当前位置： SCI文献检索 > INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE期刊下所有文献 > Impact of vitamin A supplementation on prevalence and incidence of xerophthalmia in Nepal.

Impact of vitamin A supplementation on prevalence and incidence of xerophthalmia in Nepal.

Abstract：

PURPOSE:To assess the impact of vitamin A supplementation at 4-month intervals on the prevalence and incidence of xerophthalmia among preschool-age children. METHODS:A stratified, random sample of 40 wards with 4766 children in Sarlahi district of Nepal was selected to participate in a randomized, controlled, community trial. In the vitamin A group, at 4-month intervals, neonates received 50,000 IU, 1- to 11-month-old infants received 100,000 IU, and children 1 through 4 years of age received 200,000 IU. Children underwent eye examination before the intervention and 16 months later. RESULTS:Before the intervention, 4318 children were examined for xerophthalmia. The prevalence was 2.3% in the vitamin A group and 3.3% in the placebo group. All children with xerophthalmia were treated with vitamin A at the time of the examination. Of those examined at baseline, 38 in the vitamin A group and 48 in the placebo group died in the 16 months after intervention. There were 1871 (84%) surviving children in the vitamin A group and 1711 (85%) in the placebo group examined at follow-up. After adjustment for the baseline prevalence of xerophthalmia, vitamin A reduced the prevalence at follow-up by 63% (95% confidence interval, 21% to 83%). The apparent incidence was 3.2/1000 per year in the vitamin A group and 9.2/1000 per year in the placebo group, an adjusted reduction of 62% (95% confidence interval, 0% to 86%). CONCLUSIONS:Supplementation was effective at reducing the prevalence and incidence of xerophthalmia.

journal_name

Invest Ophthalmol Vis Sci

journal_title

Investigative ophthalmology & visual science

authors

Katz J,West KP Jr,Khatry SK,Thapa MD,LeClerq SC,Pradhan EK,Pokhrel RP,Sommer A

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

2577-83

issue

13

eissn

0146-0404

issn

1552-5783

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验

相关文献

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE文献大全
  • Prevention of ornithine cytotoxicity by nonpolar side chain amino acids in retinal pigment epithelial cells.

    abstract：PURPOSE:To investigate the effect of amino acids on ornithine cytotoxicity in ornithine-delta-aminotransferase (OAT)-deficient human retinal pigment epithelial (RPE) cells as an in vitro model of gyrate atrophy (GA) of the choroid and retina. METHODS:RPE cells were treated with 0.5 mM 5-fluoromethylornithine (5-FMOrn)...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.03-0403

    authors： Nakauchi T,Ando A,Ueda-Yamada M,Yamazaki Y,Uyama M,Matsumura M,Ito S

    更新日期：2003-11-01 00:00:00

  • The effect of prednisolone on antibody-dependent cell-mediated cytotoxicity and the growth of type I herpes simplex virus in human cells.

    abstract：:Treatment of human skin and corneal fibroblasts with prednisolone-21-phosphate did not increase the capacity of these cells to replicate type I herpes simplex virus (HSV). The steroid however was found to (1) inhibit human lymphocytes from mediating antibody-dependent cell-mediated cytotoxicity (ADCC) against HSV-infe...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Cooper JA Jr,Daniels CA,Trofatter EF Jr

    更新日期：1978-04-01 00:00:00

  • Relationship between inositol 1,4,5-trisphosphate receptor isoforms and subcellular Ca2+ signaling patterns in nonpigmented ciliary epithelia.

    abstract：PURPOSE:Subcellular Ca2+ signaling patterns, such as Ca2+ waves, gradients, and oscillations, are an important aspect of cell regulation, but the molecular basis for these signaling patterns is not understood. Because Ca2+ release patterns differ among isoforms of the inositol 1,4,5-trisphosphate (InsP3) receptor, the ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Hirata K,Nathanson MH,Burgstahler AD,Okazaki K,Mattei E,Sears ML

