Effect of optical defocus on detection and recognition of vanishing optotype letters in the fovea and periphery.

abstract：PURPOSE:The objective of the study was to investigate the effect of glial cell line-derived neurotrophic factor (GDNF) on the multifocal electroretinogram (mfERG) following an induced branch retinal vein occlusion (BRVO) in pigs. METHODS:Electrophysiological examination of the retina was performed in 20 pigs with stan...

journal_title：Investigative ophthalmology & visual science

authors： Ejstrup R,Cour Ml,Kyhn MV,Heegaard S,Kiilgaard JF

更新日期：2012-09-14 00:00:00

abstract：PURPOSE:To investigate the topographic relationship between ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) defects in open-angle glaucoma patients with localized RNFL defects, using spectral-domain optical coherence tomography (SD-OCT). METHODS:We analyzed 140 eyes of 1...

journal_title：Investigative ophthalmology & visual science

authors： Kim KE,Park KH,Yoo BW,Jeoung JW,Kim DM,Kim HC

更新日期：2014-05-06 00:00:00

abstract：PURPOSE:Cultured human corneal endothelial cells (cHCECs) are anticipated to become an alternative to donor corneas for the treatment of corneal endothelial dysfunction. However, cHCECs reportedly tend to exhibit chromosomal abnormality during in vitro cell division, thereby hampering their use in the clinical setting....

journal_title：Investigative ophthalmology & visual science

authors： Hamuro J,Ueno M,Toda M,Sotozono C,Montoya M,Kinoshita S

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:This study was designed to examine whether retinal function can be rescued by allogeneic normal retinal pigment epithelial (RPE) grafts in Royal College of Surgeons (RCS) with retinal degeneration and, if so, whether this rescued function can be measured and followed by recording the corneal electroretinogram (...

journal_title：Investigative ophthalmology & visual science

authors： Jiang LQ,Hamasaki D

更新日期：1994-12-01 00:00:00

abstract：PURPOSE:To investigate the involvement of the p38 mitogen-activated protein (MAP) kinase and phosphatidylinositol-3 (PI-3) kinase-Akt signaling pathways after pathologic stimulation by N-methyl-D-aspartate (NMDA) receptors of retinal neurons in vivo. METHODS:NMDA (2-200 nmol), SB203580 (0.2-10 nmol, an inhibitor of p3...

journal_title：Investigative ophthalmology & visual science

authors： Manabe S,Lipton SA

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Leber hereditary optic neuropathy (LHON) is an inherited mitochondrial optic neuropathy characterized by bilateral, severe loss of central vision. In this study, the first formal assessment was conducted of visual disability in affected and unaffected individuals from molecularly confirmed LHON pedigrees. METH...

journal_title：Investigative ophthalmology & visual science

authors： Kirkman MA,Korsten A,Leonhardt M,Dimitriadis K,De Coo IF,Klopstock T,Griffiths PG,Hudson G,Chinnery PF,Yu-Wai-Man P

更新日期：2009-07-01 00:00:00

abstract：Purpose:To review the usefulness of local and systemic inflammatory biomarkers of diabetic retinopathy (DR) to implement a more personalized treatment. Methods:An integrated research (from ophthalmologist and diabetologist point of view) of most significant literature on serum, vitreous, and aqueous humor (AH) biochem...

journal_title：Investigative ophthalmology & visual science

authors： Vujosevic S,Simó R

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Transforming growth factor beta-induced protein (TGFBIp; 68 kDa) is a secreted extracellular matrix (ECM) protein that has been demonstrated to regulate cell attachment in a variety of cell types. The sclera synthesizes and secretes TGFBIp, which may function to facilitate scleral ECM remodeling events associat...

journal_title：Investigative ophthalmology & visual science

authors： Shelton L,Rada JA

更新日期：2009-08-01 00:00:00

abstract：:Purpose: To compare efficacy and safety between subconjunctival and intrascleral methods of mitomycin C (MMC) application during trabeculectomy Methods: This retrospective study included 165 eyes treated by trabeculectomy and compared clinical outcomes between eyes that received subconjunctival MMC (Group 1, 80 eyes, ...

journal_title：Investigative ophthalmology & visual science

authors： Zhang M,Li B,Wang J,Liu W,Wu X

更新日期：2014-07-21 00:00:00

abstract：PURPOSE:Tubby-like proteins (TULPs) are a family of four proteins, two of which have been linked to neurosensory disease phenotypes. TULP1 is a photoreceptor-specific protein that is mutated in retinitis pigmentosa, an inherited retinal disease characterized by the degeneration of rod and cone photoreceptor cells. To i...

journal_title：Investigative ophthalmology & visual science

authors： Xi Q,Pauer GJ,Ball SL,Rayborn M,Hollyfield JG,Peachey NS,Crabb JW,Hagstrom SA

更新日期：2007-06-01 00:00:00

abstract：PURPOSE:Since, to our knowledge, there are no reports on the prevalence of the blaNDM-1 gene among ocular isolates of Enterobacteriaceae, and only limited information on the prevalence of extended spectrum beta-lactamases (ESBLs) among ocular bacterial isolates are available, our study was undertaken. METHODS:A prospe...

