology & visual science

authors： van Lith-Verhoeven JJ,Hoyng CB,van den Helm B,Deutman AF,Brink HM,Kemperman MH,de Jong WH,Kremer H,Cremers FP

更新日期：2004-01-01 00:00:00

abstract：:The authors investigated the mechanisms underlying the head shaking shown by some patients with congenital nystagmus (CN). In order to improve visual function by head shaking, a patient with CN must have some visual acuity loss due to retinal image motion created by the nystagmus; an abnormal vestibulo-ocular reflex (...

journal_title：Investigative ophthalmology & visual science

authors： Carl JR,Optican LM,Chu FC,Zee DS

更新日期：1985-08-01 00:00:00

abstract：PURPOSE:The relative effect of simultaneously administered oxygen and carbon dioxide on the retinal and cerebral vessels is still controversial. The purpose of this study was to quantify and compare the superior-temporal retinal arteriole (RA) and middle cerebral artery (MCA) responses to hypercarbic and combined hyper...

journal_title：Investigative ophthalmology & visual science

authors： Kisilevsky M,Mardimae A,Slessarev M,Han J,Fisher J,Hudson C

更新日期：2008-12-01 00:00:00

abstract：:An animal model of chronic cicatrizing trachoma has been produced by repeated ocular inoculation with Chlamydia trachomatis serotype E, a genitally transmitted strain. We have now produced a chronic follicular conjunctivitis on cynomolgus monkeys by repeated inoculation with C. trachomatis serotype A, which has been i...

journal_title：Investigative ophthalmology & visual science

authors： Taylor HR,Johnson SL,Prendergast RA,Schachter J,Dawson CR,Silverstein AM

更新日期：1982-10-01 00:00:00

abstract：PURPOSE:To investigate the alterations in microRNA (miRNA) expression during replicative senescence (RS) in human trabecular meshwork (HTM) cells. METHODS:Two HTM cell lines were serially passaged until they reached RS. Changes in expression of 30 miRNAs were assessed by real-time quantitative (q)-PCR. The effects of ...

journal_title：Investigative ophthalmology & visual science

authors： Li G,Luna C,Qiu J,Epstein DL,Gonzalez P

更新日期：2010-06-01 00:00:00

abstract：:Cataracts removed intracapsularly by cryoprobe technique from human diabetics were analyzed for sugars and polyols by gas liquid chromatography. The contents of sorbitol and fructose of lenses followed blood glucose levels at least up to 250 mg/dl. Studies indicate that human lens is capable of synthesizing substantia...

journal_title：Investigative ophthalmology & visual science

authors： Varma SD,Schocket SS,Richards RD

更新日期：1979-03-01 00:00:00

abstract：PURPOSE:The efficacy of the peptide Ac-EEED on reducing cell adhesion and proliferation in vitro and choroidal neovascularization (CNV) in vivo was examined. METHODS:The peptide chimera containing the Ac-EEED sequence was chemically linked to the N terminus of the XMTM delivery peptide from the E(rns) viral surface pr...

journal_title：Investigative ophthalmology & visual science

authors： Caballero S,Yang R,Grant MB,Chaqour B

更新日期：2011-04-16 00:00:00

abstract：PURPOSE:To investigate the discrepancy between grating and optotype visual acuity in children with visual impairment due to brain and/or ocular abnormalities. METHODS:Better eye acuity at 114 cm was studied in 81 patients (ages, 5-24 years) attending special schools for the visually handicapped. Fourteen patients had ...

journal_title：Investigative ophthalmology & visual science

authors： Stiers P,Vanderkelen R,Vandenbussche E

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:To compare adult discrimination performance on nine pediatric visual acuity tests to determine the consistency of optotype design. METHODS:After their binocular acuity was measured with each test, eight adult observers (mean age, 27 years ± 6.3 SD; three emmetropes and five corrected myopes) were shown isolate...

journal_title：Investigative ophthalmology & visual science

authors： Candy TR,Mishoulam SR,Nosofsky RM,Dobson V

更新日期：2011-06-16 00:00:00

abstract：Purpose:Suppression in amblyopia may be an unequal form of normal interocular suppression or a distinct pathophysiology. To explore this issue, we examined the orientation tuning and contrast dependence of continuous flash suppression (CFS) in adults with amblyopia and visually normal controls. Methods:Nine patients (...

journal_title：Investigative ophthalmology & visual science

authors： Gao TY,Ledgeway T,Lie AL,Anstice N,Black J,McGraw PV,Thompson B

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:We previously developed a method to measure visual function progression using "Progression sectors," which were derived from a clustering analysis of pointwise rates of glaucomatous visual field (VF) progression; however, only short series of VFs, where pointwise linear regression (PLR) is typically not reliabl...