    更新日期：1999-08-01 00:00:00

  • Susceptibility to TGFbeta2-induced cataract increases with aging in the rat.

    abstract：PURPOSE:Cataract is the most common cause of blindness in the world today, and yet there is no generally accepted treatment other than surgical intervention. Studies in rodent models designed to increase understanding of the molecular basis of cataract have shown that transforming growth factor (TGF)-beta induces morph...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Hales AM,Chamberlain CG,McAvoy JW

    更新日期：2000-10-01 00:00:00

  • Implantation and explantation of a wireless epiretinal retina implant device: observations during the EPIRET3 prospective clinical trial.

    abstract：PURPOSE:Visual sensations in patients with blindness and retinal degenerations may be restored by electrical stimulation of retinal neurons with implantable microelectrode arrays. A prospective trial was initiated to evaluate the safety and efficacy of a wireless intraocular retinal implant (EPIRET3) in six volunteers ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 临床试验,杂志文章

    doi：10.1167/iovs.08-2752

    authors： Roessler G,Laube T,Brockmann C,Kirschkamp T,Mazinani B,Goertz M,Koch C,Krisch I,Sellhaus B,Trieu HK,Weis J,Bornfeld N,Röthgen H,Messner A,Mokwa W,Walter P

    更新日期：2009-06-01 00:00:00

  • Cholesterol, phospholipid, and protein changes in focal opacities in the human eye lens.

    abstract：PURPOSE:Focal opacities are signs of early cataractogenesis in the human lens. They progress slowly over a lifetime and may be precursors of mature cataracts. The authors analyzed changes in proteins, phospholipids, and cholesterol in these opacities using in situ techniques: Raman microspectroscopy, filipin cytochemis...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Duindam JJ,Vrensen GF,Otto C,Greve J

    更新日期：1998-01-01 00:00:00

  • The insensitivity of the chicken eye to the inflammatory effects of x-rays in contrast to its sensitivity to other inflammatory agents.

    abstract：:The effects of x-rays and three chemical agents, known to cause intraocular inflammation in mammalian eyes, were studied on the chicken eye because this species was reported to be insensitive to the cataractogenic effects of x-rays. Intravitreal injection of Shigella endotoxin and topical and/or intravitreal administr...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Stetz DE,Bito LZ

    更新日期：1978-05-01 00:00:00

  • Ocular absorption of topically applied FK506 from liposomal and oil formulations in the rabbit eye.

    abstract：PURPOSE:To investigate the use of topically applied FK506, a new immunosuppressive compound, systemic and ocular absorption was determined in serum and various ocular tissues. METHODS:Two drops of 20 microliters FK506 were applied using oil dissolved (OD-FK506) or liposome-bound (LIP-FK506) drug. FK506 concentrations ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Pleyer U,Lutz S,Jusko WJ,Nguyen KD,Narawane M,Rückert D,Mondino BJ,Lee VH,Nguyen K

    更新日期：1993-08-01 00:00:00

  • Age-related macular degeneration and the other double helix. The Cogan Lecture.

    abstract：:The study and therapy of age-related macular degeneration (AMD), a leading cause of blindness worldwide, have taken great strides over the past decade. During the same time, a central role for RNA in many human diseases has been discovered. We have identified anti-angiogenic functions for synthetic double stranded RNA...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 传,历史文章

    doi：10.1167/iovs.11-7328

    authors： Ambati J

    更新日期：2011-04-06 00:00:00

  • Trabecular meshwork glycosaminoglycans in human and cynomolgus monkey eye.

    abstract：:The glycosaminoglycans (GAGs) extractable from the trabecular meshworks (TM) of human and non-human primate eye have been analyzed by sequential enzymatic degradation and cellulose acetate electrophoresis. For comparison, similar extracts of the cornea, sclera, iris, and ciliary body have also been analyzed. The distr...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Acott TS,Westcott M,Passo MS,Van Buskirk EM