journal_title：Investigative ophthalmology & visual science

authors： Sowmiya M,Malathi J,Madhavan HN

更新日期：2012-08-07 00:00:00

abstract：:Although the lens has been shown to have the capacity to respond to insulin in vitro, little is known concerning the biochemical relationships of insulin to the lens in vivo. Therefore we have measured insulin in the aqueous humor of rabbits by a sensitive radioimmunoassay after paracentesis and feeding. The insulin c...

journal_title：Investigative ophthalmology & visual science

authors： Coulter JB 3rd,Engelke JA,Eaton DK

更新日期：1980-12-01 00:00:00

abstract：PURPOSE:The authors investigated the effect of brain-derived neurotrophic factor (BDNF) administration on the expression of Ca(2+)-binding proteins in the developing bdnf(-/-) mouse retina. METHODS:Intraocular injections of BDNF (0.5 microg) were applied on postnatal day (P) 11 bdnf(-/-) mice, and their effects were e...

journal_title：Investigative ophthalmology & visual science

authors： Arango-González B,Cellerino A,Kohler K

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Disruption of the normally antiangiogenic environment of the retina leads to aberrant angiogenesis, the major cause of vision loss throughout the world. Prolactin (PRL), the hormone originally associated with milk production, can be proteolytically processed to 16K-PRL, a 16 kDa N-terminal PRL fragment with pot...

journal_title：Investigative ophthalmology & visual science

authors： Aranda J,Rivera JC,Jeziorski MC,Riesgo-Escovar J,Nava G,López-Barrera F,Quiróz-Mercado H,Berger P,Martínez de la Escalera G,Clapp C

更新日期：2005-08-01 00:00:00

abstract：PURPOSE:To determine whether the relative amounts of mucin mRNA in the conjunctival epithelium and mucin protein in the tears are altered in patients with Sjögren syndrome compared with healthy individuals. METHODS:Tear fluid was collected from the inferior fornix of normal subjects (n = 17) and patients with Sjögren ...

journal_title：Investigative ophthalmology & visual science

authors： Argüeso P,Balaram M,Spurr-Michaud S,Keutmann HT,Dana MR,Gipson IK

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:Peripheral and limbal corneal stromal cells (PLCSCs), which contain keratocytes, have a complex phenotype. Knowledge of keratocyte cell properties, function, and origin is limited. Evidence available thus far has suggested both mesenchymal stromal and hematopoietic characteristics. Multipotent mesenchymal strom...

journal_title：Investigative ophthalmology & visual science

authors： Branch MJ,Hashmani K,Dhillon P,Jones DR,Dua HS,Hopkinson A

更新日期：2012-08-03 00:00:00

abstract：:Previous investigations have shown that corneal epithelium, migrating to cover a wound, synthesizes protein and glycoprotein at a faster rate than does normal stratified epithelium. The authors have found that the maximal rate of synthesis, as indicated by the incorporation of leucine and glucosamine, occurs 16 hr aft...

journal_title：Investigative ophthalmology & visual science

authors： Zieske JD,Gipson IK

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To determine the effect of human recombinant TIGR/myocilin (MYOC) protein on outflow resistance in the human anterior segment. METHODS:A cDNA for MYOC was inserted into a bacterial expression system and purified with nickel ion affinity chromatography. The anterior segments of 12 pairs of human eyes were place...

journal_title：Investigative ophthalmology & visual science

authors： Fautsch MP,Bahler CK,Jewison DJ,Johnson DH

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:To determine the accommodative accuracy of infants and young children before they had had any form of clinical intervention or treatment, in an attempt to determine the difference between 'normal' and 'abnormal' visual experience for these individuals. METHODS:Nott retinoscopy was performed on 111 subjects in ...

journal_title：Investigative ophthalmology & visual science

authors： Candy TR,Gray KH,Hohenbary CC,Lyon DW

更新日期：2012-01-17 00:00:00

abstract：:Bovine rod outer segments (ROS) specifically stimulate DNA synthesis in lymphocyte cultures from guinea pigs preimmunized with ROS. At doses above 10 microgram/ml protein, however, preparations of ROS inhibit DNA and RNA synthesis by the sensitized lymphocytes or by normal lymphocytes reacting to mitogens. The inhibti...

journal_title：Investigative ophthalmology & visual science

authors： Gery I

更新日期：1980-07-01 00:00:00

abstract：PURPOSE:To evaluate the possible correlation between the visual field defects in patients with primary open-angle glaucoma (POAG) and the expression and enzymatic activity of nitric oxide synthase (NOS) isoenzymes and nitrotyrosine in trabecular meshwork (TM) samples. METHODS:TM specimens were collected from 146 patie...

journal_title：Investigative ophthalmology & visual science

authors： Fernández-Durango R,Fernández-Martínez A,García-Feijoo J,Castillo A,de la Casa JM,García-Bueno B,Pérez-Nievas BG,Fernández-Cruz A,Leza JC