journal_title：Investigative ophthalmology & visual science

authors： Hirasawa K,Murata H,Asaoka R

更新日期：2015-07-01 00:00:00

abstract：:Stevens-Johnson syndrome (SJS), and its more severe variant, toxic epidermal necrolysis (TEN), are life-threatening diseases of the skin and mucous membranes. After the acute-stage damage subsides, serious visual impairment and severe dry eye remains as ocular sequelae. At the acute stage, ocular complications occur i...

journal_title：Investigative ophthalmology & visual science

authors： Sotozono C,Ueta M,Yokoi N

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Skeletal and craniofacial muscles are frequently composed of multiple neuromuscular compartments that serve different physiological functions. Evidence of possible regional selectivity in LR intramuscular innervation was sought in a study of the anatomic potential of lateral rectus (LR) muscle compartmentalizat...

journal_title：Investigative ophthalmology & visual science

authors： Peng M,Poukens V,da Silva Costa RM,Yoo L,Tychsen L,Demer JL

更新日期：2010-09-01 00:00:00

abstract：PURPOSE:FGF-2 stimulates cell proliferation of rabbit corneal endothelial cells (rCECs) by degrading the cyclin-dependent kinase inhibitor p27(Kip1) (p27) through its phosphorylation mechanism. The authors investigated whether the cell proliferation of human CECs (hCECs) is also induced by FGF-2 stimulation through the...

journal_title：Investigative ophthalmology & visual science

authors： Lee JG,Song JS,Smith RE,Kay EP

更新日期：2011-10-17 00:00:00

abstract：PURPOSE:To examine the extent to which the two major determinants of refractive error, corneal curvature and axial length, are scaled relative to one another by shared genetic variants, along with their relationship to the genetic scaling of height. METHODS:Corneal curvature, axial length, and height were measured in ...

journal_title：Investigative ophthalmology & visual science

authors： Guggenheim JA,Zhou X,Evans DM,Timpson NJ,McMahon G,Kemp JP,St Pourcain B,Northstone K,Ring SM,Fan Q,Wong TY,Cheng CY,Khor CC,Aung T,Saw SM,Williams C

更新日期：2013-03-07 00:00:00

abstract：PURPOSE:The role of VEGF-A in the normal ciliary body is largely unexplored. The ciliary body is similar in many respects to the choroid plexus of the brain, and we demonstrated previously the importance of VEGF-A in maintenance of choroid plexus vasculature and ependymal cells. Therefore, the role of VEGF-A in ciliary...

journal_title：Investigative ophthalmology & visual science

authors： Ford KM,Saint-Geniez M,Walshe TE,D'Amore PA

更新日期：2012-11-07 00:00:00

abstract：PURPOSE:The aim of this study was to determine the function of the tight junction protein occludin in the control of permeability, under diffusive and hydrostatic pressures, and its contribution to the control of cell division in retinal pigment epithelium. METHODS:Occludin expression was inhibited in the human retina...

journal_title：Investigative ophthalmology & visual science

authors： Phillips BE,Cancel L,Tarbell JM,Antonetti DA

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:To assess the impact of vitamin A supplementation at 4-month intervals on the prevalence and incidence of xerophthalmia among preschool-age children. METHODS:A stratified, random sample of 40 wards with 4766 children in Sarlahi district of Nepal was selected to participate in a randomized, controlled, communit...

journal_title：Investigative ophthalmology & visual science

authors： Katz J,West KP Jr,Khatry SK,Thapa MD,LeClerq SC,Pradhan EK,Pokhrel RP,Sommer A

更新日期：1995-12-01 00:00:00

abstract：PURPOSE:To investigate the interobserver agreement for the detection of optical coherence tomography (OCT) features of disease activity in patients with neovascular age-related macular degeneration (nAMD). METHODS:This was a cross-sectional agreement study in which grading of OCT line scans from patients with nAMD was...

journal_title：Investigative ophthalmology & visual science

authors： Patel PJ,Browning AC,Chen FK,Da Cruz L,Tufail A

更新日期：2009-11-01 00:00:00

abstract：:Axonal transport studies were undertaken to determine the effect of chronic demyelination on axonal function in experimental allergic optic neuritis in the guinea pig, an animal model for multiple sclerosis. Fast and slow components of axonal transport over the prelaminar, laminar, and retrolaminar portions of the opt...

journal_title：Investigative ophthalmology & visual science

authors： Rao NA,Guy J,Sheffield PS

更新日期：1981-10-01 00:00:00

abstract：PURPOSE:To assess the safety of a possible substitute treatment for intraocular steroid injections, intraocular injections of ketorolac tromethamine, one of the nonsteroidal anti-inflammatory drugs, were performed in rabbits. METHODS:Either 0.5% or 0.25% preservative-free ketorolac tromethamine ophthalmic solution (0....