    更新日期：1985-10-01 00:00:00

  • Clinical and antiviral efficacy of an ophthalmic formulation of dexamethasone povidone-iodine in a rabbit model of adenoviral keratoconjunctivitis.

    abstract：PURPOSE:To determine the efficacy of a new formulation of topical dexamethasone 0.1%/povidone-iodine 0.4% (FST-100) in reducing clinical symptoms and infectious viral titers in a rabbit model of adenoviral keratoconjunctivitis. METHODS:Rabbit corneas were inoculated bilaterally with 2×10(6) plaque-forming-units (PFU) ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.10-5944

    authors： Clement C,Capriotti JA,Kumar M,Hobden JA,Foster TP,Bhattacharjee PS,Thompson HW,Mahmud R,Liang B,Hill JM

    更新日期：2011-01-21 00:00:00

  • Lactoferrin Concentration in Human Tears and Ocular Diseases: A Meta-Analysis.

    abstract：Purpose:To evaluate the potential of lactoferrin (Lf) as a diagnostic biomarker for ocular diseases using a meta-analytic approach. Methods:All original studies reporting an estimate of the average Lf concentration in healthy subjects and those affected by ocular diseases were searched up to March 2020. The DerSimonia...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.61.12.9

    authors： Ponzini E,Scotti L,Grandori R,Tavazzi S,Zambon A

    更新日期：2020-10-01 00:00:00

  • Elevated plasma pentraxin 3 levels are associated with development and progression of diabetic retinopathy in Korean patients with type 2 diabetes mellitus.

    abstract：PURPOSE:To evaluate the association between elevated levels of plasma pentraxin 3 (PTX3) and the development and/or progression of diabetic retinopathy (DR). METHODS:In this case-control study, 92 diabetic patients with DR (group 3), 30 diabetic patients without DR (group 2), and 41 normal subjects (group 1) were enro...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.14-14864

    authors： Yang HS,Woo JE,Lee SJ,Park SH,Woo JM

    更新日期：2014-08-26 00:00:00

  • Effect of leukocytes on corneal cellular proliferation and wound healing.

    abstract：PURPOSE:To establish whether fucoidin, by blocking the adhesion of leukocytes on the limbal vascular endothelium, prevents extravasation of the cells from the blood stream into the limbal stroma and the wounded area after corneal injury. Successful leukocyte blocking enabled investigation of the influence of leukocytes...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Gan L,Fagerholm P,Kim HJ

    更新日期：1999-03-01 00:00:00

  • Diabetic Optic Neuropathy and Its Risk Factors in Chinese Patients With Diabetic Retinopathy.

    abstract：Purpose:To investigate diabetic optic neuropathy (DON) prevalence and risk factors in Chinese diabetic retinopathy (DR) patients. Methods:This retrospective study included 1067 eyes (550 patients) that underwent ocular imaging. The diabetes duration, systolic blood pressure (SBP), hemoglobin A1c (HbA1c), and high-dens...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.19-26825

    authors： Hua R,Qu L,Ma B,Yang P,Sun H,Liu L

    更新日期：2019-08-01 00:00:00

  • Removal of biofilm from contact lens storage cases.

    abstract：PURPOSE:Lens case hygiene practices are important in maintaining safe contact lens wear. However, the effectiveness of various lens case cleaning practices have not been evaluated and compared. This in vitro study aimed to evaluate and compare the efficacy of cleaning practices that are most commonly carried out by len...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.10-5796

    authors： Wu YT,Zhu H,Willcox M,Stapleton F

    更新日期：2010-12-01 00:00:00

  • Invasion of retinal pigment epithelial cells: N-cadherin, hepatocyte growth factor, and focal adhesion kinase.