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:The purpose of this study was to evaluate the ability of second-harmonic imaging to identify differences in corneal stromal collagen organization between normal human and keratoconus corneas. METHODS:Six normal corneas from eye bank donors and 13 corneas of patients with keratoconus, obtained after penetrating...

journal_title：Investigative ophthalmology & visual science

authors： Morishige N,Wahlert AJ,Kenney MC,Brown DJ,Kawamoto K,Chikama T,Nishida T,Jester JV

更新日期：2007-03-01 00:00:00

abstract：Purpose:To enumerate the ocular surface fungal microbiome of healthy human eyes by using next-generation sequencing (NGS). Methods:Tarsal and fornix conjunctiva from the lower and upper lids of both eyes of healthy individuals were swabbed in duplicate separately. A total of 34 samples were collected from both the eye...

journal_title：Investigative ophthalmology & visual science

authors： Shivaji S,Jayasudha R,Sai Prashanthi G,Kalyana Chakravarthy S,Sharma S

更新日期：2019-01-02 00:00:00

abstract：PURPOSE:To establish whether fucoidin, by blocking the adhesion of leukocytes on the limbal vascular endothelium, prevents extravasation of the cells from the blood stream into the limbal stroma and the wounded area after corneal injury. Successful leukocyte blocking enabled investigation of the influence of leukocytes...

journal_title：Investigative ophthalmology & visual science

authors： Gan L,Fagerholm P,Kim HJ

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:To evaluate changes in the multifocal electroretinogram (mfERG) in patients with neovascular age-related macular degeneration (nAMD) undergoing ranibizumab treatment. METHODS:This was an observational, longitudinal, prospective study. Treatment-naive patients with nAMD who met the inclusion and exclusion crite...

journal_title：Investigative ophthalmology & visual science

authors： Campa C,Hagan R,Sahni JN,Brown MC,Beare NA,Heimann H,Harding SP

更新日期：2011-06-01 00:00:00

abstract：Purpose:Little is known regarding the therapeutic effect of carbonic anhydrase inhibitors (CAIs) in the management of cystic macular lesions in children with X-linked juvenile retinoschisis (XLRS) despite the fact that this disease often manifests during childhood. Therefore, our goal was to determine the efficacy of C...

journal_title：Investigative ophthalmology & visual science

authors： Verbakel SK,van de Ven JP,Le Blanc LM,Groenewoud JM,de Jong EK,Klevering BJ,Hoyng CB

更新日期：2016-10-01 00:00:00

abstract：Purpose:To describe the phenotypic spectrum of retinal disease caused by the c.2991+1655A>G mutation in CEP290 and to compare disease severity between homozygous and compound heterozygous patients. Methods:Medical records were reviewed for best-corrected visual acuity (BCVA), age of onset, fundoscopy descriptions. Fov...

journal_title：Investigative ophthalmology & visual science

authors： Valkenburg D,van Cauwenbergh C,Lorenz B,van Genderen MM,Bertelsen M,Pott JR,Coppieters F,de Zaeytijd J,Thiadens AAHJ,Klaver CCW,Kroes HY,van Schooneveld MJ,Preising M,Hoyng CB,Leroy BP,van den Born LI,Collin RWJ

更新日期：2018-09-04 00:00:00

abstract：Purpose:To characterize intraocular pressure (IOP) dynamics by identifying the sources of transient IOP fluctuations and quantifying the frequency, magnitude, associated cumulative IOP-related mechanical energy, and temporal distribution. Methods:IOP was monitored at 500 Hz for periods of 16 to 451 days in nine normal...

journal_title：Investigative ophthalmology & visual science

authors： Turner DC,Edmiston AM,Zohner YE,Byrne KJ,Seigfreid WP,Girkin CA,Morris JS,Downs JC

更新日期：2019-06-03 00:00:00

abstract：PURPOSE:VEGF has been shown to be necessary, but not sufficient alone, for the development of subretinal pathologic angiogenesis. In the current study, the influence of placental growth factor (PlGF), a member of the VEGF family, in human and experimental choroidal neovascularization (CNV) was investigated. METHODS:Th...

journal_title：Investigative ophthalmology & visual science

authors： Rakic JM,Lambert V,Devy L,Luttun A,Carmeliet P,Claes C,Nguyen L,Foidart JM,Noël A,Munaut C

更新日期：2003-07-01 00:00:00

abstract：Purpose:To compare the changes in human tear proteome and clinical effects following topical cyclosporine A (CsA) 0.05% or diquafosol tetrasodium (DQS) 3% treatment of dry eye disease (DED), and to identify biomarkers for determining disease severity and treatment effectiveness in DED. Methods:A total of 18 patients w...

journal_title：Investigative ophthalmology & visual science

authors： Ji YW,Kim HM,Ryu SY,Oh JW,Yeo A,Choi CY,Kim MJ,Song JS,Kim HS,Seo KY,Kim KP,Lee HK

更新日期：2019-12-02 00:00:00