journal_title：Investigative ophthalmology & visual science

authors： Margalit E,Kugler LJ,Brumm MV,Meza JL,Kompella UB,Escobar ER,Christensen GR

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:To investigate the neural basis of contraction anisocoria and any implications for assessments using pupillary responses, through analysis of topographic variation in amplitudes of direct and consensual pupil responses. METHODS:Direct and consensual pupillary contraction amplitudes were analyzed from six studi...

journal_title：Investigative ophthalmology & visual science

authors： Carle CF,Maddess T,James AC

更新日期：2011-04-12 00:00:00

abstract：PURPOSE:A human biovar of Chlamydia trachomatis was used to develop a murine model of ocular chlamydial infection. The inbred mouse model will allow detailed immunologic studies during ocular infection, and use of a human biovar for infection may aid in identification of appropriate vaccine strategies against chlamydia...

journal_title：Investigative ophthalmology & visual science

authors： Whittum-Hudson JA,O'Brien TP,Prendergast RA

更新日期：1995-09-01 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) ocular shedding and recurrent corneal epithelial lesions were assessed following an intravenous injection of cyclophosphamide (75 mg/kg) and 24 hr later an intravenous injection of dexamethasone (4 mg/kg) in 24 eyes of 15 rabbits latently infected with HSV-1 strain McKrae. Sampling ...

journal_title：Investigative ophthalmology & visual science

authors： Haruta Y,Rootman DS,Xie LX,Kiritoshi A,Hill JM

更新日期：1989-03-01 00:00:00

abstract：PURPOSE:To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head. METHODS:This experimental study included nine monkeys that underwent implantation of a lumbar-peritoneal cerebrospinal fluid (C...

journal_title：Investigative ophthalmology & visual science

authors： Yang D,Fu J,Hou R,Liu K,Jonas JB,Wang H,Chen W,Li Z,Sang J,Zhang Z,Liu S,Cao Y,Xie X,Ren R,Lu Q,Weinreb RN,Wang N

更新日期：2014-04-15 00:00:00

abstract：PURPOSE:To investigate whether polymorphisms in the gene encoding the chemokine receptor CX3CR1, which has been linked to changes in functional ligand-binding activity, are associated with retinal vasculitis (RV) in a cohort of patients in the United Kingdom. METHODS:DNA was prepared from whole blood of 126 patients w...

journal_title：Investigative ophthalmology & visual science

authors： Wallace GR,Vaughan RW,Kondeatis E,Mathew R,Chen Y,Graham EM,Stanford MR

更新日期：2006-07-01 00:00:00

abstract：:Flow cytometry (FCM) was used to investigate antigenic expression and modulation during the cell cycle of Y-79 and WERI-Rb1 tissue cultured retinoblastoma cell lines using a polyclonal anti-Y-79 antibody and fluorescein conjugated lectins. Several Y-79 resting cell populations were identified by FCM analysis of antibo...

journal_title：Investigative ophthalmology & visual science

authors： Felberg NT,Augsburger JJ,Shields JA,Goldschmidt J,Pronesti G,Haimowitz A

更新日期：1985-09-01 00:00:00

abstract：PURPOSE:The role of macular pigment (MP) in age-related maculopathy (ARM) is still not clearly understood. Recent studies have reported on variations in the spatial distribution of MP optical density (MPOD) including a secondary peak ("ring") in the slope of the MPOD profile. The authors investigated in a cross-section...

journal_title：Investigative ophthalmology & visual science

authors： Dietzel M,Zeimer M,Heimes B,Pauleikhoff D,Hense HW

更新日期：2011-10-11 00:00:00

abstract：PURPOSE:We described the optical coherence tomography (OCT) features of diabetic macular ischemia (DMI), and correlate these findings with visual acuity (VA). METHODS:Clinical and imaging data were collected from 100 patients with type 2 diabetes. Qualitative grading of DMI severity was determined according to criteri...

journal_title：Investigative ophthalmology & visual science

authors： Sim DA,Keane PA,Fung S,Karampelas M,Sadda SR,Fruttiger M,Patel PJ,Tufail A,Egan CA

更新日期：2014-01-21 00:00:00

abstract：:An automated Minigel electrophoresis system (PhastSystem, Pharmacia, Uppsala, Sweden) was tested for human tear protein analysis. Tear samples were treated under nonreducing or reducing conditions before sodium dodecyl sulphate polyacryl amide gel electrophoresis (SDS-PAGE). Micro-amounts of tears (2 microliters) were...

journal_title：Investigative ophthalmology & visual science

authors： Kuizenga A,van Haeringen NJ,Kijlstra A

更新日期：1991-02-01 00:00:00