    abstract：PURPOSE:To investigate the role of N-cadherin and hepatocyte growth factor (HGF) in the invasion of collagen type I by human retinal pigment epithelial (RPE) cells. METHODS:RPE sheets from eight human eyes were used for characterization through Western blot analysis of the expression of cadherin in total lysates or af...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.01-1096

    authors： Van Aken EH,De Wever O,Van Hoorde L,Bruyneel E,De Laey JJ,Mareel MM

    更新日期：2003-02-01 00:00:00

  • A comparison of HLA genotype with inflammation in uveal melanoma.

    abstract：PURPOSE:Human leukocyte antigen (HLA) polymorphisms have been associated with the development of autoimmune diseases. In uveal melanoma, a high expression of HLA classes I and II, and infiltration with lymphocytes and macrophages are associated with a bad prognosis. Inflammation has an important role in this malignancy...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-8901

    authors： van Essen TH,Bronkhorst IH,Maat W,Verduyn W,Roelen DL,Luyten GP,Jager MJ

    更新日期：2012-05-04 00:00:00

  • The Effect of Light Level and Small Pupils on Presbyopic Reading Performance.

    abstract：Purpose:To examine the impact of small pupils and light levels on reading performance of distance-corrected presbyopes. To determine whether small pupils would enable presbyopes to read at near even at low light levels. Methods:To establish the lower range of text luminances, we quantified the space-averaged luminance...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-20008

    authors： Xu R,Gil D,Dibas M,Hare W,Bradley A

    更新日期：2016-10-01 00:00:00

  • Gamma-interferon effects on human fibroblasts from Tenon's capsule.

    abstract：:Gamma-interferon (G-IFN) exhibits antiproliferative effects, inhibits collagen synthesis by fibroblasts, and may help to regulate the turnover of fibrous tissue. Fibroblasts from Tenon's capsule are cellular components that contribute to unsuccessful glaucoma filtration surgery. Therefore, the authors studied the effe...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Latina MA,Belmonte SJ,Park C,Crean E

    更新日期：1991-09-01 00:00:00

  • Inhibitory Effects of 2,2'-Dipyridyl and 1,2,3,4,6-Penta-O-Galloyl-b-D-Glucopyranose on Biofilm Formation in Contact Lens Cases.

    abstract：PURPOSE:This study observed biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus in contact lens cases and investigated the inhibitory effects of 2,2'-dipyridyl (2DP) and 1,2,3,4,6-penta-O-galloyl-b-D-glucopyranose (PGG). METHODS:Biofilm formation of P. aeruginosa ATCC 9027 and S. aureus ATCC 25923 an...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.15-17723

    authors： Cho P,Shi GS,Boost M

    更新日期：2015-11-01 00:00:00

  • Blockade of insulin receptor substrate-1 inhibits corneal lymphangiogenesis.

    abstract：PURPOSE:To analyze whether insulin receptor substrate (IRS-1) is involved in lymphatic vessel development and whether IRS-1 blockade can inhibit lymphangiogenesis in vivo. METHODS:The impact of IRS-1 blockade by GS-101 (Aganirsen), an antisense oligonucleotide against IRS-1, on lymphatic endothelial cell (LEC) prolife...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.10-6816

    authors： Hos D,Regenfuss B,Bock F,Onderka J,Cursiefen C

    更新日期：2011-07-29 00:00:00

  • Association of polymorphisms in the hepatocyte growth factor gene promoter with keratoconus.

    abstract：PURPOSE:Keratoconus is a progressive disorder of the cornea that can lead to severe visual impairment or blindness. Although several genomic regions have been linked to rare familial forms of keratoconus, no genes have yet been definitively identified for common forms of the disease. METHODS:Two genome-wide associatio...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.11-8261

    authors： Burdon KP,Macgregor S,Bykhovskaya Y,Javadiyan S,Li X,Laurie KJ,Muszynska D,Lindsay R,Lechner J,Haritunians T,Henders AK,Dash D,Siscovick D,Anand S,Aldave A,Coster DJ,Szczotka-Flynn L,Mills RA,Iyengar SK,Taylor KD,

    更新日期：2011-10-31 00:00:00

  • Pharmacokinetics of intravitreal carbenicillin, cefazolin, and gentamicin in rhesus monkeys.

    abstract：:Although intravitreal injection of antibiotics is being used more widely in treatment of bacterial endophthalmitis, the pharmacokinetic principles that underlie such therapy have been derived exclusively from experiments in the rabbit. Therefore, we studied several representative antibiotics in normal eyes of rhesus m...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Barza M,Kane A,Baum J

    更新日期：1983-12-01 00:00:00

  • Stretch to see: lateral tension strongly determines cell survival in long-term cultures of adult porcine retina.

    abstract：PURPOSE:To explore the effect of lateral tension as a survival factor for retinal explants in vitro. The central nervous system (CNS) resides in a highly mechanical milieu. However, the importance of biomechanical homeostasis for normal CNS function has not been extensively explored. Diseases in which normal mechanical...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.12-11420

    authors： Taylor L,Moran D,Arnér K,Warrant E,Ghosh F

    更新日期：2013-03-13 00:00:00

  • Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys.

    abstract：PURPOSE:To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head. METHODS:This experimental study included nine monkeys that underwent implantation of a lumbar-peritoneal cerebrospinal fluid (C...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.13-13657

    authors： Yang D,Fu J,Hou R,Liu K,Jonas JB,Wang H,Chen W,Li Z,Sang J,Zhang Z,Liu S,Cao Y,Xie X,Ren R,Lu Q,Weinreb RN,Wang N

    更新日期：2014-04-15 00:00:00

  • Thy-1 Regulates VEGF-Mediated Choroidal Endothelial Cell Activation and Migration: Implications in Neovascular Age-Related Macular Degeneration.

    abstract：Purpose:This study addresses the hypothesis that age-related stresses upregulate Thy-1 in choroidal endothelial cells (CECs) and contribute to CEC activation and migration, processes important in choroidal neovascularization (CNV). Methods:Measurements were made of Thy-1 protein (Western blot) in CECs and Thy-1 mRNA (...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.16-19691

    authors： Wang H,Han X,Kunz E,Hartnett ME

    更新日期：2016-10-01 00:00:00

  • Age-related change in retinal nerve fiber layer thickness measured with spectral domain optical coherence tomography.

    abstract：PURPOSE:We investigated age-related change in peripapillary retinal nerve fiber layer thicknesses (RNFLT) measured with spectral domain optical coherence tomography (SD-OCT) in healthy individuals. METHODS:In this cross-sectional study, peripapillary RNFL measurement was performed using a Cirrus SD-OCT device. Linear ...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：10.1167/iovs.13-12634

    authors： Celebi AR,Mirza GE

    更新日期：2013-12-11 00:00:00

  • Visual dysfunction between migraine events.

    abstract：PURPOSE:To evaluate interictal visual dysfunction in persons with migraine in terms of spatiotemporal selectivity and location within the visual pathways. METHODS:The vision of a group of 15 persons who had experienced migraine with aura was compared with that of 15 normal age-matched control subjects. A range of thre...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： McKendrick AM,Vingrys AJ,Badcock DR,Heywood JT

    更新日期：2001-03-01 00:00:00

  • Scanning electron microscopy of normal and lased rabbit pigment epithelium.

    abstract：:Scanning electron microscopic (SEM) observations of the rabbit retinal pigment epithelium (RPE) are reported both for normal tissue and for tissue subjected to laser radiation. In normal RPE, cells were observed to be closely packed and to have the characteristic hexagonal shape. The microvilli were abundant and of tw...

    journal_title：Investigative ophthalmology & visual science

    pub_type： 杂志文章

    doi：

    authors： Borwein B,Sanwal M,Medeiros JA,McGowan JW

    更新日期：1977-08-01 00:00:00